Ngowuphi umhlaza onokuzuza ngokubandakanya iLuteolin ekudleni kwabo?

Iimbalasane

I-Luteolin iyaziwa ngokubanzi ngeenzuzo zayo zempilo kwaye isetyenziswa rhoqo ngabaguli abanomhlaza kunye nabo basengozini yofuzo. Nangona kunjalo, ukhuseleko kunye nokusebenza kweLuteolin kwizigulana ezinomhlaza kuxhomekeke kwizinto ezininzi ezinjengomhlaza, ichemotherapy, olunye unyango, kunye nemfuza yethumba. Ukwazi ukuba okunye ukutya kunye nezongezelelo, ezinje ngegrapefruit kunye nesipinatshi, zinokusebenzisana kakubi namayeza omhlaza kwaye zibangele ukusabela okubi kubalulekile.

Ukutya kubaluleke kakhulu kunyango lomhlaza njengoko kunokuchaphazela iziphumo zonyango. Izigulana ezinomhlaza kufuneka zikhethe ngononophelo kwaye zifake ukutya okufanelekileyo kunye nezongezo kwizidlo zabo. Umzekelo, iLuteolin inokuzuza abo banePrayimari yePenile Squamous Cell Carcinoma ephantsi kweMitomycin, kodwa isenokungabi ilungile kwizigulana ezifumana iRadiation yePrimary Adamantinoma. Ngaphaya koko, ngelixa i-Luteolin inokunceda abantu abane-genetic risk factor "TERT", ayinakucetyiswa kwabo banomngcipheko ohlukileyo wemfuza "CTNNB1". Ukwenza izicwangciso zokutya ezisekelwe kwimpilo, unyango, kunye nofuzo kubalulekile.

Ukuqonda ukuba ukwenza isigqibo malunga nokufaneleka kweLuteolin kwisigulana somhlaza kufuneka sibe ngumntu ngamnye kubalulekile. Izinto ezibalulekileyo ezifana nohlobo lomhlaza, iindlela zonyango, i-genetic makeup, ingozi yemfuza, ubudala, ubunzima bomzimba, kunye nendlela yokuphila ibalulekile ekuthatheni isigqibo sokuba i-Luteolin lukhetho olufanelekileyo. I-Genomics kunye ne-genomics, ngokukodwa, yingqwalasela ebalulekileyo. Kuba ezi zinto zinokuvela, kubalulekile ukuphonononga rhoqo kwaye ulungelelanise ukhetho lokutya ukuhambelana notshintsho kwisimo sempilo kunye nonyango.

Ukuqukumbela, indlela epheleleyo yokhetho lokutya ibalulekile, ijolise kwiziphumo ezipheleleyo zazo zonke izinto ezisebenzayo kukutya / izongezo ezifana neLuteolin endaweni yokuvavanya isithako ngasinye esisebenzayo ngokwahlukileyo okanye ukungayinaki ngokupheleleyo. Lo mbono ubanzi ukhuthaza indlela enengqiqo nenzululwazi kwisicwangciso sokutya somhlaza.

Uluhlu olufutshane

Ukusetyenziswa kokutya okusekelwe kwizityalo kunye nezongezelelo, ezinje ngeevithamini, imifuno, iiminerali, iiprobiotics, kunye nezongezelelo ezahlukeneyo ezikhethekileyo, ziyenyuka phakathi kwabaguli abanomhlaza. Ezi zongezo ziyilelwe ukuhambisa ugxininiso oluphezulu lwezithako ezithile ezisebenzayo, uninzi lwazo zikwakukutya okwahlukeneyo. Ugxininiso kunye nokwahlukana kwezithako ezisebenzayo ziyahluka phakathi kokutya okupheleleyo kunye nezongezelelo. Ukutya ngokuqhelekileyo kunika uluhlu lwezithako ezisebenzayo kodwa kwiindawo ezisezantsi, ngelixa izongezelelo zibonelela ngoxinzelelo oluphezulu lwezithako ezithile.

Ukuthathela ingqalelo imisebenzi eyahlukeneyo yesayensi kunye neyebhayoloji yesithako ngasinye esisebenzayo kwinqanaba leemolekyuli, kubalulekile ukunika ingxelo ngeziphumo ezidityanisiweyo zala malungu xa uthatha isigqibo malunga nokutya kunye nezongezo eziza kutyiwa okanye hayi.

Umbuzo obalulekileyo uvela: Ngaba ufanele udibanise i-Luteolin ekudleni kwakho njengento yokutya okanye isongezelelo? Ngaba kuyacetyiswa ukuba utye i-Luteolin ukuba unemfuza ekhokelela kumhlaza onxulumene nofuzo lwe-TERT? Kuthekani ukuba endaweni yoko ingozi yakho yemfuza ivela kwi-CTNNB1 gene? Ngaba kunenzuzo ukubandakanya i-Luteolin ekutyeni kwakho ukuba ufunyaniswe une-Adamantinoma ePhambili, okanye ukuba uxilongo lwakho luyiPrimary Penile Squamous Cell Carcinoma? Ngaphezu koko, kufuneka kuhlengahlengiswe njani ukusetyenziswa kwakho kweLuteolin ukuba ufumana unyango lwe-Mitomycin okanye ukuba isicwangciso sakho sonyango siyatshintsha sisuka kwiMitomycin siye kwiRadiation? Kubalulekile ukuqaphela ukuba iinkcazo ezilula ezifana 'neLuteolin yendalo, ngoko isoloko iluncedo' okanye 'iLuteolin yonyusa ukhuselo lomzimba' akonelanga kukhetho lokutya / lokongezelela.

Ukongezelela, kubalulekile ukuphinda uhlolisise ukufaneleka kokubandakanya i-Luteolin ekudleni kwakho ukuba kukho utshintsho kwirejimeni yonyango. Isishwankathelo, xa usenza izigqibo malunga nokubandakanya ukutya okanye izongezo ezifana ne-Luteolin kwisidlo sakho ngenxa yezibonelelo zayo, kuya kufuneka uqwalasele iziphumo ze-biochemical yazo zonke izithako, ngokuqwalasela izinto ezifana nohlobo lomhlaza, unyango oluthile olwenzayo, i-genetic predispositions. , kunye nokukhetha indlela yokuphila.

Cancer

Umhlaza usengumceli mngeni obalulekileyo kwicandelo lezonyango, ngokufuthi ubangela unxunguphalo oluxhaphakileyo. Nangona kunjalo, ukuqhubela phambili kwamva nje kuye kwaphucula iziphumo zonyango, ngakumbi ngeendlela zonyango zomntu, iindlela zokujonga ezingaphazamisiyo kusetyenziswa igazi kunye neesampulu zamathe, kunye nophuhliso lwe-immunotherapy. Ukufunyaniswa kwangethuba kunye nokungenelela kwangethuba kuye kwaba yinto ebalulekileyo ekuphembeleleni ngokufanelekileyo iziphumo zonyango ngokubanzi.

Uvavanyo lwemfuzo lunikeza isithembiso esibalulekileyo ekuvavanyeni umngcipheko womhlaza kunye nokuba sesichengeni kwangoko. Nangona kunjalo, kubantu abaninzi abaneemeko zosapho kunye nemfuzo kumhlaza, ukhetho longenelelo lonyango, nokuba lubekwe esweni rhoqo, luhlala lulinganiselwe okanye alukho. Nje ukuba kufunyaniswe ukuba unohlobo oluthile lomhlaza, njengePrimary Penile Squamous Cell Carcinoma okanye i-Primary Adamantinoma, izicwangciso zonyango kufuneka zenziwe ngokwezifiso ngokusekwe kwi-tumor genetics yomntu, inqanaba lesi sifo, kunye nezinto ezifana nobudala kunye nesini.

Emva konyango, ukubeka iliso okuqhubekayo kubalulekile ukuze kubonwe naziphi na iimpawu zokubuyela kwakhona komhlaza kunye nokwazisa izigqibo ezilandelayo. Uninzi lwezigulana ezinomhlaza kunye nabo basemngciphekweni bahlala befuna iingcebiso malunga nokubandakanya ukutya okuthile kunye nezongezo kwizidlo zabo, ezidlala indima ebalulekileyo kwinkqubo yabo yokuthatha isigqibo malunga nolawulo lwezempilo.

Umbuzo obalulekileyo ngowokuba ingaba unobangela wemingcipheko yemfuza kunye noxilongo oluthile lomhlaza xa uthatha isigqibo malunga nokhetho lokutya, olufana neLuteolin. Ngaba umngcipheko wemfuzo womhlaza osuka kutshintsho kwi-TERT uneempembelelo zendlela yebhayokhemikhali efanayo njengotshintsho kwi-CTNNB1? Ukusuka kwimbono yesondlo, ngaba umngcipheko ohambelana nePrayimari yePenile Squamous Cell Carcinoma ilingana nePrimary Adamantinoma? Ngaphaya koko, ngaba uqwalaselo lokutya luhlala lufana kwabo baphantsi kweRadiation njengabo bafumana iMitomycin? Ezi ngqwalasela zibalulekile ekwenzeni ukhetho lokutya olunolwazi lwabantu abaneengozi ezahlukeneyo zemfuza kunye nonyango lomhlaza.

I-Luteolin-Isongezelelo seSondlo

I-Luteolin eyongezelelweyo iquka uluhlu lwezithako ezisebenzayo, kuquka i-Luteolin, nganye ekhoyo kwiimpawu ezihlukeneyo. Ezi zithako zinefuthe kwiindlela zeemolekyuli, ngokukodwa i-Apoptosis, i-Oxidative Stress, i-WNT Beta Catenin Signaling kunye neCell Cycle Checkpoints, elawula imiba ebalulekileyo yomhlaza kwinqanaba leeselula, ezifana nokukhula kwethumba, ukusasazeka, kunye nokufa kweeseli. Ukunikezelwa kwale mpembelelo yebhayoloji, ukukhetha izongezo ezifanelekileyo njengeLuteolin, yedwa okanye ngokudibeneyo, iba sisigqibo esibalulekileyo kumxholo wesondlo somhlaza. Xa ucinga ukusebenzisa iLuteolin kumhlaza, kubalulekile ukuqwalasela ezi zinto zahlukeneyo kunye neendlela. Oku kungenxa yokuba, ngokufana nonyango lomhlaza, ukusetyenziswa kwe-Luteolin ayisosigqibo sehlabathi lonke esifanelekileyo kuwo onke ama-cancer kodwa kufuneka ibe yeyomntu.

Ukukhetha iLuteolin Supplements

Ukuphendula umbuzo othi 'Ndifanele ndiyiphephe nini i-Luteolin kwimeko yoMhlaza' ngumngeni kuba impendulo ixhomekeke kumntu ngamnye kakhulu - ngokulula 'Kuxhomekeke!'. Ngokufana nendlela naluphi na unyango lomhlaza olunokuthi lungasebenzi kwisigulane ngasinye, ukufaneleka kunye nokhuseleko okanye inzuzo ye-Luteolin iyahluka ngokuxhomekeka kwiimeko zomntu. Izinto ezifana nohlobo oluthile lomhlaza, i-genetic predispositions, unyango lwangoku, ezinye izongezo ezithathwayo, iindlela zokuphila, i-BMI, kunye naluphi na uhlobo oluthile lwe-allergies, zonke zidlala indima ekunqumeni ukuba i-Luteolin ifanelekile okanye kufuneka igwenywe, igxininisa ukubaluleka koqwalaselo lomntu izigqibo ezinjalo.

1. Ngaba iLuteolin Supplements iya kunceda iZigulana zaseAdamantinoma eziphantsi konyango lweRadiation?

I-Adamantinoma eyiprayimari ibonakaliswe ngokuguqulwa kofuzo oluthile, oku kukuthi i-ARHGAP45, i-PI4KB kunye ne-SDSL, ekhokelela kwiinguqu kwiindlela ze-biochemical, ngokukodwa i-Oxidative Stress kunye ne-Inositol Phosphate Signaling. Ukusebenza konyango lomhlaza, njengeRadiation, kuxhomekeke kwindlela yokusebenza kwezi ndlela zikhethekileyo. Esona sicwangciso sifanelekileyo siquka ukulungelelanisa isenzo sonyango kunye neendlela eziqhuba umhlaza, ngaloo ndlela kuqinisekiswa indlela yobuqu nesebenzayo. Kwiimeko ezinjalo, ukuphepha ukutya okanye izongezo zesondlo ezinokuchasa iziphumo zonyango okanye ukunciphisa olu lungelelwaniso kubalulekile. Ngokomzekelo, i-Luteolin supplement, echaphazela i-Oxidative Stress, ayinakuba yinto efanelekileyo yokukhetha kwimeko ye-Primary Adamantinoma xa i-Radiation. Oku kungenxa yokuba isenokuthi iqhubele phambili ngakumbi isifo okanye iphazamise ukusebenza konyango. Xa ukhetha isicwangciso sesondlo, kubalulekile ukuqwalasela izinto ezifana nohlobo lomhlaza, unyango oluqhubekayo, ubudala, isini, i-BMI, indlela yokuphila, kunye naluphi na utshintsho lwemfuza olwaziwayo.

2. Ngaba iLuteolin Supplements iya kuxhamla kwi-Primary Penile Squamous Cell Carcinoma Izigulana eziphantsi koNyango lwe-Mitomycin?

I-Primary Penile Squamous Cell Carcinoma ichongiwe ngokuguqulwa kofuzo oluthile, olufana ne-ABRAXAS1, i-PIK3CB kunye ne-NUP93, ebangela utshintsho kwiindlela ze-biochemical pathways, ngokukodwa i-Apoptosis, i-Hematopoiesis kunye ne-Inositol Phosphate Signaling. Ukusebenza konyango lomhlaza, njengeMitomycin, kumiselwa kukudibana kwayo nezi ndlela. Injongo kukuqinisekisa ukuba unyango luhambelana kakuhle neendlela eziqhuba umhlaza, okwenza kube nendlela yonyango lomntu. Kulo mxholo, ukutya okanye izongezo ezihambelana nonyango okanye ukuphucula oku kulungelelaniswa kufuneka kuthathelwe ingqalelo. Ngokomzekelo, isongezelelo seLuteolin lukhetho olunengqiqo kulabo abanePrayimari yePenile Squamous Cell Carcinoma ehamba neMitomycin. Oku kungenxa yokuba i-Luteolin inefuthe kwiindlela ezifana ne-Apoptosis, ezinokuthi zithintele izinto eziqhuba i-Primary Penile Squamous Cell Carcinoma okanye zizuze ukusebenza kweMitomycin.

3. Ingaba izongezo zeLuteolin zikhuselekile kubantu abasempilweni abaneCTNNB1 Mutation Associated Genetic Risk?

Iinkampani ezahlukeneyo zibonelela ngeephaneli zemfuza zokuvavanya umngcipheko wemfuza weentlobo ezahlukeneyo zomhlaza. Ezi panels ziquka imizila yemfuza enxulunyaniswa nebele, i-ovarian, i-uterine, i-prostate, kunye nomhlaza wesisu. Ukuvavanya ezi genes kunokuqinisekisa ukuxilongwa kunye nokwazisa unyango kunye nezicwangciso zokulawula. Ukuchonga umahluko obangela isifo kunokuncedisa ngakumbi ekuvavanyeni nasekuxilongweni kwezalamane ezinokuba sengozini. I-gene ye-CTNNB1 idla ngokubandakanywa kwezi panels zovavanyo lomngcipheko womhlaza.

Ukuguqulwa kwe-CTNNB1 gene kuchaphazela iindlela ze-biochemical okanye iinkqubo, ezifana ne-WNT Beta Catenin Signaling, i-Adherens junction kunye ne-Epithelial ukuya kwi-Mesenchymal Transition, ebandakanyeka ngokuthe ngqo okanye ngokungathanga ngqo ekuqhubeni umhlaza kwinqanaba le-molecular. Xa iphaneli yofuzo ichonga ukuguqulwa kwe-CTNNB1 ehambelana nomngcipheko okhulayo we-Adrenocortical Carcinoma, ingqiqo yesayensi ibonisa ukuphepha ukusetyenziswa kweLuteolin yokuncedisa. Oku kungenxa yokuba ukongeza i-Luteolin inefuthe kwiindlela ezifana ne-WNT Beta Catenin Signaling, enokukhokelela kwimiphumo emibi kumxholo we-CTNNB1 utshintsho kunye neemeko zomhlaza ezinxulumene nazo.

4. Ingaba izongezo zeLuteolin zikhuselekile kubantu abasempilweni abane-TERT Mutation eManyaniswa neMngcipheko yeGenetic?

I-TERT idlala indima ebalulekileyo kuvavanyo lomngcipheko womhlaza. Uguquko kwi-TERT lunokuphazamisa iindlela ezibalulekileyo ze-biochemical, kuquka i-Cell Cycle Checkpoints kunye nokulungiswa kwe-DNA, echaphazela ukuphuhliswa komhlaza. Ukuba iphaneli yakho yemfuza ityhila utshintsho kwi-TERT ehambelana noMhlaza we-Hematological, cinga ukufaka izongezo zeLuteolin kwisicwangciso sakho sesondlo. Ezi zongezo zinokuphembelela ngendlela eyiyo iindlela ezinje ngeCell Cycle Checkpoints, inzuzo ngokubonelela ngenkxaso efanelekileyo kubantu abanotshintsho lwe-TERT kunye neenkxalabo zempilo ezinxulumeneyo.

Ukuququmbela

Ezona zinto zimbini zibalulekileyo ekufuneka uzikhumbule kukuba unyango lomhlaza kunye nesondlo azinakuze zifane kumntu wonke. Isondlo, kuquka ukutya kunye nezongezelelo ezifana neLuteolin, sisixhobo esisebenzayo esinokulawulwa nguwe ngelixa ujongene nomhlaza.

"Ndingatya ntoni?" ngowona mbuzo udla ngokubuzwa ngabaguli abanomhlaza kunye nabo basemngciphekweni womhlaza. Impendulo echanekileyo kukuba ixhomekeke kwizinto ezifana nohlobo lomhlaza, imfuzo yethumba, unyango lwangoku, ukungezwani komzimba, indlela yokuphila, kunye ne-BMI.

Fumana isondlo sakho somhlaza kwi-addon ngokucofa ikhonkco elingezantsi kwaye uphendule imibuzo malunga nohlobo lomhlaza wakho, unyango, indlela yokuphila, i-allergies, ubudala, kunye nesini.

Ucaphulo

• Indima ye-KEAP1/NRF2 kunye ne-TP53 yoGuquko kwiLung Squamous Cell Carcinoma Development kunye noKuchasana neRadiation.
• cBioPortal for Cancer Genomics
• cBioPortal for Cancer Genomics
• Ubume beCrystal bomntu oxhomekeke kwi-cyclin-kinase 6 ene-flavonol inhibitor, i-fisetin.
• Uhlalutyo lwe-pan-cancer lwe-genomes epheleleyo.
• Iinhibitors ze-molecule ezincinci ze-NADPH oxidase 4.
• Unyango lomhlaza lubumba ubume bokuqina be-clonal hematopoiesis.
• I-Mitomycin C inamandla e-TRAIL-induced apoptosis ngokusebenzisa i-p53-independent upregulation of death receptors: ubungqina bendima ye-c-Jun N-terminal kinase activation.
• I-Flavonoids ibonise iziphumo ze-anticancer kwiiseli zomhlaza we-ovarian: Ukubandakanywa kweentlobo ze-oksijini ezisebenzayo, i-apoptosis, umjikelo weseli kunye nokuhlasela.