Nderipi gomarara raizobatsirwa nekubatanidza Vitamin E mukudya kwavo?

Muchidimbu

Vitamin E inozivikanwa zvakanyanya nekuda kwehutano hwayo uye inowanzoshandiswa nevanorwara nekenza uye avo vari panjodzi yemagene. Asi, kuchengetedza uye kushanda kweVitamin E kune varwere vegomarara kunoenderana nezvinhu zvakawanda senge chiratidzo chegomarara, chemotherapy, kumwe kurapwa, uye genetics yebundu. Kuziva kuti zvimwe zvekudya uye zvekuwedzera, senge mazambiringa uye sipinashi, zvinogona kupindirana zvisina kunaka nemishonga yekenza uye kukonzera kusawirirana kwakakosha.

Kudya kwakakosha pakurapwa kenza nekuti kunogona kukanganisa mhedzisiro yekurapa. Varwere vegomarara vanofanira kunyatsosarudza uye nekubatanidza chikafu chakakodzera uye chekuwedzera mukudya kwavo. Semuenzaniso, Vitamin E inogona kubatsira avo vane Primary Penile Squamous Cell Carcinoma vari pasi peMitomycin, asi zvingasava zvakanaka kune varwere vanowana Fluorouracil yePrimary Pediatric Hepatoblastoma. Uyezve, nepo Vitamin E ichigona kubatsira vanhu vane genetic risk factor "ERBB2", inogona kunge isingakurudzirwe kune avo vane imwe genetic njodzi. Kugadzirisa zvirongwa zvekudya zvinoenderana nehutano, kurapwa, uye genetics kwakakosha.

Kunzwisisa kuti kuita sarudzo pakukodzera kweVitamin E kune murwere wegomarara kunofanirwa kuve munhu mumwe kwakakosha. Zvinhu zvakakosha serudzi rwegomarara, nzira dzekurapa, genetic makeup, genetic njodzi, zera, uremu hwemuviri, uye mararamiro zvakakosha pakusarudza kana Vitamin E iriyo sarudzo yakakodzera. Genetics uye genomics, kunyanya, inonyanya kutariswa. Sezvo zvinhu izvi zvichigona kushanduka, zvakakosha kuti ugare uchiongorora uye kugadzirisa sarudzo dzekudya kuti dzienderane nekuchinja kwehutano uye kurapwa.

Mukupedzisa, maitiro akazara esarudzo dzekudya akakosha, achitarisa pane zvese zvinokonzeresa zvese zvinoshanda zvinoringana muzvikafu / zvekuwedzera seVitamin E pane kuongorora yega yega inoshanda chimedu zvakasiyana kana kuifuratira zvachose. Maonero akafara aya anosimudzira nzira inonzwisisika uye yesainzi yekuronga kudya kwegomarara.

Pfupiso Pfupiso

Kushandiswa kwezvikafu zvakadyarwa nezvirimwa uye zvekuwedzera, senge mavhitamini, maruva, zvicherwa, probiotics, uye akasiyana siyana ekuwedzera, ari kuwedzera pakati pevarwere vegomarara. Izvi zvekuwedzera zvakagadzirirwa kuendesa yakakwira yakakwira yeaya anoshanda zvimisikidzo, mazhinji acho ari mukudya kwakasiyana. Iko kusungirirwa uye kusiyanisa kwezvinhu zvinoshanda zvinosiyana pakati pezvikafu zvese uye zvekuwedzera. Zvokudya zvinowanzopa huwandu hwezvinhu zvinoshanda asi pazvishoma zvakadzika, nepo ma supplements achipa huwandu hwepamusoro hwezvimwe zvinhu.

Tichifunga nezveakasiyana esainzi uye biological mabasa ega ega rinoshanda padanho remamorekuru, zvakakosha kuti uzvidavirire kune akasanganiswa mhedzisiro yezvikamu izvi kana uchifunga nezvechikafu uye chekuwedzera chekudya kana kusadya.

Mubvunzo wakaoma unomuka: Unofanira kuisa Vitamin E mukudya kwako sechinhu chekudya kana chekuwedzera? Zvinokurudzirwa here kushandisa Vitamin E kana uine genetic predisposition kugomarara rakabatana neERBB2 gene? Ko kana pachinzvimbo njodzi yako yemajini ichibva kune gene? Zvinobatsira here kuisa Vitamin E mukudya kwako kana waonekwa kuti une Primary Pediatric Hepatoblastoma, kana kuti chirwere chako chiri Primary Penile Squamous Cell Carcinoma? Uyezve, manwiro ako eVitamin E anofanira kugadziriswa sei kana uri kurapwa neMitomycin kana chirongwa chako chekurapa chichibva kuMitomycin kuenda kuFluorouracil? Izvo zvakakosha kuti uzive kuti kutaura kwakapusa senge 'Vitamin E ndeyechisikigo, saka inogara ichibatsira' kana 'Vitamin E inosimudzira kusadzivirirwa' haina kukwana kune ruzivo rwekudya / yekuwedzera sarudzo.

Pamusoro pezvo, zvakakosha kuti uongorore zvakare kukodzera kwekusanganisira Vitamin E mukudya kwako kana paine shanduko muchirongwa chako chekurapa. Muchidimbu, kana uchiita sarudzo dzekubatanidza chikafu kana ma supplements seVitamin E mukudya kwako nekuda kwemabhenefiti ayo, iwe unofanirwa kufunga nezvese biochemical mhedzisiro yezvese zvinongedzo, uchifunga zvinhu zvakaita serudzi rwegomarara, marapirwo chaiwo auri kuita, genetic. predispositions, uye mararamiro esarudzo.

kenza

Kenza inoramba iri dambudziko rakakura mune zvekurapa, kazhinji ichikonzera kunetseka kwakapararira. Nekudaro, kufambira mberi kwazvino kwakavandudza marapirwo ekurapa, kunyanya kuburikidza nemaitiro ekurapa emunhu, nzira dzisingapindire dzekutarisa uchishandisa ropa uye mate samples, uye kuvandudzwa kweimmunotherapy. Kuonekwa kwekutanga uye kupindira panguva yakakodzera kwave kwakakosha mukupesvedzera zvakanaka mhedzisiro yekurapa.

Kuongororwa kweGenetic kunopa vimbiso yakakosha mukuongorora njodzi yegomarara uye kukurumidza kutanga. Nekudaro, kune vanhu vazhinji vane mhuri uye genetic predispositions kugomarara, sarudzo dzekupindira kwekurapa, kunyangwe nekutarisa nguva dzose, kazhinji dzinogumira kana hapana. Kana ukangoonekwa uine imwe mhando yegomarara, yakadai sePrimary Penile Squamous Cell Carcinoma kana Primary Pediatric Hepatoblastoma, nzira dzekurapa dzinoda kugadziriswa zvichienderana nebundu remunhu, danho rechirwere, pamwe nezvinhu zvakaita sezera uye murume.

Mushure mekurapa, kuenderera mberi kwekutarisa kwakakosha kuti uone chero zviratidzo zvekenza kudzoka uye kuzivisa sarudzo dzinotevera. Vazhinji varwere vegomarara uye avo vari panjodzi vanowanzo tsvaga zano rekubatanidza zvimwe zvekudya uye zvekuwedzera mukudya kwavo, izvo zvinotora basa rakakosha mukuita kwavo kwese kwekuita sarudzo maererano nehutano hwehutano.

Mubvunzo unokosha ndewekuti ungaita sei mungozi dzemajini uye chirwere chegomarara chaiyo pakusarudza nezvechikafu chekudya, seVitamin E. Ko genetic ngozi yekenza inokonzerwa nekuchinja muERBB2 ine zvakafanana biochemical pathway zvinoreva sekuchinja mune imwe gene. ? Kubva pane zvinovaka muviri, njodzi inosanganisirwa nePrimary Penile Squamous Cell Carcinoma inofananidzwa nePrimary Pediatric Hepatoblastoma? Uyezve, kutariswa kwekudya kunoramba kwakafanana here kune avo vari kuita Fluorouracil kune avo vanogamuchira Mitomycin? Aya mafungidziro akakosha pakuita sarudzo dzechikafu kune vanhu vane njodzi dzakasiyana dzemajini uye marapirwo egomarara.

Vitamin E - A Nutritional Supplement

Iyo yekuwedzera Vitamin E inosanganisa huwandu hwezvinhu zvinoshanda, kusanganisira Vitamin E, yega yega iripo panguva dzakasiyana. Izvi zvinongedzo zvinopesvedzera nzira dzemamorekuru, kunyanya DNA Kugadzirisa, Oxidative Stress uye Cell Cycle Checkpoints, iyo inogadzirisa zvakakosha zvegomarara padanho remaserura, senge bundu kukura, kupararira, uye kufa kwesero. Tichifunga izvi biological pesvedzero, kusarudza iyo yakakodzera yekuwedzera seVitamin E, yega kana musanganiswa, inova sarudzo yakakosha mumamiriro ehutano hwegomarara. Paunenge uchifunga nezvekushandisa Vitamin E kwegomarara, zvakakosha kufunga izvi zvakasiyana siyana uye maitiro. Izvi zvinodaro nekuti, zvakafanana nekurapa gomarara, kushandiswa kweVitamin E haisi sarudzo yepasirese yakakodzera vese vane cancer asi inoda kuve munhu.

Kusarudza Vitamin E Zvekuwedzera

Kutarisana nemubvunzo wekuti 'Ndirini pandinofanira kudzivisa Vitamin E mumamiriro ezvinhu eCancer' zvinonetsa nokuti mhinduro yacho ndeyemunhu oga - zvinongoreva 'Zvinoenderana!'. Zvakafanana nemabatirwo api egomarara anogona kusashanda kune wese murwere, kukosha uye kuchengetedzeka kana mabhenefiti eVitamin E anosiyana zvichienderana nemamiriro emunhu. Zvinhu zvakadai semhando chaiyo yegomarara, genetic predispositions, marapirwo aripo, zvimwe zvekuwedzera zviri kutorwa, mararamiro, BMI, uye chero allergies zvese zvine basa mukuona kuti Vitamin E yakakodzera here kana kuti inofanira kudziviswa, zvichisimbisa kukosha kwekufunga kwemunhu. muzvisarudzo zvakadaro.

1. Ko Vitamin E Supplements ichabatsira Pediatric Hepatoblastoma Varwere vari kurapwa neFluorouracil?

Primary Pediatric Hepatoblastoma inoratidzwa nekumwe kushanduka kwemajini, anoti CTNNB1, HUWE1 uye NFE2L2, izvo zvinotungamira kune shanduko mubiochemical nzira, kunyanya Adherens junction, Androgen Signaling, Oxidative Stress uye Immune Checkpoints. Kubudirira kwekurapwa kwegomarara, senge Fluorouracil, zvinoenderana nemabatiro ayo ekuita pane idzi nzira. Iro zano rakakodzera rinosanganisira kuenzanisa chiito chekurapa nenzira dzinotyaira cancer, nekudaro kuve nechokwadi chemunhu uye nzira inoshanda. Mumamiriro ezvinhu akadai, kudzivirira chikafu kana kudya kunovaka muviri kunogona kupokana nemhedzisiro yekurapa kana kuderedza kurongeka uku kwakakosha. Semuenzaniso, iyo Vitamin E yekuwedzera, iyo inobata iyo Oxidative Stress, inogona kunge isiri iyo sarudzo yakanaka munyaya yePrimary Pediatric Hepatoblastoma kana ichiitwa Fluorouracil. Izvi zvinodaro nekuti zvinogona kuwedzera kufambira mberi kwechirwere kana kukanganisa kushanda kwekurapa. Pakusarudza chirongwa chekudya, zvakakosha kuti utarise zvinhu zvakaita serudzi rwegomarara, marapirwo anoenderera mberi, zera, murume kana mukadzi, BMI, mararamiro, uye chero inozivikanwa genetic mutations.

2. Ko Vitamin E Supplements ichabatsira here Primary Penile Squamous Cell Carcinoma Varwere vari kurapwa Mitomycin?

Primary Penile Squamous Cell Carcinoma inotaridzwa neakananga genetic mutations, senge ABRAXAS1, PIK3CB uye NUP93, izvo zvinokonzeresa shanduko mubiochemical nzira, kunyanya DNA Repair, Hematopoiesis uye Inositol Phosphate Signaling. Kushanda kwekurapa kenza, seMitomycin, kunotemerwa nekudyidzana kwayo nenzira idzi. Chinangwa ndechekuona kuti kurapwa kunoenderana nemakwara anotyaira cancer, achigonesa nzira yemunhu yekurapa. Muchirevo chechinyorwa chino, zvikafu kana zvekuwedzera zvinowirirana nekurapa kana kuwedzera kurongeka uku kunofanirwa kutariswa. Semuenzaniso, iyo Vitamin E yekuwedzera isarudzo ine musoro kune avo vane Primary Penile Squamous Cell Carcinoma iri pasi peMitomycin. Izvi zvinodaro nekuti Vitamin E inokanganisa nzira dzakadai seDNA Repair, inogona kuvharidzira zvinhu zvinotyaira Primary Penile Squamous Cell Carcinoma kana kubatsira kushanda kweMitomycin.

4. Ko Vitamin E Supplements Yakachengeteka Kune Vanhu Vane Utano Vane ERBB2 Mutation Associated Genetic Risk?

ERBB2 inoita basa rakakosha mukuongorora njodzi yegomarara. Kuchinja muERBB2 kunogona kukanganisa nzira dzakakosha dzebiochemical, kusanganisira Cell Cycle Checkpoints, Growth Factor Signaling uye PI3K-AKT-MTOR Signaling, iyo inokonzera kukura kwekenza. Kana genetic panel yako ikaratidza shanduko muERBB2 yakabatana neEsophageal Adenocarcinoma, funga kuisa Vitamin E zvinowedzera muchirongwa chako chekudya. Izvi zvinowedzera zvinogona kupesvedzera nzira dzakaita seCell Cycle Checkpoints, kubatsirwa nekupa rutsigiro rwakakodzera kune vanhu vane ERBB2 shanduko uye zvine chekuita nehutano.

Mhedziso

Zvinhu zviviri zvakakosha zvekuyeuka ndezvekuti marapirwo egomarara uye chikafu chinovaka muviri hazvina kumbofanana kune wese munhu. Zvokudya zvinovaka muviri, kusanganisira chikafu uye zvinowedzera seVitamin E, chishandiso chinoshanda chinogona kudzorwa newe uchitarisana negomarara.

"Ndodyei?" ndiwo mubvunzo unonyanya kubvunzwa nevarwere vegomarara uye avo vari panjodzi yegomarara. Mhinduro chaiyo ndeyekuti zvinoenderana nezvinhu zvakaita serudzi rwegomarara, genetics yebundu, marapirwo azvino, allergies, mararamiro, uye BMI.

Tora kudya kwako kwegomarara kubva kuAddon nekudzvanya chinongedzo pazasi uye kupindura mibvunzo nezve rudzi rwegomarara rako, marapirwo, mararamiro, allergies, zera, uye murume kana mukadzi.

References

• Gamma- uye delta-tocotrienols inoshandisa zvakanyanya anticancer mhedzisiro kupfuura alpha-tocopheryl succinate pamatanho ekenza yemazamu zvisinei neHER-2/neu kutaura.
• Inhibitory mhedzisiro ye tocotrienol pane eukaryotic DNA polymerase lambda uye angiogenesis.
• cBioPortal yeCancer Genomics
• Palm tocotrienol yakaita zvirinani antioxidant zviitiko mupfupa kupfuura alpha-tocopherol.
• Mhedzisiro yeDNA kugadzirisa kushomeka pane cytotoxicity yemishonga inoshandiswa mukurapa cancer - ongororo.
• Cancer therapy inoumba kusimba kwenzvimbo ye clonal hematopoiesis.
• [Chirwere chisingaperi chinoputira ura. Extra-intestinal zviratidzo uye perianal complications].
• Mutational landscape yekenza yemetastatic yakaratidzwa kubva kune vangangove vanotarisirwa kutevedzana kwevarwere zviuru gumi.