Iimbalasane
Ulingo olwahlukeneyo olwandulelayo lwezonyango, izifundo zoqwalaselo kunye nohlalutyo lwe-meta lucebisa ukuba isicatshulwa se-Astragalus sinokuba neenzuzo zempilo kwaye inokunceda ukunciphisa iziphumo ebezingalindelekanga ezibangelwa yi-chemotherapy ezifana nesicaphucaphu, ukuhlanza, isifo sohudo, ukucinezelwa kwamathambo, ukuphucula umgangatho wobomi izigulane ezinomhlaza ophezulu; ukuphucula ukudinwa okunxulumene nomhlaza kunye ne-anorexia kunye nokusebenzisana neekhemotherapies ezithile kunye nokuphucula ukusebenza kwazo konyango, ngakumbi kumhlaza wemiphunga weseli ongemncinci. Nangona kunjalo, i-astragalus extract inokunxibelelana namachiza athile kubandakanya i-chemotherapies umhlaza, ekhokelela kwiziganeko ezimbi. Ke ngoko, ukusetyenziswa ngokungakhethiyo kwezongezelelo ze-Astragalus kufuneka kuthintelwe.
Yintoni iAstragalus?
I-Astragalus yimifuno esetyenzisiweyo kumayeza esiNtu amaTshayina kangangamakhulu eminyaka. Ikwaziwa njenge "vetch yobisi" okanye "huang qi" ethetha "inkokheli etyheli", kuba ingcambu yayo imthubi ngombala.
Isicatshulwa se-Astragalus saziwa ngokuba nezinto zonyango kwaye sisetyenziselwa ukuxhasa amajoni omzimba asempilweni. Kukho iintlobo ezingaphezu kwama-3000 ezahlukeneyo ze-Astragalus. Nangona kunjalo, ezona ntlobo ziqhelekileyo zisetyenziswayo kwizongezo ze-astragalus I-Astragalus membranaceus.
Izibonelelo zezeMpilo ze-Astragalus Extract
Ingcambu yinxalenye yonyango yesityalo se-Astragalus. Izibonelelo zezempilo zokukhutshwa kwe-Astragalus zinxulunyaniswa nezinto ezahlukeneyo ezisebenzayo ezikhoyo kwisityalo kubandakanya:
- Iipolysaccharides
- Iisaponins
- Flavonoids
- I-Linoleic acid
- Amino acid
- Alkaloids
Kwezi, i-Astragalus polysaccharide ithathwa njengeyona nto ibaluleke kakhulu eneempembelelo ezininzi ze-pharmacological.
KwiNyango yamaTshayina yesiNtu, isicatshulwa se-Astragalus sisetyenziswe sodwa okanye ngokudibeneyo namanye amayeza eemeko ezahlukeneyo zempilo. Ezi zilandelayo zezinye zezibonelelo zezempilo kunye neempawu zonyango ezenzelwe i-Astragalus.
- Ngaba unokuba neepropathi zokulwa ne-antioxidant
- Ngamana unokuba ne-antimicrobial, antiviral kunye ne-anti-inflammatory properties
- Ngaba unokufumana iziphumo zentliziyo / ukunceda ukuphucula ukusebenza kwentliziyo
- Ngamana unokunyusa inkqubo ye-Immune system / ibe neziphumo zokuzikhusela emzimbeni
- Ngamana unokunciphisa ukudinwa okungapheliyo / ukuphucula amandla kunye namandla
- Ngamana unokukhusela izintso
- Ngamana unokunceda ukulawula amanqanaba eswekile yegazi
- Ngaba unokuba nefuthe elithile lomhlaza
- Ngaba unokunciphisa iziphumo ebezingalindelekanga ezithile zechemotherapy
- Ngamana unokunceda ekunyangeni ukubanda okuqhelekileyo kunye nezinye izifo
Iziphumo ebezingalindelekanga kunye nokunxibelelana okunokwenzeka kwe-Astragalus kunye nezinye iziyobisi
Nangona i-astragalus ithathwa njengekhuselekileyo, inokuphazamisa iziyobisi ezithile kwaye inokukhokelela kwiziphumo ebezingalindelekanga ezithile.
- Kuba i-Astragalus inezixhobo ezonyusa amajoni omzimba, ukusetyenziswa kwayo kunye neziyobisi ezichaphazela umzimba ezifana ne-prednisone, cyclosporine kunye ne-tacrolimus zinokwehla okanye zinciphise ukusebenza kwala machiza enzelwe ukuthintela ukusebenza komzimba.
- I-Astragalus ineziphumo zomchamo. Yiyo loo nto ukusetyenziswa kwayo kunye nezinye iziyobisi ezichazayo kunokwandisa iziphumo zazo. Ukongeza, ukuthatha i-astragalus kunokuba nefuthe kwindlela umzimba osusa ngayo i-lithium, ngaloo ndlela kukhokelela ekwandeni kwamanqanaba e-lithium kunye neziphumo ebezingalindelekanga ezinxulumene noko.
- I-Astragalus inokuba neepropathi zokucoca igazi. Ngenxa yoko, ukusetyenziswa kwayo kunye nezinye iziyobisi ezichasayo kunokunyusa umngcipheko wokopha.
Ukutya okuTyiwa emva kokuChongwa koMhlaza!
Akukho mhlaza mibini ifanayo. Yiya ngaphaya kwezikhokelo zesondlo esiqhelekileyo kuwo wonke umntu kwaye wenze izigqibo ezizezakho malunga nokutya kunye nezongezo ngokuzithemba.
Izifundo kwi-Astragalus Extract Use in Cancer
1. Umhlaza weParyary okanye weLaryngeal
Impembelelo ye-Astragalus Polysaccharides kunye neComoradiotherapy ngokuQhelekileyo kwiZiganeko eziGwenxa kunye noMgangatho woBomi beZigulana ezinomhlaza.
Kutshanje, okokuqala, inqanaba lesibini lokuvavanywa kweklinikhi okwenziwe ngabaphandi beYunivesithi yaseChang Gung e-China, bafundile ifuthe le-Asparagus polysaccharides inaliti kunyango olufanayo lwe-chemoradiation therapy (CCRT) ehambelana neziganeko ezimbi kwizigulana ezinomhlaza we-pharyngeal okanye we-laryngeal. Inkqubo ye-chemotherapy ibandakanya i-cisplatin, tegafur-uracil kunye ne-leucovorin. Izigulana ezili-17 zibandakanyiwe kolu phando. (U-Chia-Hsun Hsieh okqhubekayo, J I-Cancer Res Clin Oncol., 2020)
Uphononongo lufumanise ukuba iziganeko ezichaseneyo nonyango bezingaqhelekanga kwiqela lezigulana ezinomhlaza ezifumana zombini i-astragalus polysaccharides kunye nonyango olufanayo lwe-chemoradiation (CCRT), xa kuthelekiswa neqela elifumene i-CCRT kuphela. Uphononongo lufumene nomgangatho omncinci wobomi obahlukeneyo kwi-astragalus kunye neqela leCCRT, xa kuthelekiswa neqela elifumene iCCRT kuphela. Umahluko wawubalulekile kwi-QOL (umgangatho wobomi) izinto kubandakanya iintlungu, ukulahleka kwesidlo, kunye nokuziphatha kokutya ekuhlaleni.
Nangona kunjalo, uphononongo alufumananga zizibonelelo zongezelelweyo kwimpendulo ye-tumor, ukusinda kwesifo esithile kunye nokusinda xa ulawulwa nge-Astragalus polysaccharides ngexesha le-chemoradiotherapy kwi-pharyngeal okanye kwi-laryngeal. umhlaza izigulane.
2. Umhlaza wemiphunga ongeyiyo encinci
Izibonelelo zenaliti ye-Astragalus idityaniswe nePlatinum-based Chemotherapy kwizigulana ezinomhlaza
Kuhlalutyo lwe-meta olwenziwe ngo-2019 ngabaphandi beSibhedlele esiDibeneyo seYunivesithi yaseNanjing ye-Chinese Medicine, e-China, bavavanya izibonelelo zokusebenzisa i-astragalus ngokudibanisa ne-platinum-based chemotherapy kwizigulana ezinomhlaza wesifo somhlaza wamaphaphu ongekho mncinci. Uhlalutyo, bafumana idatha ngophando loncwadi kwi-PubMed, EMBASE, Database yeZiseko zoLwazi zaseChina, iThala leencwadi laseCochrane, iDatabase yeWanfang, iDathabheyisi yeChina yeBiological Medicine, kunye neDatabase yaseTshayina yeNzululwazi yezeNzululwazi kude kube nguJulayi 2018. Olu phononongo lubandakanya i-19 iyonke eyenziwe ngokungahleliwe. izilingo ezilawulwayo kubandakanya abaguli abali-1635. (Ukugula kukaCao okqhubekayo, amayeza (eBaltimore)., 2019)
Uhlalutyo lwe-meta lufumanise ukuba ukusetyenziswa kwenaliti ye-astragalus kudityaniswe ne-chemotherapy kungaphucula ukusebenza kwe-chemotherapy esekwe kwiplatinam, kunye nokuphucula izinga lokusinda konyaka-1, ukunciphisa imeko ye-leukopenia (ubalo lweeseli ezimhlophe zegazi), iplateletityityity, kunye ukugabha. Nangona kunjalo, inqanaba lobungqina laliphantsi. Uvavanyo oluchazwe kakuhle lwezonyango luyafuneka ukuseka ezi zinto zifunyanisiweyo.
Uhlalutyo olufanayo lwenziwe kwishumi leminyaka ngaphambili, olubandakanya iimvavanyo zeklinikhi ezingama-65 ezibandakanya izigulana ezingama-4751 zacebisa nefuthe elifanelekileyo lokulawula i-astragalus kunye ne-chemotherapy esekwe kwiplatinam. Nangona kunjalo, abaphandi bachaze isidingo sokuqinisekisa ezo zinto zifunyanisiweyo kuvavanyo oluqhutywa kakuhle lweklinikhi ngaphambi kokuba kuqhubeke naziphi na iingcebiso. (UJean Jacques Dugoua okqhubekayo, Umhlaza wemiphunga (Auckl)., 2010)
Izibonelelo zokuSetyenziswa ngokuBumbeneyo kwamayeza e-Chinese Herbal kunye neRadiotherapy kwizigulana ezinomhlaza
Kuphononongo olucwangcisiweyo olwenziwe ngo-2013 ngabaphandi beSibhedlele esiDibeneyo seYunivesithi yaseNanjing yeTshayina yamayeza e-China, bavavanya izibonelelo zokusebenzisa amayeza e-Astragalus aqukethe amayeza amaTshayina kunye ne-radiotherapy kwizigulana ezingesosincinci somhlaza wesifo somhlaza. Uphengululo lubandakanya izifundo ezingama-29 ezifanelekileyo. (Hailang He et al, Ubungqina obusekelwe kwi-Alternat Med., 2013)
Uphononongo lufumanise ukuba ukusetyenziswa ngokudibeneyo kwe-Astragalus equkethe amayeza e-Chinese amayeza e-herbal kunye ne-radiotherapy kunokuba luncedo kwizigulana ezinomhlaza wesifo somhlaza esincinci ngokunyusa ukusebenza konyango kunye nokunciphisa ubuthi be-radiotherapy. Nangona kunjalo, abaphandi bacebise ukuba kwenziwe izilingo ezinkulu zeklinikhi ukuqinisekisa ezi ziphumo.
Iziphumo zenaliti ye-Astragalus polysaccharide edityaniswe neVinorelbine kunye neCisplatin kumgangatho wobomi kunye nokusinda kwabaguli abanomhlaza.
Abaphandi abavela kwiSibhedlele esiDibeneyo seThathu seYunivesithi yaseHarbin yezoNyango, e-China baqhuba uvavanyo lokuvavanya ukuba inaliti ye-Astragalus polysaccharide (APS) edityaniswe ne-vinorelbine kunye ne-cisplatin (VC) iphucule umgangatho wobomi bezigulana ezinomhlaza wesifo somhlaza wamaphaphu ongekho mncinci (NSCLC ). Uphononongo luvavanye nefuthe lalo ekuphenduleni ithumba, kwityhefu, nakwiziphumo zokusinda ngokusekwe kwidatha evela kwizigulana ezingama-136 ze-NSCLC ezazibhalise kufundo phakathi kuka-Meyi 2008 ukuya ngoMatshi 2010. (Li Guo okqhubekayo, Med Oncol., 2012)
Inqanaba lokuphendula kunye nexesha lokusinda liphuculwe kancinci (i-42.64% kunye ne-10.7 iinyanga ngokulandelelana) kwezi zigulana zifumene inaliti ye-Astragalus polysaccharide (APS) edityaniswe ne-vinorelbine kunye ne-cisplatin (VC) xa kuthelekiswa nabo bafumana i-vinorelbine kunye ne-cisplatin (36.76% kunye ne-10.2 iinyanga ngokulandelelana).
Uphononongo lufumanise ukuba kukho ukuphucuka komgangatho wobomi besigulana, ukusebenza komzimba, ukudinwa, isicaphucaphu nokugabha, iintlungu, kunye nelahleko yokutya kwizigulana ze-NSCLC eziphathwe nge-Astragalus polysaccharide kunye ne-VC, xa kuthelekiswa ne-VC iyodwa.
Impembelelo yefomula esekwe kwi-Astragalus esekwe kwi-pharmacokinetics ye-Docetaxel
Abaphandi abavela kwi-Memorial Sloan-Kettering Cancer Centre, eNew York, e-US baqhube isifundo ukuvavanya iimpembelelo ze-Astragalus esekwe kwifomula ye-herbal kwi-pharmacokinetics ye-docetaxel kwizigulana ezine-NSCLC. Iziphumo ezivela kuphononongo zibonise ukuba ukusetyenziswa kwefomula esekwe kwi-Astragalus ayitshintshanga i-pharmacokinetics ye-docetaxel okanye ifuthe ekusindeni kwezigulana ezinomhlaza wemiphunga. (UBarrie R Cassileth okqhubekayo, iCancer Chemother Pharmacol., 2009)
Impembelelo kuxinzelelo lomongo wethambo emva kweChemotherapy
Kwisifundo esenziwe yi-ZHENG Zhao-peng et al. Ngo-2013, bavavanya impembelelo yokuthatha inaliti ye-astragalus polysaccharide kuxinzelelo lomongo wethambo obangelwa yi-chemotherapy kwizigulana ezinomhlaza wemiphunga. Olu pho nonongo lubandakanya izigulane ezingama-61 ezinomdlavuza ongaphantsi kwamancinci wesifo somhlaza. (ZHENG Zhao-peng et al, Chin. Herbal Med., 2013)
Uphononongo lufumanise ukuba imeko yokucinezelwa komongo wethambo kwizigulana ezafumana inaliti ye-astragalus polysaccharide kunye ne-chemotherapy yayiyi-31.3%, eyayiphantsi kakhulu kune-58.6% kwabo bafumana ichemotherapy kuphela.
Abaphandi bagqiba kwelokuba inaliti ye-Astragalus polysaccharide inokunciphisa uxinzelelo lomongo wethambo emva kwekhemotherapy.
3. Umhlaza weColorectal
Kuhlalutyo lwe-meta lwango-2019 olwenziwe ngabaphandi base China, bavavanya ukhuseleko kunye nokusebenza kokusebenzisa amayeza asekwe eTshayina e-Astragalus kunye nechemotherapy xa kuthelekiswa nokusebenzisa ichemotherapy yodwa kunyango lomhlaza. Zizonke izifundo ze-22 ezibandakanya abaguli be-1,409 zafunyanwa ngophando loncwadi kwi-PubMed, EMBASE, Ovid, Web of Science, Cochrane Library, Chinese Science and Technology Journals (CQVIP), China Academic Journals (CNKI), and Chinese Biomedical Literature database.
Uhlalutyo lwe-meta lufumanise ukuba indibaniselwano yamayeza ase-China ase-Astragalus kunye ne-chemotherapy inokuphucula izinga lokuphendula kwizigulana ezinomhlaza weColorectal, ukuphucula umgangatho wobomi kunye nokunciphisa izehlo ezinje nge-neutropenia (uxinzelelo oluphantsi lwee-neutrophils -uhlobo lwegazi elimhlophe iseli) egazini, i-anemia, i-thrombocytopenia (ukubalwa kweplatelet ephantsi), isicaphucaphu kunye nokugabha, urhudo kunye ne-neurotoxicity. Nangona kunjalo, iimvavanyo ezinkulu zeklinikhi eziyilelwe kakuhle ziyafuneka ukuseka ezi zinto zifunyanisiweyo (uShuang Lin okqhubekayo, Front Oncol.
Olunye uphononongo olwenziwe ngabaphandi e-China bavavanya isiphumo sokudityaniswa okubandakanya i-Astragalus membranaceus kunye ne-Jiaozhe, kwimisebenzi yesithintelo samathumbu kwizigulana zomhlaza we-colorectal emva kokusebenza. Uphononongo lufumanise ukuba indibaniselwano ineziphumo ezikhuselayo kwisithintelo samathumbu ukungasebenzi kakuhle kwi-postoperative colorectal. umhlaza izigulane. (Qian-zhu Wang et al, Zhongguo Zhong Xi Yi Jie He Za Zhi., 2015)
4. I-Astragalus polysaccharide iphucula uMgangatho woBomi beMetastatic Cancer Patients
Kuphononongo lwamva nje olwenziwe ngabaphandi baseTaipei, eTaiwan, bavavanye iziphumo ze-Astragalus polysaccharides (PG2) kwiziphawuli ezinxulumene nomhlaza kunye noMgangatho woBomi.
Uphononongo lubandakanya izigulana ezingama-23 ezinomhlaza wemastastatic kwaye zafumanisa ukuba ukusetyenziswa kwe-Astragalus polysaccharides kunokunciphisa iintlungu, isicaphucaphu, ukugabha nokudinwa, kunye nokuphucula ukuthanda ukutya nokulala. Uphononongo lufumanise ukuba i-Astragalus inokunciphisa amanqaku amakishayo ahlukeneyo. (UWen-Chien Huang okqhubekayo, umhlaza (iBasel)., 2019)
Uphononongo lubonelele ngobungqina bokuqala bomanyano phakathi kwe-Astragalus polysaccharides kunye nomgangatho wobomi kwizigulana ezinomhlaza kwinqanaba lesigaba. Nangona kunjalo, iimvavanyo ezinkulu zeklinikhi eziyilelwe kakuhle ziyafuneka ukuze kuqinisekiswe ezi zinto zifunyanisiweyo
Abaphandi abavela kwisibhedlele iMackay Memorial eTaipei, eTaiwan baphanda ifuthe lokusebenzisa isicatshulwa se-Astragalus kunyango lokuthambisa lokulawula ukudinwa okunxulumene nomhlaza. Uphononongo lufumanise ukuba i-Astragalus polysaccharides inokuba lunyango olusebenzayo nolukhuselekileyo lokunciphisa ukudinwa okunxulumene nomhlaza phakathi kwabaguli abanomdla wokunyamekela. (U-Hong-Wen Chen okqhubekayo, uKlinikhi yokuTyala iMed. 2012)
6. Impembelelo kwi-Anorexia ehambelana nomhlaza kwizigulana ezinomhlaza ophezulu
Kwinqanaba lesibini lokuvavanywa kweklinikhi okwenziwe ngo-2010 ngabaphandi be-East-West NeoMedical Centre, iYunivesithi yaseKyung Hee eSeoul, Korea, bavavanya ukusebenza kunye nokukhuseleka kwe-herbal decoction kunye ne-Astragalus ekhutshwe kwizigulana ezinomhlaza ezine-anorexia. (UJae Jin Lee okqhubekayo, Ther. Cancer Ther., 2010)
Zizonke izigulana ezili-11 ezineminyaka yobudala engama-59.8 ezazifunwa phakathi kukaJanuwari, 2007 ukuya kuJanuwari, 2009 zibandakanyiwe kolu phando. Uphononongo lufumanise ukuba ukusetyenziswa kwe-Astragalus decoction kuphucule ukutya kunye nobunzima bomzimba kwizigulana ezinomhlaza ophezulu.
Abaphandi bagqiba kwelokuba i-herbal decoction ekhutshwe yi-Astragalus extract inokubanakho ukulawula i-anorexia enxulumene nomhlaza.
isiphelo
Izilingo ezininzi zokuqala zeklinikhi, uphando lwabantu kunye nohlalutyo lwe-meta lubonisa ukuba i-Astragalus extract inokuba namandla okunciphisa i-chemotherapy-induced side-effects ezifana ne-nausea, ukuhlanza, isifo sohudo, ukunyanzeliswa kwamathambo kuphucula umgangatho wobomi bezigulane ezinomhlaza ophezulu; ukuphucula ukudinwa okunxulumene nomhlaza kunye ne-anorexia; kunye nokunxibelelana kunye neekhemotherapies ezithile kunye nokuphucula ukusebenza kwabo kunyango, ngakumbi kwimiphunga yeseli engeyincinci. umhlaza. Nangona kunjalo, i-astragalus inokunxibelelana namanye amachiza akhokelela kwiziganeko ezimbi. Ke ngoko, ukusetyenziswa ngokungakhethiyo kwe-Astragalus kufuneka kuphetshwe. Thetha nomboneleli wakho wezempilo kunye nengcali yezondlo kwaye ufumane iingcebiso zomntu malunga nesondlo ngaphambi kokuba uthathe izongezo ze-Astragalus zomhlaza wemiphunga.
Kukuphi ukutya okutyayo kwaye okuncedisayo kukuthatha sisigqibo osithathayo. Isigqibo sakho kufuneka sibandakanye ukuthathelwa ingqalelo kotshintsho lomhlaza kuhlobo lomhlaza, unyango oluqhubekayo kunye nezongezelelo, nakuphi na ukwaliwa, ulwazi ngobomi bakho, ubunzima, ukuphakama kunye nemikhwa.
Isicwangciso sesondlo somhlaza esivela kwi-addon asisekelwanga kukhangelo lwe-Intanethi. Isebenza ngokuzenzekelayo ukwenza izigqibo zakho kusekwe kwisayensi yemolekyuli ephunyezwe ngoososayensi kunye neenjineli zesoftware. Nokuba ukhathalele na ukuqonda iindlela ezisisiseko seemolekyuli okanye hayi - zokucwangciswa kwesondlo somhlaza ukuqonda kuyafuneka.
Qalisa NGOKU ngokucwangciswa kwesondlo ngokuphendula imibuzo ngegama lomhlaza, uguquko kwimfuza, unyango oluqhubekayo kunye nezincedisi, nakuphi na ukwaliwa, imikhwa, indlela yokuphila, iqela lobudala kunye nesini.
ISondlo esiSiqu soMhlaza!
Umhlaza uyatshintsha ngokuhamba kwexesha. Yenza ngokwezifiso kwaye uguqule isondlo sakho ngokusekwe kwisalathiso somhlaza, unyango, indlela yokuphila, ukhetho lokutya, i-allergies kunye nezinye izinto.
Izigulana ezinomhlaza zihlala zisebenza ngeendlela ezahlukeneyo iziphumo ebezingalindelekanga ezichaphazela umgangatho wobomi babo kwaye bajonge ezinye iindlela zonyango lomhlaza. Ukuthatha isondlo esifanelekileyo kunye nezongezelelo ezisekwe kuqwalaselo lwenzululwazi (ukunqanda ukuqikelela kunye nokukhetha okungahleliwe) sesona sixhobo sendalo somhlaza kunye neziphumo ebezingalindelekanga zonyango.