Ngowuphi umhlaza onokuzuza ngokubandakanya iVithamin B2 kwisidlo sabo?

Iimbalasane

I-Vitamin B2 iyaziwa ngokubanzi ngeenzuzo zayo zempilo kwaye isetyenziswa rhoqo ngabaguli abanomhlaza kunye nabo basengozini yemfuzo. Nangona kunjalo, ukhuseleko kunye nokusebenza kweVithamin B2 kwizigulana ezinomhlaza kuxhomekeke kwizinto ezininzi ezifana nesalathiso somhlaza, ichemotherapy, olunye unyango, kunye nemfuzo yethumba. Ukwazi ukuba ezinye ukutya kunye nezongezelelo, ezinje ngegrapefruit kunye nesipinatshi, zinokusebenzisana kakubi namayeza omhlaza kwaye zibangele ukusabela okubi kubalulekile.

Ukutya kubaluleke kakhulu kunyango lomhlaza njengoko kunokuchaphazela iziphumo zonyango. Izigulana ezinomhlaza kufuneka zikhethe ngononophelo kwaye zifake ukutya okufanelekileyo kunye nezongezo kwizidlo zabo. Umzekelo, iVithamin B2 inokuba luncedo kwabo banePrimary Angiocentric Glioma ephantsi kweLomustine, kodwa isenokungabi ilungile kwizigulana ezifumana iPembrolizumab yePrimary High-Grade Neuroepithelial Tumor. Ngapha koko, ngelixa i-Vitamin B2 inokunceda abantu abane-genetic risk factor "B2M", ayinakucetyiswa kwabo banomngcipheko ohlukileyo wemfuza "ASXL1". Ukwenza izicwangciso zokutya ezisekelwe kwimpilo, unyango, kunye nofuzo kubalulekile.

Ukuqonda ukuba ukwenza isigqibo malunga nokufaneleka kweVithamin B2 kwisigulana somhlaza kufuneka sibe ngumntu ngamnye kubalulekile. Izinto ezibalulekileyo ezifana nohlobo lomhlaza, iindlela zonyango, ukwakheka kwemfuzo, imingcipheko yemfuza, ubudala, ubunzima bomzimba, kunye nendlela yokuphila zibalulekile ekwenzeni isigqibo sokuba iVithamin B2 lukhetho olufanelekileyo. I-Genomics kunye ne-genomics, ngokukodwa, yingqwalasela ebalulekileyo. Kuba ezi zinto zinokuvela, kubalulekile ukuphonononga rhoqo kwaye ulungelelanise ukhetho lokutya ukuhambelana notshintsho kwisimo sempilo kunye nonyango.

Ukuqukumbela, indlela epheleleyo yokhetho lokutya ibalulekile, igxile kwiziphumo ezipheleleyo zazo zonke izinto ezisebenzayo kukutya / izongezo ezifana neVithamin B2 endaweni yokuvavanya isithako ngasinye esisebenzayo ngokwahlukileyo okanye ukungayinaki ngokupheleleyo. Lo mbono ubanzi ukhuthaza indlela enengqiqo nenzululwazi kwisicwangciso sokutya somhlaza.

Uluhlu olufutshane

Ukusetyenziswa kokutya okusekelwe kwizityalo kunye nezongezelelo, ezinje ngeevithamini, imifuno, iiminerali, iiprobiotics, kunye nezongezelelo ezahlukeneyo ezikhethekileyo, ziyenyuka phakathi kwabaguli abanomhlaza. Ezi zongezo ziyilelwe ukuhambisa ugxininiso oluphezulu lwezithako ezithile ezisebenzayo, uninzi lwazo zikwakukutya okwahlukeneyo. Ugxininiso kunye nokwahlukana kwezithako ezisebenzayo ziyahluka phakathi kokutya okupheleleyo kunye nezongezelelo. Ukutya ngokuqhelekileyo kunika uluhlu lwezithako ezisebenzayo kodwa kwiindawo ezisezantsi, ngelixa izongezelelo zibonelela ngoxinzelelo oluphezulu lwezithako ezithile.

Ukuthathela ingqalelo imisebenzi eyahlukeneyo yesayensi kunye neyebhayoloji yesithako ngasinye esisebenzayo kwinqanaba leemolekyuli, kubalulekile ukunika ingxelo ngeziphumo ezidityanisiweyo zala malungu xa uthatha isigqibo malunga nokutya kunye nezongezo eziza kutyiwa okanye hayi.

Umbuzo obalulekileyo uvela: Ngaba kufuneka udibanise i-Vitamin B2 ekudleni kwakho njengento yokutya okanye isongezelelo? Ngaba kuyacetyiswa ukuba utye iVithamin B2 ukuba unemfuza enokuthanani nomhlaza onxulumene nejini ye-B2M? Kuthekani ukuba endaweni yoko ingozi yakho yemfuza ivela kwi-ASXL1 gene? Ngaba kuluncedo ukuquka iVithamin B2 kwisidlo sakho ukuba ufunyaniswe uneTumor yeBanga eliPhakamileyo leNeuroepithelial, okanye ukuba uxilongo lwakho yiPrimary Angiocentric Glioma? Ngaphezu koko, kufuneka uhlengahlengiso njani ukusetyenziswa kwakho kweVithamin B2 ukuba ufumana unyango lweLomustine okanye ukuba isicwangciso sakho sonyango siyatshintsha sisuka eLomustine siye ePembrolizumab? Kubalulekile ukuqonda ukuba iinkcazo ezilula ezifana 'neVithamin B2 yendalo, ngoko isoloko iluncedo' okanye 'iVithamin B2 yomeleza ukhuselo lomzimba' akonelanga kukhetho lokutya / lokongezelela.

Ukongeza, kubalulekile ukuvavanya kwakhona ukufaneleka kokubandakanya iVithamin B2 kwisidlo sakho ukuba kukho utshintsho kwirejimeni yonyango lwakho. Isishwankathelo, xa usenza izigqibo malunga nokubandakanya ukutya okanye izongezo ezifana neVithamin B2 kwisidlo sakho ngezibonelelo zayo, kuya kufuneka uqwalasele iziphumo ezipheleleyo ze-biochemical yazo zonke izithako, uqwalasele izinto ezifana nohlobo lomhlaza, unyango oluthile olwenzayo, imfuzo. izinto ezilindelekileyo, kunye nokukhetha indlela yokuphila.

Cancer

Umhlaza usengumceli mngeni obalulekileyo kwicandelo lezonyango, ngokufuthi ubangela unxunguphalo oluxhaphakileyo. Nangona kunjalo, ukuqhubela phambili kwamva nje kuye kwaphucula iziphumo zonyango, ngakumbi ngeendlela zonyango zomntu, iindlela zokujonga ezingaphazamisiyo kusetyenziswa igazi kunye neesampulu zamathe, kunye nophuhliso lwe-immunotherapy. Ukufunyaniswa kwangethuba kunye nokungenelela kwangethuba kuye kwaba yinto ebalulekileyo ekuphembeleleni ngokufanelekileyo iziphumo zonyango ngokubanzi.

Uvavanyo lwemfuzo lunikeza isithembiso esibalulekileyo ekuvavanyeni umngcipheko womhlaza kunye nokuba sesichengeni kwangoko. Nangona kunjalo, kubantu abaninzi abaneemeko zosapho kunye nemfuzo kumhlaza, ukhetho longenelelo lonyango, nokuba lubekwe esweni rhoqo, luhlala lulinganiselwe okanye alukho. Nje ukuba kufunyaniswe ukuba unohlobo oluthile lomhlaza, njenge-Primary Angiocentric Glioma okanye i-Primary High-Grade Neuroepithelial Tumor, izicwangciso zonyango kufuneka zenziwe ngokusekwe kwi-tumor genetics yomntu, inqanaba lesi sifo, kunye nezinto ezifana nobudala kunye nesini. ”

Emva konyango, ukubeka iliso okuqhubekayo kubalulekile ukuze kubonwe naziphi na iimpawu zokubuyela kwakhona komhlaza kunye nokwazisa izigqibo ezilandelayo. Uninzi lwezigulana ezinomhlaza kunye nabo basemngciphekweni bahlala befuna iingcebiso malunga nokubandakanya ukutya okuthile kunye nezongezo kwizidlo zabo, ezidlala indima ebalulekileyo kwinkqubo yabo yokuthatha isigqibo malunga nolawulo lwezempilo.

Umbuzo obalulekileyo ngowokuba ingaba kujongwe kwimingcipheko yemfuza kunye noxilongo oluthile lomhlaza xa uthatha isigqibo malunga nokhetho lokutya, olufana neVithamin B2. Ngaba umngcipheko wemfuza womhlaza ovela kuguquko kwi-B2M unefuthe elifanayo le-biochemical pathway njengenguqu kwi-ASXL1? Ukusuka kwimbono yesondlo, ngaba umngcipheko ohambelana ne-Primary Angiocentric Glioma ulingana ne-Primary High-Grade Neuroepithelial Tumor? Ngapha koko, ngaba uqwalaselo lokutya luhlala lufana kwabo baphantsi kwePembrolizumab njengabo bafumana iLomustine? Ezi ngqwalasela zibalulekile ekwenzeni ukhetho lokutya olunolwazi lwabantu abaneengozi ezahlukeneyo zemfuza kunye nonyango lomhlaza.

I-Vitamin B2-Isongezelelo seSondlo

I-Vitamin B2 eyongezelelweyo iquka uluhlu lwezithako ezisebenzayo, kuquka i-Vitamin B2, nganye ekhoyo kwiimpawu ezahlukeneyo. Ezi zithako zinefuthe kwiindlela zeemolekyuli, ngokukodwa i-Oncogenic Cancer Epigenetics kunye ne-Oncogenic Histone Methylation, elawula imiba ebalulekileyo yomhlaza kwinqanaba leeselula, ezifana nokukhula kwethumba, ukusasazeka, kunye nokufa kweeseli. Ukunikezelwa kwale mpembelelo yebhayoloji, ukukhetha izongezo ezifanelekileyo njengeVithamin B2, iyodwa okanye ngokudibeneyo, iba sisigqibo esibalulekileyo kumxholo wesondlo somhlaza. Xa ucinga ukusebenzisa i-Vitamin B2 kumhlaza, kubalulekile ukuqwalasela ezi zinto zahlukeneyo kunye neendlela. Oku kungenxa yokuba, ngokufana nonyango lomhlaza, ukusetyenziswa kweVithamin B2 ayisosigqibo sehlabathi lonke esilungele zonke iicancer kodwa kufuneka ibe yeyomntu.

Ukukhetha izongezo zeVithamini B2

Ukuphendula umbuzo othi 'Ndifanele ndiyiphephe nini iVithamin B2 kwimeko yoMhlaza' kulucelomngeni kuba impendulo yeyomntu ngamnye kakhulu - ngokulula 'Kuxhomekeke!'. Ngokufana nendlela naluphi na unyango lomhlaza olunokuthi lungasebenzi kwisigulane ngasinye, ukubaluleka kunye nokhuseleko okanye izibonelelo zeVithamini B2 ziyahluka ngokuxhomekeke kwiimeko zomntu. Izinto ezifana nohlobo oluthile lomhlaza, i-genetic predispositions, unyango lwangoku, ezinye izongezo ezithathwayo, iindlela zokuphila, i-BMI, kunye naluphi na uhlobo lomzimba, zonke zidlala indima ekunqumeni ukuba i-Vitamin B2 ifanelekile okanye kufuneka igwenywe, igxininisa ukubaluleka koqwalaselo lomntu. kwizigqibo ezinjalo.

1. Ngaba izongezo zeVithamini B2 ziya kuzuzisa iZigulana ezikwiBanga eliPhezulu le-Neuroepithelial Tumor eziphantsi konyango lwe-Pembrolizumab?

I-Primary High-Grade Neuroepithelial Tumor ibonakaliswe ngokuguqulwa kofuzo oluthile, oko kukuthi, i-ASXL1, i-DNMT3A kunye ne-MYCN, ekhokelela kutshintsho kwiindlela ze-biochemical, ngokukodwa i-Oncogenic Cancer Epigenetics, i-Suppressive Histone Methylation, i-Focal Adhesion kunye ne-Cell Cycle. Ukusebenza konyango lomhlaza, njengePembrolizumab, kuxhomekeke kwindlela yokusebenza kwezi ndlela zithile. Esona sicwangciso sifanelekileyo siquka ukulungelelanisa isenzo sonyango kunye neendlela eziqhuba umhlaza, ngaloo ndlela kuqinisekiswa indlela yobuqu nesebenzayo. Kwiimeko ezinjalo, ukuphepha ukutya okanye izongezo zesondlo ezinokuchasa iziphumo zonyango okanye ukunciphisa olu lungelelwaniso kubalulekile. Ngokomzekelo, i-Vitamin B2 eyongezelelweyo, echaphazela i-Oncogenic Cancer Epigenetics, ayinakuba yinto efanelekileyo yokukhetha kwimeko ye-Primary High-Grade Neuroepithelial Tumor xa i-Pembrolizumab. Oku kungenxa yokuba isenokuthi iqhubele phambili ngakumbi isifo okanye iphazamise ukusebenza konyango. Xa ukhetha isicwangciso sesondlo, kubalulekile ukuqwalasela izinto ezifana nohlobo lomhlaza, unyango oluqhubekayo, ubudala, isini, i-BMI, indlela yokuphila, kunye naluphi na utshintsho olwaziwayo lwemfuzo.

2. Ngaba izongezo zeVithamin B2 ziya kuxhamla kwiZigulana zePrimary Angiocentric Glioma eziphantsi koNyango lweLomustine?

I-Primary Angiocentric Glioma ichongiwe ngoguquko oluthile lwemfuza, olufana ne-KMT2D, i-KRAS kunye ne-MEF2B, ebangela utshintsho kwiindlela ze-biochemical pathways, ngokukodwa i-Oncogenic Cancer Epigenetics, i-Oncogenic Histone Methylation, i-Amino Acid Metabolism, i-G-protein-coupled Receptor Signaling kunye ne-Growth Factor Signaling. . Ukusebenza konyango lomhlaza, njenge-Lomustine, kugqitywe ngokunxibelelana kwezi ndlela. Injongo kukuqinisekisa ukuba unyango luhambelana kakuhle neendlela eziqhuba umhlaza, okwenza kube nendlela yonyango lomntu. Kulo mxholo, ukutya okanye izongezo ezihambelana nonyango okanye ukuphucula oku kulungelelaniswa kufuneka kuthathelwe ingqalelo. Umzekelo, isongezelelo seVithamin B2 lukhetho olunengqiqo kwabo banePrimary Angiocentric Glioma ephantsi kweLomustine. Oku kungenxa yokuba i-Vitamin B2 inefuthe kwiindlela ezifana ne-Oncogenic Cancer Epigenetics, enokuthi ithintele izinto eziqhuba i-Primary Angiocentric Glioma okanye izuze ukusebenza kweLomustine.

3. Ingaba izongezo zeVithamin B2 zikhuselekile kubantu abasempilweni abaneASXL1 yoGuquko oluNxulumene neMngcipheko yemfuzo?

Iinkampani ezahlukeneyo zibonelela ngeephaneli zemfuza zokuvavanya umngcipheko wemfuza weentlobo ezahlukeneyo zomhlaza. Ezi panels ziquka imizila yemfuza enxulunyaniswa nebele, i-ovarian, i-uterine, i-prostate, kunye nomhlaza wesisu. Ukuvavanya ezi genes kunokuqinisekisa ukuxilongwa kunye nokwazisa unyango kunye nezicwangciso zokulawula. Ukuchonga umahluko obangela isifo kunokuncedisa ngakumbi ekuvavanyeni nasekuxilongweni kwezalamane ezinokuba sengozini. I-ASXL1 gene idla ngokubandakanywa kwezi panels zovavanyo lomngcipheko womhlaza.

Ukuguqulwa kwe-ASXL1 gene kuchaphazela iindlela ze-biochemical okanye iinkqubo, ezifana ne-Oncogenic Cancer Epigenetics kunye ne-Suppressive Histone Methylation, ezibandakanyeka ngokuthe ngqo okanye ngokungathanga ngqo ekuqhubeni umhlaza kwinqanaba le-molecular. Xa iphaneli yofuzo ichonga ukuguqulwa kwe-ASXL1 ehambelana nomngcipheko okhulayo we-Chronic Myelomonocytic Leukemia, ingqiqo yesayensi ibonisa ukuphepha ukusetyenziswa kwe-Vitamin B2. Oku kungenxa yokuba ukongeza i-Vitamin B2 ichaphazela iindlela ezifana ne-Oncogenic Cancer Epigenetics, enokukhokelela kwimiphumo emibi kumxholo wenguqu ye-ASXL1 kunye neemeko zomhlaza ezinxulumene nazo.

4. Ingaba izongezo zeVithamin B2 zikhuselekile kubantu abasempilweni abaneB2M yoGuquko oluNxulunyaniswe neMngcipheko yeMfuzo?

I-B2M idlala indima ebalulekileyo kuvavanyo lomngcipheko womhlaza. Ukuguqulwa kwe-B2M kunokuphazamisa iindlela ezibalulekileyo ze-biochemical, kuquka i-Oncogenic Histone Methylation kunye ne-Antigen Presentation, echaphazela ukuphuhliswa komhlaza. Ukuba iphaneli yakho yemfuza ityhila utshintsho kwi-B2M ehambelana ne-Diffuse Large B-cell Lymphoma, cinga ngokufaka izongezo ze-Vitamin B2 kwisicwangciso sakho sesondlo. Ezi zongezelelo zinokuphembelela kakuhle iindlela ezifana ne-Oncogenic Histone Methylation, inzuzo ngokubonelela ngenkxaso efanelekileyo kubantu abaneenguqu ze-B2M kunye neenkxalabo zempilo ezinxulumene nazo.

Ukuququmbela

Ezona zinto zimbini zibalulekileyo ekufuneka uzikhumbule kukuba unyango lomhlaza kunye nesondlo azinakuze zifane kumntu wonke. Isondlo, kubandakanya ukutya kunye nezongezelelo ezifana neVithamin B2, sisixhobo esisebenzayo esinokulawulwa nguwe ngelixa ujongene nomhlaza.

"Ndingatya ntoni?" ngowona mbuzo udla ngokubuzwa ngabaguli abanomhlaza kunye nabo basemngciphekweni womhlaza. Impendulo echanekileyo kukuba ixhomekeke kwizinto ezifana nohlobo lomhlaza, imfuzo yethumba, unyango lwangoku, ukungezwani komzimba, indlela yokuphila, kunye ne-BMI.

Fumana isondlo sakho somhlaza kwi-addon ngokucofa ikhonkco elingezantsi kwaye uphendule imibuzo malunga nohlobo lomhlaza wakho, unyango, indlela yokuphila, i-allergies, ubudala, kunye nesini.

Ucaphulo

• I-PD-1 blockade ibangela iimpendulo ngokuthintela ukuxhathisa okuguquguqukayo kwe-immune.
• I-Methyl Donor Micronutrients eguqula i-DNA Methylation kunye neSiphumo soMhlaza.
• Uguqulo lwe-IDH1/2 luphawu olulindelekileyo lokusinda kwaye luqikelela impendulo kwi-chemotherapy ye-gliomas yeBakala II enyangwe ngaxeshanye nonyango lwemitha.
• Unyango lomhlaza lubumba ubume bokuqina be-clonal hematopoiesis.
• Umsebenzi ophantsi we-LSD1 ufuna iprofayili ye-pro-inflammatory gene expression in riboflavin-deficially human T Lymphoma Jurkat cells.
• cBioPortal for Cancer Genomics