Ngowuphi umhlaza onokuzuza ngokuquka iLuobuma kwisidlo sabo?

Iimbalasane

I-Luobuma yaziwa ngokubanzi ngeenzuzo zayo zempilo kwaye isetyenziswa rhoqo zizigulana ezinomhlaza kunye nabo basengozini yemfuzo. Nangona kunjalo, ukhuseleko kunye nokusebenza kweLuobuma kwizigulana ezinomhlaza kuxhomekeke kwizinto ezininzi ezinjengomhlaza, ichemotherapy, olunye unyango, kunye nemfuza yethumba. Ukwazi ukuba okunye ukutya kunye nezongezelelo, ezinje ngegrapefruit kunye nesipinatshi, zinokusebenzisana kakubi namayeza omhlaza kwaye zibangele ukusabela okubi kubalulekile.

Ukutya kubaluleke kakhulu kunyango lomhlaza njengoko kunokuchaphazela iziphumo zonyango. Izigulana ezinomhlaza kufuneka zikhethe ngononophelo kwaye zifake ukutya okufanelekileyo kunye nezongezo kwizidlo zabo. Umzekelo, i-Luobuma inokuba luncedo kwabo bane-Primary Penile Squamous Cell Carcinoma befumana i-Mitomycin, kodwa isenokungabi ilungile kwizigulana ezifumana iRadiation yePrimary Embryonal Carcinoma. Ngaphaya koko, ngexa i-Luobuma inokunceda abantu abanomngcipheko wemfuzo “TERT”, isenokungacetyiswa kwabo banomngcipheko wemfuzo owahlukileyo. Ukwenza izicwangciso zokutya ezisekelwe kwimpilo, unyango, kunye nofuzo kubalulekile.

Ukuqonda ukuba ukwenza isigqibo malunga nokufaneleka kweLuobuma kwisigulana somhlaza kufuneka sibe ngumntu ngamnye kubalulekile. Imiba ebalulekileyo njengodidi lomhlaza, iindlela zonyango, ukwakheka kwemfuzo, imingcipheko yemfuza, ubudala, ubunzima bomzimba, kunye nendlela yokuphila zibalulekile ekuthatheni isigqibo sokuba iLuobuma lolona khetho lufanelekileyo. I-Genomics kunye ne-genomics, ngokukodwa, yingqwalasela ebalulekileyo. Kuba ezi zinto zinokuvela, kubalulekile ukuphonononga rhoqo kwaye ulungelelanise ukhetho lokutya ukuhambelana notshintsho kwisimo sempilo kunye nonyango.

Ukuqukumbela, indlela ebanzi ekukhetheni ukutya ibalulekile, igxile kwiziphumo ezipheleleyo zawo onke amacandelo asebenzayo ekutyeni/ezongezelelo njengeLuobuma endaweni yokuvavanya isithako ngasinye esisebenzayo ngokwahlukileyo okanye ukungayihoyi ngokupheleleyo. Lo mbono ubanzi ukhuthaza indlela enengqiqo nenzululwazi yokucwangcisa ukutya komhlaza.

Uluhlu olufutshane

Ukusetyenziswa kokutya okusekelwe kwizityalo kunye nezongezelelo, ezinje ngeevithamini, imifuno, iiminerali, iiprobiotics, kunye nezongezelelo ezahlukeneyo ezikhethekileyo, ziyenyuka phakathi kwabaguli abanomhlaza. Ezi zongezo ziyilelwe ukuhambisa ugxininiso oluphezulu lwezithako ezithile ezisebenzayo, uninzi lwazo zikwakukutya okwahlukeneyo. Ugxininiso kunye nokwahlukana kwezithako ezisebenzayo ziyahluka phakathi kokutya okupheleleyo kunye nezongezelelo. Ukutya ngokuqhelekileyo kunika uluhlu lwezithako ezisebenzayo kodwa kwiindawo ezisezantsi, ngelixa izongezelelo zibonelela ngoxinzelelo oluphezulu lwezithako ezithile.

Ukuthathela ingqalelo imisebenzi eyahlukeneyo yesayensi kunye neyebhayoloji yesithako ngasinye esisebenzayo kwinqanaba leemolekyuli, kubalulekile ukunika ingxelo ngeziphumo ezidityanisiweyo zala malungu xa uthatha isigqibo malunga nokutya kunye nezongezo eziza kutyiwa okanye hayi.

Umbuzo obalulekileyo ophakamayo: Ngaba kufuneka udibanise iLuobuma kwisidlo sakho njengento yokutya okanye isongezelelo? Ngaba kuyacetyiswa ukuba utye i-Luobuma ukuba unemfuzo enokuthanani nomhlaza onxulumene nofuzo lwe-TERT? Kuthekani ukuba endaweni yoko umngcipheko wakho wemfuza usuka kumfuza? Ngaba kuluncedo ukuquka iLuobuma kukutya kwakho ukuba ufunyaniswe unePrimary Embryonal Carcinoma, okanye ukuba uxilongo lwakho yiPrimary Penile Squamous Cell Carcinoma? Ngaphezu koko, indlela oyisebenzisa ngayo iLuobuma kufuneka ilungelelaniswe njani ukuba ufumana unyango lwe-Mitomycin okanye ukuba isicwangciso sakho sonyango siyatshintsha sisuka kwiMitomycin siye kwiRadiation? Kubalulekile ukuqonda ukuba iinkcazo ezilula ezifana 'neLuobuma yeyendalo, ngoko ke isoloko iluncedo' okanye 'i-Luobuma yonyusa ukhuselo lomzimba' akonelanga kukhetho lokutya/ lokongezelela.

Ukongeza, kubalulekile ukuvavanya kwakhona ukufaneleka kokubandakanya i-Luobuma kwisidlo sakho ukuba kukho utshintsho kwirejimeni yonyango lwakho. Isishwankathelo, xa usenza izigqibo malunga nokubandakanya ukutya okanye izongezo ezinje ngeLuobuma kwisidlo sakho ngezibonelelo zayo, kuya kufuneka uqwalasele iziphumo ezipheleleyo ze-biochemical yazo zonke izithako, uqwalasele izinto ezifana nohlobo lomhlaza, unyango oluthile olwenzayo, i-genetic predispositions. , kunye nokukhetha indlela yokuphila.

Cancer

Umhlaza usengumceli mngeni obalulekileyo kwicandelo lezonyango, ngokufuthi ubangela unxunguphalo oluxhaphakileyo. Nangona kunjalo, ukuqhubela phambili kwamva nje kuye kwaphucula iziphumo zonyango, ngakumbi ngeendlela zonyango zomntu, iindlela zokujonga ezingaphazamisiyo kusetyenziswa igazi kunye neesampulu zamathe, kunye nophuhliso lwe-immunotherapy. Ukufunyaniswa kwangethuba kunye nokungenelela kwangethuba kuye kwaba yinto ebalulekileyo ekuphembeleleni ngokufanelekileyo iziphumo zonyango ngokubanzi.

Uvavanyo lwemfuzo lunikeza isithembiso esibalulekileyo ekuvavanyeni umngcipheko womhlaza kunye nokuba sesichengeni kwangoko. Nangona kunjalo, kubantu abaninzi abaneentsapho kunye ne-genetic predispositions kumhlaza, imingcipheko yemfuza, iinketho zongenelelo lonyango, kunye nokubeka iliso rhoqo, zihlala zilinganiselwe okanye akukho nanye. Nje ukuba kufunyaniswe ukuba unohlobo oluthile lomhlaza, njengePrayimari yePenile Squamous Cell Carcinoma okanye iPrimary Embryonal Carcinoma, iindlela zonyango kufuneka zenziwe ngokwezifiso ngokusekwe kwi-tumor genetics yomntu, inqanaba lesi sifo, kunye nezinto ezifana nobudala kunye nesini.

Emva konyango, ukubeka iliso okuqhubekayo kubalulekile ukuze kubonwe naziphi na iimpawu zokubuyela kwakhona komhlaza kunye nokwazisa izigqibo ezilandelayo. Uninzi lwezigulana ezinomhlaza kunye nabo basemngciphekweni bahlala befuna iingcebiso malunga nokubandakanya ukutya okuthile kunye nezongezo kwizidlo zabo, ezidlala indima ebalulekileyo kwinkqubo yabo yokuthatha isigqibo malunga nolawulo lwezempilo.

Umbuzo obalulekileyo ngowokuba ingaba kubandakanyeka kwimingcipheko yemfuza kunye noxilongo oluthile lomhlaza xa uthatha isigqibo malunga nokhetho lokutya, olufana noLuobuma. Ngaba umngcipheko wemfuzo womhlaza osuka kutshintsho kwi-TERT uneempembelelo zendlela yebhayoloji efanayo njengotshintsho kwenye imfuza? Ukusuka kwimbono yesondlo, ngaba umngcipheko ohambelana ne-Primary Penile Squamous Cell Carcinoma ulingana nePrimary Embryonal Carcinoma? Ngaphaya koko, ngaba uqwalaselo lokutya luhlala lufana kwabo baphantsi kweRadiation njengabo bafumana iMitomycin? Ezi ngqwalasela zibalulekile ekwenzeni ukhetho lokutya olunolwazi lwabantu abaneengozi ezahlukeneyo zemfuza kunye nonyango lomhlaza.

ILuobuma – iSongezo seSondlo

I-Luobuma eyongezelelweyo iquka uluhlu lwezithako ezisebenzayo, kubandakanywa ne-Hyperoside, nganye ekhoyo kwiindawo ezahlukeneyo. Ezi zithako zinefuthe kwiindlela zeemolekyuli, ngokukodwa i-Apoptosis, i-Oxidative Stress, i-Carbohydrate Metabolism kunye ne-P53 Signaling, elawula imiba ebalulekileyo yomhlaza kwinqanaba leeselula, ezifana nokukhula kwethumba, ukusasazeka, kunye nokufa kweeseli. Ukunika le mpembelelo yebhayoloji, ukukhetha izongezo ezifanelekileyo njengeLuobuma, iyodwa okanye ngokudibeneyo, iba sisigqibo esibalulekileyo kwimeko yesondlo somhlaza. Xa ucinga ukusebenzisa i-Luobuma kumhlaza, kubalulekile ukuqwalasela ezi zinto zahlukeneyo kunye neendlela. Oku kungenxa yokuba, ngokufanayo nonyango lomhlaza, ukusetyenziswa kwe-Luobuma ayisosigqibo sehlabathi lonke esilungele zonke ii-cancer kodwa kufuneka ibe yeyomntu.

Ukukhetha iLuobuma Supplements

Ukuphendula umbuzo othi 'Ndingayiphepha nini i-Luobuma kwimeko yoMhlaza' kulucelomngeni kuba impendulo yeyomntu ngamnye kakhulu - ngokulula 'Kuxhomekeke!'. Ngokufana nendlela naluphi na unyango lomhlaza olunokuthi lungasebenzi kwisigulana ngasinye, ukubaluleka kunye nokhuseleko okanye iinzuzo zeLuobuma ziyahluka ngokuxhomekeke kwiimeko zomntu. Imiba efana nohlobo oluthile lomhlaza, i-genetic predispositions, unyango lwangoku, ezinye izongezo ezithathwayo, indlela yokuphila, i-BMI, kunye nayo nayiphi na i-allergies zonke zidlala indima ekuqinisekiseni ukuba i-Luobuma ifanelekile okanye kufuneka ithintelwe, kugxininisa ukubaluleka koqwalaselo lomntu izigqibo ezinjalo.

1. Ngaba iLuobuma Supplements iya kuxhamla kwi-Primary Embrynal Carcinoma Patients eziphantsi konyango lweRadiation?

I-Primary Embryonal Carcinoma ibonakaliswe ngokuguqulwa kofuzo oluthile, okuyi-CAPN7, B3GNT8 kunye ne-KNTC1, ekhokelela ekuguquleni kwiindlela ze-biochemical, ngokukodwa i-Oxidative Stress. Ukusebenza konyango lomhlaza, njengeRadiation, kuxhomekeke kwindlela yokusebenza kwezi ndlela zikhethekileyo. Esona sicwangciso sifanelekileyo siquka ukulungelelanisa isenzo sonyango kunye neendlela eziqhuba umhlaza, ngaloo ndlela kuqinisekiswa indlela yobuqu nesebenzayo. Kwiimeko ezinjalo, ukuphepha ukutya okanye izongezo zesondlo ezinokuchasa iziphumo zonyango okanye ukunciphisa olu lungelelwaniso kubalulekile. Ngokomzekelo, i-Luobuma supplement, echaphazela i-Oxidative Stress, ayinakuba yinto efanelekileyo yokukhetha kwimeko ye-Primary Embryonal Carcinoma xa i-Radiation. Oku kungenxa yokuba isenokuthi iqhubele phambili ngakumbi isifo okanye iphazamise ukusebenza konyango. Xa ukhetha isicwangciso sesondlo, kubalulekile ukuqwalasela izinto ezifana nohlobo lomhlaza, unyango oluqhubekayo, ubudala, isini, i-BMI, indlela yokuphila, kunye naluphi na utshintsho lwemfuza olwaziwayo.

2. Ngaba iLuobuma Supplements iya kuxhamla kwi-Primary Penile Squamous Cell Carcinoma Izigulana eziphantsi koNyango lwe-Mitomycin?

I-Primary Penile Squamous Cell Carcinoma ichongiwe ngokuguqulwa kofuzo oluthile, olufana ne-ABRAXAS1, i-PIK3CB kunye ne-NUP93, ebangela utshintsho kwiindlela ze-biochemical pathways, ngokukodwa i-Apoptosis, i-Hematopoiesis kunye ne-Inositol Phosphate Signaling. Ukusebenza konyango lomhlaza, njengeMitomycin, kumiselwa kukudibana kwayo nezi ndlela. Injongo kukuqinisekisa ukuba unyango luhambelana kakuhle neendlela eziqhuba umhlaza, okwenza kube nendlela yonyango lomntu. Kulo mxholo, ukutya okanye izongezo ezihambelana nonyango okanye ukuphucula oku kulungelelaniswa kufuneka kuthathelwe ingqalelo. Umzekelo, isongezelelo seLuobuma lukhetho olunengqiqo kwabo banePrayimari yePenile Squamous Cell Carcinoma ehamba neMitomycin. Oku kungenxa yokuba i-Luobuma inefuthe kwiindlela ezifana ne-Apoptosis, enokuthi ithintele izinto eziqhuba iPrayimari yePenile Squamous Cell Carcinoma okanye izuze impumelelo yeMitomycin.

3. Ingaba izongezo zeLuobuma zikhuselekile kubantu abasempilweni abane-TERT Mutation eManyaniswe neMngcipheko yeGenetic?

I-TERT idlala indima ebalulekileyo kuvavanyo lomngcipheko womhlaza. Ukuguqulwa kwe-TERT kunokuphazamisa iindlela ezibalulekileyo ze-biochemical, kuquka i-P53 Signaling kunye ne-DNA Repair, echaphazela ukuphuhliswa komhlaza. Ukuba iphaneli yakho yemfuzo ityhila utshintsho kwi-TERT ehambelana noMhlaza we-Hematological, cinga ngokubandakanya izongezo zeLuobuma kwisicwangciso sakho sesondlo. Ezi zongezo zinokuphembelela ngendlela eyiyo iindlela ezifana neP53 Umqondiso, inzuzo ngokubonelela ngenkxaso efanelekileyo kubantu abaneenguqu ze-TERT kunye neenkxalabo zempilo ezinxulumeneyo.

Ukuququmbela

Ezona zinto zimbini zibalulekileyo ekufuneka uzikhumbule kukuba unyango lomhlaza kunye nesondlo azinakuze zifane kumntu wonke. Isondlo, kubandakanywa ukutya kunye nezongezo ezifana neLuobuma, sisixhobo esisebenzayo esinokulawulwa nguwe ngelixa ujongene nomhlaza okanye ingozi yemfuzo.

"Ndingatya ntoni?" ngowona mbuzo udla ngokubuzwa ngabaguli abanomhlaza kunye nabo basemngciphekweni womhlaza. Impendulo echanekileyo kukuba ixhomekeke kwizinto ezifana nohlobo lomhlaza, imfuzo yethumba, unyango lwangoku, ukungezwani komzimba, indlela yokuphila, kunye ne-BMI.

Fumana isondlo sakho somhlaza kwi-addon ngokucofa ikhonkco elingezantsi kwaye uphendule imibuzo malunga nohlobo lomhlaza wakho, unyango, indlela yokuphila, i-allergies, ubudala, kunye nesini.

Ucaphulo

• Indima ye-KEAP1/NRF2 kunye ne-TP53 yoGuquko kwiLung Squamous Cell Carcinoma Development kunye noKuchasana neRadiation.
• I-Hyperioside Ibangela iiSeli zoMhlaza wamabele i-Apoptosis nge-ROS-Mediated NF-κB Indlela yokuSawula.
• cBioPortal for Cancer Genomics
• cBioPortal for Cancer Genomics
• I-Hyperoside kunye ne-rutin ye-Nelumbo nucifera yenza i-mitochondrial apoptosis ngokusebenzisa indlela exhomekeke kwi-caspase kwi-HT-29 yeeseli zomhlaza wekholoni yomntu.
• Unyango lomhlaza lubumba ubume bokuqina be-clonal hematopoiesis.
• I-Mitomycin C inamandla e-TRAIL-induced apoptosis ngokusebenzisa i-p53-independent upregulation of death receptors: ubungqina bendima ye-c-Jun N-terminal kinase activation.
• Iipateni zeCell-of-Origin ziLawula uHlelo lweMolekyuli ye-10,000 ye-Tumors ukusuka kwiintlobo ze-33 ze-Cancer.
• Iziphumo zothintelo lwe-hyperoside kumhlaza wemiphunga kwi-vitro ngokubangela i-apoptosis kunye nokuthintela ukwanda ngeCaspase-3 kunye ne-P53 indlela yokubonisa.