Ukutya kwi-Marginal Zone Lymphoma!

intshayelelo

Ukutya kwi-Marginal Zone Lymphoma kufuneka ilungiselelwe umntu ngamnye kwaye kufuneka ilungelelanise xa unyango lomhlaza okanye utshintsho lwemfuzo yethumba. Ukwenziwa komntu kunye nokulungelelaniswa kufuneka kuthathelwe ingqalelo zonke izithako ezisebenzayo okanye i-bioactives equlethwe kukutya okwahlukeneyo malunga nebhayoloji yethishu yomhlaza, imfuzo, unyango, iimeko zokuphila kunye nokukhethwa kokutya. Kungoko ngexa isondlo sesinye sezigqibo ezibaluleke kakhulu kwisigulana somhlaza kunye nomntu osemngciphekweni wokuba nomhlaza – ukukhetha ukutya oza kukutya akuyondlwan’ iyanetha.

Kwi-Marginal Zone Lymphoma ingaba ibalulekile ukuba yeyiphi imifuno, iziqhamo, amandongomane, imbewu umntu ayityayo?

Umbuzo oxhaphake kakhulu ngezondlo obuzwa zizigulane ezinomhlaza kunye nabantu abasengozini yomhlaza kukuba - kwimihlaza efana ne-Marginal Zone Lymphoma ingaba ayinamsebenzi ukuba kukuphi ukutya endikutyayo kwaye ndingakwenzi? Okanye ukuba ndilandela ukutya okusekwe kwisityalo oko kwanele umhlaza onje ngeMarginal Zone Lymphoma?

Umzekelo ingaba iyabaluleka na into yokuba imifuno i-Brussels Sprouts ityiwa kakhulu xa ithelekiswa ne-Mexican Groundcherry? Ngaba kuyawenza umahluko ukuba isiqhamo iPummelo siyakhethwa kuneBlack Mulberry? Kwakhona ukuba ukhetho olufanayo lwenziwa kwiindongomane/iimbewu ezifana neHazelnut eqhelekileyo ngaphezu kweCashew Nut kunye nezityalo ezifana neBroad Bean phezu kweLentils. Kwaye ukuba into endiyityayo ibalulekile - umntu uchonga njani ukutya okucetyiswayo kwi-Marginal Zone Lymphoma kwaye ingaba impendulo efanayo kuye wonke umntu onoxilongo olufanayo okanye umngcipheko wemfuzo?

Ewe! Ukutya okutyayo kubalulekile kwi-Marginal Zone Lymphoma!

Iingcebiso zokutya zisenokungafani kumntu wonke kwaye zinokwahluka nakwisifo esifanayo kunye nomngcipheko wemfuzo.

Konke ukutya (imifuno, iziqhamo, amandongomane, iimbewu, i-pulses, i-oyile njl.njl.) kunye nezongezo zesondlo zenziwe ngaphezu kwesinye isithako esisebenzayo semolekyuli okanye i-bio-actives ngokwemilinganiselo eyahlukeneyo kunye nezixa. Isithako ngasinye esisebenzayo sinendlela ekhethekileyo yokusebenza - enokuthi isebenze okanye ithintele iindlela ezahlukeneyo ze-biochemical. Ukutya okuchazwe ngokulula kunye nezongezo ezicetyiswayo zezo zingabangeli ukwanda kwabaqhubi beemolekyuli zomhlaza kodwa zibanciphise. Okanye oko kutya akufuneki kunconywe. Ukutya kuqulethe izithako ezininzi ezisebenzayo - kungoko xa uvavanya ukutya kunye nezongezelelo kufuneka uqwalasele ifuthe lazo zonke izithako ezisebenzayo ngokongezelekayo kunomntu ngamnye.

Umzekelo iPummelo iqulethe izithako ezisebenzayo iQuercetin, iCatechol, iLupeol, iApigenin, iPhloretin. Kwaye i-Black Mulberry iqulethe izithako ezisebenzayo i-Quercetin, i-Morrusin, i-Catechol, i-Lupeol, i-Apigenin kwaye mhlawumbi nabanye.

Iphutha eliqhelekileyo elenziwe xa kuthathwa isigqibo kunye nokukhetha ukutya okutyayo kwi-Marginal Zone Lymphoma - kukuvavanya kuphela izithako ezikhethiweyo ezisebenzayo eziqulethwe kukutya kwaye ungayihoyi enye. Ngenxa yokuba izithako ezahlukeneyo ezisebenzayo eziqulethwe kukutya zinokuba neziphumo ezichasayo kubaqhubi bomhlaza - awukwazi ukukhetha izithako ezisebenzayo ekutyeni kunye nezongezelelo zokwenza isigqibo sesondlo seMarginal Zone Lymphoma.

EWE – UKHETHO LOKUTYA LUYINGABA NOMHLAZA. IZIGQIBO ZOKUTYA KUFUNEKA IZIQWELELE ZONKE IZINTO EZISEBENZAYO ZOKUTYA.

Izakhono ezifunekayo kuMntu weSondlo kwi-Marginal Zone Lymphoma?

Isondlo esilungiselelwe wena somhlaza njengeMarginal Zone Lymphoma ibandakanya ukutya okucetyiswayo / izongezo; ukutya okungacetyiswanga / izongezo ezinomzekelo weeresiphi ezibeka phambili ukusetyenziswa kokutya okucetyiswayo. Umzekelo wesondlo somntu unokubonwa koku ikhonkco.

Ukugqiba ukuba kukuphi ukutya okucetyiswayo okanye okungacetyiswayo kuntsonkothile kakhulu, kufuna ubuchwephesha kwi-Marginal Zone Lymphoma biology, isayensi yokutya, imfuzo, i-biochemistry kunye nokuqonda kakuhle ukuba unyango lomhlaza lusebenza njani kunye nokuba sesichengeni okunxulumene nonyango olunokuthi luyeke ukusebenza.

UBUCHULE OBUBONA ULWAZI OLUFUNEKAYO UKUZE SONDLWE UMNTU WOMHLAZA ZI: IBHALOJI YOMHLAZA, ISAYENSI YOKUTYA, UNYANGO LOMHLAZA KUNYE NEMFUZO.

Iimpawu zomhlaza ezifana ne-Marginal Zone Lymphoma

Zonke ii-cancer ezifana ne-Marginal Zone Lymphoma zinokubonakaliswa ngeseti eyodwa yeendlela ze-biochemical - iindlela zokutyikitya ze-Marginal Zone Lymphoma. Iindlela ze-Biochemical ezifana ne-RAS-RAF Signaling, i-Growth Factor Signaling, i-PI3K-AKT-MTOR Ukubonakaliswa, i-Oncogenic Histone Methylation iyingxenye yenkcazo yesignesha ye-Marginal Zone Lymphoma. Imfuzo yomhlaza yomntu ngamnye inokwahluka kwaye kungoko utyikityo lwabo lomhlaza lunokwahluka.

Unyango olusebenzayo kwi-Marginal Zone Lymphoma kufuneka luthathele ingqalelo utyikityo olunxulumene neendlela zebhayokhemikhali kwisigulana ngasinye somhlaza kunye nomntu osengozini yemfuzo. Ngoko ke unyango oluhlukeneyo ngeendlela ezahlukeneyo zezenzo zisebenza kakuhle kwizigulane ezahlukeneyo. Ngokufanayo kwaye ngenxa yezizathu ezifanayo ukutya kunye nezongezo kufuneka zenziwe kumntu ngamnye. Yiyo loo nto ukutya kunye nezongezo zicetyiswayo kwi-Marginal Zone Lymphoma xa uthatha unyango lomhlaza iHerceptin, kwaye okunye ukutya kunye nezongezo azikhuthazwa.

Imithombo efana cBioPortal kunye nabanye abaninzi banikezela ngedatha emele isigulana esingaziwa kulingo lwezonyango kuzo zonke iimpawu zomhlaza. Le datha iqulathe iinkcukacha zophononongo lwezonyango ezifana nobungakanani besampulu / inani lezigulana, amaqela obudala, isini, ubuhlanga, unyango, indawo yethumba kunye naluphi na utshintsho lwemfuza.

I-KMT2D, i-TBL1XR1, i-CXCR4, i-B2M kunye ne-SPEN zezona ziphezulu iigenes ezixeliweyo ze-Marginal Zone Lymphoma. I-KMT2D ixelwe kwi-15.4% yezigulane ezimele kuzo zonke izilingo zonyango. Kwaye i-TBL1XR1 ichazwe kwi-15.4%. Idatha yesigulana esidityanisiweyo sigubungela iminyaka ukusuka ukuya . I-50.0% yedatha yesigulane ichongwa njengamadoda. Ibhayoloji ye-Marginal Zone Lymphoma kunye ne-genetics exeliweyo kunye zichaza inani labantu elimelwe utyikityo lweendlela zebhayoloji kulo mhlaza. Ukuba ithumba lomhlaza lomntu ngamnye lifuzo okanye imfuza enegalelo kumngcipheko nayo iyaziwa ke leyo kufuneka isetyenziselwe ukwenza isondlo somntu.

UKHETHO LWESONDLO MELE LUHAMBANE NOMNTU NGAMNYE WOMNTU WOMNTU.

Ukutya kunye nezongezelelo kwi-Marginal Zone Lymphoma

Kwizigulane zoMhlaza

Izigulana zomhlaza ezikunyango okanye kukhathalelo lokuthomalalisa kufuneka zenze izigqibo ngokutya kunye nezongezelelo - kwiikhalori ezifunekayo zokutya, ukulawula naziphi na iziphumo ebezingalindelekanga zonyango kunye nokuphuculwa kolawulo lomhlaza. Konke ukutya okusekelwe kwizityalo akulingani kwaye ukukhetha kunye nokubeka phambili ukutya okwenziwa ngumntu kwaye kulungiselelwe unyango oluqhubekayo lomhlaza kubalulekile kwaye kunzima. Nantsi eminye imizekelo ebonelela ngezikhokelo zokwenza izigqibo zesondlo.

Khetha imifuno yeBRUSSEL sprouts okanye iMEXICAN GROUNDCHERRY?

Imifuno ye-Brussel Sprouts iqulethe izithako ezininzi ezisebenzayo okanye i-bioactives efana neCatechol, iLupeol, iPhloretin, iFormononetin, iDelphinidin. Ezi zithako ezisebenzayo zilawula iindlela ezahlukeneyo ze-biochemical ezifana ne-MAPK yokuSayina, i-MYC Signaling, i-Growth Factor Signaling kunye ne-PI3K-AKT-MTOR Umqondiso kunye nabanye. I-Brussel Sprouts icetyiswa kwi-Marginal Zone Lymphoma xa unyango lomhlaza oluqhubekayo i-Herceptin. Oku kungenxa yokuba i-Brussel Sprouts ilungisa ezo ndlela zebhayoloji ezixelwe ngokwenzululwazi ukuze zikhuthaze isiphumo seHerceptin.

Ezinye zezinto ezisebenzayo okanye i-bioactives kwimifuno yaseMexico yaseGroundcherry yiCatechol, Lupeol, Apigenin, Phloretin, Formononetin. Ezi zithako ezisebenzayo zilawula iindlela ezahlukeneyo ze-biochemical ezifana ne-PI3K-AKT-MTOR Umqondiso kunye nabanye. I-Mexican Groundcherry ayikhuthazwa kwi-Marginal Zone Lymphoma xa unyango lomhlaza oluqhubekayo yi-Herceptin kuba iguqula ezo ndlela ze-biochemical ezenza ukuba unyango lomhlaza luxhathise okanye lungaphenduli.

IZIPHUMO ZEBRUSSEL ZEMIFUNO KUCEBISWA NGAPHEZU KWE-MEXICAN GROUNDCHERRY YEMANDLA EKUPHELELEYO iLymphoma KUNYE NONYANGO I-Herceptin.

Khetha iSiqhamo EMNYAMA UMULBERRY okanye iPUMMELO?

Iziqhamo zeMulberry eziMnyama ziqulethe izithako ezininzi ezisebenzayo okanye i-bioactives efana ne-Quercetin, i-Morrusin, iCatechol, i-Lupeol, i-Apigenin. Ezi zithako ezisebenzayo zilawula iindlela ezahlukeneyo ze-biochemical ezifana ne-MAPK Signaling, i-MYC Signaling, i-Cell Junctions kunye ne-PI3K-AKT-MTOR Umqondiso kunye nabanye. I-Black Mulberry icetyiswa kwi-Marginal Zone Lymphoma xa unyango lomhlaza oluqhubekayo yi-Herceptin. Oku kungenxa yokuba iBlack Mulberry iguqula iindlela zebhayoloji eziye zaxelwa ngokwesayensi ukwazisa isiphumo seHerceptin.

Ezinye zezithako ezisebenzayo okanye i-bioactives kwiziqhamo iPummelo yiQuercetin, iCatechol, iLupeol, iApigenin, iPhloretin. Ezi zithako ezisebenzayo zilawula iindlela ezahlukeneyo ze-biochemical ezifana ne-Notch Signaling kunye ne-PI3K-AKT-MTOR Umqondiso kunye nabanye. IPummelo ayikhuthazwa kwi-Marginal Zone Lymphoma xa unyango lomhlaza oluqhubekayo yi-Herceptin kuba iguqula ezo ndlela ze-biochemical ezenza ukuba unyango lomhlaza luxhathise okanye lungaphenduli.

ISIQHAMO OMNYAMA EMNYAMA KUNCEBISWA NGAPHEZU KWE-PUMMELO YE-Marginal Zone Lymphoma KUNYE NONYANGO I-Herceptin.

Khetha i-Nutt EQHELEKILEYO I-HAZELNUT okanye i-CASHEW NUT?

I-Hazelnut eqhelekileyo iqulethe izithako ezininzi ezisebenzayo okanye i-bioactives efana ne-Quercetin, iCatechol, i-Lupeol, i-Phloretin, i-Formononetin. Ezi zithako ezisebenzayo zilawula iindlela ezahlukeneyo ze-biochemical ezifana ne-MAPK Signaling, i-Angiogenesis, i-Growth Factor Signaling kunye ne-PI3K-AKT-MTOR yokuSayina kunye nabanye. IHazelnut eqhelekileyo icetyiswa kwiMarginal Zone Lymphoma xa unyango lomhlaza oluqhubekayo yiHerceptin. Oku kungenxa yokuba iHazelnut eqhelekileyo iguqula ezo ndlela zebhayoloji ezixelwe ngokwesayensi ukwazisa isiphumo seHerceptin.

Ezinye zezinto ezisebenzayo okanye i-bioactives kwi-Cashew Nut yi-Quercetin, iCatechol, i-Lupeol, i-Phloretin, i-Formononetin. Ezi zithako ezisebenzayo zilawula iindlela ezahlukeneyo ze-biochemical ezifana ne-MAPK Signaling kunye ne-PI3K-AKT-MTOR Umqondiso kunye nabanye. I-Cashew Nut ayikhuthazwa kwi-Marginal Zone Lymphoma xa unyango lomhlaza oluqhubekayo yi-Herceptin kuba iguqula ezo ndlela ze-biochemical ezenza ukuba unyango lomhlaza luxhathise okanye lungaphenduli.

I-HAZELNUT EQHELEKILEYO IYANCEBISWA NGAPHEZU KWE-CASHEW NUTI YEMANDLA EKUGQIBELELE iLymphoma KUNYE NONYANGO I-Herceptin.

Kubantu ngabanye abaneMngcipheko yeGenetic yoMhlaza

Umbuzo obuzwa ngabantu abasengozini yemfuzo ye-Marginal Zone Lymphoma okanye imbali yentsapho "Yintoni endimele ndiyitye ngokwahlukileyo ngaphambili?" kunye nendlela ekufuneka bakhethe ngayo ukutya kunye nezongezo zokulawula imingcipheko yesi sifo. Kuba kumngcipheko womhlaza akukho nto inokwenzeka malunga nonyango - izigqibo zokutya kunye nezongezo zibalulekile kwaye yenye yezinto ezimbalwa ezinokuthi zenziwe. Konke ukutya okusekelwe kwizityalo akulingani kwaye kusekelwe kwi-genetics echongiweyo kunye nendlela yokutyikitya - ukhetho lokutya kunye nezongezelelo kufuneka lube lolwakho.

Khetha iVegetable CAULIFLOWER okanye iSAVOY CABBAGE?

I-Cauliflower yemifuno iqulethe izithako ezininzi ezisebenzayo okanye i-bioactives efana ne-Curcumin, i-Daidzein, i-Lupeol, i-Formononetin, i-Beta-sitosterol. Ezi zithako ezisebenzayo zilawula iindlela ezahlukeneyo ze-biochemical ezifana ne-RAS-RAF Signaling, i-MYC Signaling, i-NFKB Signaling kunye ne-PI3K-AKT-MTOR yokuSayina kunye nabanye. ICauliflower icetyiswa kumngcipheko weMarginal Zone Lymphoma xa umngcipheko wemfuzo ohambelana neB2M. Oku kungenxa yokuba iCauliflower yonyusa ezo pathways biochemical ezichasa utyikityo lwabaqhubi bayo.

Ezinye zezinto ezisebenzayo okanye i-bioactives kwimifuno ye-Savoy Cabbage yi-Curcumin, i-Lycopene, i-Daidzein, i-Lupeol, i-Formononetin. Ezi zithako zisebenzayo zilawula iindlela ezahlukeneyo ze-biochemical ezifana ne-Cell Cycle Checkpoints kunye ne-NFKB Signaling kunye nezinye. Ikhaphetshu yeSavoy ayikhuthazwa xa umngcipheko weMarginal Zone Lymphoma xa umngcipheko wemfuzo unxulunyaniswa neB2M kuba yonyusa iindlela zokutyikitya.

I-CAULIFLOWER YOMFUNO INCEBISWA NGAPHEZU KWE-SAVOY ikhaphetshu ye-B2M YOMNGCIPHEKO WOMFUZO WOMHLAZA.

Khetha iSiqhamo iRABITEYE BLUEBERRY okanye iMIDILIYA YOMUSCADINE?

I-Fruit Rabbiteye I-Blueberry iqulethe izithako ezininzi ezisebenzayo okanye i-bioactives efana ne-Quercetin, i-Linalool, i-Eugenol, i-Ferulic Acid, i-Epicatechin. Ezi zithako ezisebenzayo zilawula iindlela ezahlukeneyo ze-biochemical ezifana ne-MYC Signaling, i-NFKB Signaling, i-Chemokine Signaling kunye ne-PI3K-AKT-MTOR Ukubonakaliswa kunye nabanye. I-Rabbiteye Blueberry icetyiswa kumngcipheko we-Marginal Zone Lymphoma xa umngcipheko wemfuzo ohambelana ne-B2M. Oku kungenxa yokuba iRabbiteye Blueberry yonyusa ezo ndlela zebhayoloji ezichasene nabaqhubi bayo.

Ezinye zezinto ezisebenzayo okanye i-bioactives kwiziqhamo ze-Muscadine Grape yi-Apigenin, i-Curcumin, i-Ellagic Acid, i-Daidzein, i-Lupeol. Ezi zithako zisebenzayo zilawula iindlela ezahlukeneyo ze-biochemical ezifana ne-Oncogenic Cancer Epigenetics kunye nokudumba kunye nabanye. IMuscadine Grape ayikhuthazwa xa umngcipheko weMarginal Zone Lymphoma xa umngcipheko wezofuzo uhambelana neB2M kuba yonyusa iindlela zokutyikitya kuyo.

ISIQHAMO I-RABITEYE BLUEBERRY IYAKUNCEBISWA NGAPHEZU KWEMIDILIYA YOMUSCADINE NGE-B2M YOMNGCIPHEKO WEMFUZO YOMHLAZA.

Khetha i-Nutt BUTTERNUT okanye i-FLEXSEED?

I-Butternut iqulethe izithako ezininzi ezisebenzayo okanye i-bioactives efana ne-Apigenin, i-Curcumin, i-Lycopene, i-Daidzein, i-Lupeol. Ezi zithako ezisebenzayo zilawula iindlela ezahlukeneyo ze-biochemical ezifana ne-RAS-RAF Signaling, i-NFKB Signaling, i-Inflammation kunye ne-PI3K-AKT-MTOR Ukubonakaliswa kunye nabanye. I-Butternut icetyiswa kumngcipheko we-Marginal Zone Lymphoma xa umngcipheko wemfuzo ohambelana ne-B2M. Oku kungenxa yokuba i-Butternut yonyusa ezo ndlela zebhayoloji ezichasene nabaqhubi bayo.

Ezinye zezinto ezisebenzayo okanye i-bioactives kwi-Flaxseed yi-Apigenin, i-Curcumin, i-Daidzein, i-Lupeol, i-Formononetin. Ezi zithako ezisebenzayo zilawula iindlela ezahlukeneyo ze-biochemical ezifana ne-NFKB Signaling, i-Oncogenic Cancer Epigenetics kunye ne-PI3K-AKT-MTOR Ukubonakaliswa kunye nabanye. I-Flaxseed ayikhuthazwa xa umngcipheko we-Marginal Zone Lymphoma xa umngcipheko wezofuzo uhambelana ne-B2M kuba yonyusa iindlela zokutyikitya kuyo.

IBHUTTERNUT IYANCEBISWA NGAPHEZU KWEFLAXSEED YE-B2M YOMNGCIPHEKO WEMFUZO YOMHLAZA.

Ukuququmbela

Ukutya kunye nezongezo ezikhethiweyo zizigqibo ezibalulekileyo zomhlaza ezifana ne-Marginal Zone Lymphoma. Izigulane zoMmandla weLymphoma kunye nabantu abasengozini yemfuza bahlala benalo mbuzo: "Kukuphi ukutya kunye nezongezo zesondlo ezicetyiswayo kum kwaye zingekho?" Kukho inkolelo eqhelekileyo eyingcamango ephosakeleyo yokuba konke ukutya okusekelwe kwizityalo kunokuba luncedo okanye akunjalo kodwa akuyi kuba yingozi. Ukutya okuthile kunye nezongezelelo zinokuphazamisana nonyango lomhlaza okanye zikhuthaze abaqhubi beendlela zeemolekyuli zomhlaza.

Kukho iintlobo ezahlukeneyo zezalathisi zomhlaza ezifana ne-Marginal Zone Lymphoma, nganye ine-tumor genetics eyahlukeneyo kunye nokwahluka kwe-genomic kumntu ngamnye. Ngaphaya koko, lonke unyango lomhlaza kunye nechemotherapy linendlela eyodwa yokusebenza. Ukutya ngakunye okufana ne-Brussels Sprouts kuqulethe iintlobo ngeentlobo ze-bioactives ngokwemiyinge eyahlukeneyo, enempembelelo kwiiseti ezahlukeneyo kunye nezahlukileyo zeendlela ze-biochemical. Inkcazo yesondlo somntu siqu zingcebiso zokutya zomntu ngamnye kwisalathiso somhlaza, unyango, imfuzo, indlela yokuphila kunye nezinye izinto. Izigqibo zokwenziwa kwesondlo somhlaza zifuna ulwazi lwebhayoloji yomhlaza, isayensi yokutya kunye nokuqonda iindlela ezahlukeneyo zonyango lwechemotherapy. Ekugqibeleni xa kukho utshintsho lonyango okanye i-genomics entsha ichongiwe - isondlo somntu sidinga ukuphononongwa kwakhona.

Isisombululo se-addon yesondlo somntu senza ukuba isigqibo sibe lula kwaye sisuse yonke into eqikelelwayo ekuphenduleni umbuzo, "Kukuphi ukutya endimele ndikukhethe okanye ndingakhethi kwi-Marginal Zone Lymphoma?". Iqela le-addon multi-disciplinary libandakanya oogqirha bomhlaza, izazinzulu zeklinikhi, iinjineli zesoftware kunye nososayensi bedatha.

Ucaphulo

• Mbn Mdacc 2013
• Imbonakalo yomhlaba eguqukayo yomhlaza we-metastatic ityhilwe kulandelelwano lwezonyango olulindelekileyo lwezigulana ezili-10,000.
• Hesperetin, unyango olunokubakho kumhlaza we-carcinoid.
• I-Indole-3-Carbinol (I3C) iphakamisa ukuvakalelwa kweeseli ze-murine ze-adenocarcinoma kwi-doxorubicin (DOX) ngokuvimbela i-NF-κβ, ukuvimbela i-angiogenesis kunye nokulawulwa kwe-mitochondrial apoptotic pathway.
• I-Paederia foetida yenza umsebenzi we-anticancer ngokumodareyitha i-chromatin modification enzymes kunye nokuguqula i-pro-inflammatory cytokine gene expression kwiiseli zomhlaza we-prostate.
• Ukungeniswa kwe-apoptosis ye-SW480 yeeseli zomhlaza wekholoni yomntu ngo (-)-epicatechin ekwanti kwi-Bulnesia sarmienti.
• I-Lycopene metabolite, i-apo-10'-lycopenoic acid, inqanda i-diethylnitrosamine-iqaliswe, i-fat high-fat fat-promoted inflammation ye-hepatic kunye ne-tumorigenesis kwiigundane.