Muchidimbu
DIM kana diindolylmethane, inowanzo shandiswa kuwedzera, imetabolite yeI3C (indole-3-carbinol), inowanikwa yakawanda mumiriwo ine hutano yakadai se broccoli, kabichi, cauliflower uye kare. Varwere veCancer vanowanzoedza kusanganisa zvekudya zvisina kujairika zvinowedzerwa pamwe nekwavo kenza yekurapa kenza kuvandudza hupenyu hwavo kana hutano hwekurapa, pamwe nekufungidzira kuti kutora chero zvakasikwa kana zvinomera zvinowedzerwa pamwe nemushonga wavo unogara wakachengeteka uye hazvikonzere kukuvadza. Izvi hazvisi zvechokwadi nguva dzose. Zvichienderana nerudzi rwegomarara uye kurapwa, kukanganisa kweizvi zvinowedzera zvinogona kusiyanisa uye zvinogona kutokanganisa mamwe marapirwo ekenza Mune ino blog, tinokurukura pane imwe yakadaro kiriniki yekudzidza iyo yakawana kuti DIM (diindolylmethane) inogona kukanganisa Tamoxifen, muyero wekurapa kurapwa kwekenza yemazamu, uye kudzikisira iwo mazinga eanoshanda metabolite yeTamoxifen. Iko kusangana kweDIM-tamoxifen kunogona kukanganisa kugona kwekurapa kweTamoxifen uye nekudaro zvirinani kusaisa DIM zvinowedzera sechikamu chezamu kanzuru yevarwere chikafu panguva yekurapwa kweTamoxifen. Izvi zvinosimbisa kudiwa kwechirongwa chekudya chemunhu chine chikafu chakakodzera uye zvekuwedzera kuti utsigire izvo chaizvo kenza kurapwa uye kuwana mabhenefiti uye kugara wakachengeteka.
Kushandiswa kweDIM (diindolylmethane) muCancer yeCancer
Kune huwandu hukuru hwevanopona kenza yemazamu avo vanozvipa bio-inoshanda chikafu chirimwa chakatorwa ma supplements nechinangwa chekudzivirira. kenza dzokorora uye kuwana mabhenefiti ekupona. Sarudzo yezvekuwedzera yavanotora yakasarudzika zvichienderana nekutumirwa kubva kushamwari nemhuri, kana zvichienderana nekutsvaga kwavo pawebhu uye ruzivo rweinternet.
Chinowanzo shandiswa chinowedzera ndeye DIM (diindolylmethane), metabolite yeI3C (indole-3-carbinol), inowanikwa mumiti yemuchinjikwa senge broccoli, kolifulawa, kare, kabichi, zvinomera zveBrussels. Uku kushandiswa kwakapararira kweDIM pakati pevarwere vegomarara repazamu kunogona kunge kwakavakirwa pane zvakawanikwa kubva pakucherekedza zvekuongorora zvekiriniki kusanganisira yeVakadzi Vehutano Kudya uye Kurarama (WHEL) kudzidza kwevanopfuura 3000 varwere vegomarara repazamu vakawana mubatanidzwa wekudzikira kwenjodzi yekudzoka kwekenza yemazamu muvakadzi vachitora. Tamoxifen kurapwa, iyo zvakare yaidya cruciferous miriwo sechikamu chekudya kwavo. Kushamwaridzana uku sekutsvagurudza kunogona kuve kwakabatana nebasa rezve phytochemicals senge DIM mune iyi miriwo inouraya ine anti-cancer uye anti-inflammatory properties (Thomson CA, Chipfuva Chegomarara Res Rapa., 2011). Imwe yazvino meta-ongororo ye13 kesi-kutonga uye vangangoita cohort zvidzidzo zvakare zvakaratidza kuti huwandu hwakawanda hwekudyiwa kweiyo cruciferous miriwo (yakafuma mune indole-3-carbinol) senge broccoli, kare, kabichi, cauliflower uye sipinashi mune chikafu zvakabatana zvakanyanya iine 15% yakaderera njodzi yekenza yemazamu (Liu X et al, Chipfuva, 2013).
Chikafu chekudya Mushure meKenza Kuongorora!
Hapana kanzura mbiri dzakafanana. Enda pamusoro peyakajairwa nhungamiro yemunhu wese uye utore sarudzo dzakagadzirirwa nezve chikafu uye zvinowedzerwa uine chivimbo.
DIM (diindolylmethane) uye Kubatana kweTamoxifen muCancer yeCancer
Varwere vegomarara repazamu vane hormone yakanaka (Estrogen Receptor ER +) kenza yemazamu inorapwa neadjuvant Tamoxifen endocrine therapy kwenguva yakareba yemakore mashanu kusvika pagumi mushure mekuvhiyiwa uye chemo-radiation kurapwa. Tamoxifen inosarudza estrogen receptor modulator (SERM) inoshanda nekukwikwidza neiyo estrogen hormone yekusunga kune iyo ER mumatumbu ezamu, nekudaro ichitadzisa pro-cancer mhedzisiro yeestrogen. Tamoxifen, chinodhaka chemumuromo, inogadziriswa neiyo cytochrome P5 enzymes muchiropa mune yayo bioactive metabolites ayo ndiwo mamiririri akakosha e tamoxifen efficacy. Kune zvimwe zvakajairika zvinomera zvinowedzerwa zvinomera zvinogona kukanganisa metabolism yeTamoxifen uye nekudaro zvichideredza kuwanda kwemushonga pazasi pechikamu chekurapa. Imwe yakarongedzwa, yakapofomara-yakapofumara, placebo inodzora kiriniki kuyedzwa kwekushandiswa kweDIM yekuwedzera, iyo metabolite yeiyo indole-10-carbinol komputa kubva kune cruciferous miriwo, pamwe neTamoxifen, mune varwere vegomarara repazamu, yaratidza ichi chinotyisa chiitiko chetamoxifen metabolite rutapudzo. , varwere vekenza yemazamu paDIM yekuwedzera vanofanirwa kuziva nezvazvo.
Nhoroondo dzeChidzidzo
Details of the randomized, placebo-controlled controlled clinical trial to kuongorora zamu rataurwa kenza chemopreventive basa reDIM muvarwere vekenza yemazamu vanotora Tamoxifen therapy inopfupikiswa pasi apa (NCT01391689) (Ref: Thomson CA, Breast Cancer Res. Treat., 2017).
- Paive nevakadzi zana nemakumi matatu vakarairwa Tamoxifen, avo vakakamurwa zvakapatsanurwa kuita mapoka maviri: boka rakagamuchira kwemwedzi gumi nemaviri kana DIM yekuwedzera pa130 mg, kaviri pazuva, kana placebo. 12 vakadzi vakapedza kudzidza (150 placebo boka, 98 DIM boka).
- Mhedzisiro yekupedzisira yechidzidzo ichi yaive yekuongorora shanduko yemurinari mametabolite eestrogen hormone 2/16-hydroxyestrone, ndiyo inorwisa-tumorigenic metabolite. Mamwe magumo echipiri akaongororwawo kusanganisira serum estrogens, kuwanda kwemazamu uchishandisa mammography kana MRI, uye nhanho dze tamoxifen metabolites.
- DIM yakawedzera mwero weanti-tumorigenic estrogen metabolite kana ichienzaniswa ne placebo, inova yakanaka chemopreventive mhedzisiro.
- Pakanga pasina shanduko yakawanikwa muhuwandu hwezamu pakati pemapoka maviri.
- Kutsvaga kunoshamisa ndekwekuti kwaive nekuderedzwa kwemazinga eplasma emasikemikari anoshanda emagetsi emamoxifen (endoxifen, 4-hydroxy tamoxifen, uye N-desmethyl tamoxifen). Muboka reDIM, pakanga paine kuderedzwa kwakakosha muzvikamu zveplasma zveiyo inoshanda metabolites yetamoxifen, nemhedzisiro yekudzikisira kunoonekwa pamasvondo matanhatu uye yakadzikama nekufamba kwenguva. Iwo mazinga eanoshanda tamoxifen metabolites evakadzi muboka reDIM akaonekwa kunge ari pazasi pekurapa chikumbaridzo chetamoxifen kushanda.
mhedziso
Kunyange zvazvo kuderera kwemazinga etamoxifen kunoratidza kupindira kana kupindirana pakati peDIM neTamoxifen metabolism, vatsvakurudzi vechidzidzo ichi vanopa humwe tsvakurudzo kuti vaone kana kuderera kwemaitiro etamoxifen metabolites kungaderedza zvakanyanya kliniki inobatsira yetamoxifen. Nekudaro, sezvo data rekiriniki riri kuratidza maitiro ekudyidzana pakati peDIM (metabolite ye indole-3-carbinol) uye tamoxifen, zvingave zviri nani kuzamu. kenza varwere vari patamoxifen therapy kuti vaende kune rumwe rutivi rwekuchenjerera uye kudzivisa kutora DIM pavanenge vari paTamoxifen therapy. Chikafu-chakagadzirwa nechirimwa chinosanganisira cruciferous miriwo ine indole-3-carbinol inogona kupa bhenefiti inodiwa pakutora chikafu chekuwedzera cheDIM uchiri pahomoni yekurapa kenza yemazamu.
Chikafu chipi chaunodya uye chinowedzera iwe kutora chisarudzo chaunoita. Sarudzo yako inofanirwa kusanganisira kutarisisa kwecancer genes shanduko, iyo kenza, kurapwa kuri kuenderera uye zvinowedzerana, chero mairigeji, ruzivo rwemararamiro, huremu, kukwirira uye maitiro.
Kurongeka kwehutano kwekenza kubva kuAddon hakubvi pakutsvaga kweinternet. Iyo inoshandura sarudzo kuitirwa iwe zvichibva pane samorekuru sainzi inoitwa nemasayendisiti edu uye mainjiniya esoftware. Zvisinei kuti une hanya here nekunzwisisa iyo yepasi biochemical molecular pathways kana kwete - yekuronga kudya kwemukenza kunzwisiswa kunodiwa.
Tanga IZVOZVO nekuronga kwako kudya kunovaka muviri nekupindura mibvunzo pazita rekenza, majini masayendisiti, kurapwa kuri kuenderera uye zvinowedzerana, chero kurwara, tsika, mararamiro, boka rezera uye murume kana murume.
Hunhu Hwakakosheswa Nekamwe Kenza!
Gomarara rinoshanduka nekufamba kwenguva. Gadzirisa uye gadzirisa chikafu chako zvichibva pachiratidzo chegomarara, marapirwo, mararamiro, zvaunofarira zvekudya, allergies uye zvimwe zvinhu.
Varwere veCancer kazhinji vanofanirwa kubata zvakasiyana chemotherapy mhedzisiro izvo zvinokanganisa kwavo hupenyu hwehupenyu uye kutarisa kune dzimwe nzira dzokurapa kenza. Kutora iyo kudya kwakakwana uye zvekuwedzera zvinoenderana nesainzi (Kudzivirira kufungidzira uye kusarudzika kusarudza) ndiyo yakanyanya kurongeka mushonga wekenza uye kurapwa kwakanangana nemhedzisiro.