Lintlha-khōlō Tsa
Phuputso ea bongaka e bontšitse hore ho bolokehile ho sebelisa tlatsetso ea soy isoflavone Genistein hammoho le chemotherapy ea motsoako FOLFOX kalafong ea bakuli ba mofets'e ba metastatic colorectal. Ho kopanya Genistein ho eketsa phepelo ea chemotherapy ho na le monyetla oa ho ntlafatsa litlamorao tsa kalafo ea chemotherapy ea FOLFOX ho bakuli ba mofets'e ba metastatic colorectal.
Kankere ea Metastatic Colorectal
Kankere ea Metastatic Colorectal (mCRC) e na le bofokoli bo bobe ba ho phela ha lilemo tse 2 ho ka tlase ho 40% mme ho phela ha lilemo tse 5 ho ka tlase ho 10%, leha ho na le likhetho tse matla haholo tsa kalafo ea chemotherapy. (AJCC Cancer Staging Handbook, 8th Edn).
Metastatic Colorectal Chemotherapy Regimens
Melao ea mofets'e oa Metastatic Colorectal e kenyelletsa 5-Fluorouracil hammoho le sethethefatsi sa platinum Oxaliplatin, e nang le antiangiogenic kapa ntle le eona (e thibela ho thehoa ha methapo ea mali ho hlahala) moemeli oa Bevacizumab (Avastin). Mekhoa e mecha e kenyelletsang FOLFIRI (fluorouracil, leucovorin, irinotecan), FOLFOX (5-Fuorouracil, oxaliplatin), CAPOX (capecitabine, oxaliplatin) le FOLFOXIRI (fluorouracil, oxaliplatin, leucovorin, irinotecan liphetho tsa bakuli ba irinotecan) le tsona li bontšitse liphetho tsa proCmisi.
Mona, re tla tšohla mekhoa e hlahelletseng ea mCRC e litekong tsa bongaka mme e nkuoa e sebetsa khahlano le Metastatic Colorectal Cancer (mCRC).
Katleho ea FOLFOXIRI ho Bakuli ba Kankere ea Metastatic Colorectal
Lithuto tse ngata li tsepamisitse maikutlo ho metastatic colorectal e fapaneng tsoaroa ke kankere mekhoa le katleho ea bona ho bakuli ba mCRC. FOLFOXIRI ke motsoako oa pele oa phekolo mCRC o kenyelletsang motsoako oa fluorouracil, oxaliplatin, leucovorin le irinotecan. Tekong ea TRIBE, e sa tsoa hatisoa ka 2020, ho hlahisoa hape ha FOLFOXIRI ka bevacizumab ho hlahisitse liphetho tse betere ho feta FOLFIRI le bevacizumab empa ka monyetla oa ho ba chefo e phahameng joalo ka ha ho ne ho hlokahala nako e telele ea chemotherapy mme litlamorao tse 'maloa tse mpe li ile tsa bonoa ho bakuli ba joalo. (Glynne-Jones R, le ba bang. Lancet Oncology, 2020). Leano lena la ho kopanya lithethefatsi tse sebetsang hantle empa e le tsa cytotoxic le litlhare tse thibelang angiogenic li hlahisitse matšoenyeho a mang bakeng sa litsebi tsa oncologists mabapi le polokeho le chefo.
Lintlha tsa tlhahlobo ea Meta: XELOX vs. FOLFOX ho Metastatic Colorectal Cancer
Thuto ka 2016 ke Guo Y, et al. bapisa katleho ea capecitabine le fluorouracil, e 'ngoe le e' ngoe e kopantsoe le oxaliplatin, ho bakuli ba mCRC hammoho le chemotherapy (Guo, Yu et al. Patlisiso ea mofets'e, 2016).
- Liteko tse robeli tse laoloang ka nako e telele (RCTs) li ile tsa sebelisoa bakeng sa tlhahlobo e amang bakuli ba 4,363 ka kakaretso.
- Qetello e ka sehloohong ea thuto e ne e le ho hlahloba polokeho le katleho ea chemotherapy regimens XELOX (capecitabine plus oxaliplatin) vs. FOLFOX (fluorouracil plus oxaliplatin) ho bakuli ba kankere ea metastatic colorectal.
- Kakaretso ea bakuli ba 2,194 ba ile ba phekoloa ka mofuta oa XELOX athe bakuli ba 2,169 ba ile ba phekoloa ka mokhoa oa FOLFOX.
Liphetho tsa tlhahlobo ea Meta: XELOX vs. FOLFOX ho Metastatic Colorectal Cancer
- Sehlopha sa XELOX se ne se e-na le tšoaetso e phahameng ea lefu la maoto a matsoho, letšollo le thrombocytopenia athe sehlopha sa FOLFOX se ne se e-na le tšoaetso e phahameng ea neutropenia feela.
- Lintlha tsa chefo tse fumanoeng tlhahlobisong e kopaneng bakeng sa lihlopha tsena ka bobeli li ne li fapane empa lipatlisiso tse ling mabapi le taba ena lia hlokahala.
- Ho sebetsa ha XELOX ho bakuli ba mCRC ho tšoana le ho sebetsa ha FOLFOX.
Lijo Tseo U ka li Jang Kamora Ho Khetholla Kankere!
Ha ho kankere tse peli tse tšoanang. Fetela ka n the'ane ho tataiso e tloaelehileng ea phepo bakeng sa motho e mong le e mong 'me u etse liqeto tse ikhethileng mabapi le lijo le li-supplement ka kholiseho.
Lisebelisoa tsa Genistein bakeng sa Kankere
Genistein ke isoflavone ka tlhaho e fumanoang lijong tse kang soya le lihlahisoa tsa soya. Genistein e boetse e fumaneha ka mokhoa oa li-supplement tsa lijo 'me e tsejoa hore e na le melemo e mengata ea bophelo bo botle ka lebaka la thepa ea eona ea antioxidant, anti-inflammatory le anti-cancer. Melemo e meng e akaretsang ea bophelo bo botle ea li-supplement tsa genistein (ntle le thepa e thibelang mofetše) e kenyelletsa:
- E ka thusa ho fokotsa maemo a tsoekere maling
- E ka thusa ho fokotsa matšoao a ho khaotsa ho ilela khoeli
- E ka thusa ho ntlafatsa bophelo bo botle ba pelo
- E kanna ea khothaletsa bophelo bo botle ba masapo le boko
Ho blog ena re tla tšohla hore na tšebeliso ea tlatsetso ea Genistein e na le melemo ho metastatic colorectal tsoaroa ke kankere bakuli.
Ts'ebeliso ea Tlatsetso ea Genistein ho Kankere e Colorectal
Liphuputso tse ngata li bonts'itse mokhatlo oa likotsi tse tlase tsa mofetše oa 'mala ho batho ba Asia bochabela ba jang lijo tse ruileng tsa Soy. Ho na le lithuto tse ngata tsa tlhahlobo ea liteko tse bonts'itseng litšobotsi tse khahlanong le mofets'e tsa isoflavone Genistein, le bokhoni ba eona ba ho fokotsa ho hanyetsa chemotherapy liseleng tsa mofetše. Kahoo, bafuputsi Sekolong sa Bongaka sa Icahn sa Thabeng ea Sinai, New York, ba lekile polokeho le katleho ea ts'ebeliso ea soya isoflavone Genistein hammoho le tekanyetso ea kalafo e kopantseng chemotherapy ho ba lebelletsoeng ho ithuta ka lingaka ho bakuli ba mofets'e ba nang le mofets'e. (NCT01985763) (Pintova S et al, Kankere Chemotherapy le Pharmacol., 2019)
Lintlha tsa Thutong ea Bongaka ts'ebelisong ea Genistein Supplement ho Cancer e Colorectal
- Ho ne ho e-na le bakuli ba 13 ba nang le mCRC ba se nang phekolo ea pele ba ileng ba phekoloa ka motsoako oa FOLFOX le Genistein (N=10) le FOLFOX + Bevacizumab + Genistein (N=3).
- Qetellong ea thuto e ne e le ho lekola ts'ireletseho le mamello ea ts'ebeliso ea Genistein ka chemotherapy e kopaneng. Sephetho sa bobeli e ne e le ho lekola karabelo e nepahetseng ka ho fetesisa (BOR) kamora methati e 6 ea chemotherapy.
- Genistein ka tekanyo ea 60 mg / letsatsi, o ile a fuoa molomo ka matsatsi a 7 libeke tse ling le tse ling tse 2, ho qala matsatsi a mane pele ho chemo le ho tsoela pele ka matsatsi a 4-1 a chemo infusion. Sena se lumelletse bafuputsi ho lekola litla-morao le Genistein a le mong le boteng ba chemo.
Liphetho tsa Thutong ea Bongaka ts'ebelisong ea Genistein Supplement ho Cancer e Colorectal
- Motsoako oa Genistein le chemotherapy o fumanoe o bolokehile ebile o mamelleha.
- Liketsahalo tse mpe tse tlalehiloeng le Genistein a le mong li ne li le bobebe haholo, joalo ka hlooho, ho nyekeloa ke pelo le mahlaseli a chesang.
- Liketsahalo tse mpe li tlalehiloe ha Genistein a fanoa hammoho le chemotherapy li ne li amana le litlamorao tsa chemotherapy, joalo ka neuropathy, mokhathala, letshollo, leha ho le joalo, ha ho le ea mong oa bakuli ea ileng a ba le ketsahalo e mpe ea sehlopha sa 4.
- Ho bile le ntlafatso ea karabelo e akaretsang ka ho fetesisa (BOR) ho bakuli bana ba mCRC ba sebelisang chemotherapy hammoho le Genistein, ha ba bapisoa le ba tlalehiloeng bakeng sa kalafo ea chemotherapy feela lithutong tsa pejana. BOR e ne e le 61.5% phuputsong ena khahlanong le 38-49% lithutong tse fetileng ka kalafo e ts'oanang ea chemotherapy. (Saltz LB le al, J Clin Oncol, 2008)
- Le metric ea pholoho e sa lefelloeng, e supang nako eo hlahala e so tsoetseng pele ka kalafo, e ne e le moeli oa likhoeli tse 11.5 le kopanyo ea Genistein le likhoeli tse 8 bakeng sa chemotherapy feela ho ipapisitsoe le thuto ea pele. (Saltz LB le al, J Clin Oncol., 2008)
fihlela qeto e
Phuputso ena, leha e le palo e nyane haholo ea bakuli, e bonts'a ho sebelisa soya isoflavone Genistein tlatsetso hammoho le chemotherapy e kopaneng e ne e sireletsehile mme ha ea ka ea eketsa chefo ea chemotherapy ho Colorectal Cancer. Ntle le moo, ho sebelisa Genistein hammoho le FOLFOX ho na le monyetla oa ho ntlafatsa katleho ea kalafo mme mohlomong le ho fokotsa litlamorao tsa chemotherapy. Liphuputso tsena, leha li ts'episa, li tla hloka ho hlahlojoa le ho netefatsoa lithutong tse kholo tsa bongaka.
U ja lijo life, le hore na u nka li-supplement life ke qeto eo u e etsang. Qeto ea hau e lokela ho kenyelletsa ho nahanisisa ka liphetoho tsa lefutso la mofetše, e leng mofetše, liphekolo tse tsoelang pele le li-supplement, lintho life kapa life tse amanang le ho kula, lintlha tsa mokhoa oa bophelo, boima ba 'mele, bolelele le litloaelo.
Morero oa phepo bakeng sa mofets'e ho tsoa ho addon ha oa ipapisa le lipatlisiso tsa marang-rang. E iketsetsa liqeto ho latela mahlale a limolek'hule a sebelisoang ke bo-ramahlale ba rona le lienjineri tsa software. Ho sa tsotelehe hore na o tsotella ho utloisisa litsela tsa limolek'hule tsa biochemical kapa che - bakeng sa moralo oa phepo bakeng sa mofetše, kutloisiso ea hlokahala.
Qala hona joale ka moralo oa hau oa phepo e nepahetseng ka ho araba lipotso lebitsong la mofetše, phetoho ea lefutso, kalafo e tsoelang pele le litlatsetso, ho kula hohle, litloaelo, mokhoa oa bophelo, sehlopha sa lilemo le bong.
Lijo tseo u li jang le tse u tlatsetsang ke qeto eo u e etsang. Qeto ea hau e lokela ho kenyelletsa ho nahanisisa ka liphetoho tsa liphatsa tsa lefutso tsa mofetše, e leng mofetše, kalafo e tsoelang pele le litlatsetso, ho kula hohle, leseli la bophelo, boima, bolelele le litloaelo.
Morero oa phepo e nepahetseng bakeng sa mofets'e ho tsoa addon ha o ea ipapisa le lipatlisiso tsa inthanete. E iketsetsa liqeto bakeng sa hau e ipapisitse le mahlale a limolek'hule a kentsoeng tšebetsong ke bo-rasaense ba rona le lienjineri tsa software. Ho sa tsotelehe hore na o tsotella ho utloisisa metheo ea limolek'hule kapa che - bakeng sa moralo oa phepo ea mofets'e kutloisiso ea hlokahala.
Qala hona joale ka moralo oa hau oa phepo e nepahetseng ka ho araba lipotso lebitsong la mofetše, phetoho ea lefutso, kalafo e tsoelang pele le litlatsetso, ho kula hohle, litloaelo, mokhoa oa bophelo, sehlopha sa lilemo le bong.
Phepo e ikhethileng bakeng sa Kankere!
Kankere e fetoha ha nako e ntse e ea. Iketsetse 'me u fetole phepo ea hau ho latela sesupo sa mofets'e, kalafo, mokhoa oa bophelo, khetho ea lijo, lintho tse allergy le lintlha tse ling.
Bakuli ba mofets'e hangata ba tlameha ho sebetsana le tse fapaneng litla-morao tsa chemotherapy tse amang boleng ba bona ba bophelo le ho batla mekhoa e meng ea kalafo ea mofets'e. Ho nka phepo e nepahetseng le litlatsetso ho latela maikutlo a mahlale (ho qoba ho inahanela le ho khetha ka mokhoa o sa reroang) ke pheko ea tlholeho bakeng sa mofets'e le litla-morao tse amanang le kalafo