Iimbalasane
Imbewu emnyama kunye neoyile yembewu emnyama inokunciphisa iziphumo ebezingalindelekanga zonyango lwechemotherapy kwiindidi ezahlukeneyo zomhlaza. Imbewu emnyama iqulethe izithako ezahlukeneyo zesondlo ezisebenzayo njenge-Thymoquinone. Izibonelelo ze-anticancer zembewu emnyama kunye ne-Thymoquinone ziye zavavanywa kwizigulana kunye nezifundo zaselebhu. Imizekelo embalwa yeenzuzo ze-thymoquinone, njengoko igxininiswe kwezi zifundo ibandakanya ukunciphisa umkhuhlane kunye nosulelo olusuka kwinani eliphantsi le-neutrophil kwi-cancer yobuchopho yabantwana, ukunciphisa i-methotrexate (i-chemotherapy) ehambelana ne-side-effect ye-toxicity kwi-leukemia kunye nempendulo engcono kwizigulane zomhlaza wamabele ezinyangwa nge-tamoxifen. unyango. Ngenxa yokuba ioli yembewu emnyama iyakrakra - ihlala ithathwa nobusi. Ngokusekelwe kuyo umhlaza kunye nonyango, ezinye izongezo zokutya nezondlo zinokungakhuseleki. Ngoko ke, ukuba isigulana somhlaza webele sinyangwa nge-tamoxifen kwaye sisebenzisa ioli yembewu emnyama - ngoko ke kubalulekile ukuphepha iParsley, isipinatshi kunye neTea eluhlaza, kunye nezongezo zokutya ezifana neQuercetin. Ke ngoko, kubaluleke kakhulu ukwenza isondlo somntu kumhlaza othile kunye nonyango lokufumana izibonelelo kwisondlo kunye nokukhuseleka.
Kuphela ngabo bathwaxwe kukufunyaniswa komhlaza kunye nabo babathandayo bazazi kakuhle ukuba kungxama kangakanani ukuzama ukufumana indlela engaphambili, ekufumaneni abona gqirha babalaseleyo, olona khetho lonyango lungcono, kunye nayo nayiphi na enye indlela yokuphila, ukutya kunye nolunye ukhetho olongezelelweyo. bangasebenzisa ithuba lokulwa ukuze bangabi namhlaza. Kwakhona, abaninzi boyiswe lunyango lwechemotherapy ekufuneka belwenzile ngaphandle kweziphumo ebezingalindelekanga ezibi kakhulu kwaye bajonge iindlela zokuphucula unyango lwabo lwechemotherapy ngokhetho longezelelo lwendalo ukunciphisa iziphumo ebezingalindelekanga kunye nokuphucula impilo yabo jikelele. Enye yezongezo zendalo ezinedatha eyaneleyo ye-preclinical kwi umhlaza imigca yeseli kunye neemodeli zezilwanyana yioli yembewu emnyama.
Imbewu emnyama yeoyile kunye neThymoquinone
Imbewu yeoyile emnyama ifunyanwa kwimbewu emnyama, imbewu yesityalo egama linguNigella sativa ngombala omfusa, luhlaza okwesibhakabhaka okanye omhlophe, eyaziwa njengeentyatyambo zefennel. Imbewu emnyama isetyenziswa kakhulu kwiAsia naseMeditera cuisine. Imbewu emnyama yaziwa njenge cumin emnyama, kalonji, caraway emnyama kunye nembewu yeetswele emnyama.
Imbewu emnyama isetyenziselwe ukwenza amayeza amawaka eminyaka. Esinye sezithako eziphambili ze-bioactive zeoyile yembewu emnyama ene-antioxidant, anti-inflammatory kunye ne-anti-cancer properties yi-Thymoquinone.
IziBonelelo zezeMpilo ngokubanzi zeMbewu eMnyama yeoyile / iThymoquinone
Ngenxa yeempawu zayo zokulwa ne-antioxidant kunye ne-anti-inflammatory, i-oyile yembewu emnyama / i-Thymoquinone ithathwa njengezibonelelo ezininzi zempilo. Ezinye zeemeko ezinokuthi zisebenze ngeoli yeMbewu eMnyama zezi:
- Isifuba: Imbewu emnyama inokunciphisa ukukhwehlela, ukuvutha, kunye nokusebenza kwemiphunga kwabanye abantu abane-asthma.
- seswekile: Imbewu emnyama inokuphucula amanqanaba eswekile yegazi kunye namanqanaba e-cholesterol kubantu abanesifo seswekile.
- Igazi elonyukayo: Ukuthatha imbewu emnyama kunokunciphisa uxinzelelo lwegazi ngesixa esincinci.
- Ukungachumi kwabesilisa: Ukuthatha ioyile yembewu emnyama kunokunyusa inani lobudoda kunye nokuba bahamba ngokukhawuleza kangakanani emadodeni ngokungachumi.
- Intlungu yesifuba (imastalgia): Ukufaka ijeli equkethe ioyile embewu emnyama emabeleni ngexesha lokuya exesheni kunokunciphisa iintlungu kubafazi abaneentlungu zebele.
Iziphumo ebezingalindelekanga zeMbewu eMnyama yeoyile / iThymoquinone
Xa isetyenziswa ngesixa esincinci njengesiqholo ekutyeni, imbewu emnyama kunye neoyile yembewu emnyama kunokwenzeka ukuba ikhuseleke kuninzi lwabantu. Nangona kunjalo, ukusebenzisa ioyile yembewu emnyama okanye izongezo kwezi meko zilandelayo kunokuba kungakhuselekanga.
- Ukukhulelwa: Kuphephe ukutya kakhulu ioyile yembewu emnyama okanye izicatshulwa ngexesha lokukhulelwa njengoko kunokucothisa isibeleko ekungeneni kwisivumelwano.
- Iingxaki zokopha: Ukutya imbewu yeoyile emnyama kunokuba nefuthe ekunqandeni igazi kunye nokunyusa umngcipheko wokopha. Ngenxa yoko, kukho ukubakho kokutya imbewu emnyama kunokubangela ukuphazamiseka kokopha ngakumbi.
- I-Hypoglycemia: Kuba ioyile yembewu emnyama inokunciphisa amanqanaba eswekile yegazi, abaguli abaneswekile abathatha amayeza kufuneka bajonge imiqondiso yeswekile esezantsi yegazi.
- Uxinzelelo lwegazi oluphantsi: Gwema ioyile yembewu emnyama ukuba unoxinzelelo lwegazi kuba imbewu emnyama inokuhlisa uxinzelelo lwegazi ngakumbi.
Ngenxa yobungozi obunokubakho kunye neziphumo ebezingalindelekanga, umntu kufuneka aphephe ukusebenzisa ioyile yembewu emnyama ukuba icwangciselwe utyando.
Ukutya okuTyiwa emva kokuChongwa koMhlaza!
Akukho mhlaza mibini ifanayo. Yiya ngaphaya kwezikhokelo zesondlo esiqhelekileyo kuwo wonke umntu kwaye wenze izigqibo ezizezakho malunga nokutya kunye nezongezo ngokuzithemba.
I-Thymoquinone / Ukusetyenziswa kweoyile eMnyama ngeMbewu ekuphuculeni ukusebenza kweChemotherapy ngokuSebenza okanye ukunciphisa iZiphumo zeCala kwiCancer
Uphengululo lwamva nje koolindixesha bovavanyo lwenzululwazi lushwankathela inani elikhulu lezifundo zovavanyo kwiiseli okanye kwiimodeli zezilwanyana zomhlaza ezahlukeneyo ezibonisa iipropathi ezininzi ze-Thymoquinone ezivela kwioyile yembewu emnyama, kubandakanya nendlela ezinokuthi zivuselele ngayo amathumba kwezinye zonyango oluqhelekileyo kunye nonyango lwemitha (Uninzi lwe -afaafa AGM okqhubekayo, ngaphambili Pharmacol, 2017; Khan MA okqhubekayo, Oncotarget 2017).
Nangona kunjalo, kukho kuphela uphando olulinganiselwe kunye nezifundo ezifumanekayo ebantwini ezivavanya iziphumo ze-thymoquinone okanye ioli yembewu emnyama kwiindawo ezahlukeneyo. i cancer xa unyangwa kunye okanye ngaphandle kweekhemotherapies ezithile. Ngomhlaza omninzi, ichemotherapy okanye unyango lweradiation lunikezelwa emva kotyando ukuphelisa naziphi na iiseli zomhlaza eziseleyo. Kodwa olu nyango lwe-adjuvant alusoloko luphumelela kwaye lunokuphazamisa umgangatho wobomi besigulane. Kule bhlog, siza kuphonononga izifundo ezahlukeneyo zeklinikhi zeoyile yembewu emnyama okanye i-thymoquinone kumhlaza kwaye sifumanise ukuba ukusetyenziswa kwayo kuluncedo kwizigulana ezinomhlaza kwaye ingasetyenziselwa ukwenza ngcono Ukutya kwabaguli abanomhlaza.
Imbewu emnyama / i-Thymoquinone kunye ne-Chemotherapy inokunciphisa i-Side-Effect ye-Febrile Neutropenia kuBantwana abane-Brain Tumors
Yintoni i-Febrile Neutropenia?
Esinye seziphumo ebezingalindelekanga ze-chemotherapy kukucinezelwa komongo wethambo kunye neeseli zomzimba. I-neutropenia ye-Febrile yimeko apho ngenxa yenani eliphantsi kakhulu le-neutrophils, uhlobo lweeseli ezimhlophe zegazi emzimbeni, isiguli sinokukhula sisifo kunye nomkhuhlane. Esi sisiphumo secala esiqhelekileyo esibonwayo kubantwana abanezicubu zobuchopho abafumana unyango lwe-chemotherapy.
UkuFunda kunye nokuFunyanwa okuPhambili
Kwisifundo sezonyango esenziwe ngokungahleliwe, esenziwe kwiYunivesithi yaseAlexandria e-Egypt, abaphandi bavavanye isiphumo sokuthatha imbewu emnyama nge-chemotherapy, kwicala lesiphumo se-febrile neutropenia ebantwaneni abane tumors yengqondo. Ngama-80 abantwana abaphakathi kweminyaka emi-2-18 ubudala abanamathumba obuchopho, abafumana unyango lwe-chemotherapy, ababelwa amaqela amabini. Iqela elinye labantwana abangama-40 lifumene i-5 g yembewu emnyama yonke imihla kunyango lwabo lwe-chemotherapy ngelixa elinye iqela labantwana abangama-40 lifumana ichemotherapy. (UMousa HFM okqhubekayo, Isistim seNervous Syst., 2017).
Iziphumo zolu phononongo zibonise ukuba kuphela yi-2.2% yabantwana kwiqela abathatha imbewu emnyama babenefebrile neutropenia ngelixa bekwiqela lolawulo, i-19.2% yabantwana ineziphumo ebezingalindelekanga zefebrile neutropenia. Oku kuthetha ukuba ukutya imbewu emnyama kunye ne-chemotherapy kunciphise izehlo ze-febrile neutropenia episodes nge-88% xa kuthelekiswa neqela lolawulo.
I-oyile emnyama yeMbewu / i-Thymoquinone inokunciphisa i-Methotrexate Chemotherapy-Isiphumo seSiphumo seSibindi / iHepato-ityhefu kubantwana abane-Leukemia
I-leukemia ye-lymphoblastic leukemia yenye yezona zinto zomhlaza zixhaphakileyo ebantwaneni. I-Methotrexate yichemotherapy eqhelekileyo esetyenziselwa ukwandisa izinga lokusinda kubantwana abane-leukemia. Nangona kunjalo, unyango lwe-methotrexate lunokukhokelela kwiziphumo ezinobuzaza be-chemotherapy ye-hepatotoxicity okanye ityhefu yesibindi, ngaloo ndlela inciphisa ifuthe layo.
UkuFunda kunye nokuKhangela okuPhambili
A Uvavanyo olulawulwa ngokungakhethiyo olwenziwe ngabaphandi abasuka kwiYunivesithi yaseTanta e-Egypt bavavanya ifuthe lonyango lweoyile yembewu emnyama kwi-methotrexate eyenze ukuba i-hepatotoxicity kubantwana abangama-40 base-Egypt bafumaniswe ukuba bane-leukemia ebukhali ye-lymphoblastic. Isiqingatha sezigulana sanyangwa ngonyango lwe-methotrexate kunye neoyile yembewu emnyama kunye nesiqingatha sokuphumla sanyangwa ngamayeza e-methotrexate kunye ne-placebo (into engenaxabiso lonyango). Olu phononongo lukwabandakanya abantwana abangama-20 abasempilweni abafanelana nobudala kunye nokwabelana ngesondo kwaye babesetyenziswa njengeqela lolawulo. (I-Adel A Hagag okqhubekayo, Ukuchaphazela iiThagethi zoThintelo lweziyobisi., 2015)
Uphononongo lufumanise ukuba ioyile yembewu emnyama / i-thymoquinone inciphise i-methotrexate chemotherapy ebangelwe sisiphumo se-hepatotoxicity kwaye inyuse ipesenti yezigulana ezifumana uxolelo olupheleleyo malunga ne-30%, ukunciphisa ukubuyela umva malunga ne-33%, kunye nokuphucula ukusinda kwezifo ngaphandle kwe-60% xa kuthelekiswa ne-placebo ebantwaneni abane-leukemia ebukhali ye-lymphoblastic; Nangona kunjalo, kwakungekho phuculo lubalulekileyo ekusindeni ngokubanzi. Abaphandi bagqiba kwelokuba ioyile yembewu emnyama / i-thymoquinone inokucetyiswa njengesiyobisi esincedisayo kubantwana abane-Leukemia abafumana unyango lwe-methotrexate.
Ukuthatha i-Thymoquinone kunye neTamoxifen kunokuphucula ukusebenza kwayo kwizigulana ezinomhlaza wamabele
Umhlaza wamabele ngowona uxhaphakileyo i cancer kwabasetyhini kwihlabathi liphela. I-Tamoxifen ngumgangatho wokunyamekela unyango lwe-hormonal olusetyenziswa kwi-estrogen receptor positive (ER+ve) yomhlaza wamabele. Nangona kunjalo, ukuphuhliswa kokumelana ne-tamoxifen yenye yezona zinto zithintelayo. I-Thymoquinone, eyona nto isebenzayo kwi-oyile yembewu emnyama, yafunyanwa iyi-cytotoxic kwiindidi ezininzi zemigca yeeseli zomhlaza womntu onganyangekiyo ngamachiza.
UkuFunda kunye nokuFunyanwa okuPhambili
Kwisifundo esenziwe ngabaphandi abasuka kwiDyunivesithi yaseGujarat eIndiya, kwiYunivesithi yaseTanta eYiputa, kwiYunivesithi yaseTaif eSaudi Arabia naseYunivesithi yaseBenha e-Egypt, bavavanya isiphumo sokusebenzisa i-thymoquinone (eyona nto iphambili yeoyile yembewu emnyama) tamoxifen kwizigulana ezinomhlaza wamabele. Uphononongo lubandakanya abaguli abangama-80 ababhinqileyo abanomhlaza wamabele abanganyangwa, baphathwa nge-tamoxifen bodwa, baphathwa nge-thymoquinone (ukusuka kwimbewu emnyama) iyodwa okanye baphathwa nge-thymoquinone kunye ne-tamoxifen. (U-Ahmed M Kabel okqhubekayo, J Unokwenza iSci Res., 2016)
Uphononongo lufumanise ukuba ukuthatha i-thymoquinone kunye neTamoxifen kube nefuthe elingcono kunelinye lala machiza kuphela kwizigulana ezinomhlaza wamabele. Abaphandi bagqiba kwelokuba ukongezwa kwe-thymoquinone (ukusuka kwioyile embewu emnyama) ukuya kwi-tamoxifen kunokubonisa indlela yonyango entsha yolawulo lomhlaza wamabele.
I-Thymoquinone inokukhuseleka kwizigulana ezinomhlaza ophambili, kodwa isenokungabi nayo impembelelo yonyango
UkuFunda kunye nokuFunyanwa okuPhambili
Kwinqanaba lokufunda kwam elenziwe ngo-2009, ngabaphandi baseKing Fahd Hospital yaseYunivesithi nase-King Faisal University e-Saudi Arabia, bavavanya ukhuseleko, ubungozi kunye nefuthe lonyango lwe-thymoquinone kwizigulana ezinomhlaza ophambili apho kwakungekho nyango lusemgangathweni okanye amanyathelo okudambisa. Kwisifundo, abaguli abangama-21 abadala abanezilonda eziqinileyo okanye i-hematological malignancies abaye basilela okanye babuyela kunyango oluqhelekileyo banikwa i-thymoquinone ngomlomo kwinqanaba le-3, 7, okanye 10mg / kg / ngosuku. Emva kwexesha eliphakathi le-3.71 iiveki, akukho ziphumo zichaphazelekayo. Nangona kunjalo, akukho ziphumo zichasene nomhlaza eziye zajongwa kolu phononongo. Ngokusekwe kuphononongo abaphandi bagqibe kwelokuba i-thymoquinone ibinyamezeleke kakuhle kwithamo elisusela kwi-75mg / ngosuku ukuya kwi-2600mg / ngosuku ngaphandle kwetyhefu okanye iimpendulo zonyango ezichaziweyo. (UAli M. Al-Amri kunye no-Abdullah O. Bamosa, uShiraz E-Med J., 2009)
isiphelo
Izifundo ezininzi ze-preclinical kwimigca yeeseli kunye nezahlukeneyo umhlaza Iinkqubo zemodeli sele zifumene iipropathi ezininzi ze-anticancer ze-Thymoquinone ukusuka kwioli yembewu emnyama. Izifundo ezimbalwa zeklinikhi zikwabonise ukuba ukuthatha i-oyile yembewu emnyama / i-thymoquinone kunokunciphisa i-chemotherapy-induced side-effect ye-febrile neutropenia kubantwana abane-brain tumors, i-Methotrexate yenza i-toxicity yesibindi kubantwana abane-leukemia kwaye inokuphucula impendulo kunyango lwe-tamoxifen kwizigulane zomhlaza wamabele. . Nangona kunjalo, izongezo zeoli yembewu emnyama okanye izongezelelo ze-thymoquinone kufuneka zithathwe njengenxalenye yokutya kuphela emva kokubonisana nomboneleli wakho wezempilo ukuze ugweme nayiphi na intsebenziswano embi kunye nonyango oluqhubekayo kunye nemiphumo emibi ngenxa yezinye iimeko zempilo.
Kukuphi ukutya okutyayo kwaye okuncedisayo kukuthatha sisigqibo osithathayo. Isigqibo sakho kufuneka sibandakanye ukuthathelwa ingqalelo kotshintsho lomhlaza kuhlobo lomhlaza, unyango oluqhubekayo kunye nezongezelelo, nakuphi na ukwaliwa, ulwazi ngobomi bakho, ubunzima, ukuphakama kunye nemikhwa.
Isicwangciso sesondlo somhlaza esivela kwi-addon asisekelwanga kukhangelo lwe-Intanethi. Isebenza ngokuzenzekelayo ukwenza izigqibo zakho kusekwe kwisayensi yemolekyuli ephunyezwe ngoososayensi kunye neenjineli zesoftware. Nokuba ukhathalele na ukuqonda iindlela ezisisiseko seemolekyuli okanye hayi - zokucwangciswa kwesondlo somhlaza ukuqonda kuyafuneka.
Qalisa NGOKU ngokucwangciswa kwesondlo ngokuphendula imibuzo ngegama lomhlaza, uguquko kwimfuza, unyango oluqhubekayo kunye nezincedisi, nakuphi na ukwaliwa, imikhwa, indlela yokuphila, iqela lobudala kunye nesini.
ISondlo esiSiqu soMhlaza!
Umhlaza uyatshintsha ngokuhamba kwexesha. Yenza ngokwezifiso kwaye uguqule isondlo sakho ngokusekwe kwisalathiso somhlaza, unyango, indlela yokuphila, ukhetho lokutya, i-allergies kunye nezinye izinto.
Izigulana ezinomhlaza zihlala zisebenza ngeendlela ezahlukeneyo iziphumo ebezingalindelekanga ezichaphazela umgangatho wobomi babo kwaye bajonge ezinye iindlela zonyango lomhlaza. Ukuthatha isondlo esifanelekileyo kunye nezongezelelo ezisekwe kuqwalaselo lwenzululwazi (ukunqanda ukuqikelela kunye nokukhetha okungahleliwe) sesona sixhobo sendalo somhlaza kunye neziphumo ebezingalindelekanga zonyango.