Nderipi gomarara raizobatsirwa nekubatanidza Vitamin D3 mukudya kwavo?

Muchidimbu

Vitamin D3 inozivikanwa zvakanyanya nekuda kwehutano hwayo uye inowanzoshandiswa nevanorwara nekenza uye avo vari panjodzi yemagene. Asi, kuchengetedzeka uye kushanda kweVitamin D3 kune varwere vegomarara kunoenderana nezvinhu zvakawanda senge chiratidzo chegomarara, chemotherapy, kumwe kurapwa, uye genetics yebundu. Kuziva kuti zvimwe zvekudya uye zvekuwedzera, senge mazambiringa uye sipinachi, zvinogona kudyidzana zvisina kunaka nemishonga yekenza uye kukonzera kusawirirana kwakakosha.

Kudya kwakakosha pakurapwa kenza nekuti kunogona kukanganisa mhedzisiro yekurapa. Varwere vegomarara vanofanira kunyatsosarudza uye nekubatanidza chikafu chakakodzera uye chekuwedzera mukudya kwavo. Semuenzaniso, Vitamin D3 inogona kubatsira avo vane Primary Basal Cell Carcinoma vari pasi peVismodegib, asi zvingasava zvakanaka kune varwere vanowana Gemcitabine yePrimary Urachal adenocarcinoma. Uyezve, nepo Vitamin D3 ichigona kubatsira vanhu vane genetic risk factor "CDH1", inogona kunge isingafungidzirwe kune avo vane imwe genetic ngozi "B2M". Kugadzirisa zvirongwa zvekudya zvinoenderana nehutano, kurapwa, uye genetics kwakakosha.

Kunzwisisa kuti kuita sarudzo pakukodzera kweVitamin D3 kune murwere wegomarara kunofanirwa kuve munhu mumwe kwakakosha. Zvinhu zvakakosha zvakaita serudzi rwegomarara, nzira dzekurapa, genetic makeup, genetic njodzi, zera, uremu hwemuviri, uye mararamiro zvakakosha pakusarudza kana Vitamin D3 iriyo sarudzo yakakodzera. Genetics uye genomics, kunyanya, inonyanya kutariswa. Sezvo zvinhu izvi zvichigona kushanduka, zvakakosha kuti ugare uchiongorora uye kugadzirisa sarudzo dzekudya kuti dzienderane nekuchinja kwehutano uye kurapwa.

Mukupedzisa, maitiro akazara ekusarudzwa kwekudya kwakakosha, kutarisa kune zvese zvinokonzeresa zvese zvinoshanda zvinoringana mukudya / zvinowedzera seVitamin D3 pachinzvimbo chekuongorora chimwe nechimwe chinoshandiswa chinoshandiswa zvakasiyana kana kuregeredza zvachose. Maonero akafara aya anosimudzira nzira inonzwisisika uye yesainzi yekuronga kudya kwegomarara.

Pfupiso Pfupiso

Kushandiswa kwezvikafu zvakadyarwa nezvirimwa uye zvekuwedzera, senge mavhitamini, maruva, zvicherwa, probiotics, uye akasiyana siyana ekuwedzera, ari kuwedzera pakati pevarwere vegomarara. Izvi zvekuwedzera zvakagadzirirwa kuendesa yakakwira yakakwira yeaya anoshanda zvimisikidzo, mazhinji acho ari mukudya kwakasiyana. Iko kusungirirwa uye kusiyanisa kwezvinhu zvinoshanda zvinosiyana pakati pezvikafu zvese uye zvekuwedzera. Zvokudya zvinowanzopa huwandu hwezvinhu zvinoshanda asi pazvishoma zvakadzika, nepo ma supplements achipa huwandu hwepamusoro hwezvimwe zvinhu.

Tichifunga nezveakasiyana esainzi uye biological mabasa ega ega rinoshanda padanho remamorekuru, zvakakosha kuti uzvidavirire kune akasanganiswa mhedzisiro yezvikamu izvi kana uchifunga nezvechikafu uye chekuwedzera chekudya kana kusadya.

Mubvunzo wakaoma unomuka: Iwe unofanirwa here kuisa Vitamin D3 mukudya kwako sechinhu chekudya kana chekuwedzera? Zvinokurudzirwa here kushandisa Vitamin D3 kana uine genetic predisposition kugomarara rakabatana neCDH1 gene? Ko kana pachinzvimbo chako genetic njodzi ichibva kuB2M gene? Zvinobatsira here kuisa Vitamin D3 mukudya kwako kana waonekwa kuti une Primary Urachal adenocarcinoma, kana kuti chirwere chako chiri Primary Basal Cell Carcinoma? Uyezve, manwiro ako eVitamin D3 anofanira kugadziriswa sei kana uri kurapwa neVismodegib kana chirongwa chako chekurapa chichibva kuVismodegib kuenda kuGemcitabine? Izvo zvakakosha kuti uzive kuti kutaura kwakapusa senge 'Vitamin D3 ndeyemusikirwo, saka inogara ichibatsira' kana 'Vitamin D3 inosimudzira kusadzivirirwa kwemuviri' haina kukwana kune ruzivo rwekudya / yekuwedzera sarudzo.

Pamusoro pezvo, zvakakosha kuti uongorore zvakare kukodzera kwekusanganisira Vitamin D3 mukudya kwako kana paine shanduko muchirongwa chako chekurapa. Muchidimbu, kana uchiita sarudzo dzekubatanidza chikafu kana ma supplements seVitamin D3 mukudya kwako nekuda kwemabhenefiti ayo, unofanirwa kufunga nezvesese biochemical mhedzisiro yezvese zvinongedzo, uchifunga nezvemhando dzakadai serudzi rwegomarara, marapirwo chaiwo auri kuita, genetic. predispositions, uye mararamiro esarudzo.

kenza

Kenza inoramba iri dambudziko rakakura mune zvekurapa, kazhinji ichikonzera kunetseka kwakapararira. Nekudaro, kufambira mberi kwazvino kwakavandudza marapirwo ekurapa, kunyanya kuburikidza nemaitiro ekurapa emunhu, nzira dzisingapindire dzekutarisa uchishandisa ropa uye mate samples, uye kuvandudzwa kweimmunotherapy. Kuonekwa kwekutanga uye kupindira panguva yakakodzera kwave kwakakosha mukupesvedzera zvakanaka mhedzisiro yekurapa.

Kuongororwa kweGenetic kunopa vimbiso yakakosha mukuongorora njodzi yegomarara uye kukurumidza kutanga. Nekudaro, kune vanhu vazhinji vane mhuri uye genetic predispositions kugomarara, sarudzo dzekupindira kwekurapa, kunyangwe nekutarisa nguva dzose, kazhinji dzinogumira kana hapana. Kana ukangoonekwa uine imwe mhando yegomarara, yakadai sePrimary Basal Cell Carcinoma kana Primary Urachal adenocarcinoma, nzira dzekurapa dzinoda kugadziridzwa zvichienderana nebundu remunhu genetics, danho rechirwere, pamwe nezvinhu zvakaita sezera uye murume.

Mushure mekurapa, kuenderera mberi kwekutarisa kwakakosha kuti uone chero zviratidzo zvekenza kudzoka uye kuzivisa sarudzo dzinotevera. Vazhinji varwere vegomarara uye avo vari panjodzi vanowanzo tsvaga zano rekubatanidza zvimwe zvekudya uye zvekuwedzera mukudya kwavo, izvo zvinotora basa rakakosha mukuita kwavo kwese kwekuita sarudzo maererano nehutano hwehutano.

Mubvunzo wakaoma ndewekuti ungakonzeresa njodzi dzemajini uye negomarara rekuongororwa kana uchifunga nezvesarudzo dzekudya, senge Vitamin D3. Ko genetic njodzi yegomarara kubva mukuchinjika muCDH1 ine zvakafanana biochemical nzira nzira sekuchinja muB2M? Kubva pane zvinovaka muviri, njodzi inosanganisirwa nePrimary Basal Cell Carcinoma inoenzana nePrimary Urachal adenocarcinoma? Uyezve, kutariswa kwechikafu kunoramba kwakafanana here kune avo vari kuenda kuGemcitabine kune avo vanogamuchira Vismodegib? Aya mafungidziro akakosha pakuita sarudzo dzechikafu kune vanhu vane njodzi dzakasiyana dzemajini uye marapirwo egomarara.

Vitamin D3 - A Nutritional Supplement

Iyo yekuwedzera Vitamin D3 inosanganisira huwandu hwezvinhu zvinoshanda, zvinosanganisira Vitamin D3, yega yega iripo panguva dzakasiyana. Izvi zvinongedzo zvinopesvedzera nzira dzemamorekuru, kunyanya Vitamin D Signaling, Oxidative Stress, TGFB Signaling uye Adherens junction, iyo inoronga zvakakosha zvegomarara padanho remasero, sekukura kwebundu, kupararira, uye kufa kwesero. Tichifunga izvi biological pesvedzero, kusarudza iyo yakakodzera yekuwedzera seVitamin D3, yega kana musanganiswa, inova sarudzo yakakosha mumamiriro ehutano hwegomarara. Paunenge uchifunga nezvekushandisa Vitamin D3 kune cancer, zvakakosha kufunga nezve izvi zvakasiyana zvinhu uye maitiro. Izvi zvinodaro nekuti, zvakafanana nekurapa cancer, kushandiswa kweVitamin D3 haisi sarudzo yepasirese yakakodzera vese vane cancer asi inoda kuve munhu.

Kusarudza Vitamin D3 Zvekuwedzera

Kutarisana nemubvunzo wekuti 'Ndirini pandinofanira kudzivirira Vitamin D3 mumamiriro ezvinhu eCancer' zvinonetsa nekuti mhinduro yacho ndeyemunhu oga - zvinongoreva 'Zvinoenderana!'. Zvakafanana nemabatirwo api neapi egomarara anogona kusashanda kune wese murwere, kukosha uye kuchengetedzeka kana mabhenefiti eVitamin D3 anosiyana zvichienderana nemamiriro emunhu. Zvinhu zvakadai semhando chaiyo yegomarara, genetic predispositions, marapirwo azvino, mamwe ma supplements ari kutorwa, mararamiro, BMI, uye chero allergies zvese zvine basa mukuona kuti Vitamin D3 yakakodzera here kana kuti inofanira kudziviswa, zvichisimbisa kukosha kwekufunga nezvemunhu. muzvisarudzo zvakadaro.

1. Ko Vitamin D3 Supplements ichabatsira here Primary Urachal adenocarcinoma Varwere vari kurapwa neGemcitabine?

Yekutanga Urachal adenocarcinoma inoratidzwa neakanyanya genetic mutations, anoti NFE2L2, TP53 uye GNAS, izvo zvinotungamira kune shanduko mubiochemical nzira, kunyanya Oxidative Stress, Immune Checkpoints, Cell Cycle Checkpoints, Apoptosis, G-protein-yakabatana Receptor Signaling uye Reproductive Hormone. Kubudirira kwekurapwa kwegomarara, senge Gemcitabine, zvinoenderana nemaitiro ayo ekuita pane idzi nzira dzakananga. Iro zano rakakodzera rinosanganisira kuenzanisa chiito chekurapa nenzira dzinotyaira cancer, nekudaro kuve nechokwadi chemunhu uye nzira inoshanda. Mumamiriro ezvinhu akadai, kudzivirira chikafu kana kudya kunovaka muviri kunogona kupokana nemhedzisiro yekurapa kana kuderedza kurongeka uku kwakakosha. Semuenzaniso, iyo Vitamin D3 yekuwedzera, iyo inobata iyo Oxidative Stress, inogona kunge isiri iyo sarudzo yakanaka munyaya yePrimary Urachal adenocarcinoma paunenge uchienda kuGemcitabine. Izvi zvinodaro nekuti zvinogona kuwedzera kufambira mberi kwechirwere kana kukanganisa kushanda kwekurapa. Pakusarudza chirongwa chekudya, zvakakosha kuti utarise zvinhu zvakaita serudzi rwegomarara, marapirwo anoenderera mberi, zera, murume kana mukadzi, BMI, mararamiro, uye chero inozivikanwa genetic mutations.

2. Ko Vitamin D3 Supplements ichabatsira here Varwere veBasal Cell Carcinoma vari kurapwa neVismodegib?

Primary Basal Cell Carcinoma inotaridzwa neiyo chaiyo genetic mutations, yakadai sePTCH1, CSMD3 uye CSMD1, izvo zvinoguma nekuchinja mune biochemical nzira, kunyanya Vitamin D Signaling. Kushanda kwekurapa cancer, seVismodegib, kunotemerwa nekudyidzana kwayo nenzira idzi. Chinangwa ndechekuona kuti kurapwa kunoenderana nemakwara anotyaira cancer, achigonesa nzira yemunhu yekurapa. Muchirevo chechinyorwa chino, zvikafu kana zvekuwedzera zvinowirirana nekurapa kana kuwedzera kurongeka uku kunofanirwa kutariswa. Semuenzaniso, iyo Vitamin D3 yekuwedzera isarudzo ine musoro kune avo vane Primary Basal Cell Carcinoma iri pasi peVismodegib. Izvi zvinodaro nekuti Vitamin D3 inokanganisa nzira dzakadai seVitamin D Signaling, inogona kuvharisa zvinhu zvinotyaira Primary Basal Cell Carcinoma kana kubatsira kushanda kweVismodegib.

3. Ko Vitamin D3 Supplements Yakachengeteka Kune Vanhu Vane Utano Vane B2M Mutation Associated Genetic Risk?

Makambani akasiyana-siyana anopa gene mapaneru ekuongorora njodzi yemajini emhando dzakasiyana dzegomarara. Aya mapaneru anosanganisira majini akabatana nezamu, ovarian, uterine, prostate, uye gomarara remudumbu. Kuedza aya majini kunogona kusimbisa kuongororwa uye kuzivisa kurapwa uye manejimendi nzira. Kuziva musiyano unokonzera chirwere kunogona kubatsira mukuyedza uye kuongororwa kwehama dzinogona kunge dziri panjodzi. Iyo B2M gene inowanzo verengerwa mune aya mapaneru ekuongorora njodzi yegomarara.

Shanduko muB2M gene inokanganisa nzira dzebiochemical kana maitirwo, akadai seTGFB Signaling uye Antigen Presentation, ayo anobatanidzwa zvakananga kana zvisina kunanga mukutyaira cancer padanho remamorekuru. Kana genetic panel yakaratidza shanduko muB2M ine chekuita nenjodzi yakawedzera yeDiffuse Large B-cell Lymphoma, zvikonzero zvesainzi zvinoratidza kudzivirira kushandiswa kweVitamin D3 yekuwedzera. Izvi zvinodaro nekuti kuwedzera Vitamin D3 inopesvedzera nzira dzakaita seTGFB Chiratidzo, izvo zvinogona kutungamira kune yakaipa mhedzisiro mumamiriro eiyo B2M shanduko uye ane hukama nekenza mamiriro.

4. Ko Vitamin D3 Supplements Yakachengeteka Kune Vanhu Vane Utano Vane CDH1 Mutation Associated Genetic Risk?

CDH1 inobata basa rakakosha mukuongorora njodzi yegomarara. Kuchinja muCDH1 kunogona kukanganisa nzira dzakakosha dzebiochemical, kusanganisira Adherens junction uye Epithelial kuMesenchymal Transition, iyo inokonzera kukura kwegomarara. Kana genetic panel yako ichiratidzira shanduko muCDH1 yakabatana neGastric Cancer, funga kuisa Vitamin D3 yekuwedzera muchirongwa chako chekudya. Izvi zvinowedzera zvinogona kupesvedzera nzira dzakaita seAdherens junction, kubatsirwa nekupa rubatsiro rwakakodzera kune vanhu vane CDH1 shanduko uye zvine chekuita nehutano.

Mhedziso

Zvinhu zviviri zvakakosha zvekuyeuka ndezvekuti marapirwo egomarara uye chikafu chinovaka muviri hazvina kumbofanana kune wese munhu. Zvokudya zvinovaka muviri, kusanganisira chikafu uye zvinowedzera seVitamin D3, chishandiso chinoshanda chinogona kudzorwa newe uchitarisana negomarara.

"Ndodyei?" ndiwo mubvunzo unonyanya kubvunzwa nevarwere vegomarara uye avo vari panjodzi yegomarara. Mhinduro chaiyo ndeyekuti zvinoenderana nezvinhu zvakaita serudzi rwegomarara, genetics yebundu, marapirwo azvino, allergies, mararamiro, uye BMI.

Tora kudya kwako kwegomarara kubva kuAddon nekudzvanya chinongedzo pazasi uye kupindura mibvunzo nezve rudzi rwegomarara rako, marapirwo, mararamiro, allergies, zera, uye murume kana mukadzi.

References

• Vitamin D mhedzisiro pane monocytes 'CCL-2, IL6 uye CD14 transcription muAddison's chirwere uye HLA susceptibility.
• Iyo Molecular Landscape yeRecurrent uye Metastatic Head uye Neck Cancers: Insights Kubva kune Precision Oncology Sequencing Platform.
• Kubatanidzwa kweSMRT corepressor mukudhindwa kwechinyorwa nevhitamini D receptor.
• cBioPortal yeCancer Genomics
• Mhedzisiro yepiritsi yekudzivirira yemuromo pakukura kwefollicular muIVF / ICSI varwere vanogamuchira GnRH anopikisa: chidzidzo che randomized.
• Nzira dzekukunda Intrinsic Resistance kuGemcitabine muPancreatic Ductal Adenocarcinoma kuburikidza neRedox Modulation.
• Mutational landscape yekenza yemetastatic yakaratidzwa kubva kune vangangove vanotarisirwa kutevedzana kwevarwere zviuru gumi.
• Vitamin D (3) inokurudzira kupatsanurwa kwemasero emucolon carcinoma nekuiswa kweE-cadherin uye kuvharirwa kwebeta-catenin chiratidzo.