Ngowuphi umhlaza onokuxhamla ekufakeni iVithamin A ekutyeni kwabo?

Iimbalasane

IVithamin A yamkelwa ngokubanzi ngezibonelelo zayo zempilo kwaye isetyenziswa rhoqo ngabaguli abanomhlaza kunye nabo basengozini yemfuzo. Nangona kunjalo, ukhuseleko kunye nokusebenza kweVithamin A kwizigulana ezinomhlaza kuxhomekeke kwizinto ezininzi ezinjengomhlaza, ichemotherapy, olunye unyango, kunye nemfuza yethumba. Ukwazi ukuba ezinye ukutya kunye nezongezelelo, ezinje ngegrapefruit kunye nesipinatshi, zinokusebenzisana kakubi namayeza omhlaza kwaye zibangele ukusabela okubi kubalulekile.

Ukutya kubaluleke kakhulu kunyango lomhlaza njengoko kunokuchaphazela iziphumo zonyango. Izigulana ezinomhlaza kufuneka zikhethe ngononophelo kwaye zifake ukutya okufanelekileyo kunye nezongezo kwizidlo zabo. Umzekelo, iVithamin A inokuba luncedo kwabo baneNtloko yePrayimari kunye neNeck Squamous Cell Carcinoma ephantsi kweCisplatin, kodwa isenokungabi ilungile kwizigulana ezifumana iPembrolizumab yePrimary Infiltrating Lobular Carcinoma. Ngaphaya koko, ngexa iVithamin A inokunceda abantu abanomngcipheko wemfuzo “TERT”, ayinakucetyiswa kwabo banengozi yemfuzo eyahlukileyo “ERBB2”. Ukwenza izicwangciso zokutya ezisekelwe kwimpilo, unyango, kunye nofuzo kubalulekile.

Ukuqonda ukuba ukwenza isigqibo malunga nokufaneleka kweVithamin A kwisigulana somhlaza kufuneka sibe ngumntu ngamnye kubalulekile. Izinto ezibalulekileyo ezifana nohlobo lomhlaza, iindlela zonyango, ukwakheka kwemfuzo, imingcipheko yemfuza, ubudala, ubunzima bomzimba, kunye nendlela yokuphila zibalulekile ekwenzeni isigqibo sokuba iVithamin A lukhetho olufanelekileyo. I-Genomics kunye ne-genomics, ngokukodwa, yingqwalasela ebalulekileyo. Kuba ezi zinto zinokuvela, kubalulekile ukuphonononga rhoqo kwaye ulungelelanise ukhetho lokutya ukuhambelana notshintsho kwisimo sempilo kunye nonyango.

Ukuqukumbela, indlela ebanzi ekukhetheni ukutya ibalulekile, ijolise kwiziphumo ezipheleleyo zazo zonke izinto ezisebenzayo ekutyeni / nezongezo ezifana neVithamin A endaweni yokuvavanya isithako ngasinye esisebenzayo ngokwahlukileyo okanye ukungahoyi ngokupheleleyo. Lo mbono ubanzi ukhuthaza indlela enengqiqo nenzululwazi kwisicwangciso sokutya somhlaza.

Uluhlu olufutshane

Ukusetyenziswa kokutya okusekelwe kwizityalo kunye nezongezelelo, ezinje ngeevithamini, imifuno, iiminerali, iiprobiotics, kunye nezongezelelo ezahlukeneyo ezikhethekileyo, ziyenyuka phakathi kwabaguli abanomhlaza. Ezi zongezo ziyilelwe ukuhambisa ugxininiso oluphezulu lwezithako ezithile ezisebenzayo, uninzi lwazo zikwakukutya okwahlukeneyo. Ugxininiso kunye nokwahlukana kwezithako ezisebenzayo ziyahluka phakathi kokutya okupheleleyo kunye nezongezelelo. Ukutya ngokuqhelekileyo kunika uluhlu lwezithako ezisebenzayo kodwa kwiindawo ezisezantsi, ngelixa izongezelelo zibonelela ngoxinzelelo oluphezulu lwezithako ezithile.

Ukuthathela ingqalelo imisebenzi eyahlukeneyo yesayensi kunye neyebhayoloji yesithako ngasinye esisebenzayo kwinqanaba leemolekyuli, kubalulekile ukunika ingxelo ngeziphumo ezidityanisiweyo zala malungu xa uthatha isigqibo malunga nokutya kunye nezongezo eziza kutyiwa okanye hayi.

Umbuzo obalulekileyo uvela: Ngaba kufuneka udibanise i-Vitamin A kwisidlo sakho njengento yokutya okanye isongezelelo? Ngaba kuyacetyiswa ukuba utye iVithamin A ukuba unemfuzo enokuthanani nomhlaza onxulunyaniswa nofuzo lwe-TERT? Kuthekani ukuba endaweni yoko ingozi yakho yemfuza ivela kwi-ERBB2 gene? Ngaba kunenzuzo ukuquka iVithamin A ekutyeni kwakho ukuba ufunyaniswe une-Primary Infiltrating Lobular Carcinoma, okanye ukuba uxilongo lwakho yiNtloko yeNtloko kunye neNeck Squamous Cell Carcinoma? Ngaphezu koko, kufuneka kuhlengahlengiswe njani ukusetyenziswa kwakho kweVithamin A ukuba ufumana unyango lweCisplatin okanye ukuba isicwangciso sakho sonyango siyatshintsha sisuka eCisplatin siye ePembrolizumab? Kubalulekile ukuqonda ukuba iinkcazo ezilula ezifana 'neVithamin A yendalo, ngoko isoloko iluncedo' okanye 'iVithamin A yomeleza ukhuselo lomzimba' ayonelanga ekukhetheni ukutya/yezongezo ezinolwazi.

Ukongeza, kubalulekile ukuba uphinde uvavanye ukufaneleka kokuquka iVithamin A kwisidlo sakho ukuba kukho utshintsho kwirejimeni yonyango lwakho. Isishwankathelo, xa usenza izigqibo malunga nokubandakanya ukutya okanye izongezo ezifana neVithamin A kwisidlo sakho ngezibonelelo zayo, kuya kufuneka uqwalasele iziphumo zebhayoloji yazo zonke izithako, uqwalasele izinto ezifana nohlobo lomhlaza, unyango oluthile olwenzayo, imfuzo. izinto ezilindelekileyo, kunye nokukhetha indlela yokuphila.

Cancer

Umhlaza usengumceli mngeni obalulekileyo kwicandelo lezonyango, ngokufuthi ubangela unxunguphalo oluxhaphakileyo. Nangona kunjalo, ukuqhubela phambili kwamva nje kuye kwaphucula iziphumo zonyango, ngakumbi ngeendlela zonyango zomntu, iindlela zokujonga ezingaphazamisiyo kusetyenziswa igazi kunye neesampulu zamathe, kunye nophuhliso lwe-immunotherapy. Ukufunyaniswa kwangethuba kunye nokungenelela kwangethuba kuye kwaba yinto ebalulekileyo ekuphembeleleni ngokufanelekileyo iziphumo zonyango ngokubanzi.

Uvavanyo lwemfuzo lunikeza isithembiso esibalulekileyo ekuvavanyeni umngcipheko womhlaza kunye nokuba sesichengeni kwangoko. Nangona kunjalo, kubantu abaninzi abaneemeko zosapho kunye nemfuzo kumhlaza, ukhetho longenelelo lonyango, nokuba lubekwe esweni rhoqo, luhlala lulinganiselwe okanye alukho. Emva kokuba ufumene uhlobo oluthile lomhlaza, njengeNtloko yePrayimari kunye neNeck Squamous Cell Carcinoma okanye i-Primary Infiltrating Lobular Carcinoma, izicwangciso zonyango kufuneka zenziwe ngokwezifiso ngokusekelwe kwi-tumor genetics yomntu, inqanaba lesi sifo, kunye nezinto ezifana nobudala kunye . isini.”

Emva konyango, ukubeka iliso okuqhubekayo kubalulekile ukuze kubonwe naziphi na iimpawu zokubuyela kwakhona komhlaza kunye nokwazisa izigqibo ezilandelayo. Uninzi lwezigulana ezinomhlaza kunye nabo basemngciphekweni bahlala befuna iingcebiso malunga nokubandakanya ukutya okuthile kunye nezongezo kwizidlo zabo, ezidlala indima ebalulekileyo kwinkqubo yabo yokuthatha isigqibo malunga nolawulo lwezempilo.

Umbuzo obalulekileyo kukuba ingaba umngcipheko wezofuzo kunye nokuxilongwa komhlaza othile xa usenza isigqibo malunga nokhetho lokutya, olufana ne-Vitamin A. Ngaba umngcipheko wofuzo womhlaza ovela kwinguqu kwi-TERT unefuthe elifanayo le-biochemical pathway njengenguqu kwi-ERBB2 ? Ukusuka kumbono wesondlo, ngaba umngcipheko ohambelana neNtloko yePrayimari kunye neNeck Squamous Cell Carcinoma ilingana nePrimary Infiltrating Lobular Carcinoma? Ngaphaya koko, ngaba uqwalaselo lokutya luhlala lufana kwabo baphantsi kwePembrolizumab njengakwabo bafumana iCisplatin? Ezi ngqwalasela zibalulekile ekwenzeni ukhetho lokutya olunolwazi lwabantu abaneengozi ezahlukeneyo zemfuza kunye nonyango lomhlaza.

IVithamin A-Isongezelelo seSondlo

I-Vitamin A eyongezelelweyo iquka uluhlu lwezithako ezisebenzayo, kuquka i-Vitamin A, nganye ekhoyo kwiindawo ezahlukeneyo. Ezi zithako zinefuthe kwiindlela zeemolekyuli, ngokukodwa i-WNT Beta Catenin Signaling, i-PI3K-AKT-MTOR Ukubonakaliswa kunye ne-Apoptosis, elawula imiba ebalulekileyo yomhlaza kwinqanaba leeselula, ezifana nokukhula kwethumba, ukusasazeka, kunye nokufa kweeseli. Ukunikezelwa kwale mpembelelo yebhayoloji, ukukhetha izongezo ezifanelekileyo njengeVithamin A, iyodwa okanye ngokudibeneyo, iba sisigqibo esibalulekileyo kumxholo wesondlo somhlaza. Xa ucinga ukusebenzisa iVithamin A kumhlaza, kubalulekile ukuqwalasela ezi zinto zahlukeneyo kunye neendlela. Oku kungenxa yokuba, ngokufanayo nonyango lomhlaza, ukusetyenziswa kweVithamin A ayisosigqibo sehlabathi lonke esilungele zonke iimhlaza kodwa kufuneka ibe yeyomntu.

Ukukhetha izongezo zeVithamini A

Ukuphendula umbuzo othi 'Ndifanele ndiyiphephe nini iVithamin A kwimeko yoMhlaza' kulucelomngeni kuba impendulo yeyomntu ngamnye kakhulu - ngokulula 'Kuxhomekeke!'. Ngokufana nendlela naluphi na unyango lomhlaza olunokuthi lungasebenzi kwisigulana ngasinye, ukubaluleka kunye nokhuseleko okanye iinzuzo zeVithamini A ziyahluka ngokuxhomekeke kwiimeko zomntu. Izinto ezifana nohlobo oluthile lomhlaza, i-genetic predispositions, unyango lwangoku, ezinye izongezo ezithathwayo, indlela yokuphila, i-BMI, kunye nayo nayiphi na i-allergies, zonke zidlala indima ekunqumeni ukuba i-Vitamin A ifanelekile okanye ifanele ukuphetshwa, kugxininisa ukubaluleka koqwalaselo lomntu. kwizigqibo ezinjalo.

1. Ngaba izongezo zeVithamin A ziya kuxhamla kwiZigulana eziNgena Phambili kwiLobular Carcinoma eziphantsi konyango lwePembrolizumab?

I-Primary Infiltrating Lobular Carcinoma ibonakaliswe ngokuguqulwa kofuzo oluthile, okuyi-ABCA8, i-PDE6C kunye ne-RUBCN, ekhokelela ekuguquleni kwiindlela ze-biochemical, ngokukodwa i-PI3K-AKT-MTOR Umqondiso. Ukusebenza konyango lomhlaza, njengePembrolizumab, kuxhomekeke kwindlela yokusebenza kwezi ndlela zithile. Esona sicwangciso sifanelekileyo siquka ukulungelelanisa isenzo sonyango kunye neendlela eziqhuba umhlaza, ngaloo ndlela kuqinisekiswa indlela yobuqu nesebenzayo. Kwiimeko ezinjalo, ukuphepha ukutya okanye izongezo zesondlo ezinokuchasa iziphumo zonyango okanye ukunciphisa olu lungelelwaniso kubalulekile. Ngokomzekelo, i-Vitamin A yongezelela, echaphazela i-PI3K-AKT-MTOR Ukubonakaliswa, ayinakuba yinto ekhethekileyo kwimeko ye-Primary Infiltrating Lobular Carcinoma xa i-Pembrolizumab. Oku kungenxa yokuba isenokuthi iqhubele phambili ngakumbi isifo okanye iphazamise ukusebenza konyango. Xa ukhetha isicwangciso sesondlo, kubalulekile ukuqwalasela izinto ezifana nohlobo lomhlaza, unyango oluqhubekayo, ubudala, isini, i-BMI, indlela yokuphila, kunye naluphi na utshintsho olwaziwayo lwemfuzo.

2. Ngaba izongezo zeVithamini A ziya kuzuzisa iZigulana zeCarcinoma eziNgqonyela kwiNtloko kunye neNtamo kwiZigulana eziphantsi koNyango lweCisplatin?

Intloko eyiNtloko kunye neNeck Squamous Cell Carcinoma ichongiwe ngokuguqulwa kwemfuza ethile, njenge-FRG1BP, TP53 kunye ne-PCDH11X, ebangela utshintsho kwiindlela ze-biochemical, ngokukodwa i-WNT Beta Catenin Signaling, i-Cell Cycle Checkpoints kunye ne-Apoptosis. Ukusebenza konyango lomhlaza, njengeCisplatin, kumiselwa yintsebenziswano nezi ndlela. Injongo kukuqinisekisa ukuba unyango luhambelana kakuhle neendlela eziqhuba umhlaza, okwenza kube nendlela yonyango lomntu. Kulo mxholo, ukutya okanye izongezo ezihambelana nonyango okanye ukuphucula oku kulungelelaniswa kufuneka kuthathelwe ingqalelo. Umzekelo, isongezelelo seVithamini A lukhetho olunengqiqo kwabo baneNtloko eyiNtloko kunye neNeck Squamous Cell Carcinoma ehamba neCisplatin. Oku kungenxa yokuba i-Vitamin A ichaphazela iindlela ezifana ne-WNT Beta Catenin Signaling, enokuthi ithintele izinto eziqhuba iNtloko yeNtloko kunye neNeck Squamous Cell Carcinoma okanye izuze ukusebenza kweCisplatin.

3. Ingaba izongezo zeVithamin A zikhuselekile kubantu abasempilweni abaneERBB2 Mutation Associated Genetic Risk?

Iinkampani ezahlukeneyo zibonelela ngeephaneli zemfuza zokuvavanya umngcipheko wemfuza weentlobo ezahlukeneyo zomhlaza. Ezi panels ziquka imizila yemfuza enxulunyaniswa nebele, i-ovarian, i-uterine, i-prostate, kunye nomhlaza wesisu. Ukuvavanya ezi genes kunokuqinisekisa ukuxilongwa kunye nokwazisa unyango kunye nezicwangciso zokulawula. Ukuchonga umahluko obangela isifo kunokuncedisa ngakumbi ekuvavanyeni nasekuxilongweni kwezalamane ezinokuba sengozini. I-gene ye-ERBB2 idla ngokubandakanywa kwezi panels zovavanyo lomngcipheko womhlaza.

Ukuguqulwa kwe-gene ye-ERBB2 kuchaphazela iindlela ze-biochemical okanye iinkqubo, ezifana ne-Growth Factor Signaling kunye ne-PI3K-AKT-MTOR Signaling, ezibandakanyeka ngokuthe ngqo okanye ngokungathanga ngqo ekuqhubeni umhlaza kwinqanaba le-molecular. Xa iphaneli yezofuzo ichaza ukuguqulwa kwe-ERBB2 ehambelana nomngcipheko okhulayo we-Esophageal Adenocarcinoma, ingqiqo yesayensi ibonisa ukuphepha ukusetyenziswa kwe-vitamin A. Oku kungenxa yokuba ukongeza i-Vitamin A ichaphazela iindlela ezifana ne-PI3K-AKT-MTOR Ukubonakaliswa, oku kunokukhokelela ekuchaseni kakubi. iziphumo kumxholo we-ERBB2 ukuguqulwa kunye neemeko zomhlaza ezinxulumene nazo.

4. Ingaba izongezo zeVithamin A zikhuselekile kuBantu abasempilweni abane-TERT Mutation eManyaniswa neMngcipheko yeGenetic?

I-TERT idlala indima ebalulekileyo kuvavanyo lomngcipheko womhlaza. Utshintsho kwi-TERT lunokuphazamisa iindlela ezibalulekileyo ze-biochemical, kubandakanywa i-Apoptosis kunye nokulungiswa kwe-DNA, ezichaphazela ukukhula komhlaza. Ukuba iphaneli yakho yemfuza ityhila utshintsho kwi-TERT enxulumene noMhlaza we-Hematological, cinga ngokubandakanya izongezo zeVithamini A kwisicwangciso sakho sesondlo. Ezi zongezo zinokuphembelela ngendlela eyiyo iindlela ezifana ne-Apoptosis, inzuzo ngokubonelela ngenkxaso efanelekileyo kubantu abanotshintsho lwe-TERT kunye neenkxalabo zempilo ezinxulumeneyo.

Ukuququmbela

Ezona zinto zimbini zibalulekileyo ekufuneka uzikhumbule kukuba unyango lomhlaza kunye nesondlo azinakuze zifane kumntu wonke. Isondlo, kuquka ukutya kunye nezongezo ezifana neVithamin A, sisixhobo esisebenzayo esinokulawulwa nguwe ngelixa ujongene nomhlaza.

"Ndingatya ntoni?" ngowona mbuzo udla ngokubuzwa ngabaguli abanomhlaza kunye nabo basemngciphekweni womhlaza. Impendulo echanekileyo kukuba ixhomekeke kwizinto ezifana nohlobo lomhlaza, imfuzo yethumba, unyango lwangoku, ukungezwani komzimba, indlela yokuphila, kunye ne-BMI.

Fumana isondlo sakho somhlaza kwi-addon ngokucofa ikhonkco elingezantsi kwaye uphendule imibuzo malunga nohlobo lomhlaza wakho, unyango, indlela yokuphila, i-allergies, ubudala, kunye nesini.

Ucaphulo

• I-Wnt/β‑catenin inhibition ibuyisela umva ukunganyangeki kweziyobisi kwi-acute lymphoblastic leukemia yabantwana.
• cBioPortal for Cancer Genomics
• Ukonyuka kwe-serum thyrotropin ngokucacileyo kwizigulana ze-euthyroid hypercholesterolemic: ngaba ithetha i-occult hypothyroidism?
• Uhlalutyo lolandelelwano lweenguqu kunye nokudluliselwa kuzo zonke iintlobo zomhlaza wamabele.
• cBioPortal for Cancer Genomics
• Ilahleko ye-PTEN ikhuthaza ukuxhathisa kwi-T Cell-Mediated Immunotherapy.
• Uhlalutyo lwe-pan-cancer lwe-genomes epheleleyo.
• I-Vitamin A ilawula ukubonakaliswa kwe-Akt ngokusebenzisa i-phospholipid fatty acid composition.
• I-Retinol inciphisa amanqanaba eprotheyini ye-beta-catenin kwimigca yeseli ye-retinoic acid-resistant colon cancer.