Nderipi gomarara raizobatsirwa nekubatanidza Vitamin K mukudya kwavo?

Muchidimbu

Vitamin K inozivikanwa zvakanyanya nekuda kwehutano hwayo uye inowanzoshandiswa nevarwere vegomarara uye avo vari panjodzi yemajini. Asi, kuchengetedzeka uye kushanda kweVitamin K kune varwere vegomarara kunoenderana nezvinhu zvakawanda senge chiratidzo chegomarara, chemotherapy, kumwe kurapwa, uye genetics yebundu. Kuziva kuti zvimwe zvekudya uye zvekuwedzera, senge mazambiringa uye sipinachi, zvinogona kudyidzana zvisina kunaka nemishonga yekenza uye kukonzera kusawirirana kwakakosha.

Kudya kwakakosha pakurapwa kenza nekuti kunogona kukanganisa mhedzisiro yekurapa. Varwere vegomarara vanofanira kunyatsosarudza uye nekubatanidza chikafu chakakodzera uye chekuwedzera mukudya kwavo. Semuenzaniso, Vitamin K inogona kubatsira avo vane Primary Glioblastoma vari pasi peTemozolomide, asi zvingasava zvakanaka kune varwere vanowana Prednisone yePrimary Follicular Lymphoma. Uyezve, nepo Vitamin K ichigona kubatsira vanhu vane genetic risk factor "ALK", inogona kunge isinga taurirwe kune avo vane imwe genetic njodzi. Kugadzirisa zvirongwa zvekudya zvinoenderana nehutano, kurapwa, uye genetics kwakakosha.

Kunzwisisa kuti kuita sarudzo pakukodzera kweVitamin K kune murwere wegomarara kunofanirwa kuve munhu mumwe kwakakosha. Zvinhu zvakakosha zvakaita serudzi rwegomarara, nzira dzekurapa, genetic makeup, genetic njodzi, zera, uremu hwemuviri, uye mararamiro zvakakosha pakusarudza kana Vitamin K iriyo sarudzo yakakodzera. Genetics uye genomics, kunyanya, inonyanya kutariswa. Sezvo zvinhu izvi zvichigona kushanduka, zvakakosha kuti ugare uchiongorora uye kugadzirisa sarudzo dzekudya kuti dzienderane nekuchinja kwehutano uye kurapwa.

Mukupedzisa, maitiro akazara esarudzo dzekudya akakosha, achitarisa pane zvese zvinokonzeresa zvese zvinoshanda zvinoringana muzvikafu/zvinowedzera zvakaita seVitamin K pachinzvimbo chekuongorora chega chega chega chega chega kana kuchifuratira zvachose. Maonero akafara aya anosimudzira nzira inonzwisisika uye yesainzi yekuronga kudya kwegomarara.

Pfupiso Pfupiso

Kushandiswa kwezvikafu zvakadyarwa nezvirimwa uye zvekuwedzera, senge mavhitamini, maruva, zvicherwa, probiotics, uye akasiyana siyana ekuwedzera, ari kuwedzera pakati pevarwere vegomarara. Izvi zvekuwedzera zvakagadzirirwa kuendesa yakakwira yakakwira yeaya anoshanda zvimisikidzo, mazhinji acho ari mukudya kwakasiyana. Iko kusungirirwa uye kusiyanisa kwezvinhu zvinoshanda zvinosiyana pakati pezvikafu zvese uye zvekuwedzera. Zvokudya zvinowanzopa huwandu hwezvinhu zvinoshanda asi pazvishoma zvakadzika, nepo ma supplements achipa huwandu hwepamusoro hwezvimwe zvinhu.

Tichifunga nezveakasiyana esainzi uye biological mabasa ega ega rinoshanda padanho remamorekuru, zvakakosha kuti uzvidavirire kune akasanganiswa mhedzisiro yezvikamu izvi kana uchifunga nezvechikafu uye chekuwedzera chekudya kana kusadya.

Mubvunzo wakaoma unomuka: Iwe unofanirwa here kuisa Vitamin K mukudya kwako sechinhu chekudya kana chekuwedzera? Zvinokurudzirwa here kushandisa Vitamin K kana uine genetic predisposition kune cancer yakabatana neiyo ALK gene? Ko kana pachinzvimbo njodzi yako yemajini ichibva kune gene? Zvinobatsira here kuisa Vitamin K mukudya kwako kana ukawanikwa uine Primary Follicular Lymphoma, kana kuti chirwere chako chiri Primary Glioblastoma? Uyezve, manwiro ako eVitamin K anofanira kugadziriswa sei kana uri kurapwa neTemozolomide kana kana chirongwa chako chekurapa chichichinja kubva kuTemozolomide kuenda kuPrednisone? Izvo zvakakosha kuti uzive kuti kutaura kwakapusa senge 'Vitamin K ndekwechisikigo, saka inogara ichibatsira' kana 'Vitamin K inosimudzira kusadzivirirwa' haina kukwana kune ruzivo rwekudya / yekuwedzera sarudzo.

Pamusoro pezvo, zvakakosha kuti uongorore zvakare kukodzera kwekusanganisira Vitamin K mukudya kwako kana paine shanduko muchirongwa chako chekurapa. Muchidimbu, kana uchiita sarudzo dzekubatanidza chikafu kana ma supplements seVitamin K mukudya kwako kune zvakanakira, iwe unofanirwa kufunga nezvese biochemical mhedzisiro yezvese zvinongedzo, uchifunga zvinhu zvakaita serudzi rwegomarara, marapirwo auri kuita, genetic. predispositions, uye mararamiro esarudzo.

kenza

Kenza inoramba iri dambudziko rakakura mune zvekurapa, kazhinji ichikonzera kunetseka kwakapararira. Nekudaro, kufambira mberi kwazvino kwakavandudza marapirwo ekurapa, kunyanya kuburikidza nemaitiro ekurapa emunhu, nzira dzisingapindire dzekutarisa uchishandisa ropa uye mate samples, uye kuvandudzwa kweimmunotherapy. Kuonekwa kwekutanga uye kupindira panguva yakakodzera kwave kwakakosha mukupesvedzera zvakanaka mhedzisiro yekurapa.

Kuongororwa kweGenetic kunopa vimbiso yakakosha mukuongorora njodzi yegomarara uye kukurumidza kutanga. Nekudaro, kune vanhu vazhinji vane mhuri uye genetic predispositions kugomarara, sarudzo dzekupindira kwekurapa, kunyangwe nekutarisa nguva dzose, kazhinji dzinogumira kana hapana. Kana ukangoonekwa uine imwe mhando yegomarara, sePrimary Glioblastoma kana Primary Follicular Lymphoma, nzira dzekurapa dzinofanirwa kugadziridzwa zvichienderana nebundu remunhu genetics, danho rechirwere, pamwe nezvinhu zvakaita sezera uye murume.

Mushure mekurapa, kuenderera mberi kwekutarisa kwakakosha kuti uone chero zviratidzo zvekenza kudzoka uye kuzivisa sarudzo dzinotevera. Vazhinji varwere vegomarara uye avo vari panjodzi vanowanzo tsvaga zano rekubatanidza zvimwe zvekudya uye zvekuwedzera mukudya kwavo, izvo zvinotora basa rakakosha mukuita kwavo kwese kwekuita sarudzo maererano nehutano hwehutano.

Mubvunzo wakaoma ndewekuti kukonzeresa njodzi dzema genetic uye kutariswa kwegomarara chairo kana uchifunga nezvesarudzo dzekudya, seVitamin K. Ko genetic njodzi yegomarara rinobva mukushanduka muALK ine zvakafanana biochemical pathway nzira sekuchinja mune imwe gene. ? Kubva pane zvinovaka muviri, njodzi inosanganisirwa nePrimary Glioblastoma inofanana nePrimary Follicular Lymphoma? Uyezve, kudya kwekudya kunoramba kwakafanana kune avo vari pasi pePrednisone kune avo vanogamuchira Temozolomide? Aya mafungidziro akakosha pakuita sarudzo dzechikafu kune vanhu vane njodzi dzakasiyana dzemajini uye marapirwo egomarara.

Vitamin K - A Nutritional Supplement

Iyo yekuwedzera Vitamin K inosanganisira huwandu hwezvinhu zvinoshanda, zvinosanganisira Vitamin K, yega yega iripo pane akasiyana siyana. Izvi zvinongedzo zvinopesvedzera nzira dzemamorekuru, kunyanya NFKB Signaling uye TWEAK Signaling, iyo inoronga zvakakosha zvegomarara padanho remaserura, sekukura kwebundu, kupararira, uye kufa kwesero. Tichifunga izvi biological pesvedzero, kusarudza akakodzera ekuwedzera seVitamin K, ega kana musanganiswa, inova sarudzo yakakosha mumamiriro ehutano hwegomarara. Paunenge uchifunga nezvekushandisa Vitamin K kwegomarara, zvakakosha kuti utarise izvi zvakasiyana zvinhu uye maitiro. Izvi zvinodaro nekuti, zvakafanana nekurapwa kwegomarara, kushandiswa kweVitamin K haisi sarudzo yepasirese yakakodzera vese vane cancer asi inoda kuve munhu.

Kusarudza Vitamin K Supplements

Kutarisana nemubvunzo wekuti 'Ndirini pandinofanira kudzivirira Vitamin K mumamiriro ezvinhu eCancer' zvinonetsa nokuti mhinduro yacho ndeyemunhu oga - zvinongoreva 'Zvinoenderana!'. Zvakafanana nemabatirwo api egomarara anogona kusashanda kune wese murwere, kukosha uye kuchengetedzeka kana mabhenefiti eVitamin K anosiyana zvichienderana nemamiriro emunhu. Zvinhu zvakadai semhando chaiyo yegomarara, genetic predispositions, marapirwo aripo, zvimwe zvekuwedzera zviri kutorwa, mararamiro, BMI, uye chero allergies zvese zvine basa mukuona kuti Vitamin K yakakodzera here kana kuti inofanira kudziviswa, zvichisimbisa kukosha kwekufunga kwemunhu. muzvisarudzo zvakadaro.

1. Ko Vitamin K Supplements ichabatsira here Primary Follicular Lymphoma Varwere vari kurapwa Prednisone?

Primary Follicular Lymphoma inoratidzirwa neakanyanya genetic mutations, anoti KMT2D, BCL2 uye IGLV5-45, izvo zvinotungamira kune shanduko mubiochemical nzira, kunyanya TWEAK Signaling, Oncogenic Histone Methylation, Amino Acid Metabolism, Autophagy uye Hypoxia. Kubudirira kwekurapwa kwegomarara, sePrednisone, kunoenderana nemabatiro ayo ekuita pane idzi nzira chaidzo. Iro zano rakakodzera rinosanganisira kuenzanisa chiito chekurapa nenzira dzinotyaira cancer, nekudaro kuve nechokwadi chemunhu uye nzira inoshanda. Mumamiriro ezvinhu akadai, kudzivirira chikafu kana kudya kunovaka muviri kunogona kupokana nemhedzisiro yekurapa kana kuderedza kurongeka uku kwakakosha. Semuyenzaniso, iyo Vitamin K yekuwedzera, iyo inobata TWEAK Signaling, inogona kunge isiri iyo sarudzo yakanaka munyaya yePrimary Follicular Lymphoma kana ichiitwa Prednisone. Izvi zvinodaro nekuti zvinogona kuwedzera kufambira mberi kwechirwere kana kukanganisa kushanda kwekurapa. Pakusarudza chirongwa chekudya, zvakakosha kuti utarise zvinhu zvakaita serudzi rwegomarara, marapirwo anoenderera mberi, zera, murume kana mukadzi, BMI, mararamiro, uye chero inozivikanwa genetic mutations.

2. Ko Vitamin K Supplements ichabatsira Primary Glioblastoma Varwere vari kurapwa neTemozolomide?

Primary Glioblastoma inoonekwa neiyo chaiyo genetic mutations, seTRBV7-7, TAS2R46 uye TP53, izvo zvinokonzeresa shanduko mubiochemical nzira, kunyanya NFKB Signaling, Cell Cycle Checkpoints uye Apoptosis. Kubudirira kwekurapa kenza, seTemozolomide, inotarwa nekudyidzana kwayo nenzira idzi. Chinangwa ndechekuona kuti kurapwa kunoenderana nemakwara anotyaira cancer, achigonesa nzira yemunhu yekurapa. Muchirevo chechinyorwa chino, zvikafu kana zvekuwedzera zvinowirirana nekurapa kana kuwedzera kurongeka uku kunofanirwa kutariswa. Semuenzaniso, iyo Vitamin K yekuwedzera isarudzo ine musoro kune avo vane Primary Glioblastoma vari pasi peTemozolomide. Izvi zvinodaro nekuti Vitamin K inopesvedzera nzira dzakadai seNFKB Signaling, iyo inogona kuvharisa zvinhu zvinotyaira Primary Glioblastoma kana kubatsira kushanda kweTemozolomide.

3. Ko Vitamin K Supplements Yakachengeteka Kune Vanhu Vane Utano Vane ALK Mutation Associated Genetic Risk?

ALK inoita basa rakakosha mukuongorora njodzi yegomarara. Kuchinja muALK kunogona kukanganisa nzira dzakakosha dzebiochemical, kusanganisira NFKB Kuratidzira uye Kukura Kwekuita Chiratidzo, izvo zvinokanganisa kukura kwegomarara. Kana genetic panel yako ichiratidza shanduko muALK yakabatana neCentral Nervous System, funga kuisa Vitamin K yekuwedzera muchirongwa chako chekudya. Izvi zvinowedzera zvinogona kupesvedzera nzira dzakaita seNFKB Signaling, kubatsirwa nekupa rubatsiro rwakakodzera kune vanhu vane ALK mutations uye zvine chekuita nehutano.

Mhedziso

Zvinhu zviviri zvakakosha zvekuyeuka ndezvekuti marapirwo egomarara uye chikafu chinovaka muviri hazvina kumbofanana kune wese munhu. Zvokudya zvinovaka muviri, zvinosanganisira chikafu uye zvinowedzera seVitamin K, chishandiso chinoshanda chinogona kudzorwa newe uchitarisana negomarara.

"Ndodyei?" ndiwo mubvunzo unonyanya kubvunzwa nevarwere vegomarara uye avo vari panjodzi yegomarara. Mhinduro chaiyo ndeyekuti zvinoenderana nezvinhu zvakaita serudzi rwegomarara, genetics yebundu, marapirwo azvino, allergies, mararamiro, uye BMI.

Tora kudya kwako kwegomarara kubva kuAddon nekudzvanya chinongedzo pazasi uye kupindura mibvunzo nezve rudzi rwegomarara rako, marapirwo, mararamiro, allergies, zera, uye murume kana mukadzi.

References

• cBioPortal yeCancer Genomics
• Tsvagiridzo inofambira mberi pane anticancer mhedzisiro yevhitamini K2.
• NF-κB inoshandiswa mukupindura temozolomide nenzira yeAKT-inotenderera uye inopa dziviriro kubva pakukura kudzvinyirira maitiro emushonga.
• Pan-cancer kuongororwa kweiyo genomes yakazara.
• Kuchinja kweunzenza kunomutsa nzira isiri yeNF-kappaB mune dzakawanda myeloma.
• Iyo somatic genomic landscape ye glioblastoma.