Ngowuphi umhlaza onokuzuza ngokubandakanya i-Lutein kwisidlo sabo?

Iimbalasane

I-Lutein yaziwa ngokubanzi ngezibonelelo zayo zempilo kwaye isetyenziswa rhoqo ngabaguli abanomhlaza kunye nabo basengozini yemfuza. Nangona kunjalo, ukhuseleko kunye nokusebenza kweLutein kwizigulana ezinomhlaza kuxhomekeke kwizinto ezininzi ezinjengomhlaza, ichemotherapy, olunye unyango, kunye nemfuza yethumba. Ukwazi ukuba okunye ukutya kunye nezongezelelo, ezinje ngegrapefruit kunye nesipinatshi, zinokusebenzisana kakubi namayeza omhlaza kwaye zibangele ukusabela okubi kubalulekile.

Ukutya kubaluleke kakhulu kunyango lomhlaza njengoko kunokuchaphazela iziphumo zonyango. Izigulana ezinomhlaza kufuneka zikhethe ngononophelo kwaye zifake ukutya okufanelekileyo kunye nezongezo kwizidlo zabo. Ngokomzekelo, i-Lutein inokuzuza abo bane-Primary Low-Grade Serous Ovarian Cancer ehamba ne-Cisplatin, kodwa isenokungabi kuhle kwizigulane ezifumana i-Ibrutinib ye-Primary Waldenstrom Macroglobulinemia. Ngaphaya koko, ngelixa i-Lutein inokunceda abantu abane-genetic risk factor "CDH1", ayinakucetyiswa kwabo banomngcipheko wofuzo owahlukileyo "CALR". Ukwenza izicwangciso zokutya ezisekelwe kwimpilo, unyango, kunye nofuzo kubalulekile.

Ukuqonda ukuba ukwenza isigqibo malunga nokufaneleka kweLutein kwisigulana somhlaza kufuneka sibe ngumntu ngamnye kubalulekile. Izinto ezibalulekileyo ezifana nohlobo lomhlaza, iindlela zonyango, ukwakheka kwemfuzo, umngcipheko wemfuza, ubudala, ubunzima bomzimba, kunye nendlela yokuphila zibalulekile ekuthatheni isigqibo sokuba iLutein lukhetho olufanelekileyo. I-Genomics kunye ne-genomics, ngokukodwa, yingqwalasela ebalulekileyo. Kuba ezi zinto zinokuvela, kubalulekile ukuphonononga rhoqo kwaye ulungelelanise ukhetho lokutya ukuhambelana notshintsho kwisimo sempilo kunye nonyango.

Ukuqukumbela, indlela epheleleyo yokhetho lokutya ibalulekile, ijolise kwiziphumo ezipheleleyo zazo zonke izinto ezisebenzayo kukutya / izongezo ezifana neLutein endaweni yokuvavanya isithako ngasinye esisebenzayo ngokwahlukileyo okanye ukungayinaki ngokupheleleyo. Lo mbono ubanzi ukhuthaza indlela enengqiqo nenzululwazi kwisicwangciso sokutya somhlaza.

Uluhlu olufutshane

Ukusetyenziswa kokutya okusekelwe kwizityalo kunye nezongezelelo, ezinje ngeevithamini, imifuno, iiminerali, iiprobiotics, kunye nezongezelelo ezahlukeneyo ezikhethekileyo, ziyenyuka phakathi kwabaguli abanomhlaza. Ezi zongezo ziyilelwe ukuhambisa ugxininiso oluphezulu lwezithako ezithile ezisebenzayo, uninzi lwazo zikwakukutya okwahlukeneyo. Ugxininiso kunye nokwahlukana kwezithako ezisebenzayo ziyahluka phakathi kokutya okupheleleyo kunye nezongezelelo. Ukutya ngokuqhelekileyo kunika uluhlu lwezithako ezisebenzayo kodwa kwiindawo ezisezantsi, ngelixa izongezelelo zibonelela ngoxinzelelo oluphezulu lwezithako ezithile.

Ukuthathela ingqalelo imisebenzi eyahlukeneyo yesayensi kunye neyebhayoloji yesithako ngasinye esisebenzayo kwinqanaba leemolekyuli, kubalulekile ukunika ingxelo ngeziphumo ezidityanisiweyo zala malungu xa uthatha isigqibo malunga nokutya kunye nezongezo eziza kutyiwa okanye hayi.

Umbuzo obalulekileyo uvela: Ngaba kufuneka udibanise iLutein kwisidlo sakho njengento yokutya okanye isongezelelo? Ngaba kuyacetyiswa ukuba utye i-Lutein ukuba unemfuzo yomhlaza ohambelana ne-CDH1 gene? Kuthekani ukuba endaweni yoko umngcipheko wakho wemfuza uvela kumfuza we-CALR? Ngaba kunenzuzo ukuquka iLutein ekutyeni kwakho ukuba ufunyaniswe unePrimary Waldenstrom Macroglobulinemia, okanye ukuba uxilongo lwakho luyiPrimary Low-Grade Serous Ovarian Cancer? Ngaphezu koko, ukusetyenziswa kwakho kweLutein kufuneka kuhlengahlengiswe njani ukuba ufumana unyango lweCisplatin okanye ukuba isicwangciso sakho sonyango siyatshintsha ukusuka eCisplatin ukuya kwi-Ibrutinib? Kubalulekile ukuqaphela ukuba iinkcazo ezilula ezifana 'neLutein yendalo, ngoko isoloko iluncedo' okanye 'iLutein yonyusa ukhuselo lomzimba' akonelanga kukhetho lokutya / lokongezelela.

Ukongeza, kubalulekile ukuvavanya kwakhona ukufaneleka kokubandakanya i-Lutein kwisidlo sakho ukuba kukho utshintsho kwirejimeni yonyango lwakho. Isishwankathelo, xa usenza izigqibo malunga nokubandakanya ukutya okanye izongezo ezifana neLutein kwisidlo sakho ngezibonelelo zayo, kuya kufuneka uthathele ingqalelo ifuthe le-biochemical yazo zonke izithako, uqwalasele izinto ezifana nohlobo lomhlaza, unyango oluthile olwenzayo, i-genetic predispositions. , kunye nokukhetha indlela yokuphila.

Cancer

Umhlaza usengumceli mngeni obalulekileyo kwicandelo lezonyango, ngokufuthi ubangela unxunguphalo oluxhaphakileyo. Nangona kunjalo, ukuqhubela phambili kwamva nje kuye kwaphucula iziphumo zonyango, ngakumbi ngeendlela zonyango zomntu, iindlela zokujonga ezingaphazamisiyo kusetyenziswa igazi kunye neesampulu zamathe, kunye nophuhliso lwe-immunotherapy. Ukufunyaniswa kwangethuba kunye nokungenelela kwangethuba kuye kwaba yinto ebalulekileyo ekuphembeleleni ngokufanelekileyo iziphumo zonyango ngokubanzi.

Uvavanyo lwemfuzo lunikeza isithembiso esibalulekileyo ekuvavanyeni umngcipheko womhlaza kunye nokuba sesichengeni kwangethuba. Nangona kunjalo, kubantu abaninzi abaneemeko zosapho kunye nemfuzo kumhlaza, ukhetho longenelelo lonyango, nokuba lubekwe esweni rhoqo, luhlala lulinganiselwe okanye lungabikho. Nje ukuba kufunyaniswe ukuba unohlobo oluthile lomhlaza, njengePrimary Low-Grade Serous Ovarian Cancer or Primary Waldenstrom Macroglobulinemia, izicwangciso zonyango kufuneka zenziwe ngokwezifiso ngokusekelwe kwi-tumor genetics yomntu, inqanaba lesi sifo, kunye nezinto ezifana nobudala kunye nesini. .”

Emva konyango, ukubeka iliso okuqhubekayo kubalulekile ukuze kubonwe naziphi na iimpawu zokubuyela kwakhona komhlaza kunye nokwazisa izigqibo ezilandelayo. Uninzi lwezigulana ezinomhlaza kunye nabo basemngciphekweni bahlala befuna iingcebiso malunga nokubandakanya ukutya okuthile kunye nezongezo kwizidlo zabo, ezidlala indima ebalulekileyo kwinkqubo yabo yokuthatha isigqibo malunga nolawulo lwezempilo.

Umbuzo obalulekileyo ngowokuba ingaba kunokubangela imingcipheko yemfuza kunye noxilongo oluthile lomhlaza xa uthatha isigqibo malunga nokhetho lokutya, olufana noLutein. Ngaba umngcipheko wemfuzo womhlaza osuka kutshintsho kwi-CDH1 unefuthe elifanayo le-biochemical pathway njengotshintsho kwi-CALR? Ukusuka kwimbono yesondlo, ngaba umngcipheko ohambelana ne-Primary Low-Grade Serous Ovarian Cancer ulingana nePrimary Waldenstrom Macroglobulinemia? Ngapha koko, ngaba ukuqwalaselwa kokutya kuhlala kuyafana kwabo baphantsi kwe-Ibrutinib njengakwabo bafumana iCisplatin? Ezi ngqwalasela zibalulekile ekwenzeni ukhetho lokutya olunolwazi lwabantu abaneengozi ezahlukeneyo zemfuza kunye nonyango lomhlaza.

I-Lutein – Isongezo seSondlo

I-Lutein eyongezelelweyo iquka uluhlu lwezithako ezisebenzayo, kuquka i-Lutein, nganye ekhoyo kwiindawo ezahlukeneyo. Ezi zithako zinefuthe kwiindlela ze-molecular, ngokukodwa i-WNT Beta Catenin Signaling, i-NFKB Signaling, i-Retinoic Acid Signaling kunye ne-Epithelial kwi-Mesenchymal Transition, elawula iinkalo ezibalulekileyo zomhlaza kwinqanaba leselula, ezifana nokukhula kwe-tumor, ukusasazeka, kunye nokufa kweseli. Ukunikezelwa kwale mpembelelo yebhayoloji, ukukhetha izongezo ezifanelekileyo njengeLutein, yedwa okanye ngokudibeneyo, iba sisigqibo esibalulekileyo kumxholo wesondlo somhlaza. Xa ucinga ukusebenzisa iLutein kumhlaza, kubalulekile ukuqwalasela ezi zinto zahlukeneyo kunye neendlela. Oku kungenxa yokuba, ngokufana nonyango lomhlaza, ukusetyenziswa kwe-Lutein ayisosigqibo sehlabathi lonke esilungele zonke ii-cancer kodwa kufuneka ibe yeyomntu.

Ukukhetha iLutein Supplements

Ukuphendula umbuzo othi 'Ndingayiphepha nini i-Lutein kwimeko yoMhlaza' kulucelomngeni kuba impendulo yeyomntu ngamnye kakhulu - ngokulula 'Kuxhomekeke!'. Ngokufana nendlela naluphi na unyango lomhlaza olunokuthi lungasebenzi kwisigulane ngasinye, ukubaluleka kunye nokhuseleko okanye izibonelelo zeLutein ziyahluka ngokuxhomekeke kwiimeko zomntu. Izinto ezifana nohlobo oluthile lomhlaza, i-genetic predispositions, unyango lwangoku, ezinye izongezo ezithathwayo, iindlela zokuphila, i-BMI, kunye naluphi na uhlobo oluthile lwe-allergies, zonke zidlala indima ekunqumeni ukuba i-Lutein ifanelekile okanye kufuneka igwenywe, igxininisa ukubaluleka koqwalaselo lomntu izigqibo ezinjalo.

1. Ngaba iLutein Supplements iya kunceda i-Primary Waldenstrom Macroglobulinemia Izigulane eziphantsi konyango lwe-Ibrutinib?

I-Primary Waldenstrom Macroglobulinemia ibonakaliswe ngokuguqulwa kofuzo oluthile, okuyi-ARID1A, IGF1R kunye ne-MAP3K1, ekhokelela ekuguquleni kwiindlela ze-biochemical pathways, ngokukodwa i-NFKB Signaling, i-Androgen Signaling, i-Chromatin Remodeling, i-Growth Factor Signaling, i-PI3K-AKT Signaling kunye ne-MTOR ye-MAPK. Ukusebenza kwonyango lomhlaza, njenge-Ibrutinib, kuxhomekeke kwindlela yayo yokusebenza kwezi ndlela zikhethekileyo. Esona sicwangciso sifanelekileyo siquka ukulungelelanisa isenzo sonyango kunye neendlela eziqhuba umhlaza, ngaloo ndlela kuqinisekiswa indlela yobuqu nesebenzayo. Kwiimeko ezinjalo, ukuphepha ukutya okanye izongezo zesondlo ezinokuchasa iziphumo zonyango okanye ukunciphisa olu lungelelwaniso kubalulekile. Ngokomzekelo, i-Lutein supplement, echaphazela i-NFKB Signaling, ayinakuba yinto efanelekileyo yokukhetha kwimeko ye-Primary Waldenstrom Macroglobulinemia xa ihamba nge-Ibrutinib. Oku kungenxa yokuba isenokuthi iqhubele phambili ngakumbi isifo okanye iphazamise ukusebenza konyango. Xa ukhetha isicwangciso sesondlo, kubalulekile ukuqwalasela izinto ezifana nohlobo lomhlaza, unyango oluqhubekayo, ubudala, isini, i-BMI, indlela yokuphila, kunye naluphi na utshintsho lwemfuza olwaziwayo.

2. Ngaba iLutein Supplements iya kuzuzisa iZigulana zoMhlaza we-Serous Ovarian okwiBanga eliPhakamileyo eliphantsi koNyango lwe-Cisplatin?

I-Primary Low-Grade Serous Ovarian Cancer ichongiwe ngokuguqulwa kofuzo oluthile, olufana ne-TP53, i-KRAS kunye ne-RUNX1, ebangela utshintsho kwiindlela ze-biochemical, ngokukodwa i-WNT Beta Catenin Signaling, i-Cell Cycle Checkpoints, i-Apoptosis, i-G-protein-coupled Receptor Signaling, Umqondiso wokuKhula kweFactor, i-NFKB yoMqondiso kunye ne-RUNX Signaling. Ukusebenza konyango lomhlaza, njengeCisplatin, kumiselwa yintsebenziswano nezi ndlela. Injongo kukuqinisekisa ukuba unyango luhambelana kakuhle neendlela eziqhuba umhlaza, okwenza kube nendlela yonyango lomntu. Kulo mxholo, ukutya okanye izongezo ezihambelana nonyango okanye ukuphucula oku kulungelelaniswa kufuneka kuthathelwe ingqalelo. Ngokomzekelo, isongezelelo seLutein lukhetho olunengqiqo kulabo abane-Primary Low-Grade Serous Ovarian Cancer eyenziwa yiCisplatin. Oku kungenxa yokuba i-Lutein ichaphazela iindlela ezifana ne-WNT Beta Catenin Signaling, enokuthi ithintele izinto eziqhuba i-Primary Low-Grade Serous Ovarian Cancer okanye izuze ukusebenza kweCisplatin.

3. Ingaba izongezo zeLutein zikhuselekile kubantu abasempilweni abaneCALR Mutation eManyaniswa neMngcipheko yeGenetic?

Iinkampani ezahlukeneyo zibonelela ngeephaneli zemfuza zokuvavanya umngcipheko wemfuza weentlobo ezahlukeneyo zomhlaza. Ezi panels ziquka imizila yemfuza enxulunyaniswa nebele, i-ovarian, i-uterine, i-prostate, kunye nomhlaza wesisu. Ukuvavanya ezi genes kunokuqinisekisa ukuxilongwa kunye nokwazisa unyango kunye nezicwangciso zokulawula. Ukuchonga umahluko obangela isifo kunokuncedisa ngakumbi ekuvavanyeni nasekuxilongweni kwezalamane ezinokuba sengozini. Ufuzo lwe-CALR luqhele ukubandakanywa kwezi panels zovavanyo lomngcipheko womhlaza.

Ukuguqulwa kwe-CALR gene kuchaphazela iindlela ze-biochemical okanye iinkqubo, ezifana ne-Retinoic Acid Signaling kunye ne-Antigen Presentation, ezibandakanyeka ngokuthe ngqo okanye ngokungathanga ngqo ekuqhubeni umhlaza kwinqanaba le-molecular. Xa iphaneli yofuzo ichonga utshintsho kwi-CALR ehambelana nomngcipheko owongeziweyo we-Myeloproliferative Neoplasms, ingqiqo yesayensi icebisa ukuphepha ukusetyenziswa kwe-lutein yokongeza. Oku kungenxa yokuba ukongeza i-Lutein inefuthe kwiindlela ezifana ne-Retinoic Acid Signaling, enokukhokelela kwimiphumo emibi kumxholo wenguqu ye-CALR kunye neemeko zomhlaza ezinxulumene nazo.

4. Ingaba izongezo zeLutein zikhuselekile kubantu abasempilweni abaneCDH1 Mutation Associated Genetic Risk?

I-CDH1 idlala indima ebalulekileyo kuvavanyo lomngcipheko womhlaza. Ukuguqulwa kwe-CDH1 kunokuphazamisa iindlela ezibalulekileyo ze-biochemical, kuquka i-Adherens junction kunye ne-Epithelial kwi-Mesenchymal Transition, echaphazela ukuphuhliswa komhlaza. Ukuba iphaneli yakho yemfuza ityhila utshintsho kwi-CDH1 ehambelana noMhlaza weGastric, cinga ukufaka izongezo zeLutein kwisicwangciso sakho sesondlo. Ezi zongezo zinokuphembelela kakuhle iindlela ezifana ne-Epithelial ukuya kwi-Mesenchymal Transition, inzuzo ngokubonelela ngenkxaso efanelekileyo kubantu abane-CDH1 yokuguqulwa kunye neenkxalabo zempilo ezinxulumene nazo.

Ukuququmbela

Ezona zinto zimbini zibalulekileyo ekufuneka uzikhumbule kukuba unyango lomhlaza kunye nesondlo azinakuze zifane kumntu wonke. Isondlo, kuquka ukutya kunye nezongezelelo ezifana neLutein, sisixhobo esisebenzayo esinokulawulwa nguwe ngelixa ujongene nomhlaza.

"Ndingatya ntoni?" ngowona mbuzo udla ngokubuzwa ngabaguli abanomhlaza kunye nabo basemngciphekweni womhlaza. Impendulo echanekileyo kukuba ixhomekeke kwizinto ezifana nohlobo lomhlaza, imfuzo yethumba, unyango lwangoku, ukungezwani komzimba, indlela yokuphila, kunye ne-BMI.

Fumana isondlo sakho somhlaza kwi-addon ngokucofa ikhonkco elingezantsi kwaye uphendule imibuzo malunga nohlobo lomhlaza wakho, unyango, indlela yokuphila, i-allergies, ubudala, kunye nesini.

Ucaphulo

• I-Wnt/β‑catenin inhibition ibuyisela umva ukunganyangeki kweziyobisi kwi-acute lymphoblastic leukemia yabantwana.
• I-CD40L ye-mediated enye indlela ye-NFκB-signal ibangela ukuxhathisa kwi-BCR-inhibitors kwizigulane ezine-mantle cell lymphoma.
• cBioPortal for Cancer Genomics
• I-Lutein inqanda ukwanda, ukuhlasela kunye nokufuduka kweeseli zomhlaza webele we-hypoxic ngokuthotyelwa kwe-HES1.
• Imbonakalo yomhlaba eguqukayo yomhlaza we-metastatic ityhilwe kulandelelwano lwezonyango olulindelekileyo lwezigulana ezili-10,000.