Unyango olunokubakho lweQuercetin kuMhlaza

Iimbalasane

I-Quercetin yi-flavonoid yendalo ekhoyo kwizinto ezahlukeneyo zokutya ezifana neziqhamo ezinemibala kunye nemifuno kwaye zineenzuzo ezininzi zempilo ngenxa ye-antioxidant enamandla, i-anti-cancer, i-anti-inflammatory, i-antiviral kunye ne-antibacterial properties. Izifundo ezahlukeneyo zovavanyo kunye nezilwanyana zibonise izibonelelo zonyango ezinokwenzeka ze-quercetin (efunyenwe ngokutya / izongezo) kwiintlobo ezithile zomhlaza ezifana ne-pancreatic, ibele, i-ovarian, isibindi, i-glioblastoma, i-prostate kunye nomhlaza wemiphunga, kunye nokuphucula ukusebenza kwe-chemotherapies ethile kunye enye umhlaza unyango. Ulingo olukhulu lwezonyango kufuneka lwenziwe ukuze kuqinisekiswe ezi zibonelelo ebantwini. Kwakhona, ukusetyenziswa okugqithisileyo kwe-quercetin kunokukhokelela kwimiphumo emibi efana nokungasebenzi kakuhle kwe-thyroid.

Yintoni iQuercetin?

I-Quercetin yiflavonoid eyenzeka ngokwendalo efumaneka kakhulu kwinani lezinto eziphekwe kukutya kubandakanya: 

• Iziqhamo eziMibala ezifana nee-apile, iidiliya kunye namaqunube
• Olubomvu anyanisi
• IiTeas
• Iibhere
• Isiselo somdiliya esibomvu
• Imifuno eluhlaza
• iitumato
• Ibrokholi

Inamandla okulwa ne-antioxidant, anti-inflammatory, anti-virus kunye ne-antibacterial.

Izibonelelo zezeMpilo zeQuercetin

Ukuba yi-antioxidant eyomeleleyo, i-quercetin kunye ne-quercetin ukutya okutyebileyo kuthathwa njengezibonelelo ezininzi zempilo. Ezinye zezibonelelo zezempilo zequercetin zibandakanya:

• Ngaba ukunciphisa izifo zentliziyo
• Ngamana unokunciphisa ukudumba
• Inganciphisa iimpawu zokwaluphala
• Ngamana unganciphisa umngcipheko wokuphefumla kunye nosulelo lwesisu
• Ngamana lunokunciphisa uxinzelelo lwegazi
• Inganciphisa ukungabikho komzimba

Iziphumo ebezingalindelekanga zeQuercetin

Ezi zilandelayo zezinye zeziphumo ebezingalindelekanga eziqhelekileyo zequercetin xa zisetyenziswe ngomlomo:

• Ubudenge ezingalweni nasemilenzeni
• intloko ebuhlungu

Ukulawulwa okungalawulekiyo kwethamo eliphezulu kakhulu le-quercetin kunokuba neziphumo ebezingalindelekanga kubantu abathile abanjengo:

• Ukuhlanza nokubila
• Isihlunu kunye nokuhlanza
• Ukuphefumla ubunzima
• Umonakalo wezintso

Esinye isiphumo esichaphazelekayo esinxulumene nokutya okungaphezulu kwe-quercetin kukuba inokuphazamisa umsebenzi we-thyroid. Ngaphandle kweziphumo ebezingalindelekanga ezifana nokungasebenzi kakuhle kwe-thyroid, ukuthatha i-quercetin nako kunokuzenza mandundu iimeko kwabo baneengxaki zezintso.

Iipropathi zokuChasana noMhlaza zeQuercetin

I-flavonoid quercetin ibonakala njenge-arhente ethembekileyo yokulwa nomhlaza esekwe kwiziphumo ezivela kwilabhoratri kunye neemodeli zezilwanyana zangaphambi kokufunda kunye nezifundo ezimbalwa zeklinikhi kunye nokujonga. Apha ngezantsi yimizekelo yezinye zezi zifundo zibonisa izibonelelo ezinokubakho zokulwa nomhlaza ze-quercetin.

Impembelelo yokusebenzisa iQuercetin kunye nezinye izongezo okanye unyango lomhlaza

I-Quercetin kunye neCurcumin inokunciphisa i-Adenomas kwizigulana ezine-Adenomatous Polyposis yoSapho- isifundo seKlinikhi

Isifundo esincinci seklinikhi esenziwe ngabaphandi abasuka eCleveland Clinic eFlorida, eUnited States bavavanya ukusebenza kakuhle kokudityaniswa kwezongezo zokutya i-curcumin kunye ne-quercetin ukunciphisa i-adenomas kwizigulana ezi-5 ezine-Familial adenomatous polyposis, imeko yelifa apho inani leepolyps ezinokuphuhliswa kwikholoni okanye kwi-rectum, ngokwenjenje kwandisa amathuba umhlaza ongathandabuzekiyo. Uphononongo lufumanise ukuba inani kunye nobungakanani bee-polyps zehlile kuzo zonke izigulana ezinesilinganiso sokuhla kwepesenti ye-60.4% kunye ne-50.9%, ngokwahlukeneyo, emva kweenyanga ezintandathu zonyango kunyango lwe-curcumin kunye ne-quercetin. (UMarcia Cruz-Correa okqhubekayo, Iklinikhi yeGastroenterol Hepatol., 6)

I-Quercetin inokuphucula ukusebenza kweTemozolomide ekunqandeni iiseli ze-Glioblastoma- uPhononongo

Uphononongo olwenziwe elebhu olwenziwe ngabaphandi benza isibhedlele i-Changshu Traditional Chinese Medical Hospital kunye ne-Second Affiliated Hospital yase Soochow e-China bafumanisa ukuba ukusetyenziswa kwe-quercetin kunye ne-temozolomide, umgangatho wokhathalelo lonyango lwe-chemotherapy kwizilonda zobuchopho, kuphuculwe kakhulu impembelelo ye-Temozolomide iiseli zomhlaza weglioblastoma / yomhlaza wobuchopho kunye nokucinezela ukusinda kweseli ye-glioblastoma. (UDong-Ping Sang okqhubekayo, Acta Pharmacol Sin., 2014)

I-Quercetin inokuphucula iziphumo ze-Doxorubicin kwiiseli zomhlaza wesibindi-Isifundo sovavanyo.

Olunye uphononongo olwenziwe elebhu olwenziwe ngabaphandi abavela kwiYunivesithi yaseZhejiang e-China lubonakalise ukuba ukusetyenziswa kwequercetin kunokuphucula iziphumo zokulwa nomhlaza zedoxorubicin chemotherapy kwiiseli zomhlaza wesibindi ngelixa kukhuselwa iiseli zesibindi eziqhelekileyo. (UGuanyu Wang okqhubekayo, PLoS One., 2012)

I-Quercetin kunye neCisplatin Chemotherapy inokunyusa i-Apoptosis / Ukufa kweeseli kweeseli zomhlaza womlomo-Isifundo sovavanyo.

Kuphononongo olwenziwe ngabaphandi abavela kwiZiko lePhondo laseGuangdong loLawulo noThintelo lwezifo, iYunivesithi yaseSun Yat-sen kunye neZiko laseSouth China lezeNzululwazi ngezeNdalo-eGuangzhou e-China, bavavanya ifuthe lokusebenzisa i-quercetin kunye ne-Cisplatin chemotherapy kwi-Oral Squamous yomntu. Imigca yeseli yeCarcinoma yeseli (ii-OSCCs) kunye nakwiimpuku ezibangelwa ngumhlaza womlomo. Uphononongo lufumanise ukuba indibaniselwano ye-quercetin kunye ne-cisplatin yonyusa ukubhubha kweseli / i-apoptosis kwiiseli zomhlaza womlomo kunye nokuthintela ukukhula komhlaza kwiimpuku, iphakamisa amandla onyango e-quercetin kunye nokudityaniswa kwe-cisplatin kwiCancer yomlomo. (Xin Li okqhubekayo, J Umhlaza., 2019)

Sebenzisa iQuercetin kwi-Ovarian Cancer Refractory kwiCisplatin Chemotherapy kunokuba luncedo- Ufundisiso lweKlinikhi

Kwinqanaba elincinci le-1 yolingo lwekliniki olwenziwa ngabaphandi beYunivesithi yaseBirmingham, e-UK, isigulane esinomhlaza we-ovarian ongazange aphendule unyango lwe-cisplatin sanikwa iikhosi ezimbini ze-quercetin, isithuba apho inani leprotein CA 125.umhlaza i-antigen 125 - isetyenziswe njengophawu lomhlaza we-ovari) egazini linciphisa kakhulu ukusuka kwi-295 ukuya kwiiyunithi ze-55 / ml. (DR Ferry et al, Clin Cancer Res. 1996)

I-Quercetin Supplement kunye ne-Resveratrol inokuxhamla ekulawuleni i-Prostate Cancer kunye ne-Colon Cancer-Preclinical Study

Uphononongo olwenziwe ngabaphandi beYunivesithi yaseWisconsin kunye noWilliam S. Middleton VA Medical Centre eWisconsin eMelika kwimouse (transgenic adenocarcinoma of the mouse prostate -TRAMP) model that mirrors the pathogenesis of human prostate cancer, found Ukuba indibaniselwano ye-quercetin kunye ne-resveratrol supplements, ii-antioxidants ezimbini ezifumaneka kakhulu kwiidiliya, zinezibonelelo ezichasene nomhlaza kule modeli yegundane lomhlaza wendlala. (UChandra K Singh et al, umhlaza (iBasel)., 2020)

Olunye uphononongo olwenziwe ngabaphandi abavela kwiYunivesithi yaseTexas A&M, eUnited States bafumanise ukuba indibaniselwano yeResveratrol kunye nequercetin inokuba nomsebenzi we-anticancer kwiiseli zomhlaza wekolon. (UArmando Del Follo-Martinez okqhubekayo, Umhlaza weNutr., 2013)

I-Quercetin inokuphucula ukusebenza konyango lwe-Fluorouracil kunyango lomhlaza wesibindi-isifundo sovavanyo

Uphononongo olwenziwa elebhu olwenziwe yiYunivesithi yaseKurume, eJapan lufumanise ukuba indibaniselwano yonyango kunye nequercetin kunye ne-fluorouracil (5-FU) inokukhokelela kwisongezo esongezelelekileyo okanye esidibeneyo sokuthintela ukwanda kweseli somhlaza wesibindi. (UToru Hisaka okqhubekayo, iAnticancer Res. 2020)

Ukusetyenziswa kweQuercetin kunye nomngcipheko womhlaza

Ukungeniswa kweQuercetin kunokunciphisa umngcipheko weCancer-Gastric Cancer

Abaphandi abavela kwiKarolinska Institutet eSweden bahlalutya idatha evela kuphando olukhulu olusekwe eSweden olubandakanya iimeko ezingama-505 zomhlaza wesisu kunye nolawulo lwe-1116 lokuvavanya umanyano phakathi kwequercetin kunye nomngcipheko weentlobo ezahlukeneyo zomhlaza wesisu ezifana necardia kunye ne-non-cardia subtypes yomhlaza wesisu. . Uphononongo lufumanise ukuba i-quercetin yokutya okuphezulu kakhulu iwunciphisile umngcipheko we-noncardia gastric adenocarcinoma, ngakumbi kubantu ababhemayo. (AM Ekström okqhubekayo, Ann Oncol., 2011)

Ukuthatha ukutya okune-quercetin okutyebileyo kunokuba luncedo ekunciphiseni umngcipheko womhlaza njengomhlaza wesisu.

Izifundo zovavanyo kwi-Anti-Cancer ye-Quercetin

Uphononongo oluninzi lwebhubhoratri luye lwenziwa ngabaphandi abavela kwiindawo ezahlukeneyo zehlabathi ukufumanisa ukuba ukutya okutyebileyo kwe-quercetin / izongezo zinefuthe lokuchasa umhlaza kwiindidi ezahlukeneyo ze i cancer. Apha ngezantsi kukho imizekelo yophononongo lwamva nje lwaselabhoratri okanye izifundo zangaphambi kweklinikhi ezivavanye amandla okuchasa umhlaza weQuercetin.

Umhlaza wesibindi: Uphononongo olwenziwe ngabaphandi abavela kwiYunivesithi yaseKurume eJapan lubonise ukuba iquercetin inokuthintela ukwanda kweeseli zomhlaza wesibindi ngokubangela ukufa kwe-apoptosis / cell kunye nokubanjwa komjikelo weseli. (UToru Hisaka okqhubekayo, iAnticancer Res., 2020)

Umhlaza wemiphunga : Uphononongo olwenziwe yiYunivesithi yaseHubei yezoNyango, e-China yaqaqambisa ukuba i-quercetin inokuthintela ukwanda kunye nomhlaza ukusasazeka kwemigca yeseli yomhlaza wemiphunga. (U-Yan Dong okqhubekayo, iMed Sci Monit ,. 2020)

Umhlaza weSibeletho: Uphononongo olwenziwe ngabaphandi abavela kwiDyunivesithi yaseMadras eIndiya kunye neYunivesithi yasePukyong eSouth Korea bafumanise ukuba iquercetin inokunciphisa ukusinda komhlaza wesifo seprostate kwiimodeli zezilwanyana zangaphambi kwexesha, kwaye inokuthintela iiprotein ezandayo nezichasene ne-apoptotic, ezibonisa izibonelelo ezinokubakho Izongezelelo zequercetin ekuthinteleni umngcipheko womhlaza wedlala lobudoda. (G Sharmila okqhubekayo, Iiklinikhi zeNutr., 2014)

Umhlaza wesibeleko: Uphononongo olwenziwe ngabaphandi abavela kwiDyunivesithi yaseMadras, eIndiya yaqaqambisa ukuba iQuercetin inako ukuthintela ukukhula komhlaza wesifo somhlaza esibelekweni somntu. (UDhanaraj Teekaraman okqhubekayo, Chem Biol Unxibelelwano., 2019)

Umhlaza webele : Kuhlolisiso olwenziwe elebhu olwenziwe ngabaphandi abasuka kwiDyunivesithi yaseMadras eIndiya, baqaqambisa ukuba ukusebenzisa iQuercetin kunganceda ekuphembeleleni iApoptosis okanye ukusweleka kweeseli kwiiseli zomhlaza webele. (Santhalakshmi Ranganathan okqhubekayo, PLoS One., 2015)

Umhlaza wePancreatic: Abaphandi abavela kwiDavid Geffen School of Medicine e-UCLA, e-US baphonononge ukusebenza kolawulo lomlomo lwe-quercetin kwimodeli yegundane yomhlaza wepancreatic kwaye bafumanisa ukuba i-quercetin yayikwazi ukuthintela ukukhula kwezidumba zepancreatic kwimodeli yegundane. (U-Eliane Angst okqhubekayo, iiPancreas., 2013)

isiphelo

Izifundo ezahlukeneyo zangaphambi kweklinikhi kunye nezaselebhu zibonise iingenelo ezinokwenzeka / ezinokubakho zokutya okutyebileyo kwe-quercetin kunye nezongezo kunyango oluthile. umhlaza iintlobo ezifana ne-pancreatic, ibele, i-ovarian, isibindi, i-glioblastoma, i-prostate kunye nomhlaza wemiphunga, kunye nokuphucula unyango olusebenzayo lwe-chemotherapies ethile kunye nolunye unyango lomhlaza. Ulingo olukhulu lwezonyango kufuneka lwenziwe ukuze kuqinisekiswe ezi zibonelelo zichasene nomhlaza zequercetin ebantwini.

I-Quercetin ine-antioxidant eyomeleleyo, anti-cancer, anti-inflammatory, anti-virus kunye ne-antibacterial. Uluhlu olubanzi lwezibonelelo zezempilo zequercetin lunokufumaneka ngokubandakanya iintlobo ezahlukeneyo zokutya ezinjengembala kunye nezondlo ezipakishwe iziqhamo kunye nemifuno njengenxalenye yokutya. Izincedisi zeQuercetin zihlala zidityaniswa nezinye izinto ezinjengeVitamin C okanye iBromelain ukuphucula ukufunxeka kwayo kunye namandla. Nangona kunjalo, ukusebenzisa kakhulu iquercetin kunokukhokelela kwiziphumo ebezingalindelekanga ezininzi kubandakanya nokuphazamiseka ekusebenzeni kakuhle kwe-thyroid. Kuphephe ukusebenzisa izongezo ze-quercetin ngaphandle kokhokelo lweengcali zakho zokhathalelo lwempilo ukuze uhlale kude neziphumo ebezingalindelekanga ezifana nokungasebenzi kakuhle kwe-thyroid kunye nokunxibelelana nonyango oluqhubekayo.

Kukuphi ukutya okutyayo kwaye okuncedisayo kukuthatha sisigqibo osithathayo. Isigqibo sakho kufuneka sibandakanye ukuthathelwa ingqalelo kotshintsho lomhlaza kuhlobo lomhlaza, unyango oluqhubekayo kunye nezongezelelo, nakuphi na ukwaliwa, ulwazi ngobomi bakho, ubunzima, ukuphakama kunye nemikhwa.

Isicwangciso sesondlo somhlaza esivela kwi-addon asisekelwanga kukhangelo lwe-Intanethi. Isebenza ngokuzenzekelayo ukwenza izigqibo zakho kusekwe kwisayensi yemolekyuli ephunyezwe ngoososayensi kunye neenjineli zesoftware. Nokuba ukhathalele na ukuqonda iindlela ezisisiseko seemolekyuli okanye hayi - zokucwangciswa kwesondlo somhlaza ukuqonda kuyafuneka.

Qalisa NGOKU ngokucwangciswa kwesondlo ngokuphendula imibuzo ngegama lomhlaza, uguquko kwimfuza, unyango oluqhubekayo kunye nezincedisi, nakuphi na ukwaliwa, imikhwa, indlela yokuphila, iqela lobudala kunye nesini.

Izigulana ezinomhlaza zihlala zisebenza ngeendlela ezahlukeneyo iziphumo ebezingalindelekanga ezichaphazela umgangatho wobomi babo kwaye bajonge ezinye iindlela zonyango lomhlaza. Ukuthatha isondlo esifanelekileyo kunye nezongezelelo ezisekwe kuqwalaselo lwenzululwazi (ukunqanda ukuqikelela kunye nokukhetha okungahleliwe) sesona sixhobo sendalo somhlaza kunye neziphumo ebezingalindelekanga zonyango.

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