Iimbalasane
Iziphumo ezivela kwizifundo ezahlukeneyo zicebise ukuba i-iron engaphezulu / i-heme iron intake ibe yingozi kwi-cancer efana ne-Breast Cancer kunye ne-Pancreatic Cancer; nangona kunjalo, i-iron intake okanye i-non-heme iron intake ingaba nefuthe lokukhusela kwi-colorectal kunye ne-esophageal cancers. Ngokusekwe kwizifundo ezivavanyiweyo kule bhlog, kwi i cancer njengomhlaza wemiphunga kunye nomhlaza wedlala lobudoda, akukho mibutho ibalulekileyo yafunyanwa. Amaphononongo achazwe kakuhle ngakumbi ayafuneka ukuseka ezi ziphumo. I-iron supplements intake with Erythropoiesis-stimulating agents for cancer chemotherapy-induced anemia (amanqanaba asezantsi e-hemoglobin) ingaba neenzuzo ezithile. Ngelixa ukuthathwa kwezixa ezifanelekileyo zentsimbi kubalulekile ekusebenzeni ngokufanelekileyo komzimba wethu, ukuthathwa kwayo ngokugqithisileyo kunokukhokelela kwiziphumo ebezingalindelekanga kwaye kusenokubulala abantwana. Ke ngoko, dibana nogqirha ngaphambi kokuba uthathe izongezo ze-iron yokutya.
Intsimbi-Esona sondlo siBalulekileyo
Isinyithi sisimbiwa esifunekayo esifanelekileyo ekusebenzeni kakuhle kwehemoglobin, iprotein efunekayo yokuhambisa ioksijini egazini, kunye nokukhula kunye nophuhliso. Ukuba sisondlo esibalulekileyo, i-iron kufuneka ifunyanwe ekutyeni kwethu. Ikwadlala indima ebalulekileyo kwezinye iinkqubo ezahlukeneyo ezinje ngokudala i-serotonin, ukusebenza kwemisipha, imveliso yamandla, iinkqubo zesisu, ukulawulwa kobushushu bomzimba, ukuhlanganiswa kwe-DNA kunye nokunyusa amajoni omzimba.
Intsimbi igcinwa ikakhulu kwisibindi kunye nomongo wethambo njenge-ferritin okanye i-hemosiderin. Isenokugcinwa kwipeni, i-duodenum kunye nesihlunu samathambo.
Imithombo yokutya ye-Iron
Eminye yemizekelo yemithombo yokutya yentsimbi ibandakanya:
- Inyama ebomvu
- Ibindi
- Iimbotyi
- ngomane
- Iziqhamo ezomileyo ezinje ngemihla eyomileyo kunye neeapilkosi
- Imbotyi yesoya
Iindidi zentsimbi
Intsimbi yokutya ikhona ngeendlela ezimbini:
- Isinyithi se-Heme
- Isinyithi esinge-heme
Isinyithi se-Heme siqulathe malunga ne-55-70% yentsimbi iyonke evela kwiimveliso zezilwanyana ezinje ngenyama ebomvu, iinkukhu kunye nentlanzi kwaye inefuthe elikhulu lokufunxa.
Isinyithi esinge-heme siquka yonke i-iron kunye ne-iron ekhoyo kukutya okusekwe kwizityalo ezinje ngeembotyi kunye nee-cereal, kunye nezongezo zentsimbi. Kunzima ukufunxa isinyithi ekutyeni okusekwe kwizityalo. Nceda uqaphele ukuba ukusebenzisa i-Vitamin C kuya kunceda ekufunxeni i-Iron.
Ukusilela kwentsimbi
Ukunqongophala kwesinyithi, okubizwa ngokuba yi-anemia, yimeko apho ukungabikho kwentsimbi emzimbeni kukhokelela kwinani elincinci leeseli ezibomvu ezisempilweni ezinokuhambisa ioksijini kwizicwili.
Isibonelelo semihla ngemihla se-Iron siyahluka ngokobudala kunye nesini:
- I-8.7mg ngemini yamadoda ngaphezulu kwe-18
- 14.8mg ngosuku kwabasetyhini abaneminyaka eli-19 ukuya kwengama-50
- 8.7mg ngosuku kubafazi abangaphezu kwama-50
Ezi mali zihlala zifumaneka kukutya kwethu.
Ukunqongophala kwentsimbi yeyona nto ixhaphakileyo emhlabeni. Ngenxa yoko, ngaphambili ukugxila okunxulumene nokutya kwentsimbi bekukho ngakumbi kukusilela kwentsimbi. Nangona kunjalo, kutshanje, abaphandi baphinde bajonga iimpembelelo zentsimbi egqithisileyo emzimbeni. Kule bhlog, siza kugxila kwezinye zezifundo ezivavanye umanyano phakathi kwentsimbi kunye nomngcipheko weentlobo ezahlukeneyo zomhlaza.
Ukutya okuTyiwa emva kokuChongwa koMhlaza!
Akukho mhlaza mibini ifanayo. Yiya ngaphaya kwezikhokelo zesondlo esiqhelekileyo kuwo wonke umntu kwaye wenze izigqibo ezizezakho malunga nokutya kunye nezongezo ngokuzithemba.
Umanyano phakathi komngcipheko womhlaza webele
I-Serum kunye ne-Tumor Tissue Iron kunye neengozi zomhlaza webele
Uhlalutyo lweemeta olwenziwe ngabaphandi abavela kwiYunivesithi yaseGolestan yeeNzululwazi zezoNyango, iYunivesithi yaseIlam yeeNzululwazi zezoNyango, iYunivesithi yaseShahid Beheshti yezeNzululwazi zezoNyango kunye neYunivesithi yaseBirjand yezeNzululwazi yezoNyango kuvavanye umanyano phakathi komngcipheko wentsimbi nomhlaza webele. Uhlalutyo lubandakanya amanqaku angama-20 (abandakanya abantu abayi-4,110 abanezigulana ezinomhlaza wamabele ezili-1,624 kunye nolawulo lwe-2,486) ezapapashwa phakathi kwe-1984 kunye ne-2017 kwaye yafunyanwa ngophando loncwadi kwi-PubMed, Scopus, Embase, kwiWebhu yeSayensi nakwithala leencwadi laseCochrane. (UAkram Sanagoo okqhubekayo, uCaspian J Intern Med., Ubusika 2020)
Uhlalutyo lufumene umngcipheko omkhulu womhlaza wesifuba kunye nokugxininiswa kwentsimbi ephezulu kumaqela apho isinyithi sasilinganiswa kwizicubu zesifuba. Nangona kunjalo, abafumananga naluphi na unxulumano phakathi koxinzelelo lwentsimbi kunye nebele umhlaza umngcipheko kumaqela apho isinyithi silinganiswa kwizinwele zentloko.
Ukutya i-Iron, imeko yentsimbi yomzimba, kunye nomngcipheko womhlaza webele
Abaphandi abavela kwiDyunivesithi yaseToronto kunye noKhathalelo lweCancer Ontario, eCanada benze uhlalutyo lweemeta ukuvavanya ubudlelwane phakathi kokubamba intsimbi kunye nenqanaba lomzimba wentsimbi kunye nomngcipheko womhlaza webele. Izifundo ze-23 zibandakanyiwe kuphononongo lophando loncwadi kwi-MEDLINE, EMBASE, CINAHL, nakwi-Scopus koovimba kude kube nguDisemba 2018. (UVicky C Chang okqhubekayo, Umhlaza weBMC, 2019)
Bafumanise ukuba xa kuthelekiswa nalawo ane-heme ye-inshurensi esezantsi, kukho i-12% yokunyuka komngcipheko webele kumngcipheko webele we-heme. Nangona kunjalo, abafumananga naluphi na unxibelelwano olubalulekileyo phakathi kokutya, ukuxhasa okanye ukungenisa i-iron iyonke kunye nomngcipheko womhlaza webele. Izifundo ezongezelelweyo ezichazwe kakuhle zeklinikhi ziyafuneka ukucacisa ngcono ubudlelwane phakathi kwentsimbi kunye nomhlaza webele.
Impembelelo yokuXhaswa kweAntioxidant kumanyano phakathi kokutya i-iron kunye nokutya okusemngciphekweni womhlaza webele
Uphononongo olwenziwe ngabaphandi eFrance ngo-2016 kuvavanya umanyano phakathi kokutya ukutya kwentsimbi kunye nomngcipheko womhlaza webele, kunye nokumodareyitha okunokubakho ngokuxhaswa kwe-antioxidant kunye nokutya kwe-lipid kuma-4646 abasetyhini abasuka kuvavanyo lweSU.VI.MAX. Ngexesha lokulandelwa kweminyaka eyi-12.6, kwaxelwa iimeko zomhlaza wamabele ezili-188. (UAbou Diallo okqhubekayo, Oncotarget., 2016)
Olu phononongo lufumanise ukuba ukutya okutyiwa ngentsimbi kwakudityaniswa nomngcipheko womhlaza webele, ngakumbi kwabasetyhini abatya ii-lipids ezininzi, nangona kunjalo, lo mbutho wafunyanwa kuphela kwabo bangakhange baxhaswe nge-antioxidants ngexesha lovavanyo. Olu pho nonongo luye lwagqiba ukuba umngcipheko wesifo somhlaza wesibeleko unokwandiswa yintsimbi ye-lipid peroxidation.
Ukutya kwe-NIH-AARP kunye noPhando lwezeMpilo
Kolunye uhlalutyo lwedatha yokutya ukusuka kwabafazi abayi-193,742 ababesakuba ngabasetyhini ababeyinxalenye yesidlo se-NIH-AARP kunye noFundo lwezeMpilo, kunye ne-9,305 yesigulo somhlaza webele esachongiweyo (1995-2006), kwafumaniseka ukuba i-heme ephezulu yentsimbi edityanisiweyo inxulunyaniswa Umngcipheko owandisiweyo womhlaza wamabele, uwonkewonke nakuwo onke amanqanaba omhlaza. (Maki Inoue-Choi okqhubekayo, Int J Cancer., 2016)
Umanyano phakathi kweNgozi yomngcipheko weColorectal Cancer
Ukufakwa kwentsimbi, ii-Indices ze-Iron Indices kunye nomngcipheko weeColorectal Adenomas
Abaphandi abavela kwiSibhedlele saBantu bePhondo laseZhejiang kunye neSibhedlele saBantu abaQalayo kwiSithili saseFuyang e-China, bavavanya umbutho phakathi kokutya i-iron, ii-indices ze-serum iron kunye nomngcipheko we-colorectal adenoma, besebenzisa idatha evela kumanqaku ali-10, abandakanya amatyala angama-3318 e-colorectal adenoma, afunyenwe kuncwadi ukukhangela kwi-MEDLINE nakwi-EMBASE kude kube nge-31 Matshi 2015. (H Cao okqhubekayo, Eur J Unonophelo loMhlaza (Engl)., 2017)
Uphononongo lufumanise ukuba ukonyuka kokutya kwe-heme iron kunxulunyaniswa nomngcipheko okhulayo we-colorectal adenoma, ngelixa ukutya i-non-heme okanye isinyithi esongezelelekileyo kunciphisa umngcipheko we-colorectal adenomas. Ngokusekwe kulwazi olulinganiselweyo olufumanekayo, kwakungekho mibutho phakathi kwee-indices zentsimbi kunye ne-colorectal adenoma risk.
Ukungeniswa kwe-heme iron kunye ne-zinc kunye ne-colorectal izehlo zomhlaza
Uphononongo olwenziwe ngabaphandi abavela kwiSibhedlele saseShengjing seYunivesithi yezoNyango yaseChina eChina bavavanya ubudlelwane phakathi kokuthathwa kwentsimbi yeheme kunye ne-zinc kunye ne-colorectal. umhlaza isiganeko. Izifundo ezisibhozo kwi-heme iron intake kunye nezifundo ezithandathu kwi-zinc intake zisetyenziselwa uhlalutyo olufunyenwe ngophando lweencwadi kwi-PubMed kunye ne-EMBASE yolwazi kude kube nguDisemba 2012. (Lei Qiao et al, uCancer Causes Control., 2013)
Olu hlalutyo lwe-meta lufumene ukonyuka okukhulu kumngcipheko womhlaza we-colorectal ngokunyuka kwe-heme iron kunye nokwehla okubonakalayo kumngcipheko womhlaza we-colorectal ngokunyuka kwe-zinc.
Umanyano phakathi komngcipheko womhlaza we-Esophageal Cancer
Abaphandi abavela kwiYunivesithi yaseZhengzhou kunye neZhejiang University School of Medicine e China benze uhlalutyo lweemeta lokuvavanya umanyano phakathi kokutya i-iron kunye ne-zinc kunye ne-heme yentsimbi esezantsi kunye nomngcipheko we-Esophageal Cancer. Idatha yohlalutyo yafunyanwa kumanqaku angama-20 ngamatyala angama-4855 avela kubathathi-nxaxheba abayi-1387482, afunyanwa kuphando loncwadi kwi-Embase, PubMed, nakwiWebhu yolwazi ngeNzululwazi ngo-Epreli 2018. (Jifei Ma e al, Nutr Res., 2018)
Uphononongo lufumanise ukuba yonke i-5 mg / usuku lokunyuka kokuthathwa kwentsimbi iyonke kunxulunyaniswa nomngcipheko we-15% wokunciphisa umhlaza womhlaza we-Esophageal Ukuncitshiswa komngcipheko kwafunyanwa ngakumbi kubantu baseAsia. Ngokuchasene noko, yonke i-1 mg / usuku lokunyuka kwe-heme iron intake yayanyaniswa ne-21% yokunyuka komngcipheko womhlaza we-Esophageal.
Umanyano phakathi komngcipheko weCancer kunye nePancreatic Cancer
Uphononongo olupapashwe kwi-2016 luvavanye umbutho wokutya inyama, iindlela zokupheka inyama kunye nomnikelo kunye ne-heme iron kunye ne-mutagen intake kunye nomhlaza we-pancreatic kwi-NIH-AARP Diet kunye ne-Health Study cohort ebandakanya abathathi-nxaxheba be-322,846 apho i-187,265 yayingamadoda kunye ne-135,581 yabasetyhini. Emva kokulandelelana okuqhelekileyo kweminyaka eyi-9.2, i-1,417 pancreatic umhlaza amatyala axeliwe. (Pulkit Taunk et al, Int J Cancer., 2016)
Uphononongo lufumanise ukuba umngcipheko womhlaza wepancreatic unyuke kakhulu ngokutya inyama iyonke, inyama ebomvu, inyama ephekiweyo enobushushu obuphezulu, inyama eyosiweyo / eyosiweyo, inyama eyenziwe kakuhle / eyenziwe kakuhle kunye nentsimbi yehemme evela kwinyama ebomvu. Abaphandi bacebise ngakumbi izifundo ezichazwe kakuhle ukuqinisekisa iziphumo zabo.
Umanyano phakathi kwengozi yomngcipheko weCancer Prostate
Kuphononongo olupapashwe ngabaphengululi abavela kumaziko e-EpidStat eMichigan naseWashington e-US, bavavanye umanyano phakathi kweendlela zokupheka inyama, i-heme iron, kunye ne-heterocyclic amine (HCA) yokutya kunye nomhlaza wesibeletho ngokusekwe kupapasho lwama-26 oluvela kwizifundo ezili-19 ezahlukeneyo . (ULauren C Bylsma okqhubekayo, uNutr J., 2015)
Uhlalutyo lwabo alufumananga unxibelelwano phakathi kwenyama ebomvu okanye ukusetyenziswa kwenyama egqityiweyo kunye nomhlaza webele; Nangona kunjalo, bafumene ukonyuka okuncinci kumngcipheko wokusetyenziswa kwenyama.
Umanyano phakathi kwamanqanaba eSerum Iron kunye nomngcipheko womhlaza wemiphunga
Uphononongo olwenziwe ngabaphandi besibhedlele iZhejiang Rongjun, iZhejiang Cancer Hospital, iFujian Medical University Cancer Hospital kunye neLishui Hospital yaseZhejiang University e China bavavanya ubudlelwane phakathi kwamanqanaba e-serum iron kunye nomngcipheko womhlaza wemiphunga. Idatha yohlalutyo yafunyanwa kwi-PubMed, WanFang, CNKI, kunye ne-SinoMed yolwazi kude kube nguMar 1, 2018. Uphononongo lufumanise ukuba amanqanaba esinyithi e-serum awanalo ubudlelwane obubalulekileyo nomngcipheko womhlaza wemiphunga. (U-Hua-Fei Chen okqhubekayo, Iseli ye-Mol Biol (Enengxolo-le-grand)., 2018)
Ukusetyenziswa kweziXhobo ze-Iron kuLawulo lwe-Chemotherapy-induction Anemia (amanqanaba aphantsi e-hemoglobin) kwizigulana ezinomhlaza
Uphononongo olwenziwe liZiko loNyango oluSekwe kubuNyango kunye noPhando lweZiphumo zezeMpilo, kwiDyunivesithi yaseMzantsi Florida, eTampa, eFlorida, e-USA kuvavanyiwe izibonelelo kunye nokwenzakala okunxulumene nokusetyenziswa kwezixhobo zentsimbi ecaleni kweearhente ze-Erythropoiesis-stimulating agents (ESAs), ezisetyenziswa rhoqo ukunyanga umhlaza we-chemotherapy-indemia anemia (amanqanaba aphantsi e-hemoglobin) -iCIA, kunye neCochrane Database Syst iron yodwa xa kuthelekiswa ne-ESA yodwa kulawulo lweCIA. (URahul Mhaskar et al, uMfu., 2016) Uphononongo lufumanise ukuba kubandakanya izongezo zentsimbi kunye nee-ESAs zomhlaza we-chemotherapy-indemia anemia kungakhokelela kwimpendulo ephezulu ye-hematopoietic, ukunciphisa umngcipheko wotofelo-gazi lweGazi elibomvu, kunye nokuphucula amanqanaba asezantsi e-hemoglobin.
Yiyo loo nto, ukongezwa kwesinyithi kunokuba nefuthe elifanelekileyo kwizigulana ezinomhlaza ezine-chemotherapy-indemia anemia (amanqanaba aphantsi e-hemoglobin).
isiphelo
Olu phononongo lucebise iziphumo ezahlukeneyo zentsimbi ngokwahlukileyo i cancer. I-iron eyongeziweyo ifunyenwe ibe yingozi kwi-cancer efana ne-Breast Cancer kunye ne-Pancreatic Cancer, mhlawumbi ngenxa yomsebenzi wayo we-pro-oxidant onokukhokelela kumonakalo we-DNA oxidative; nangona kunjalo, i-iron intake epheleleyo kunye ne-non-heme iron intake, ifunyenwe ibe nemiphumo yokukhusela kwi-colorectal and esophageal cancer. Kwimihlaza enjengomhlaza wemiphunga kunye nomhlaza wesibeleko, akukho nxulumano lubalulekileyo luxeliweyo. Izongezo ze-iron kunye nee-ESAs zomhlaza we-chemotherapy-induced anemia (amanqanaba asezantsi e-hemoglobin) kunokuba luncedo. Ngelixa ukuthathwa kwezixa ezifanelekileyo zentsimbi kubalulekile ekusebenzeni ngokufanelekileyo kwemizimba yethu, ukuthathwa kwayo ngokugqithisileyo kusetyenziswa izongezo kunokukhokelela kwiziphumo ebezingalindelekanga ezifana nokuqhinwa kunye neentlungu zesisu kwaye zinokubabulala abantwana. Ngoko ke, qhagamshelana nogqirha phambi kokuba uthathe izongezo ze-iron. Izixa ezifunekayo ze-iron zinokufunyanwa ekutyeni.
Kukuphi ukutya okutyayo kwaye okuncedisayo kukuthatha sisigqibo osithathayo. Isigqibo sakho kufuneka sibandakanye ukuthathelwa ingqalelo kotshintsho lomhlaza kuhlobo lomhlaza, unyango oluqhubekayo kunye nezongezelelo, nakuphi na ukwaliwa, ulwazi ngobomi bakho, ubunzima, ukuphakama kunye nemikhwa.
Isicwangciso sesondlo somhlaza esivela kwi-addon asisekelwanga kukhangelo lwe-Intanethi. Isebenza ngokuzenzekelayo ukwenza izigqibo zakho kusekwe kwisayensi yemolekyuli ephunyezwe ngoososayensi kunye neenjineli zesoftware. Nokuba ukhathalele na ukuqonda iindlela ezisisiseko seemolekyuli okanye hayi - zokucwangciswa kwesondlo somhlaza ukuqonda kuyafuneka.
Qalisa NGOKU ngokucwangciswa kwesondlo ngokuphendula imibuzo ngegama lomhlaza, uguquko kwimfuza, unyango oluqhubekayo kunye nezincedisi, nakuphi na ukwaliwa, imikhwa, indlela yokuphila, iqela lobudala kunye nesini.
ISondlo esiSiqu soMhlaza!
Umhlaza uyatshintsha ngokuhamba kwexesha. Yenza ngokwezifiso kwaye uguqule isondlo sakho ngokusekwe kwisalathiso somhlaza, unyango, indlela yokuphila, ukhetho lokutya, i-allergies kunye nezinye izinto.
Izigulana ezinomhlaza zihlala zisebenza ngeendlela ezahlukeneyo iziphumo ebezingalindelekanga ezichaphazela umgangatho wobomi babo kwaye bajonge ezinye iindlela zonyango lomhlaza. Ukuthatha isondlo esifanelekileyo kunye nezongezelelo ezisekwe kuqwalaselo lwenzululwazi (ukunqanda ukuqikelela kunye nokukhetha okungahleliwe) sesona sixhobo sendalo somhlaza kunye neziphumo ebezingalindelekanga zonyango.