Ngowuphi umhlaza onokuzuza ngokubandakanya iVithamin B3 kwisidlo sabo?

Iimbalasane

I-Vitamin B3 iyaziwa ngokubanzi ngeenzuzo zayo zempilo kwaye isetyenziswa rhoqo ngabaguli abanomhlaza kunye nabo basengozini yemfuzo. Nangona kunjalo, ukhuseleko kunye nokusebenza kweVithamin B3 kwizigulana ezinomhlaza kuxhomekeke kwizinto ezininzi ezifana nesalathiso somhlaza, ichemotherapy, olunye unyango, kunye nemfuzo yethumba. Ukwazi ukuba ezinye ukutya kunye nezongezelelo, ezinje ngegrapefruit kunye nesipinatshi, zinokusebenzisana kakubi namayeza omhlaza kwaye zibangele ukusabela okubi kubalulekile.

Ukutya kubaluleke kakhulu kunyango lomhlaza njengoko kunokuchaphazela iziphumo zonyango. Izigulana ezinomhlaza kufuneka zikhethe ngononophelo kwaye zifake ukutya okufanelekileyo kunye nezongezo kwizidlo zabo. Umzekelo, iVithamin B3 inokuba luncedo kwabo bane-Primary Richter syndrome abafumana i-Doxorubicin, kodwa isenokungabi ilungile kwizigulana ezifumana iMitomycin yePrimary Penile Squamous Cell Carcinoma. Ngaphaya koko, ngelixa iVithamin B3 inokunceda abantu abanomngcipheko wemfuza "ERCC2", ayinakucetyiswa kwabo banomngcipheko wemfuzo owahlukileyo "ALK". Ukwenza izicwangciso zokutya ezisekelwe kwimpilo, unyango, kunye nofuzo kubalulekile.

Ukuqonda ukuba ukwenza isigqibo malunga nokufaneleka kweVithamin B3 kwisigulana somhlaza kufuneka sibe ngumntu ngamnye kubalulekile. Izinto ezibalulekileyo ezifana nohlobo lomhlaza, iindlela zonyango, ukwakheka kwemfuzo, imingcipheko yemfuza, ubudala, ubunzima bomzimba, kunye nendlela yokuphila zibalulekile ekwenzeni isigqibo sokuba iVithamin B3 lukhetho olufanelekileyo. I-Genomics kunye ne-genomics, ngokukodwa, yingqwalasela ebalulekileyo. Kuba ezi zinto zinokuvela, kubalulekile ukuphonononga rhoqo kwaye ulungelelanise ukhetho lokutya ukuhambelana notshintsho kwisimo sempilo kunye nonyango.

Ukuqukumbela, indlela epheleleyo yokhetho lokutya ibalulekile, igxile kwiziphumo ezipheleleyo zazo zonke izinto ezisebenzayo kukutya / izongezo ezifana neVithamin B3 endaweni yokuvavanya isithako ngasinye esisebenzayo ngokwahlukileyo okanye ukungayinaki ngokupheleleyo. Lo mbono ubanzi ukhuthaza indlela enengqiqo nenzululwazi kwisicwangciso sokutya somhlaza.

Uluhlu olufutshane

Ukusetyenziswa kokutya okusekelwe kwizityalo kunye nezongezelelo, ezinje ngeevithamini, imifuno, iiminerali, iiprobiotics, kunye nezongezelelo ezahlukeneyo ezikhethekileyo, ziyenyuka phakathi kwabaguli abanomhlaza. Ezi zongezo ziyilelwe ukuhambisa ugxininiso oluphezulu lwezithako ezithile ezisebenzayo, uninzi lwazo zikwakukutya okwahlukeneyo. Ugxininiso kunye nokwahlukana kwezithako ezisebenzayo ziyahluka phakathi kokutya okupheleleyo kunye nezongezelelo. Ukutya ngokuqhelekileyo kunika uluhlu lwezithako ezisebenzayo kodwa kwiindawo ezisezantsi, ngelixa izongezelelo zibonelela ngoxinzelelo oluphezulu lwezithako ezithile.

Ukuthathela ingqalelo imisebenzi eyahlukeneyo yesayensi kunye neyebhayoloji yesithako ngasinye esisebenzayo kwinqanaba leemolekyuli, kubalulekile ukunika ingxelo ngeziphumo ezidityanisiweyo zala malungu xa uthatha isigqibo malunga nokutya kunye nezongezo eziza kutyiwa okanye hayi.

Umbuzo obalulekileyo uvela: Ngaba ufanele udibanise i-Vitamin B3 ekudleni kwakho njengento yokutya okanye isongezelelo? Ngaba kuyacetyiswa ukuba utye iVithamin B3 ukuba unemfuza ekhokelela kumhlaza onxulumene ne-ERCC2 gene? Kuthekani ukuba endaweni yoko ingozi yakho yemfuza ivela kwi-ALK gene? Ngaba kunenzuzo ukuquka iVithamin B3 ekutyeni kwakho ukuba ufunyaniswe une-Primary Penile Squamous Cell Carcinoma, okanye ukuba uxilongo lwakho yiPrimary Richter syndrome? Ngaphezu koko, kufuneka uhlengahlengiso njani ukusetyenziswa kwakho kweVithamin B3 ukuba ufumana unyango lwe-Doxorubicin okanye ukuba isicwangciso sakho sonyango siyatshintsha sisuka kwi-Doxorubicin siye kwi-Mitomycin? Kubalulekile ukuqonda ukuba iinkcazo ezilula ezifana 'neVithamin B3 yendalo, ngoko isoloko iluncedo' okanye 'iVithamin B3 yomeleza ukhuselo lomzimba' ayonelanga kukhetho lokutya / lokongezelela olunolwazi.

Ukongeza, kubalulekile ukuvavanya kwakhona ukufaneleka kokubandakanya iVithamin B3 kwisidlo sakho ukuba kukho utshintsho kwirejimeni yonyango lwakho. Isishwankathelo, xa usenza izigqibo malunga nokubandakanya ukutya okanye izongezo ezifana neVithamin B3 kwisidlo sakho ngezibonelelo zayo, kuya kufuneka uqwalasele iziphumo ezipheleleyo ze-biochemical yazo zonke izithako, uqwalasele izinto ezifana nohlobo lomhlaza, unyango oluthile olwenzayo, imfuzo. izinto ezilindelekileyo, kunye nokukhetha indlela yokuphila.

Cancer

Umhlaza usengumceli mngeni obalulekileyo kwicandelo lezonyango, ngokufuthi ubangela unxunguphalo oluxhaphakileyo. Nangona kunjalo, ukuqhubela phambili kwamva nje kuye kwaphucula iziphumo zonyango, ngakumbi ngeendlela zonyango zomntu, iindlela zokujonga ezingaphazamisiyo kusetyenziswa igazi kunye neesampulu zamathe, kunye nophuhliso lwe-immunotherapy. Ukufunyaniswa kwangethuba kunye nokungenelela kwangethuba kuye kwaba yinto ebalulekileyo ekuphembeleleni ngokufanelekileyo iziphumo zonyango ngokubanzi.

Uvavanyo lwemfuzo lunikeza isithembiso esibalulekileyo ekuvavanyeni umngcipheko womhlaza kunye nokuba sesichengeni kwangoko. Nangona kunjalo, kubantu abaninzi abaneemeko zosapho kunye nemfuzo kumhlaza, ukhetho longenelelo lonyango, nokuba lubekwe esweni rhoqo, luhlala lulinganiselwe okanye alukho. Emva kokuba ufumene uhlobo oluthile lomhlaza, njenge-Primary Richter syndrome okanye i-Primary Penile Squamous Cell Carcinoma, izicwangciso zonyango kufuneka zenziwe ngokwezifiso ngokusekelwe kwi-tumor genetics yomntu, inqanaba lesi sifo, kunye nezinto ezifana nobudala kunye nesini.

Emva konyango, ukubeka iliso okuqhubekayo kubalulekile ukuze kubonwe naziphi na iimpawu zokubuyela kwakhona komhlaza kunye nokwazisa izigqibo ezilandelayo. Uninzi lwezigulana ezinomhlaza kunye nabo basemngciphekweni bahlala befuna iingcebiso malunga nokubandakanya ukutya okuthile kunye nezongezo kwizidlo zabo, ezidlala indima ebalulekileyo kwinkqubo yabo yokuthatha isigqibo malunga nolawulo lwezempilo.

Umbuzo obalulekileyo ngowokuba ingaba kujongwe imingcipheko yemfuza kunye noxilongo oluthile lomhlaza xa uthatha isigqibo malunga nokhetho lokutya, olufana neVithamin B3. Ngaba umngcipheko wemfuzo womhlaza osuka kutshintsho kwi-ERCC2 unefuthe elifanayo le-biochemical pathway njengokuguqulwa kwe-ALK? Ukususela kumbono wesondlo, ngaba ingozi ehambelana ne-Primary Richter syndrome ilingana ne-Primary Penile Squamous Cell Carcinoma? Ngaphaya koko, ngaba uqwalaselo lokutya luhlala lufana kwabo baphantsi kweMitomycin njengakwabo bafumana iDoxorubicin? Ezi ngqwalasela zibalulekile ekwenzeni ukhetho lokutya olunolwazi lwabantu abaneengozi ezahlukeneyo zemfuza kunye nonyango lomhlaza.

I-Vitamin B3-Isongezelelo seSondlo

I-Vitamin B3 eyongezelelweyo iquka uluhlu lwezithako ezisebenzayo, kuquka i-Vitamin B3, nganye ekhoyo kwiindawo ezahlukeneyo. Ezi zithako zinempembelelo kwiindlela zeemolekyuli, ngokukodwa ukulungiswa kwe-DNA, i-PI3K-AKT-MTOR Ukubonakaliswa kunye ne-Angiogenesis, elawula iinkalo ezibalulekileyo zomhlaza kwinqanaba leselula, ezifana nokukhula kwe-tumor, ukusasazeka, kunye nokufa kweeseli. Ukunikezelwa kwale mpembelelo yebhayoloji, ukukhetha izongezo ezifanelekileyo njengeVithamini B3, iyodwa okanye ngokudibeneyo, iba sisigqibo esibalulekileyo kumxholo wesondlo somhlaza. Xa ucinga ukusebenzisa i-Vitamin B3 kumhlaza, kubalulekile ukuqwalasela ezi zinto zahlukeneyo kunye neendlela. Oku kungenxa yokuba, ngokufana nonyango lomhlaza, ukusetyenziswa kweVithamin B3 ayisosigqibo sehlabathi lonke esilungele zonke iicancer kodwa kufuneka ibe yeyomntu.

Ukukhetha izongezo zeVithamini B3

Ukuphendula umbuzo othi 'Ndifanele ndiyiphephe nini iVithamin B3 kwimeko yoMhlaza' kulucelomngeni kuba impendulo yeyomntu ngamnye kakhulu - ngokulula 'Kuxhomekeke!'. Ngokufana nendlela naluphi na unyango lomhlaza olunokuthi lungasebenzi kwisigulane ngasinye, ukubaluleka kunye nokhuseleko okanye izibonelelo zeVithamini B3 ziyahluka ngokuxhomekeke kwiimeko zomntu. Izinto ezifana nohlobo oluthile lomhlaza, i-genetic predispositions, unyango lwangoku, ezinye izongezo ezithathwayo, iindlela zokuphila, i-BMI, kunye naluphi na uhlobo lomzimba, zonke zidlala indima ekunqumeni ukuba i-Vitamin B3 ifanelekile okanye kufuneka igwenywe, igxininisa ukubaluleka koqwalaselo lomntu. kwizigqibo ezinjalo.

1. Ingaba izongezo zeVithamin B3 ziya kunceda izigulana eziphantsi konyango lweMitomycin kwiPenile Squamous Cell Carcinoma?

I-Primary Penile Squamous Cell Carcinoma ibonakaliswe ngokuguqulwa kofuzo oluthile, okuyi-ABRAXAS1, i-PIK3CB kunye ne-NUP93, ekhokelela ekuguquleni kwiindlela ze-biochemical, ngokukodwa i-PI3K-AKT-MTOR Ukubonakaliswa, i-Hematopoiesis kunye ne-Inositol Phosphate Signaling. Ukusebenza konyango lomhlaza, njenge-Mitomycin, kuxhomekeke kwindlela yokusebenza kwezi ndlela zikhethekileyo. Esona sicwangciso sifanelekileyo siquka ukulungelelanisa isenzo sonyango kunye neendlela eziqhuba umhlaza, ngaloo ndlela kuqinisekiswa indlela yobuqu nesebenzayo. Kwiimeko ezinjalo, ukuphepha ukutya okanye izongezo zesondlo ezinokuchasa iziphumo zonyango okanye ukunciphisa olu lungelelwaniso kubalulekile. Ngokomzekelo, i-Vitamin B3 yongezelela, echaphazela i-PI3K-AKT-MTOR Ukubonakaliswa, ayinakuba yinto efanelekileyo kwimeko ye-Primary Penile Squamous Cell Carcinoma xa i-Mitomycin. Oku kungenxa yokuba isenokuthi iqhubele phambili ngakumbi isifo okanye iphazamise ukusebenza konyango. Xa ukhetha isicwangciso sesondlo, kubalulekile ukuqwalasela izinto ezifana nohlobo lomhlaza, unyango oluqhubekayo, ubudala, isini, i-BMI, indlela yokuphila, kunye naluphi na utshintsho olwaziwayo lwemfuzo.

2. Ingaba izongezo zeVithamini B3 ziya kuzuzisa i-Primary Richter syndrome Izigulana eziphantsi koNyango lwe-Doxorubicin?

I-syndrome ye-Primary Richter ichongiwe ngokuguqulwa kofuzo oluthile, njenge-MYC, i-TRAF3 kunye ne-TP53, ebangela utshintsho kwiindlela ze-biochemical, ngokukodwa i-DNA Repair, i-Noncoding RNA Signaling, i-MAPK Signaling, i-Cytokine Signaling, i-Antigen Presentation, i-Cell Cycle Checkpoints kunye ne-Apoptosis. Ukusebenza konyango lomhlaza, njenge-Doxorubicin, kumiselwa kukudibana kwayo nezi ndlela. Injongo kukuqinisekisa ukuba unyango luhambelana kakuhle neendlela eziqhuba umhlaza, okwenza kube nendlela yonyango lomntu. Kulo mxholo, ukutya okanye izongezo ezihambelana nonyango okanye ukuphucula oku kulungelelaniswa kufuneka kuthathelwe ingqalelo. Ngokomzekelo, isongezelelo se-Vitamin B3 lukhetho olunengqiqo kwabo bane-Primary Richter syndrome abafumana i-Doxorubicin. Oku kungenxa yokuba i-Vitamin B3 ichaphazela iindlela ezifana nokulungiswa kwe-DNA, enokuthi ithintele izinto eziqhuba i-Primary Richter syndrome okanye izuze ukusebenza kwe-Doxorubicin.

3. Ingaba izongezo zeVithamini B3 zikhuselekile kubantu abasempilweni abane-ALK Mutation eNxulunyaniswe neMngcipheko yeGenetic?

Iinkampani ezahlukeneyo zibonelela ngeephaneli zemfuza zokuvavanya umngcipheko wemfuza weentlobo ezahlukeneyo zomhlaza. Ezi panels ziquka imizila yemfuza enxulunyaniswa nebele, i-ovarian, i-uterine, i-prostate, kunye nomhlaza wesisu. Ukuvavanya ezi genes kunokuqinisekisa ukuxilongwa kunye nokwazisa unyango kunye nezicwangciso zokulawula. Ukuchonga umahluko obangela isifo kunokuncedisa ngakumbi ekuvavanyeni nasekuxilongweni kwezalamane ezinokuba sengozini. I-ALK gene idla ngokubandakanywa kwezi panels zovavanyo lomngcipheko womhlaza.

Ukuguqulwa kwe-ALK gene kuchaphazela iindlela ze-biochemical okanye iinkqubo, ezifana ne-Angiogenesis kunye ne-Growth Factor Signaling, ezibandakanyeka ngokuthe ngqo okanye ngokungathanga ngqo ekuqhubeni umhlaza kwinqanaba le-molecular. Xa iphaneli yezofuzo ichonga ukuguqulwa kwe-ALK ehambelana nomngcipheko owongeziweyo weNkqubo yeNervous ePhakathi, ingqiqo yesayensi icebisa ukuphepha ukusetyenziswa kwe-Vitamin B3. Oku kungenxa yokuba ukongeza i-Vitamin B3 inefuthe kwiindlela ezifana ne-Angiogenesis, enokukhokelela kwimiphumo emibi kumxholo wenguqu ye-ALK kunye neemeko zomhlaza ezinxulumene nazo.

4. Ingaba izongezo zeVithamin B3 zikhuselekile kubantu abasempilweni abaneERCC2 Mutation Associated Genetic Risk?

I-ERCC2 idlala indima ebalulekileyo kuvavanyo lomngcipheko womhlaza. Ukuguqulwa kwe-ERCC2 kunokuphazamisa iindlela ezibalulekileyo ze-biochemical, kuquka ukulungiswa kwe-DNA, echaphazela ukuphuhliswa komhlaza. Ukuba iphaneli yakho yemfuza ityhila utshintsho kwi-ERCC2 ehambelana noMhlaza woLusu, cinga ukufaka izongezo ze-Vitamin B3 kwisicwangciso sakho sesondlo. Ezi zongezo zinokuphembelela kakuhle iindlela ezifana nokulungiswa kwe-DNA, inzuzo ngokubonelela ngenkxaso efanelekileyo kubantu abanokuguqulwa kwe-ERCC2 kunye neenkxalabo zempilo ezinxulumeneyo.

Ukuququmbela

Ezona zinto zimbini zibalulekileyo ekufuneka uzikhumbule kukuba unyango lomhlaza kunye nesondlo azinakuze zifane kumntu wonke. Isondlo, kubandakanya ukutya kunye nezongezelelo ezifana neVithamin B3, sisixhobo esisebenzayo esinokulawulwa nguwe ngelixa ujongene nomhlaza.

"Ndingatya ntoni?" ngowona mbuzo udla ngokubuzwa ngabaguli abanomhlaza kunye nabo basemngciphekweni womhlaza. Impendulo echanekileyo kukuba ixhomekeke kwizinto ezifana nohlobo lomhlaza, imfuzo yethumba, unyango lwangoku, ukungezwani komzimba, indlela yokuphila, kunye ne-BMI.

Fumana isondlo sakho somhlaza kwi-addon ngokucofa ikhonkco elingezantsi kwaye uphendule imibuzo malunga nohlobo lomhlaza wakho, unyango, indlela yokuphila, i-allergies, ubudala, kunye nesini.

Ucaphulo

• INicotinamide iphucula ukulungiswa komonakalo we-DNA we-ultraviolet obangelwa yimitha kwi-keratinocytes yabantu kunye nolusu lwe-ex vivo.
• cBioPortal for Cancer Genomics
• Ukubonakaliswa kwe-epidermal growth factor receptors kwi-astrocytic glial kunye neeseli ze-neuronal kwinkcubeko yokuqala.
• I-Resveratrol imodareyitha ukwanda kweeseli ze-tumor kunye nokuguqulelwa kweprotheni nge-SIRT1-exhomekeke kwi-AMPK esebenzayo.
• Unyango lomhlaza lubumba ubume bokuqina be-clonal hematopoiesis.
• I-PARP inhibitor i-olaparib yenza isiphumo se-DNA eyonakalisayo ye-doxorubicin kwi-osteosarcoma.
• I-SIRT1 ikhuthaza umsebenzi wokulungisa i-DNA kunye ne-deacetylation ye-Ku70.