Nderipi gomarara raizobatsirikana nekubatanidza Amla mukudya kwavo?

Muchidimbu

Amla inozivikanwa zvakanyanya nekuda kwehutano hwayo uye inowanzoshandiswa nevarwere vegomarara uye avo vari panjodzi yemajini. Asi, kuchengetedzeka uye kushanda kweAmla kune varwere vegomarara kunoenderana nezvinhu zvakawanda senge chiratidzo chegomarara, chemotherapy, kumwe kurapwa, uye genetics yebundu. Kuziva kuti zvimwe zvekudya uye zvekuwedzera, senge mazambiringa uye sipinachi, zvinogona kudyidzana zvisina kunaka nemishonga yekenza uye kukonzera kusawirirana kwakakosha.

Kudya kwakakosha pakurapwa kenza nekuti kunogona kukanganisa mhedzisiro yekurapa. Varwere vegomarara vanofanira kunyatsosarudza uye nekubatanidza chikafu chakakodzera uye chekuwedzera mukudya kwavo. Semuenzaniso, Amla inogona kubatsira avo vane Primary Penile Squamous Cell Carcinoma vari pasi peMitomycin, asi zvingasava zvakanaka kune varwere vanowana Radiation yePrimary Adamantinoma. Uyezve, nepo Amla achigona kubatsira vanhu vane genetic risk factor "ERBB2", inogona kunge isingafungidzirwe kune avo vane imwe genetic njodzi "ASXL1". Kugadzirisa zvirongwa zvekudya zvinoenderana nehutano, kurapwa, uye genetics kwakakosha.

Kunzwisisa kuti kuita sarudzo pakukodzera kwaAmla kune murwere wegomarara kunofanirwa kuve munhu mumwe kwakakosha. Zvinhu zvakakosha serudzi rwegomarara, nzira dzekurapa, genetic makeup, genetic njodzi, zera, uremu hwemuviri, uye mararamiro zvakakosha pakusarudza kana Amla iriyo sarudzo yakakodzera. Genetics uye genomics, kunyanya, inonyanya kutariswa. Sezvo zvinhu izvi zvichigona kushanduka, zvakakosha kuti ugare uchiongorora uye kugadzirisa sarudzo dzekudya kuti dzienderane nekuchinja kwehutano uye kurapwa.

Mukupedzisa, maitiro akazara esarudzo dzekudya akakosha, tichitarisa pane zvese zvinokonzeresa zvese zvinoshanda zvinoringana muzvikafu / zvekuwedzera seAmla pachinzvimbo chekuongorora chega chega chega chega chega kana kufuratira zvachose. Maonero akafara aya anosimudzira nzira inonzwisisika uye yesainzi yekuronga kudya kwegomarara.

Pfupiso Pfupiso

Kushandiswa kwezvikafu zvakadyarwa nezvirimwa uye zvekuwedzera, senge mavhitamini, maruva, zvicherwa, probiotics, uye akasiyana siyana ekuwedzera, ari kuwedzera pakati pevarwere vegomarara. Izvi zvekuwedzera zvakagadzirirwa kuendesa yakakwira yakakwira yeaya anoshanda zvimisikidzo, mazhinji acho ari mukudya kwakasiyana. Iko kusungirirwa uye kusiyanisa kwezvinhu zvinoshanda zvinosiyana pakati pezvikafu zvese uye zvekuwedzera. Zvokudya zvinowanzopa huwandu hwezvinhu zvinoshanda asi pazvishoma zvakadzika, nepo ma supplements achipa huwandu hwepamusoro hwezvimwe zvinhu.

Tichifunga nezveakasiyana esainzi uye biological mabasa ega ega rinoshanda padanho remamorekuru, zvakakosha kuti uzvidavirire kune akasanganiswa mhedzisiro yezvikamu izvi kana uchifunga nezvechikafu uye chekuwedzera chekudya kana kusadya.

Mubvunzo wakaoma unomuka: Unofanira kubatanidza Amla mukudya kwako sechinhu chekudya kana chekuwedzera? Zvinokurudzirwa here kushandisa Amla kana uine genetic predisposition kune cancer yakabatana neERBB2 gene? Ko kana pachinzvimbo chako genetic njodzi ichibva kuASXL1 gene? Zvinobatsira here kuisa Amla mukudya kwako kana ukawanikwa uine Primary Adamantinoma, kana kana chirwere chako chiri Primary Penile Squamous Cell Carcinoma? Uyezve, manwiro ako eAmla anofanira kugadziriswa sei kana uri kurapwa neMitomycin kana chirongwa chako chekurapa chichibva kuMitomycin kuenda kuRadiation? Izvo zvakakosha kuti uzive kuti zvirevo zviri nyore senge 'Amla ndezvakasikwa, saka zvinogara zvichibatsira' kana 'Amla inosimudzira kusadzivirirwa' hazvina kukwana pasarudzo dzechikafu/zvekuwedzera.

Pamusoro pezvo, zvakakosha kuti uongorore zvakare kukodzera kwekusanganisira Amla mukudya kwako kana paine shanduko muchirongwa chako chekurapa. Muchidimbu, kana uchiita sarudzo nezve kubatanidza chikafu kana ma supplements seAmla mukudya kwako kune mabhenefiti ayo, unofanirwa kufunga nezvese biochemical mhedzisiro yezvese zvinongedzo, uchifunga zvinhu zvakaita serudzi rwegomarara, marapirwo auri kuita, genetic predispositions. , uye sarudzo dzemararamiro.

kenza

Kenza inoramba iri dambudziko rakakura mune zvekurapa, kazhinji ichikonzera kunetseka kwakapararira. Nekudaro, kufambira mberi kwazvino kwakavandudza marapirwo ekurapa, kunyanya kuburikidza nemaitiro ekurapa emunhu, nzira dzisingapindire dzekutarisa uchishandisa ropa uye mate samples, uye kuvandudzwa kweimmunotherapy. Kuonekwa kwekutanga uye kupindira panguva yakakodzera kwave kwakakosha mukupesvedzera zvakanaka mhedzisiro yekurapa.

Kuongororwa kweGenetic kunopa vimbiso yakakosha mukuongorora njodzi yegomarara uye kukurumidza kutanga. Nekudaro, kune vanhu vazhinji vane mhuri uye genetic predispositions kugomarara, sarudzo dzekupindira kwekurapa, kunyangwe nekutarisa nguva dzose, kazhinji dzinogumira kana hapana. Kana ukangoonekwa uine imwe mhando yegomarara, yakadai sePrimary Penile Squamous Cell Carcinoma kana Primary Adamantinoma, nzira dzekurapa dzinofanirwa kugadziridzwa zvichienderana nebundu remunhu genetics, danho rechirwere, pamwe nezvinhu zvakaita sezera uye murume.

Mushure mekurapa, kuenderera mberi kwekutarisa kwakakosha kuti uone chero zviratidzo zvekenza kudzoka uye kuzivisa sarudzo dzinotevera. Vazhinji varwere vegomarara uye avo vari panjodzi vanowanzo tsvaga zano rekubatanidza zvimwe zvekudya uye zvekuwedzera mukudya kwavo, izvo zvinotora basa rakakosha mukuita kwavo kwese kwekuita sarudzo maererano nehutano hwehutano.

Mubvunzo wakaoma ndewekuti ungakonzeresa njodzi dzemajini uye negomarara rekuongororwa kana uchifunga nezvesarudzo dzekudya, senge Amla. Ko genetic njodzi yegomarara kubva mukushandurwa muERBB2 ine zvakafanana biochemical nzira nzira sekuchinja muASXL1? Kubva pane zvinovaka muviri, njodzi inosanganisirwa nePrimary Penile Squamous Cell Carcinoma inofanana nePrimary Adamantinoma? Uyezve, kutariswa kwekudya kunoramba kwakafanana here kune avo vari kuita Radiation sekune avo vanogamuchira Mitomycin? Aya mafungidziro akakosha pakuita sarudzo dzechikafu kune vanhu vane njodzi dzakasiyana dzemajini uye marapirwo egomarara.

Amla – A Nutritional Supplement

Iyo yekuwedzera Amla inosanganisira huwandu hwezvinhu zvinoshanda, zvinosanganisira Emblicanin B, Emblicanin A, Pyrogallol, Ellagic Acid uye Gallic Acid, imwe neimwe iripo panguva dzakasiyana. Izvi zvinongedzo zvinopesvedzera nzira dzemamorekuru, kunyanya Extracellular Matrix Remodelling, Epithelial to Mesenchymal Transition, Oncogenic Cancer Epigenetics uye PI3K-AKT-MTOR Signaling, iyo inotonga zvakakosha zvegomarara padanho remasero, sekukura kwebundu, kupararira, uye kufa kwesero. Tichifunga izvi biological pesvedzero, kusarudza akakodzera anowedzera seAmla, ari ega kana musanganiswa, inova sarudzo yakakosha mumamiriro ehutano hwegomarara. Kana uchifunga kushandisa Amla kenza, zvakakosha kuti utarise izvi zvakasiyana zvinhu uye maitiro. Izvi zvinodaro nekuti, zvakafanana nekurapa cancer, kushandiswa kweAmla haisi sarudzo yepasirese yakakodzera vese vane cancer asi inoda kuve munhu.

Kusarudza Amla Supplements

Kugadzirisa mubvunzo wekuti 'Ndirini pandinofanira kudzivirira Amla mumamiriro ezvinhu eCancer' zvinonetsa nekuti mhinduro yacho ndeyemunhu oga - zvinongoreva 'Zvinoenderana!'. Zvakafanana nemabatiro ekurapa kwegomarara anogona kusashanda kune wese murwere, kukosha uye kuchengetedzeka kana mabhenefiti eAmla anosiyana zvichienderana nemamiriro emunhu. Zvinhu zvakadai semhando chaiyo yegomarara, genetic predispositions, marapirwo azvino, mamwe ma supplements ari kutorwa, mararamiro, BMI, uye chero allergies zvese zvine basa mukuona kuti Amla yakakodzera here kana kuti inofanirwa kudziviswa, zvichisimbisa kukosha kwekufunga kwemunhu. zvisarudzo zvakadaro.

1. Ko Amla Supplements ichabatsira Varwere vePrayimari Adamantinoma vari kurapwa neRadiation?

Primary Adamantinoma inoratidzwa neakanyanya genetic mutations, anoti ARHGAP45, PI4KB uye SDSL, izvo zvinotungamira kune shanduko mubiochemical nzira, kunyanya Epithelial kune Mesenchymal Transition uye Inositol Phosphate Signaling. Kubudirira kwekurapwa kwegomarara, senge Radiation, zvinoenderana nemaitiro ayo ekuita pane idzi nzira dzakananga. Iro zano rakakodzera rinosanganisira kuenzanisa chiito chekurapa nenzira dzinotyaira cancer, nekudaro kuve nechokwadi chemunhu uye nzira inoshanda. Mumamiriro ezvinhu akadai, kudzivirira chikafu kana kudya kunovaka muviri kunogona kupokana nemhedzisiro yekurapa kana kuderedza kurongeka uku kwakakosha. Semuyenzaniso, iyo Amla yekuwedzera, iyo inobata Epithelial kune Mesenchymal Transition, inogona kunge isiri iyo sarudzo yakanaka munyaya yePrimary Adamantinoma kana ichiitwa neRadiation. Izvi zvinodaro nekuti zvinogona kuwedzera kufambira mberi kwechirwere kana kukanganisa kushanda kwekurapa. Pakusarudza chirongwa chekudya, zvakakosha kuti utarise zvinhu zvakaita serudzi rwegomarara, marapirwo anoenderera mberi, zera, murume kana mukadzi, BMI, mararamiro, uye chero inozivikanwa genetic mutations.

2. Ko Amla Supplements ichabatsira here Primary Penile Squamous Cell Carcinoma Varwere vari kurapwa Mitomycin?

Primary Penile Squamous Cell Carcinoma inotaridzwa neakananga genetic mutations, senge ABRAXAS1, PIK3CB uye NUP93, izvo zvinokonzeresa shanduko mubiochemical nzira, kunyanya Extracellular Matrix Remodelling, Hematopoiesis uye Inositol Phosphate Signaling. Kushanda kwekurapa kenza, seMitomycin, kunotemerwa nekudyidzana kwayo nenzira idzi. Chinangwa ndechekuona kuti kurapwa kunoenderana nemakwara anotyaira cancer, achigonesa nzira yemunhu yekurapa. Muchirevo chechinyorwa chino, zvikafu kana zvekuwedzera zvinowirirana nekurapa kana kuwedzera kurongeka uku kunofanirwa kutariswa. Semuenzaniso, iyo Amla yekuwedzera isarudzo ine musoro kune avo vane Primary Penile Squamous Cell Carcinoma iri pasi peMitomycin. Izvi zvinodaro nekuti Amla inokanganisa nzira dzakadai seExtracellular Matrix Remodelling, iyo inogona kutadzisa zvinhu zvinotyaira Primary Penile Squamous Cell Carcinoma kana kubatsira kushanda kweMitomycin.

3. Ko Amla Supplements Yakachengeteka Kune Vane Utano Vanhu vane ASXL1 Mutation Associated Genetic Risk?

Makambani akasiyana-siyana anopa gene mapaneru ekuongorora njodzi yemajini emhando dzakasiyana dzegomarara. Aya mapaneru anosanganisira majini akabatana nezamu, ovarian, uterine, prostate, uye gomarara remudumbu. Kuedza aya majini kunogona kusimbisa kuongororwa uye kuzivisa kurapwa uye manejimendi nzira. Kuziva musiyano unokonzera chirwere kunogona kubatsira mukuyedza uye kuongororwa kwehama dzinogona kunge dziri panjodzi. Iyo ASXL1 gene inowanzo verengerwa mune aya mapaneru ekuongorora njodzi yegomarara.

Shanduko iri muASXL1 gene inokanganisa nzira dzebiochemical kana maitiro, akadai seOncogenic Cancer Epigenetics uye Suppressive Histone Methylation, ayo anobatanidzwa zvakananga kana zvisina kunanga mukutyaira cancer padanho remamorekuru. Kana genetic panel yakaratidza shanduko muASXL1 yakabatana nenjodzi yakawedzera yeChronic Myelomonocytic Leukemia, chikonzero chesainzi chinoratidza kudzivirira kushandiswa kwekuwedzera Amla. Izvi zvinodaro nekuti kuwedzera Amla kunopesvedzera nzira dzakaita seOncogenic Cancer Epigenetics, iyo inogona kutungamira kune yakaipa mhedzisiro mumamiriro eiyo ASXL1 mutation uye ane hukama nekenza mamiriro.

4. Ko Amla Supplements Yakachengeteka Kune Vanhu Vane Utano Vane ERBB2 Mutation Associated Genetic Risk?

ERBB2 inoita basa rakakosha mukuongorora njodzi yegomarara. Kuchinja muERBB2 kunogona kukanganisa nzira dzakakosha dzebiochemical, kusanganisira Kukura Kwekuita Chiratidzo uye PI3K-AKT-MTOR Chiratidzo, izvo zvinokanganisa kukura kwegomarara. Kana genetic panel yako ikaratidza shanduko muERBB2 yakabatana neEsophageal Adenocarcinoma, funga kuisa Amla supplement muchirongwa chako chekudya. Izvi zvinowedzera zvinogona kupesvedzera nzira dzakaita sePI3K-AKT-MTOR Signaling, kubatsirwa nekupa rubatsiro rwakakodzera kune vanhu vane ERBB2 shanduko uye zvine chekuita nehutano.

Mhedziso

Zvinhu zviviri zvakakosha zvekuyeuka ndezvekuti marapirwo egomarara uye chikafu chinovaka muviri hazvina kumbofanana kune wese munhu. Zvokudya zvinovaka muviri, kusanganisira chikafu uye zvekuwedzera seAmla, chishandiso chinoshanda chinogona kudzorwa newe uchitarisana negomarara.

"Ndodyei?" ndiwo mubvunzo unonyanya kubvunzwa nevarwere vegomarara uye avo vari panjodzi yegomarara. Mhinduro chaiyo ndeyekuti zvinoenderana nezvinhu zvakaita serudzi rwegomarara, genetics yebundu, marapirwo azvino, allergies, mararamiro, uye BMI.

Tora kudya kwako kwegomarara kubva kuAddon nekudzvanya chinongedzo pazasi uye kupindura mibvunzo nezve rudzi rwegomarara rako, marapirwo, mararamiro, allergies, zera, uye murume kana mukadzi.

References

• Kushanda uye Nutraceutical Kukosha kweAmla (Phyllanthus emblica L.): Ongororo.
• cBioPortal yeCancer Genomics
• cBioPortal yeCancer Genomics
• Kubatanidzwa kwe integrinβ1 kunokonzeresa kuramba kwemasero egomarara redundiro kune mitomycin-C.
• Pan-cancer kuongororwa kweiyo genomes yakazara.
• Cancer therapy inoumba kusimba kwenzvimbo ye clonal hematopoiesis.
• Kuzivikanwa kwe ellagic acid seine simba inhibitor yeprotein kinase CK2: muenzaniso wakabudirira weiyo chaiyo yekuongorora application.
• Radio kuramba mumasero egomarara rezamu inoyananiswa kuburikidza neTGF-β kusaina, hybrid epithelial-mesenchymal phenotype uye cancer stem masero.
• Indeno[1,2-b]indole derivatives sechikamu chetsva chevanhu vane simba protein kinase CK2 inhibitors.