Muchidimbu
Kunyangwe hazvo chikafu chakapfuma mumalignans (sosi yezvokudya phytoestrogen ine dhizaini yakafanana nesrogen) inogona kunge iine makemikari akakosha anoshanda anogona kubatsira kudzikisa njodzi yemhando dzakasiyana dzekenza, kusangana pakati pemazinga eplasma enterolactone uye njodzi yekenza haina kujeka . Imwe ongororo ichangoburwa yakawana kuti yakakwira enterolactone mazinga anogona kuve akabatanidzwa nenjodzi yakadzikira yecolorectal cancer-yakatarisana kufa pakati pevakadzi uye nenjodzi yakawedzera yekufa pakati pevarume. Zvimwe zvidzidzo zvakaongorora kukanganiswa kweplasma enterolactone kusungwa pazamu, prostate uye kenza yemendometriya haina kuwana kushamwaridzana kana kupedzisira iine zvinopesana. Nekudaro, kusvika parizvino, hapana humbowo hwakajeka hunoratidza kuti mwero wekutenderera wakanyanya we enterolactone unogona kupa zvakakomba dziviriro panjodzi yekenza-inosangana nekenza.
Chii chinonzi Lignans?
Lignans ndiwo polyphenols pamwe neakanyanya chikafu chinobva kune phytoestrogen (chirimwa chirimwa chine chimiro chakafanana neestrogen), chinowanikwa zvakanyanya muzvikafu zvakasiyana-siyana zvezvirimwa zvakadai sembeu yeflakisi nembeu yesesame uye muzvidiki zvidiki mumanzungu, zviyo zvese, michero uye miriwo. Idzi chikafu chine lignan chinowanzo shandiswa sechikamu chekudya zvine hutano. Mamwe eanonyanya kufadza lignan anotungamira muzvirimwa-zvakavakirwa kudya ndeye secoisolariciresinol, pinoresinol, lariciresinol uye matairesinol.
Chii chinonzi Enterolactone?
Muti weLignans watinoshandisa unogadziriswa nenzira enzymatic nehutachiona hwemudumbu zvinotungamira mukuumbwa kwemakemikari anonzi Enterolignans. Iwo maviri makuru mainolignans anotenderera mumuviri wedu ndeaya:
a. Enterodiol uye
b. Enterolactone
Enterolactone ndeimwe yeakanyanya mammalian lignans. Enterodiol inogona zvakare kushandurwa kuita enterolactone nehutachiona hwemukati. (Meredith AJ Hullar et al, Cancer Epidemiol Biomarkers Prev., 2015) Ose enterodiol uye enterolactone, vanozivikanwa kuve vasina simba estrogenic chiitiko.
Kunze kwehuwandu hwekudyiwa kwezvirimwa lignans, Enterolactone mazinga mu serum uye weti inogona zvakare kuratidza chiitiko chemuviri wemabhakitiriya. Zvakare, kushandiswa kwemishonga inorwisa mabhakitiriya kwave kuchisanganiswa neyezasi serum enterolactone concentration.
Kana zvasvika kune phytoestrogen (chirimwa chirimwa chine chimiro chakafanana nesrogen) -zvikafu zvine hupfumi, soy isoflavones inowanzo kuoneka, zvisinei, maLignans ari iwo manyuko makuru e phytoestrogens kunyanya mukudya kwekuMadokero.
Chikafu chekudya Mushure meKenza Kuongorora!
Hapana kanzura mbiri dzakafanana. Enda pamusoro peyakajairwa nhungamiro yemunhu wese uye utore sarudzo dzakagadzirirwa nezve chikafu uye zvinowedzerwa uine chivimbo.
Plasma Enterolactone Kusungwa uye Kanzera Njodzi
Kunyangwe zvikafu zvakapfuma mu lignans (tsime rekudya phytoestrogen ine chimiro chakafanana neesrogen) inoonekwa seine hutano uye ine akasiyana akakosha emakemikari makomisheni anogona kubatsira mukudzikisa njodzi yemhando dzakasiyana dzegomarara, kushamwaridzana pakati pemazinga eenterolactone uye ngozi ye kanzira haina kujeka.
Plasma Enterolactone Kusungwa uye Colorectal Cancer Rufu
Muchidzidzo chakaburitswa muna 2019 nevatsvagiri vekuDenmark, vakaongorora mubatanidzwa pakati peplasma yakadzika ye enterolactone (iyo huru lignan metabolite) isati yaongororwa cancer, uye kupona mushure me colorectal. kenza, zvichibva pane data kubva kuvakadzi ve416 nevarume 537 vakaonekwa vaine cancer colorectal, vakapinda muDanish Diet, Cancer uye Health cohort Study. Munguva yekutevera, huwandu hwevakadzi mazana maviri negumi nevarume mazana matatu nemakumi maviri nevashanu vakafa, kunze kwevakadzi zana nemakumi manomwe nevarume 210 vakafa nekuda kwegomarara remukati. (Cecilie Kyrø et al, Br J Nutriti., 2019)
Zvakawanikwa pakudzidza zvainakidza. Chidzidzo ichi chakawana kuti kukwirira kweEngolactone kwakabatana neakaderera macolorectal cancer-yakatarwa kufa pakati pevakadzi, kunyanya kune avo vasina kushandisa mishonga inorwisa mabhakitiriya. Kuwedzeredza kweplasma enterolactone kusungwa mumadzimai kwaibatanidzwa ne12% panjodzi yakaderera yekufa nekuda kwekenza yakajeka. Zvakare, vakadzi vane yakakwira kwazvo plasma enterolactone yevasungwa vaive ne37% yakaderera mwero yekufa nekuda kwekenza yakajeka, ichienzaniswa neavo vane yakaderera plasma mazinga e enterolactone. Zvisinei, mumarume, kukwirira kwe enterolactone kwakabatanidzwa nepamusoro-soro wekenza-chaiyo kufa. Muchokwadi, mune varume, kupetwa kweplasma enterolactone concentration kwakabatana neiyo 10% yakanyanya njodzi yekufa nekuda kwekenza yakajeka.
Izvi zvinowirirana neongororo yapfuura iyo yakaratidza kuti estrogen, yevakadzi pabonde mahormone, ine inverse kusangana necolorectal kenza njodzi uye kufa (Neil Murphy et al, J Natl Cancer Inst., 2015). Enterolactone inoonekwa se phytoestrogen. Phytoestrogens ndiwo masanganiswa emiti pamwe nehurongwa hwakafanana nesrogen, uye lignan hupfumi hwezvirimwa-hwakavakirwa chikafu ndicho chikafu chavo chikuru.
Muchidimbu, ivo vaongorori vakagumisa kuti mwero wepamusoro we enterolactone unogona kusanganisirwa nenjodzi yakaderedzwa yecolorectal cancer-yakanangana nekufa pakati pevakadzi uye nenjodzi yakawedzera yekufa pakati pevarume.
Plasma Enterolactone Kufungisisa uye Endometrial Kenza Njodzi
Enterolactone Kusungwa uye Endometrial Kenza Njodzi muDanish Vakadzi
Mune ongororo yakaburitswa nevatsvagiri veDanish Cancer Society Research Center kuDenmark, vakaongorora kusangana pakati pematanho eplasma enterolactone uye chiitiko chegomarara remendometri, zvichibva pane data kubva kumatambudziko e173 endometrial uye 149 vakasarudzika vakadzi vechiDanish vakanyoreswa mu ' Kudya, Cancer uye Hutano 'cohort Study pakati pa1993 na1997 uye vaive zera pakati pemakore makumi mashanu nemakumi matanhatu nemana. (Julie Aarestrup et al, Br J Nutriti., 50)
Chidzidzo chacho chakawana kuti vakadzi vane 20 nmol / l yakakwira yeplasma yevasungwa ye enterolactone inogona kuve yakabatana nenjodzi yakadzikira yekenza yemendometri. Nekudaro, kudzikiswa kwanga kusiri kwakanyanya kukosha. Chidzidzo ichi chakaongororawo mubatanidzwa mushure mekusiya dhata kubva kuvakadzi vane yakaderera enterolactone kuwanda nekuda kwekushandisa kwemishonga inorwisa mabhakitiriya uye vakaona kuti mubatanidzwa wakava wakasimba zvishoma, zvisinei, zvakaramba zvisina kukosha. Chidzidzo chacho hachina kuwana musiyano musangano nekuda kwenzvimbo yekumiraopaopausal, hormone kutsiva kurapa kana BMI.
Vatsvagiridzi vakagumisa kuti yakakwira plasma enterolactone kusungwa kunogona kudzora njodzi yekenza yemendometri, asi kukanganisa kwacho kungave kusiri kukosha.
Enterolactone Kusungwa uye Endometrial Kanzera Njodzi mune vakadzi veUS
Vatsvagiri kubva kuNew York University Chikoro cheMishonga muUS vanga vamboitisa chidzidzo chakafanana chakaongorora kusangana pakati pegomarara remendometri uye kutenderera kwemazinga e enterolactone. Iyo data yeiyo kudzidza yakawanikwa kubva ku3 cohort zvidzidzo muNew York, Sweden neItari. Mushure mekutarisirwa kwekutevera kwemakore 5.3, huwandu hwezviitiko gumi nemashanu zvakaonekwa, izvo zvakaverengerwa muchidzidzo pamwe chete nemakumi maviri nematanhatu akaenzana ekudzora. Chidzidzo hachina kuwana chinodzivirira chekutenderedza enterolactone kurwisa kenza yemendometri mune premenopausal kana postmenopausal vakadzi. (Anne Zeleniuch-Jacquotte et al, Int J Cancer., 153)
Izvi zvidzidzo hazvipe chero humbowo hwekuti enterolactone inodzivirira kubva kune endometrial cancer.
Plasma Enterolactone Kusungwa uye Prostate Cancer Rufu
Muchidzidzo chakabudiswa muna 2017 nevatsvakurudzi vanobva kuDenmark neSweden, vakaongorora kushamwaridzana pakati pe prediagnostic enterolactone concentrations uye kufa pakati pevarume veDanish vane prostate. kenza. Chidzidzo ichi chaisanganisira data kubva kuvarume ve1390 vakawanikwa vaine kenza yeprostate vakanyoreswa muDanish Diet, Cancer uye Health cohort Study. (AK Eriksen et al, Eur J Clin Nutr., 2017)
Chidzidzo chacho hachina kuwana hukama hwakakosha pakati peiyo 20 nmol / l yakakwira yeplasma yekumanikidza kwe enterolactone uye kufa kwevaDanish varume vane gomarara reprostate. Chidzidzo chacho hachina kuwana musiyano musangano nekuda kwezvinhu zvakaita sekusvuta, body mass index kana mutambo, pamwe nekenza yeprostate kushungurudzika.
Muchidimbu, chidzidzo hachina kuwana hukama pakati pe enterolactone kuwanda uye kufa pakati pevarume veDanish vanoonekwa vaine kenza yeprostate.
Kubva pane iyo yakatemwa data, hapana humbowo hwekutsigira inverse kushamwaridzana pakati pe lignan (sosi yezvokudya phytoestrogen ine chimiro chakafanana neestrogen) -chikafu chekudya, serum enterolactone kuwanda uye kenza yeprostate njodzi.
Plasma Enterolactone Kufungisisa uye Gomarara reBonde
Enterolactone Kusungwa uye Breast Cancer Prognosis muDanish Postmenopausal Vakadzi
Mune ongororo yakaburitswa mu2018 nevatsvagiri veDanish Cancer Society Research Center neAarhus University kuDenmark, vakaongorora kusangana pakati pekufungidzira pre-diagnostic plasma kuwanda kwe enterolactone nekenza yemazamu kufungidzira mune postmenopausal vakadzi sekudzokorora, kenza yemazamu-yakatarisana kufa uye zvese-zvinokonzera kufa. Chidzidzo ichi chaisanganisira dhata kubva ku1457 kenza yemazamu makesi kubva kuDanish Chikafu, Cancer uye Hutano cohort Kudzidza. Munguva yekutevera yekutevera yemakore mapfumbamwe, vakadzi makumi mana nevapfumbamwe vakafa, kunze kwavo mazana maviri nemakumi mashanu vakafa nekenza yemazamu, uye mazana maviri nemakumi maviri nenomwe vakasangana nekudzokazve. (Cecilie Kyrø et al, Clin Nutriti., 9)
Chidzidzo ichi chakawana kuti yakakwira plasma enterolactone yaingova nehukama hushoma nekenza yepazasi-yakatarwa kufa mune vakadzi vanopera kuenda kumwedzi, uye hapana kubatana nezvose-zvinokonzeresa kufa nekudzokazve mushure mekufunga zvinhu zvakaita sekusvuta, kuenda kuchikoro, BMI, kurovedza muviri uye kushandiswa kwemahomoni ekumwedzi. Mhedzisiro yacho haina kuchinja mushure mekusanganisira zvinhu zvakaita semakiriniki maitiro uye kurapwa.
Chidzidzo chacho chakagumisa kuti pakanga pasina kubatana kwakajeka pakati pekufungidzira kweplasma kuwanda kwei enterolactone nekenza yemazamu kufungidzira mumashure mevakadziopaopausal.
Enterolactone uye Postmenopausal kenza yemazamu njodzi neestrogen, progesterone uye herceptin 2 chinzvimbo chekugamuchira
Mune meta-ongororo yakaitwa nevatsvagiri veGerman Cancer Research Center, Heidelberg, Germany, vakaongorora kusangana pakati pe serum enterolactone uye postmenopausal cancer cancer. Dhata yekuongororwa yakawanikwa kubva ku1,250 2,164 mazana emakenza emukaka emazamu uye 2012 kutonga kubva kuhuwandu hwevanhu-hwakavakirwa kudzidza. (Aida Karina Zaineddin et al, Int J Cancer., XNUMX)
Chidzidzo chacho chakawana kuti yakawedzera serum enterolactone mazinga aibatanidzwa neakadzikira postmenopausal kenza yemazamu njodzi. Chidzidzo ichi chakaratidzawo kuti musangano uyu wainyanya kukosha kuEstrogen Receptor (ER) -ve / Progesterone Receptor (PR) -ve kenza yemazamu kana ichienzaniswa neEER + ve / PR + ve kenza yemazamu. Kupfuurirazve, kutaura kweHER2 hakuna chakakanganisa musangano.
Ichi chidzidzo chakaratidza kuti yakakwira serum enterolactone nhanho dzinogona kuve dzakabatana neakadzikira postmenopausal kenza yemazamu njodzi, kunyanya muEstrogen Receptor (ER) -ve / Progesterone Receptor (PR) -ve ma cancer emuzamu.
Enterolactone Kusungwa uye Bonde Kenza Njodzi muFrance Postmenopausal Vakadzi
Chidzidzo chekare chakaburitswa muna 2007 nevatsvagiri veInstitut Gustave-Roussy, France yakaongororawo kubatana pakati penjodzi yekenza yemazamu yekumira kwemwedzi uye kudya kunodyiwa kwezvirimwa zvina - lino-spinoresinol, lariciresinol, secoisolariciresinol, uye matairesinol, uye kuratidzwa kune ma enterolignans maviri. - enterodiol uye enterolactone. Chidzidzo chacho chakashandisa dhata kubva kune yega-inozvipa yega nhoroondo yemibvunzo mibvunzo kubva ku58,049 postmenopausal vakadzi veFrance avo vaisatora soy isoflavone zvinowedzera. Munguva yekureva kwekutevera kwemakore 7.7, huwandu hwezviitiko zana nemakumi mana nemapfumbamwe zvegomarara repazamu zvakaonekwa. (Marina S Touillaud et al, J Natl Cancer Inst., 1469)
Chidzidzo chacho chakawana kuti zvichienzaniswa nevakadzi vane yakaderera kudyiwa kwe lignans, avo vane yakanyanya kuwanda lignan kudya inoenderana ne> 1395 microg / zuva, vaive nenjodzi yakadzikira yekenza yemazamu. Chidzidzo chacho chakawana zvakare kuti kushamwaridzana pakati pe phytoestrogen intakes uye postmenopausal kenza yemazamu njodzi yaive yakaganhurirwa kuEstrogen Receptor (ER) uye Progesterone Receptor (PR) - inovhenekera cancer.
Kiyi Yekutora-kure: Parizvino, pane zvinopesana mhedzisiro uye nekudaro, hatigone kupedzisa kana yakakwira lignan (sosi yezvokudya phytoestrogen ine chimiro chakafanana nesrogen) -zvakawanda kudya chikafu uye plasma kusangana kwe enterolactone kune zvinodzivirira zvinopesana nekenza yemazamu.
mhedziso
Kunyangwe kudyiwa kwechikafu chakapfuma mu lignans (tsime rekudya phytoestrogen ine chimiro chakafanana neestrogen) ine hutano uye inogona kunge iine akakosha anoshanda makomisheni anogona kubatsira mukudzikisa njodzi yemhando dzakasiyana dzegomarara, kushamwaridzana pakati peplasma enterolactone mazinga uye njodzi. zvegomarara dzakasiyana hazvisati zvanyatsojeka. Imwe yezvidzidzo zvenguva pfupi yapfuura yakaratidza basa rekudzivirira re enterolactone kurwisa kufa kwegomarara remukati muvakadzi, zvisinei, masangano aive akasiyana kana ari varume. Zvimwe zvidzidzo zvakaongorora mabatiro eplasma enterolactone concentration pahomoni-inosanganisirwa kenza senge gomarara rezamu, kenza yeprostate uye endometrial cancer yakawana isina hukama kana yakaguma nemhedzisiro inopokana. Nekudaro, parizvino, hapana humbowo hwakajeka hunoratidza kuti yakakwira kutenderera mazinga eenterolactone anogona kupa akakosha ekudzivirira panjodzi yehomoni-inosanganiswa. kanzira.
Chikafu chipi chaunodya uye chinowedzera iwe kutora chisarudzo chaunoita. Sarudzo yako inofanirwa kusanganisira kutarisisa kwecancer genes shanduko, iyo kenza, kurapwa kuri kuenderera uye zvinowedzerana, chero mairigeji, ruzivo rwemararamiro, huremu, kukwirira uye maitiro.
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Varwere veCancer kazhinji vanofanirwa kubata zvakasiyana chemotherapy mhedzisiro izvo zvinokanganisa kwavo hupenyu hwehupenyu uye kutarisa kune dzimwe nzira dzokurapa kenza. Kutora iyo kudya kwakakwana uye zvekuwedzera zvinoenderana nesainzi (kunzvenga kufungidzira uye kusarudzika kusarudza) ndiwo mushonga wepanyama wekenza uye mitezo inoenderana nekurapwa.