Melemo ea meriana ea lebese / Silymarin ea Kankere

Lintlha-khōlō Tsa

Milk Thistle Extract / Silymarin le karolo ea eona ea bohlokoa Silibinin e na le melemo e mengata e tsotehang ea bophelo bo botle ka lebaka la thepa ea eona ea antioxidant, anti-inflammatory le anti-cancer. Lithuto tse fapaneng tsa in vitro/in vivo le tsa liphoofolo li batlisisitse melemo ea bophelo bo botle ba mokelikeli oa lebese le matla a eona a ho thibela mefuta e fapaneng ea mofets'e mme a fumana litholoana tse ts'episang. Liteko tse fokolang tsa batho li boetse li fana ka maikutlo a hore hlaba-hlabane ea lebese le metsoako ea eona e sebetsang e ka ba molemo ho fokotsa litla-morao tse ling tse kotsi tsa chemotherapy le radiotherapy tse kang cardiotoxicity, hepatotoxicity le boko edema ka linako tse ling. tsoaroa ke kankere mefuta e tšoaroang ka khemo e khethehileng.

Lebese sekhoa ke eng?

Sejoe sa lebese ke semela sa lipalesa se 'nileng sa sebelisoa makholo a lilemo e le pheko ea tlholeho ea ho phekola mathata a sebete le a bile haholo linaheng tsa Europe. Sejoe sa lebese se fumaneha hape e le tlatsetso ea lijo. Sejoe sa lebese se reheletsoe ka lero la lebese le tsoang makhasi ha li robehile. 

Metsoako e ka Sehloohong e Sebetsang ea Letsoa la Lebese

Likarolo tsa bohlokoa tsa peo ea masiu a omisitsoeng ke flavonolignans (phenols ea tlhaho e entsoeng ka karolo ea flavonoid le karolo ea lignan) e kenyeletsang:

• Silibinin (silybin)
• Isosilybin
• Silychristin
• Silydianin.

Motsoako oa li-flavonolignans tse ntšitsoeng peo ea sehlahla se meutloa ka kakaretso e tsejoa e le Silymarin. Silibinin e tsejoang hape e le silybin, ke karolo e kholo ea silymarin. Silymarin e na le li-antioxidant, antiviral le anti-inflammatory. Milk Thistle / Silymarin e fumaneha e le tlatsetso ea lijo mme e sebelisoa hangata bakeng sa melemo ea eona ea ho phekola mathata a sebete. Lisebelisoa tse ngata li boetse li hlophisitsoe ho latela litaba tsa bona tsa silibinin. Ho boetse ho na le litlatsetso tse khethehileng tsa silymarin kapa silibinin tse ka eketsang bioavailability ea tsona ka ho kopanya le phosphatidylcholine.

Melemo e akaretsang ea bophelo bo botle ba lebese

Liphuputso tse ngata tsa liphoofolo le lithuto tse fokolang tsa bongaka li entsoe ho lekola melemo ea sehlahla sa lebese. Melemo e meng e boletsoeng ea bophelo bo botle ba morung oa lebese ke:

1. E ka thusa mathateng a Sebete ho kenyelletsa ho thatafala ha sebete, lefu la nyooko, lefu la sebete
2. E ka thusa mathateng a senya a senya
3. Ha e nooa hammoho le kalafo e tloaelehileng, e ka ntlafatsa lefu la tsoekere
4. E ka thusa ho ntlafatsa maemo a k'holeseterole ho bakuli ba nang le lefu la tsoekere
5. E ka thusa ka ts'ehetso ea pelo le indigestion
6. E ka thusa ka ho thibela mofetše

Melemo ea lebese la lebese ka mofetše

Lilemong tse mashome a mabeli tse fetileng, ho 'nile ha e-ba le thahasello e ntseng e eketseha ea ho utloisisa melemo ea kliniki ea lebese thistle ho mofetše. Tse ling tsa lithuto tsa in vitro/in vivo/phoofolo/motho tse ileng tsa hlahloba ts'ebeliso/litlamorao tsa hlabahlabane ea lebese ho tsoaroa ke kankere li akaretsoa ka tlase:

Lithuto tsa Vitro / In Vivo / Animal

1. E kanna ea Thibela Keketseho ea Kankere ea Pancreatic le Ho Fokotsa Kachexia / Bofokoli ba Kankere ea Pancreatic.

Liphuputso tsa in vitro li bonts'itse hore li-silibinin tse sebetsang ka lebese li na le monyetla oa ho thibela kholo ea lisele tsa mofetše oa pancreatic ka mokhoa o itšetlehileng ka tekanyetso. Tse ling liphuputsong tsa vivo le tsona li fana ka maikutlo a hore silibinin e fokotsa kholo ea hlahala le ho ata ha mofetše oa pancreatic mme e ka thusa ho thibela ho lahleheloa ke boima ba 'mele le mesifa. (Shukla SK le al, Oncotarget., 2015)

Ka bokhutšoanyane, liphuputso tsa vitro le liphoofolo li fana ka maikutlo a hore sejoe sa lebese / silibinin se ka una molemo ho fokotsa kholo ea mofetše oa pancreatic le mofets'e oa pancreatic o bakiloeng ke cachexia / bofokoli. Liteko tsa bongaka li hlokahala ho netefatsa se tšoanang bathong. 

2. E kanna ea Thibela Keketseho ea Kankere ea Matsoele

Boithuto ba in vitro bo bontšitse hore silibinin e thibela kholo ea lisele tsa mofetše oa matsoele mme e bakile lefu la apoptosis / seleng liseleng tsa mofetše oa matsoele. Liphuputso tse tsoang liphuputsong tse fapaneng li fana ka maikutlo a hore silibinin e na le thepa e sebetsang ea anti-cancer ea matsoele. (Tiwari P et al, Kankere Invest., 2011)

3. E kanna ea Thibela Keketseho ea Kankere ea Prostate

Phuputsong e 'ngoe, litlamorao tsa anti-cancer tsa Silibinin li ile tsa hlahlojoa ka kalafo e kopaneng hammoho le DOX / Adriamycin. Phuputsong ena, lisele tsa prostate carcinoma li ile tsa phekoloa ka silibinin le DOX li kopane.Liphuputso li bonts'itse hore motsoako oa silibinin-DOX o hlahisitse thibelo ea kholo ea 62-69% ea lisele tse phekotsoeng. (Prabha Tiwari le Kaushala Prasad Mishra, Meeli ea Patlisiso ea Kankere., 2015)

4. E kanna ea thibela Kankere ea Letlalo

Liphuputso tse ngata li boetse li entsoe ho lekola litlamorao tsa Milk Thistle e sebetsang Silibinin ho mofets'e oa letlalo. Liphuputso tse tsoang liphuputsong tsena tsa vitro li bontšitse hore kalafo ea Silibinin e ka ba le litlamorao tsa thibelo liseleng tsa mofetše oa letlalo. Phuputso e entsoeng ka vivo e fumane hore Silibinin le eona e ka thibela mofets'e oa letlalo o bakoang ke mahlaseli a kotsi a UVB mme e ka thusa ho lokisa tšenyo ea DNA e bakiloeng ke UV letlalong la toeba. (Prabha Tiwari le Kaushala Prasad Mishra, Meeli ea Patlisiso ea Kankere., 2015)

Lithuto tsena lia ts'episa ebile li fana ka maikutlo a hore mohloa oa lebese / silibinin e kanna ea ba e bolokehileng mme ea thusa letlalo tsoaroa ke kankere.

5. E kanna ea Thibela Kankere e Colorectal

Tse ling tsa lithuto tsa in vitro li bonts'itse hore Silibinin e ka baka lefu la sele liseleng tsa mofets'e oa motho ea 'mala. Boithuto ba in vitro bo fumane hape hore kalafo ea Silibinin ea 24h e ka fokotsa kholo ea lisele tsa mofetše ka 30-49%. (Prabha Tiwari le Kaushala Prasad Mishra, Meeli ea Patlisiso ea Kankere., 2015)

Melemo ea Milk Thistle / Silibinin le eona e ile ea hlahlojoa hammoho le mefuta e meng ea kalafo e kang histone-deacetylase (HDAC) inhibitors. Motsoako ona o bonts'itse litlamorao tsa lisele tse mebala-bala.

6. E kanna ea thibela Kankere ea Lung

Boithuto ba in vitro bo bontšitse hore Silibinin e kanna ea ba le litlamorao tse thibelang methapo ea lisele tsa mofetše oa motho. Boithuto bo boetse bo bontšitse hore Silibinin hammoho le DOX e thibela kholo ea lisele tsa mofetše oa matšoafo ka vitro. Silibinin hammoho le indole-3-carbinol le eona e bakile litlamorao tse matla tsa ho loants'a mafura ho feta moemeli ka mong. (Prabha Tiwari le Kaushala Prasad Mishra, Meeli ea Patlisiso ea Kankere., 2015)

Liphuputso tsena li fana ka maikutlo a hore Milk Thistle e sebetsang Silibinin le eona e ka ba le molemo oa kalafo khahlano le mofetše oa matšoafo.

7. E kanna ea thibela Kankere ea senya

Boithuto ba in vitro bo bonts'itse hore Silibinin e hlohlellelitse lefu la apoptosis / cell la lisele tsa mofetše oa senya. Boithuto bo boetse bo bontšitse hore Silibinin le eona e ka hatella ho falla le ho ata ha lisele tsa mofetše oa senya. (Prabha Tiwari le Kaushala Prasad Mishra, Meeli ea Patlisiso ea Kankere., 2015)

8. E kanna ea thibela Kankere ea Ovarian

Boithuto ba in vitro bo bontšitse hore silibinin e ka thibela kholo ea lisele tsa mofetše oa motho, hape ea baka lefu la apoptosis / cell. Boithuto bo fumane hape hore Silibinin e ka ntlafatsa kutlo ea lisele tsa mofetše oa mae a bomme ho PTX (Onxal). Silibinin ha e sebelisoa hammoho le PTX (Onxal) le eona e ka ntlafatsa lefu la apoptosis / cell. (Prabha Tiwari le Kaushala Prasad Mishra, Meeli ea Patlisiso ea Kankere., 2015)

Liphuputso tsena li fana ka maikutlo a hore silibinin e ka sebelisoa e le karolo ea litlhare tse kopantseng khahlano le mofetše oa mae a bomme.

9. E kanna ea thibela Kankere ea Cervical

Boithuto bo bontša hore Silibinin e ka thibela ho ata ha lisele tsa motho tsa popelo. Ntle le moo, silibinin hammoho le MET, e leng moemeli ea tsebahalang oa ho thibela lefu la tsoekere, li bonts'a litlamorao ho thibelo ea lisele tsa mofetše oa popelo le lefu la sele. Kahoo, silibinin e ka sebetsa joalo ka moemeli oa chemopreventive khahlanong le mofetše oa popelo. Lithuto tse ling li lokela ho lekola menyetla ea ho nts'etsapele maano a ntlafatsang a kalafo khahlano le mofetše oa popelo.

Lithuto tsa Bongaka ho Batho

Ha re shebeng lithuto tse fapaneng tsa tleliniki ho utloisisa hore na ho kenyeletsoa moutloa oa lebese e le karolo ea Lijo tsa bakuli ba mofets'e e molemo kapa che.

1. Melemo ea Lebese la 'Mele ho fokotsa Cardiotoxicity ho Acute Lymphoblastic Leukemia Children Treated with DOX (Adriamycin)

Silymarin, e leng e 'ngoe ea metsoako ea mantlha ea lebele, e bonts'itsoe ka liteko ho ba le litlamorao tsa ts'ireletso ea pelo ha e fanoa le DOX. Silymarin e ka fokotsa khatello ea maikutlo e bakoang ke oxidative, sesosa sa lefu la cardiotoxicity. Ke antioxidant mme e ka fokotsa tšenyo ea lera le liprotheine ke mefuta e sebetsang, e bōpiloeng e le karolo ea ts'ebetso ea DOX, ka ho thibela ho senyeha ha mochini oa antioxidant oa lisele tse phetseng hantle. (Roskovic A et al, Limolek'hule 2011)

Phuputso ea bongaka e tsoang Univesithing ea Tanta e Egepeta e hlahlobile phello ea pelo ea Silymarin ea tsoang lebese la 'Mele ho bana ba nang le Acute Lymphoblastic Leukemia (ALL), ba ileng ba alafshoa ka DOX. Phuputso e sebelisitse data ho tsoa ho bana ba 80 ba nang le TSOHLE, moo bakuli ba 40 ba ileng ba alafshoa ka DOX mmoho le Silymarin ka 420 mg / ka letsatsi mme ba 40 ba setseng ba alafshoa feela le DOX (placebo group). Phuputso e fumane hore sehlopheng sa Silymarin, ho bile le 'ho fokotseha ha litšitiso tsa tšebetso ea lets'oa la ventricular systolic' tse qalang tsa DOX holim'a sehlopha sa placebo. Phuputso ena ea bongaka, leha e na le palo e nyane ea bana bohle, e fana ka netefatso ea litlamorao tsa pelo tsa Silymarin joalo ka ha ho bonoa mefuteng ea liteko tsa mafu. (Adel A Hagag et al, Infect Disord Drug Target., 2019)

2. Melemo ea lebese la phoka ho fokotsa chefo ea sebete ho Acute Lymphoblastic Leukemia Children Treated with Chemotherapy

Kalafo ea bana ba nang le leukemia e matla ea lymphoblastic (ALL) ba sebelisang lithethefatsi tsa chemotherapy hangata e sitisoa ka lebaka la chefo ea hepatotoxicity / sebete e bakoang ke lithethefatsi tsa chemotherapy. Pherekano ena ea ho felisa mofetše o sebelisa lithethefatsi tsa chemotherapy khahlanong le ho sebetsana le litla-morao tse matla ebile ka linako tse ling li ke keng tsa qojoa tsa lithethefatsi tsena ke bothata bo tsoelang pele sechabeng sa mofetše. Kahoo, ho na le boiteko bo tsoelang pele ba ho fumana mekhoa e ka thusang ho fokotsa kapa ho sireletsa mokuli litlamorao tse mpe.

Phuputsong ea bongaka, bana ba nang le lefu le matla la `` lymphoblastic leukemia '' (ALL) ba nang le chefo e matla ba ne ba alafshoa ka chemotherapy feela (placebo) kapa motsoako oa lebese la thistle capsule le nang le 80 mg ea silibinin hammoho le chemotherapy (MTX / 6-MP / VCR) ka molomo ( Milk Thistle Group) matsatsi a 28 Bana ba 50 ba ngolisitsoe ho tloha ka Mots'eanong 2002 ho fihlela Phato 2005 bakeng sa thuto ena, ka lithuto tse 26 sehlopheng sa placebo le ba 24 sehlopheng sa Milk Thistle Group. Bana ba 49 ho ba 50 ba ile ba hlahlojoa bakeng sa thuto. Chefo ea sebete e ne e behiloe leihlo nakong eohle ea kalafo. (EJ Ladas et al. Kankere., 2010)

Liphuputso tse tsoang phuputsong li khothalelitse hore ho nka lebese la Thistle hammoho le chemotherapy ke bakuli bohle ho ka amahanngoa le phokotso e kholo ea chefo ea sebete. Phuputso ha ea ka ea fumana chefo e sa lebelloang, tlhoko ea ho fokotsa tekanyetso ea chemotherapy, kapa tieho efe kapa efe ea kalafo nakong ea tlatsetso ea moutloa oa lebese. Liphuputso li boetse li bontšitse hore sehlahla sa lebese ha sea ka sa ama tšebetso ea li-chemotherapy tse sebelisetsoang kalafo EHLE. 

Bafuputsi leha ho le joalo ba khothalelitse lithuto tsa nako e tlang ho fumana lethal dose e sebetsang ka ho fetisisa ea Milk Thistle le phello ea eona ho chefo ea hepatotoxicity / sebete le ho pholoha ntle le kankere ea mali.

3. Melemo ea Milk Thistle e sebetsang Silibinin bakeng sa ho fokotsa edema ea boko ho Bakuli ba Kankere ea Lung ba nang le Metastasis ea Brain

Liphuputso li fana ka maikutlo a hore tšebeliso ea lebese le hlabang le sebetsang ka silibinin-based nutraceutical e bitsoang Legasil® e ka ntlafatsa Brain Metastasis ho tsoa ho bakuli ba mofetše oa NSCLC/matšoafo ba ileng ba tsoela pele ka kalafo ka radiotherapy le chemotherapy. Liphuputso tsa lithuto tsena li boetse li fana ka maikutlo a hore tsamaiso ea silibinin e ka fokotsa haholo edema ea boko. Leha ho le joalo, litlamorao tsena tsa inhibitory tsa silibinin ho metastasis ea boko li kanna tsa se ke tsa ama hlahala ea mantlha matšoafong. tsoaroa ke kankere bakuli. (Bosch-Barrera J et al, Oncotarget., 2016)

4. Melemo ea Letlalo la Lebese ho fokotsa Chefo ea Sebete ho Mokuli oa Kankere ea Lebese

Phuputso ea linyeoe e phatlalalitsoe ho mokuli oa mofetše oa matsoele ea ileng a alafshoa ka kalafo tse 5 tse fapaneng tsa chemotherapy mme a hloleha ho tsoela pele ka sebete. Tlaleho e boletse hore liphetho tsa liteko tsa sebete li mpefetse maemong a sokelang bophelo kamora kalafo ea chemotherapy ea potoloho e mene. Mokuli o ile a eketsoa ka Silibinin-based nutraceutical e bitsoang Legasil® post eo ntlafatso ea bongaka le ea sebete e ileng ea bonoa, e ileng ea thusa mokuli ho tsoela pele ka chemotherapy e hlasimollang. (Bosch-Barrera J et al, Anticancer Res., 2014)

Phuputso ena e bontšitse molemo oa kliniki oa silibinin ho fokotsa chefo ea sebete ho bakuli ba mofets'e ba tšoaroang ka chemotherapy.

5. Melemo ea Lebese la Lebese ho Ntlafatsa Liphello tsa Pholoho ho Bakuli ba Metastatic Brain Ba phekoloa ka Radiotherapy

Liphuputso li bonts'a hore lebele la lebese le ka thusa bakuli ba metastatic ba nang le radiotherapy. Phuputso ea bongaka e kenyelelitse tlhaiso-leseling e tsoang ho bakuli ba nang le metastase ea boko ba ileng ba alafshoa ka radiotherapy feela kapa radiotherapy hammoho le omega 3 fatty acids le silymarin. Phuputso e fumane hore bakuli ba nkileng omega 3 fatty acids le silymarin ba na le linako tse telele tsa ho pholoha le radionecrosis e fokotsehileng. (Gramaglia A et al, Anticancer Res., 1999)

fihlela qeto e

Milk Thistle Extract / Silymarin le karolo ea eona ea bohlokoa Silibinin e na le melemo e mengata ea bophelo bo botle ka lebaka la antioxidant, anti-inflammatory le anti-cancer. Milk thistle extract / Silymarin hangata ha a na litla-morao tse ngata ha a nooa ka molomo ka bongata bo nepahetseng. Leha ho le joalo, ho batho ba bang, ho noa moutloa oa lebese ho ka lebisa ho letšollo, ho nyekeloa ke pelo, khase ea mala, ho ruruha, ho tlala kapa ho opeloa, le ho felloa ke takatso ea lijo. Hape, kaha ho ntšoa ha moutloa oa lebese ho ka theola tsoekere maling ho batho ba nang le lefu la tsoekere, litekanyetso tsa meriana ea lefu la tsoekere li kanna tsa tlameha ho nchafatsoa. Ho ntšoa ha ntja ea lebese le hona ho ka ba le litlamorao tsa estrogenic tse ka mpefatsang maemo a mamelang lihormone, ho kenyeletsoa mefuta e meng ea mofets'e oa matsoele.

Lithuto tse fapaneng tsa invitro/invivo le liphoofolo li batlisisitse melemo ea bophelo bo botle ea mohloa oa lebese le matla a eona a ho thibela mefuta e fapaneng ea mofetše. Liphetho tse ts'episang li tlalehiloe ke tse ngata tsa liphuputso tsena tse fanang ka maikutlo a ts'ireletso ea mofetše oa lebese mefuteng e itseng ea mofetše. Liteko tse fokolang tsa batho li boetse li tšehetsa hore hlaba-hlabane ea lebese le metsoako ea eona e sebetsang e ka ba molemo ho fokotsa tse ling tsa litla-morao tse kotsi tsa chemotherapy le radiotherapy tse kang cardiotoxicity, hepatotoxicity le boko edema mefuteng e itseng ea kankere e tšoaroang ka chemo e itseng. Leha ho le joalo, ho nka tlatsetso ea tlhaho joalo ka mohloa oa lebese ka mokhoa o sa reroang ka chemotherapy efe kapa efe tsoaroa ke kankere ha e khothalletsoe kaha e ka baka tšebelisano e mpe ea litlama le lithethefatsi. Kahoo, motho o lokela ho buisana le ngaka ea bona kamehla pele a nka tlatsetso efe kapa efe ea tlhaho hammoho le chemotherapy.

Lijo tseo u li jang le tse u tlatsetsang ke qeto eo u e etsang. Qeto ea hau e lokela ho kenyelletsa ho nahanisisa ka liphetoho tsa liphatsa tsa lefutso tsa mofetše, e leng mofetše, kalafo e tsoelang pele le litlatsetso, ho kula hohle, leseli la bophelo, boima, bolelele le litloaelo.

Morero oa phepo e nepahetseng bakeng sa mofets'e ho tsoa addon ha o ea ipapisa le lipatlisiso tsa inthanete. E iketsetsa liqeto bakeng sa hau e ipapisitse le mahlale a limolek'hule a kentsoeng tšebetsong ke bo-rasaense ba rona le lienjineri tsa software. Ho sa tsotelehe hore na o tsotella ho utloisisa metheo ea limolek'hule kapa che - bakeng sa moralo oa phepo ea mofets'e kutloisiso ea hlokahala.

Qala hona joale ka moralo oa hau oa phepo e nepahetseng ka ho araba lipotso lebitsong la mofetše, phetoho ea lefutso, kalafo e tsoelang pele le litlatsetso, ho kula hohle, litloaelo, mokhoa oa bophelo, sehlopha sa lilemo le bong.

Bakuli ba mofets'e hangata ba tlameha ho sebetsana le tse fapaneng litla-morao tsa chemotherapy tse amang boleng ba bona ba bophelo le ho batla mekhoa e meng ea kalafo ea mofets'e. Ho nka phepo e nepahetseng le litlatsetso ho latela maikutlo a mahlale (ho qoba ho inahanela le ho khetha ka mokhoa o sa reroang) ke pheko ea tlholeho bakeng sa mofets'e le litla-morao tse amanang le kalafo

• Lebese masihla a sebetsang Silymarin a fokotsa Doxorubicin-hlohlelletsoa Cardiotoxicity ho Bana ba nang le kankere ea mali
• Lebese, Lihlahisoa tsa Lebese le Kotsi ea Kankere
• Lijo / Lisebelisoa tsa Tlhaho li sebelisana joang le Chemotherapy ho Cancer?
• Mokhatlo o Ferekanyang oa Ts'ebeliso ea Vitamin E Supplement le Brain Cancers
• Lijo tsa meroho ea Lacto-Ovo le kotsi ea mofets'e