Ngowuphi umhlaza onokuzuza ngokubandakanya i-Alpha Lipoic Acid kukutya kwabo?

Iimbalasane

I-Alpha Lipoic Acid yamkelwa ngokubanzi ngezibonelelo zayo zempilo kwaye isetyenziswa rhoqo ngabaguli abanomhlaza kunye nabo basengozini yemfuzo. Nangona kunjalo, ukhuseleko kunye nokusebenza kweAlpha Lipoic Acid kwizigulana ezinomhlaza kuxhomekeke kwizinto ezininzi ezinjengomhlaza, ichemotherapy, olunye unyango, kunye nemfuza yethumba. Ukwazi ukuba ezinye ukutya kunye nezongezelelo, ezinje ngegrapefruit kunye nesipinatshi, zinokusebenzisana kakubi namayeza omhlaza kwaye zibangele ukusabela okubi kubalulekile.

Ukutya kubaluleke kakhulu kunyango lomhlaza njengoko kunokuchaphazela iziphumo zonyango. Izigulana ezinomhlaza kufuneka zikhethe ngononophelo kwaye zifake ukutya okufanelekileyo kunye nezongezo kwizidlo zabo. Umzekelo, i-Alpha Lipoic Acid inokuba luncedo kwabo bane-Primary Glioblastoma abafumana i-Temozolomide, kodwa kusenokungabi kuhle kwizigulana ezifumana olunye unyango. Ngaphaya koko, ngelixa i-Alpha Lipoic Acid inokunceda abantu abanomngcipheko wemfuzo "CDH1", ayinakucetyiswa kwabo basengozini eyahlukileyo yemfuza. Ukwenza izicwangciso zokutya ezisekelwe kwimpilo, unyango, kunye nofuzo kubalulekile.

Ukuqonda ukuba ukwenza isigqibo malunga nokufaneleka kwe-Alpha Lipoic Acid kwisigulana somhlaza kufuneka sibe ngumntu ngamnye kubalulekile. Izinto ezibalulekileyo ezifana nohlobo lomhlaza, iindlela zonyango, ukwakheka kwemfuzo, imingcipheko yemfuza, ubudala, ubunzima bomzimba, kunye nendlela yokuphila zibalulekile ekwenzeni isigqibo sokuba iAlpha Lipoic Acid lukhetho olufanelekileyo. I-Genomics kunye ne-genomics, ngokukodwa, yingqwalasela ebalulekileyo. Kuba ezi zinto zinokuvela, kubalulekile ukuphonononga rhoqo kwaye ulungelelanise ukhetho lokutya ukuhambelana notshintsho kwisimo sempilo kunye nonyango.

Ukuqukumbela, indlela ebanzi yokhetho lokutya ibalulekile, igxile kwiziphumo ezipheleleyo zazo zonke izinto ezisebenzayo ekutyeni / nezongezo ezifana ne-Alpha Lipoic Acid endaweni yokuvavanya isithako ngasinye esisebenzayo ngokwahlukileyo okanye ukungayihoyi ngokupheleleyo. Lo mbono ubanzi ukhuthaza indlela enengqiqo nenzululwazi kwisicwangciso sokutya somhlaza.

Uluhlu olufutshane

Ukusetyenziswa kokutya okusekelwe kwizityalo kunye nezongezelelo, ezinje ngeevithamini, imifuno, iiminerali, iiprobiotics, kunye nezongezelelo ezahlukeneyo ezikhethekileyo, ziyenyuka phakathi kwabaguli abanomhlaza. Ezi zongezo ziyilelwe ukuhambisa ugxininiso oluphezulu lwezithako ezithile ezisebenzayo, uninzi lwazo zikwakukutya okwahlukeneyo. Ugxininiso kunye nokwahlukana kwezithako ezisebenzayo ziyahluka phakathi kokutya okupheleleyo kunye nezongezelelo. Ukutya ngokuqhelekileyo kunika uluhlu lwezithako ezisebenzayo kodwa kwiindawo ezisezantsi, ngelixa izongezelelo zibonelela ngoxinzelelo oluphezulu lwezithako ezithile.

Ukuthathela ingqalelo imisebenzi eyahlukeneyo yesayensi kunye neyebhayoloji yesithako ngasinye esisebenzayo kwinqanaba leemolekyuli, kubalulekile ukunika ingxelo ngeziphumo ezidityanisiweyo zala malungu xa uthatha isigqibo malunga nokutya kunye nezongezo eziza kutyiwa okanye hayi.

Umbuzo obalulekileyo ophakamayo: Ngaba kufuneka udibanise iAlpha Lipoic Acid kwisidlo sakho njengento yokutya okanye isongezelelo? Ngaba kuyacetyiswa ukuba utye iAlpha Lipoic Acid ukuba unemfuzo enokuthanani nomhlaza onxulumene nejini ye-CDH1? Kuthekani ukuba endaweni yoko umngcipheko wakho wemfuza usuka kumfuza? Ngaba kuluncedo ukubandakanya iAlpha Lipoic Acid kwisidlo sakho ukuba ufunyaniswe unePrimary Glioblastoma? Ngaphezu koko, ukusetyenziswa kwakho kwe-Alpha Lipoic Acid kufanele kuhlengahlengiswe njani ukuba ufumana unyango lweTemozolomide okanye ukuba isicwangciso sakho sonyango siyatshintsha kwiTemozolomide? Kubalulekile ukuqonda ukuba iinkcazo ezilula ezifana 'neAlpha Lipoic Acid yendalo, ngoko isoloko iluncedo' okanye 'iAlpha Lipoic Acid yonyusa ukhuselo lomzimba' akonelanga kukhetho lokutya / lokongezelela.

Ukongeza, kubalulekile ukuvavanya kwakhona ukufaneleka kokubandakanya i-Alpha Lipoic Acid kwisidlo sakho ukuba kukho utshintsho kwirejimeni yonyango lwakho. Isishwankathelo, xa usenza izigqibo malunga nokubandakanya ukutya okanye izongezo ezifana ne-Alpha Lipoic Acid kwisidlo sakho ngezibonelelo zayo, kuya kufuneka uqwalasele iziphumo ze-biochemical yazo zonke izithako, uqwalasele izinto ezifana nohlobo lomhlaza, unyango oluthile olwenzayo, i-genetic predispositions, kunye nokukhetha indlela yokuphila.

Cancer

Umhlaza usengumceli mngeni obalulekileyo kwicandelo lezonyango, ngokufuthi ubangela unxunguphalo oluxhaphakileyo. Nangona kunjalo, ukuqhubela phambili kwamva nje kuye kwaphucula iziphumo zonyango, ngakumbi ngeendlela zonyango zomntu, iindlela zokujonga ezingaphazamisiyo kusetyenziswa igazi kunye neesampulu zamathe, kunye nophuhliso lwe-immunotherapy. Ukufunyaniswa kwangethuba kunye nokungenelela kwangethuba kuye kwaba yinto ebalulekileyo ekuphembeleleni ngokufanelekileyo iziphumo zonyango ngokubanzi.

Uvavanyo lwemfuzo lunikeza isithembiso esibalulekileyo ekuvavanyeni umngcipheko womhlaza kunye nokuba sesichengeni kwangethuba. Nangona kunjalo, kubantu abaninzi abaneemeko zosapho kunye nemfuzo kumhlaza, ukhetho longenelelo lonyango, nokuba lubekwe esweni rhoqo, luhlala lulinganiselwe okanye alukho. Nje ukuba kufunyaniswe ukuba unohlobo oluthile lomhlaza, njengePrimary Glioblastoma, iindlela zonyango kufuneka zenziwe ngokwezifiso ngokusekwe kwi-tumor genetics yomntu, inqanaba lesi sifo, kunye nezinto ezifana nobudala kunye nesini.

Emva konyango, ukubeka iliso okuqhubekayo kubalulekile ukuze kubonwe naziphi na iimpawu zokubuyela kwakhona komhlaza kunye nokwazisa izigqibo ezilandelayo. Uninzi lwezigulana ezinomhlaza kunye nabo basemngciphekweni bahlala befuna iingcebiso malunga nokubandakanya ukutya okuthile kunye nezongezo kwizidlo zabo, ezidlala indima ebalulekileyo kwinkqubo yabo yokuthatha isigqibo malunga nolawulo lwezempilo.

Umbuzo obalulekileyo ngowokuba ingaba kunokubangela umngcipheko wemfuza kunye noxilongo oluthile lomhlaza xa uthatha isigqibo malunga nokhetho lokutya, olufana ne-Alpha Lipoic Acid. Ngaba umngcipheko wemfuzo womhlaza osuka kutshintsho kwi-CDH1 unefuthe elifanayo le-biochemical pathway njengoguquko kwenye imfuza? Ukusuka kumbono wesondlo, ngaba umngcipheko ohambelana ne-Primary Glioblastoma ulingana nesinye isibonakaliso? Ngapha koko, ngaba ukuqwalaselwa kokutya kuhlala kuyafana kwabo baphantsi kweTemozolomide? Ezi ngqwalasela zibalulekile ekwenzeni ukhetho lokutya olunolwazi lwabantu abaneengozi ezahlukeneyo zemfuza kunye nonyango lomhlaza.

I-Alpha Lipoic Acid-Isongezelelo seZondlo

I-Alpha Lipoic Acid eyongezelelweyo iquka uluhlu lwezithako ezisebenzayo, kuquka i-Alpha Lipoic Acid, nganye ekhoyo kwiimpawu ezahlukeneyo. Ezi zithako zinempembelelo kwiindlela zeemolekyuli, ngokukodwa i-PI3K-AKT-MTOR Umqondiso, olawula imiba ebalulekileyo yomhlaza kwinqanaba leeselula, ezifana nokukhula kwethumba, ukusasazeka, kunye nokufa kweeseli. Ukunika le mpembelelo yebhayoloji, ukukhetha izongezo ezifanelekileyo njenge-Alpha Lipoic Acid, iyodwa okanye ngokudibeneyo, iba sisigqibo esibalulekileyo kumxholo wesondlo somhlaza. Xa ucinga ukusebenzisa iAlpha Lipoic Acid kumhlaza, kubalulekile ukuqwalasela ezi zinto zahlukeneyo kunye neendlela. Oku kungenxa yokuba, ngokufanayo nonyango lomhlaza, ukusetyenziswa kwe-Alpha Lipoic Acid ayisosigqibo sehlabathi lonke esifanelekileyo kubo bonke abanomhlaza kodwa kufuneka senziwe umntu.

Ukukhetha iAlpha Lipoic Acid Supplements

Ukuphendula umbuzo othi 'Ndifanele ndiyiphephe nini i-Alpha Lipoic Acid kumxholo woMhlaza' kulucelomngeni kuba impendulo yeyomntu ngamnye kakhulu - ngokulula 'Kuxhomekeke!'. Ngokufana nendlela naluphi na unyango lomhlaza olunokuthi lungasebenzi kwisigulana ngasinye, ukubaluleka kunye nokhuseleko okanye izibonelelo ze-Alpha Lipoic Acid ziyahluka ngokuxhomekeke kwiimeko zomntu. Izinto ezifana nohlobo oluthile lomhlaza, i-genetic predispositions, unyango lwangoku, ezinye izongezo ezithathwayo, indlela yokuphila, i-BMI, kunye nayo nayiphi na i-allergies yonke idlala indima ekunqumeni ukuba i-Alpha Lipoic Acid ifanelekile okanye kufuneka ithintelwe, igxininisa ukubaluleka kobuntu. ukuqwalaselwa kwizigqibo ezinjalo.

1. Ngaba i-Alpha Lipoic Acid Supplements iya kuxhamla kwiZigulana zeGlioblastoma eziphambili eziphantsi koNyango lweTemozolomide?

I-Glioblastoma eyiprayimari ichongiwe ngokuguqulwa kofuzo oluthile, njenge-TRBV7-7, i-TAS2R46 kunye ne-TP53, ebangela utshintsho kwiindlela ze-biochemical pathways, ngokukodwa i-PI3K-AKT-MTOR Ukubonakaliswa, i-Cell Cycle Checkpoints kunye ne-Apoptosis. Ukusebenza kwonyango lomhlaza, njengeTemozolomide, kuchongwa ngokusebenzisana kwayo nezi ndlela. Injongo kukuqinisekisa ukuba unyango luhambelana kakuhle neendlela eziqhuba umhlaza, okwenza kube nendlela yonyango lomntu. Kulo mxholo, ukutya okanye izongezo ezihambelana nonyango okanye ukuphucula oku kulungelelaniswa kufuneka kuthathelwe ingqalelo. Ngokomzekelo, isongezelelo se-Alpha Lipoic Acid lukhetho olunengqiqo kwabo bane-Primary Glioblastoma ehamba neTemozolomide. Oku kungenxa yokuba i-Alpha Lipoic Acid ichaphazela iindlela ezifana ne-PI3K-AKT-MTOR Ukubonakaliswa, okunokuthi kuthintele izinto eziqhuba i-Primary Glioblastoma okanye zizuze ukusebenza kweTemozolomide.

2. Ngaba iAlpha Lipoic Acid Supplements ikhuselekile kuBantu abasempilweni abaneCDH1 Mutation Associated Genetic Risk?

I-CDH1 idlala indima ebalulekileyo kuvavanyo lomngcipheko womhlaza. Ukuguqulwa kwe-CDH1 kunokuphazamisa iindlela ezibalulekileyo ze-biochemical, kuquka i-PI3K-AKT-MTOR Ukubonakaliswa, i-Adherens junction kunye ne-Epithelial kwi-Mesenchymal Transition, echaphazela ukuphuhliswa komhlaza. Ukuba iphaneli yakho yemfuza ityhila utshintsho kwi-CDH1 ehambelana noMhlaza weGastric, cinga ukufaka izongezo ze-Alpha Lipoic Acid kwisicwangciso sakho sesondlo. Ezi zongezo zinokuphembelela kakuhle iindlela ezifana ne-PI3K-AKT-MTOR Ukubonakaliswa, inzuzo ngokubonelela ngenkxaso efanelekileyo kubantu abaneenguqu ze-CDH1 kunye neenkxalabo zempilo ezinxulumene nazo.

Ukuququmbela

Ezona zinto zimbini zibalulekileyo ekufuneka uzikhumbule kukuba unyango lomhlaza kunye nesondlo azinakuze zifane kumntu wonke. Isondlo, kubandakanya ukutya kunye nezongezo ezifana ne-Alpha Lipoic Acid, sisixhobo esisebenzayo esinokulawulwa nguwe ngelixa ujongene nomhlaza.

"Ndingatya ntoni?" ngowona mbuzo udla ngokubuzwa ngabaguli abanomhlaza kunye nabo basemngciphekweni womhlaza. Impendulo echanekileyo kukuba ixhomekeke kwizinto ezifana nohlobo lomhlaza, imfuzo yethumba, unyango lwangoku, ukungezwani komzimba, indlela yokuphila, kunye ne-BMI.

Fumana isondlo sakho somhlaza kwi-addon ngokucofa ikhonkco elingezantsi kwaye uphendule imibuzo malunga nohlobo lomhlaza wakho, unyango, indlela yokuphila, i-allergies, ubudala, kunye nesini.

Ucaphulo

• cBioPortal for Cancer Genomics
• I-NF-κB ivuliwe ekuphenduleni i-temozolomide ngendlela exhomekeke kwi-AKT kwaye inika ukhuseleko kwimpembelelo yokukhula kweyeza.
• I-α-Lipoic acid inqanda ukufuduka kunye nokuhlasela kweeseli zomhlaza webele ngokunqanda ukubonakaliswa kwe-TGFβ.
• Imeko ye-somatic genomic ye-glioblastoma.