Zvokudya zveMazamu Carcinoma!

ziviso

Zvokudya zveBreast Carcinoma zvinofanirwa kuve zvakasarudzika kumunhu wega uye zvakare zvinofanirwa kuchinjika kana kurapwa kwegomarara kana bundu genetic shanduko. Iyo yemunhu uye kugadzirisa kunofanirwa kufunga nezvese zvinoshanda zvinosanganiswa kana bioactives zviri muzvokudya zvakasiyana zvine chekuita negomarara biology, genetics, marapirwo, mararamiro uye zvido zvekudya. Saka nepo chikafu chiri chimwe chezvisarudzo zvakakosha zvemurwere wegomarara uye munhu ari panjodzi yegomarara - kusarudza chikafu chekudya harisi basa riri nyore.

Breast carcinoma, inozivikanwawo segomarara rezamu, ibundu rakashata rinokura munyama yezamu, uye gomarara rinowanzoonekwa muvakadzi. Gomarara repazamu rekutanga rinorapika ukuwo gomarara rezamu rapararira (metastasized) kune dzimwe nhengo dzemuviri riine fungidziro yakaipa. Huwandu hwegomarara rezamu hwakawedzera nezera nezera repakati rekuongororwa gomarara rezamu riri pamusoro pemakore makumi mashanu. Zvimwe zvinokonzerwa nekenza yemazamu zvinosanganisira nhoroondo yemhuri, genetic susceptibility nekuda kwekuvapo kwe germline mutations muBRCA50 uye BRCA1 majini, kunwa doro, kufutisa. Zviratidzo zvebreast carcinoma zvinogona kusiyana asi zvinogona kusanganisira kuvapo kwebundu, kuchinja kwechimiro chezamu kana kukura, kubuda kwezamu, kana kuchinja kweganda. Sarudzo dzekurapa mazamu carcinoma dzinogona kusanganisira kuvhiyiwa, kurapwa neradiation, chemotherapy, uye marapirwo anonangwa akagadzirirwa kune chaiyo subtype yegomarara rezamu. Kurongeka kwemazamu carcinoma kunobva pane zvakasiyana siyana, senge mahormone receptor mamiriro uye HER2 kutaura. Pachikonzero chekutaura kweEstrogen receptor (ER), progesterone receptor (PR) uye HER2 / neu, kenza yemazamu inorondedzerwa seizvi: 2. Hormone receptor positive; 1. HER2/neu positive; kana 2. Kenza yemazamu katatu isina kunaka (TNBC) - ER, PR, HER3 yakaipa. Kugara uchizviongorora mazamu uye ongororo yenguva dzose inogona kubatsira mukukurumidza kuonekwa kwezamu recarcinoma.

Kune Breast Carcinoma zvine basa here kuti miriwo, michero, nzungu, mhodzi dzinodyiwa nemunhu?

Mubvunzo wakajairika wekudya unobvunzwa nevarwere vegomarara uye vanhu vari pa-genetic njodzi yegomarara ndeye - kugomarara senge Breast Carcinoma zvine basa here kuti ndechipi chikafu chandinodya uye chandisingade? Kana kuti ndikatevera kudya-kwekudyara kunokwana kenza seBreast Carcinoma?

Semuenzaniso zvine basa here kana muriwo weGlobe Artichoke uchidyiwa zvakanyanya kana uchienzaniswa neNapa Kabichi? Zvinoita mutsauko here kana muchero Pineapple uchifarirwa pane Purple Mangosteen? Zvakare kana sarudzo dzakafanana dzakaitirwa nzungu/mhodzi dzakaita seButternut pamusoro peCashew Nut uye nemapuruzi akaita seBroad Bean pamusoro peCatjang Pea. Uye kana zvandinodya zvine basa - zvino munhu angaziva sei chikafu chinokurudzirwa Breast Carcinoma uye ndiyo mhinduro imwechete kune wese ane chirwere chakafanana kana genetic risk?

Ehe! Zvokudya zvaunodya zvine chekuita neBreast Carcinoma!

Mazano echikafu anogona kunge asina kufanana kune wese munhu uye anogona kuve akasiyana kunyangwe kune imwechete kuongororwa uye genetic njodzi.

Zvokudya zvose (miriwo, michero, nzungu, mhodzi, pulses, mafuta nezvimwewo) uye zvokudya zvinovaka muviri zvinoumbwa nezvinodarika imwe inoshanda mamolecular ingredient kana bio-actives muzvikamu zvakasiyana uye uwandu. Chinhu chimwe nechimwe chinoshanda chine nzira yakasarudzika yekuita - iyo inogona kuve activation kana inhibition yeakasiyana biochemical nzira. Zvikafu zvakangotaurwa uye zvekuwedzera izvo zvinokurudzirwa ndezviya zvisingakonzere kuwedzera kwemamorekuru anotyaira cancer asi anodzideredza. Zvikasadaro izvo zvikafu hazvifanirwe kukurudzirwa. Chikafu chine akawanda anoshanda zvinongedzo - saka kana uchiongorora chikafu uye zvekuwedzera iwe unofanirwa kufunga nezve mabatiro ezvese zvinoshanda zvinongedzo zvakapetwa kwete zvega.

Semuenzaniso Pineapple ine zvinhu zvinoshanda Quercetin, Curcumin, Lycopene, Lupeol, Phloretin. Uye Purple Mangosteen ine zvinoshanda zvinosanganisa Apigenin, Curcumin, Myricetin, Lycopene, Lupeol uye pamwe nevamwe.

Chikanganiso chinowanzoitwa pakusarudza nekusarudza chikafu chekudya cheBreast Carcinoma - kuongorora chete zvakasarudzwa zvinoshandiswa zviri muzvokudya uye kufuratira zvimwe. Nekuti zvakasiyana-siyana zvinoshanda zviri mukudya zvinogona kuve nemhedzisiro inopikisa kune vatyairi vegomarara - haugone kutora cherry inoshanda mukudya uye ma supplements ekuita sarudzo yekudya kune Breast Carcinoma.

HONGU – ZVOKUSARUDZA ZVOKUDYA ZVINOKOSHA NEGONSA. ZVISARUDZO ZVOKUDYA ZVINOFANIRA KUFUNGA ZVINHU ZVINHU ZVINHU ZVINOSHANDA PACHIDYA.

Hunyanzvi hunodiwa paKudya Kwekudya Kwemunhu kune Breast Carcinoma?

Kudya kwakasarudzika kwegomarara senge Breast Carcinoma ine chikafu chinokurudzirwa / ma supplements; zvisingakurudzirwe chikafu / ma supplements ane semuenzaniso mabikirwo anotungamira kushandiswa kwezvikafu zvinokurudzirwa. Muenzaniso wekudya kwakasiyana-siyana unogona kuonekwa pane izvi batanidzo.

Kufunga kuti ndezvipi zvekudya zvinokurudzirwa kana kwete zvakaomesesa, zvinoda hunyanzvi muBreast Carcinoma biology, sainzi yechikafu, genetics, biochemistry pamwe nekunzwisisa kwakanaka kwemashandiro anoita marapirwo egomarara uye kusagadzikana kwakabatana uko kurapwa kwaigona kumira kushanda.

ZVINONYANYA ZVINONYANYA ZVINODIWA KUTI ZVINOVAKA ZVINOVAKA MUNHU ZVINHU ZVINHU ZVINOITA: CANCER BIOLOGY, FOOD SCIENCE, KURAPA MAKANZA UYE GENETICS.

Hunhu hwegomarara senge Breast Carcinoma

Magomarara ese akaita seBreast Carcinoma anogona kuratidzirwa neyakasiyana seti yebiochemical nzira - iyo siginicha nzira dzeBreast Carcinoma. Nzira dzeBiochemical dzakadai seSero Cycle, Extracellular Matrix Remodelling, PI3K-AKT-MTOR Signaling, MAPK Signaling chikamu chetsanangudzo yesaginecha yeBreast Carcinoma. Kenza yemunhu wega genetics inogona kuve yakasiyana uye nekudaro siginicha yavo yegomarara inogona kuve yakasarudzika.

Kurapa kunoshanda kuBreast Carcinoma kunofanirwa kuziva nzira dzakasaina dzebiochemical yemurwere wega wega wegomarara uye munhu ari panjodzi yemagene. Saka marapirwo akasiyana ane maitiro akasiyana ezviito anoshanda kune varwere vakasiyana. Saizvozvo uye nekuda kwezvikonzero zvakafanana zvekudya uye zvekuwedzera zvinoda kuitirwa munhu wega wega. Saka zvimwe zvekudya uye zvekuwedzera zvinokurudzirwa kuBreast Carcinoma kana uchitora kurapwa kenza Paclitaxel, uye zvimwe zvekudya uye zvekuwedzera hazvikurudzirwe.

Sources like cBioPortal uye vamwe vazhinji vanopa mumiriri wehuwandu hwevarwere data risingazivikanwe kubva kukiriniki miedzo yezvese zviratidzo zvegomarara. Iyi dhata ine yekiriniki yekuongorora yeruzivo senge sampuli saizi / nhamba yevarwere, mapoka ezera, murume kana mukadzi, dzinza, marapirwo, bundu saiti uye chero genetic mutations.

TP53, PIK3CA, MUC16, RYR1 uye MAP3K1 ndiwo mazita epamusoro akashumwa majini eBreast Carcinoma. TP53 inoshumwa mu2.2% yevanomiririra varwere mukati meyese miedzo yekiriniki. Uye PIK3CA inonzi mu1.7%. Kubatanidzwa kwehuwandu hwevarwere data inovhara makore kubva pa15 kusvika ku97. 0.6 % yedata remurwere inotaridzwa sevarume. Iyo Breast Carcinoma biology pamwe neyakashumwa genetics pamwe chete inotsanangura huwandu hwevanhu vanomiririrwa siginecha biochemical nzira dzegomarara iri. Kana iyo yega cancer tumor genetics kana majini anokonzera njodzi achizivikanwawo saka izvo zvinofanirwa kushandiswawo kune hutano hwemunhu.

ZVAKASARUDZA KUDYA ZVINODYA ZVINOFANIRA KUFANIRA NEMUNHU WEMUNHU WEMUNHU WEMUNHU WEGONSI.

Zvokudya uye Zvekuwedzera zveMazamu Carcinoma

Kune Varwere veCancer

Varwere vegomarara vari pakurapa kana pakuchengeta palliative vanofanira kuita sarudzo pazvekudya uye zvekuwedzera - zvemacalorie anodiwa ekudya, kubata chero mhedzisiro yekurapa uyezve nekugadzirisa kenza. Zvese zvinodyarwa-zvikafu hazvina kuenzana uye kusarudza uye kuisa pamberi pezvikafu zvakagadzirirwa munhu uye zvakagadzirirwa kuenderera mberi kurapwa kwegomarara kwakakosha uye kwakaoma. Heano mimwe mienzaniso inopa nhungamiro yekuita sarudzo dzekudya.

Sarudza Vegetable GLOBE ARTICHOKE kana NAPA KABHAGE?

Vegetable Globe Artichoke ine zvakawanda zvinoshanda zvinosanganisa kana bioactives seApigenin, Curcumin, Myricetin, Lupeol, Phloretin. Izvi zvinoshanda zvinosanganisa nzira dzakasiyana siyana dzebiochemical dzakadai seExtracellular Matrix Remodelling, Glucocorticoid Signaling, Cell Cycle uye NFKB Signaling nevamwe. Globe Artichoke inokurudzirwa kuBreast Carcinoma apo kurapwa kwegomarara kuri kuramba kuchiitwa Paclitaxel. Izvi zvinodaro nekuti Globe Artichoke inogadzirisa idzo nzira dzebiochemical dzakataurwa nesainzi kuti dzikurudzire maitiro ePaclitaxel.

Zvimwe zvezvinhu zvinoshanda kana bioactives mumuriwo weNapa Kabichi ndeye Curcumin, Lupeol, Phloretin, Genistein, Isoliquiritigenin. Izvi zvinoshanda zvinosanganisa nzira dzakasiyana dzebiochemical senge Estrogen Signaling uye nevamwe. Napa Cabbage haikurudzirwe kuBreast Carcinoma kana ichiramba ichirapwa cancer iri Paclitaxel nekuti inogadzirisa nzira dzebiochemical izvo zvinoita kuti kurapwa kwegomarara kusarambe kana kusadaira.

MURIWO GLOBE ARTICHOKE INOKURUDZWA PAMUSORO PAMUSORO PENAPA KABHCHI YEMAzamu Carcinoma NEKURAPA Paclitaxel.

Sarudza Muchero PEDU MANGOSTEEN kana PINEAPPLE?

Chibereko chePurple Mangosteen chine zvakawanda zvinoshanda zvinosanganisa kana bioactives seApigenin, Curcumin, Myricetin, Lycopene, Lupeol. Izvi zvinoshanda zvinosanganisa nzira dzakasiyana siyana dzebiochemical dzakadai seExtracellular Matrix Remodelling, RAS-RAF Signaling, Cell Cycle uye PI3K-AKT-MTOR Signaling nevamwe. Purple Mangosteen inokurudzirwa kuBreast Carcinoma apo kurapwa gomarara kuri kuramba kuchiitwa Paclitaxel. Izvi zvinodaro nekuti Purple Mangosteen inogadzirisa idzo nzira dzebiochemical dzakataurwa nesainzi kuti dzikurudzire maitiro ePaclitaxel.

Zvimwe zvezvinhu zvinoshanda kana bioactives mumuchero Pineapple ndeye Quercetin, Curcumin, Lycopene, Lupeol, Phloretin. Izvi zvinoshanda zvinosanganisa nzira dzakasiyana siyana dzebiochemical seEstrogen Signaling, Carbohydrate Metabolism uye Kukura Factor Signaling nevamwe. Pineapple haikurudzirwe paBreast Carcinoma kana ichiramba ichirapwa cancer iri Paclitaxel nekuti inogadzirisa nzira dzebiochemical idzo dzinoita kuti kurapwa kwegomarara risarambe kana kusadaira.

MUCHERO PEPE MANGOSTEEN INOKURUKURWA PAMUSORO PEPINAPPLE YEBAMA Carcinoma UYE KURAPA Paclitaxel.

Sarudza Nut BUTTERNUT kana CASHEW NUT?

Butternut ine zvakawanda zvinoshanda zvinosanganisa kana bioactives seApigenin, Curcumin, Myricetin, Lycopene, Lupeol. Izvi zvinoshandiswa zvinoshandiswa zvinoshandisa nzira dzakasiyana-siyana dzebiochemical dzakadai seExtracellular Matrix Remodelling, RAS-RAF Signaling, PI3K-AKT-MTOR Signaling uye Apoptosis nevamwe. Butternut inokurudzirwa kuBreast Carcinoma kana chirwere chegomarara chiri kuramba chiri Paclitaxel. Izvi zvinodaro nekuti Butternut inogadzirisa idzo nzira dzebiochemical dzakataurwa nesainzi kuti dzikurudzire maitiro ePaclitaxel.

Zvimwe zvezvinhu zvinoshanda kana bioactives muCashew Nut ndeye Quercetin, Curcumin, Myricetin, Lupeol, Phloretin. Izvi zvinoshanda zvinosanganisa nzira dzakasiyana siyana dzebiochemical seEstrogen Signaling uye Heat Stress Response nevamwe. Cashew Nut haikurudzirwe kuBreast Carcinoma kana ichiramba ichirapwa gomarara iri Paclitaxel nekuti inogadzirisa idzo biochemical nzira dzinoita kuti kurapwa kwegomarara kurambe kana kusadaira.

BUTTERNUT INOKURUKURIRWA PAMUSORO PAMUSORO PECASHEW NUT YEMAzamu Carcinoma NEKURAPA Paclitaxel.

Kune Vanhu Vane Genetic Risk yeCancer

Mubvunzo wakabvunzwa nevanhu vane genetic risk yeBreast Carcinoma kana nhoroondo yemhuri ndeye "Chii Chandinofanira Kudya Zvakasiyana Kubva Kare?" uye masarudzire avanofanira kuita zvekudya uye zvekuwedzera kuti vatarise njodzi dzechirwere. Sezvo kune njodzi yegomarara hapana chinogoneka maererano nekurapa - sarudzo dzezvekudya uye zvekuwedzera zvinove zvakakosha uye chimwe chezvinhu zvishoma zvingaite zvinogona kuitwa. Zvese zvinodyarwa-zvikafu hazvina kuenzana uye zvichibva pane zvakazivikanwa genetics uye nzira siginecha - sarudzo dzechikafu nekuwedzera dzinofanirwa kuve munhu.

Sarudza Vegetable WILD CARROT kana TURNIP?

Vegetable Wild Carrot ine zvinhu zvakawanda zvinoshanda kana bioactives seApigenin, Curcumin, Quercetin, Lupeol, Daidzein. Izvi zvinoshanda zvinosanganisa nzira dzakasiyana dzebiochemical seAngiogenesis, RAS-RAF Signaling, Cell Cycle uye PI3K-AKT-MTOR Signaling nevamwe. Karoti yemusango inokurudzirwa panjodzi yeBreast Carcinoma kana njodzi yemajini yakabatana iri MAP3K1. Izvi zvinodaro nekuti Wild Carrot inowedzera idzo biochemical nzira dzinopokana nemadhiraivha emasaini ayo.

Zvimwe zvezvinhu zvinoshanda kana bioactives mumuriwo Turnip ndeye Curcumin, Quercetin, Ellagic Acid, Indole-3-carbinol, Lupeol. Izvi zvinoshanda zvinosanganisa nzira dzakasiyana dzebiochemical sePI3K-AKT-MTOR Signaling uye DNA Kugadzirisa uye vamwe. Turnip haikurudzirwe kana njodzi yeBreast Carcinoma kana yakabatana neiyo genetic njodzi iri MAP3K1 nekuti inowedzera siginicha nzira dzayo.

MURIWO WAKAROTI WAKAROTI INOKURUDZWA PAKUSHANDURA MAP3K1 GENETIC RISK YECANCER.

Sarudza Chibereko NANCE kana PUMMELO?

Chibereko Nance chine zvakawanda zvinoshanda zvinosanganisa kana bioactives seApigenin, Curcumin, Lupeol, Daidzein, Formononetin. Izvi zvinoshanda zvinosanganisa nzira dzakasiyana dzebiochemical senge RAS-RAF Kuratidzira, Cell Cycle, Insulin Signaling uye P53 Signaling nevamwe. Nance inokurudzirwa kune njodzi yeBreast Carcinoma kana yakabatana genetic njodzi iri MAP3K1. Izvi zvinodaro nekuti Nance inowedzera idzo biochemical nzira dzinopokana nemadhiraivha emasaini ayo.

Zvimwe zvezvinhu zvinoshanda kana bioactives mumuchero Pummelo ndeye Apigenin, Curcumin, Quercetin, Lupeol, Daidzein. Izvi zvinoshanda zvinosanganisa nzira dzakasiyana dzebiochemical senge Insulin Signaling uye DNA Kugadzirisa uye vamwe. Pummelo haikurudzirwe kana njodzi yeBreast Carcinoma kana yakabatana genetic njodzi iri MAP3K1 nekuti inowedzera siginecha nzira dzayo.

FRUIT NANCE INOKURUDZWA PAMUSORO PAMUSORO PAMUSORO PEMAP3K1 GENETIC RISK OF CANCER.

Sarudza Nut COMMON HAZELNUT kana PILI NUT?

Common Hazelnut ine akawanda anoshanda zvinhu kana bioactives akadai Curcumin, Quercetin, Lupeol, Daidzein, Formononetin. Izvi zvinoshanda zvinosanganisa nzira dzakasiyana dzebiochemical senge RAS-RAF Kuratidzira, Cell Cycle, Insulin Signaling uye P53 Signaling nevamwe. Common Hazelnut inokurudzirwa panjodzi yeBreast Carcinoma kana njodzi yemajini yakabatana iri MAP3K1. Izvi zvinodaro nekuti Common Hazelnut inowedzera idzo biochemical nzira dzinopokana nemadhiraivha emasaini ayo.

Zvimwe zvezvinhu zvinoshanda kana bioactives muPili Nut ndeye Apigenin, Curcumin, Lupeol, Daidzein, Formononetin. Izvi zvinoshanda zvinosanganisa nzira dzakasiyana siyana dzebiochemical seDiki Molecule Yekufambisa, Extracellular Matrix Remodeling uye Insulin Signaling nevamwe. Pili Nut haikurudzirwe kana njodzi yeBreast Carcinoma kana yakabatana genetic njodzi iri MAP3K1 nekuti inowedzera siginecha nzira dzayo.

COMMON HAZELNUT INOKURUDZWA PAMUSORO PILI NUT YEMAP3K1 GENETIC RISK YECANCER.

Mhedziso

Zvokudya uye Zvekuwedzera zvakasarudzwa sarudzo dzakakosha dzegomarara senge Breast Carcinoma. Breast Carcinoma varwere uye vanhu vane genetic-njodzi vanogara vaine mubvunzo uyu: "Ndezvipi zvekudya uye zvinovaka muviri zvinokurudzirwa kwandiri uye izvo zvisiri?" Pane chitendero chakajairika chinova fungidziro isiriyo yekuti zvese zvinodyarwa-zvikafu zvinogona kubatsira kana kwete asi zvisingakuvadze. Zvimwe zvekudya uye zvekuwedzera zvinogona kukanganisa marapirwo egomarara kana kusimudzira mamorekuru enzira yegomarara.

Kune marudzi akasiyana ezviratidzo zvegomarara senge Breast Carcinoma, imwe neimwe iine bundu genetics ine mamwe ma genomic musiyano pamunhu wega wega. Kuwedzera kurapwa kwegomarara uye chemotherapy ine yakasarudzika nzira yekuita. Chikafu chega chega seGlobe Artichoke chine akasiyana bioactive muhuwandu hwakasiyana, izvo zvine chekuita neakasiyana uye akasiyana seti yebiochemical nzira. Tsanangudzo yekudya yakasarudzika ndeyakasarudzika chikafu kurudziro yegomarara chiratidzo, marapirwo, genetics, mararamiro uye zvimwe zvinhu. Sarudzo dzehutano hwemunhu hwegomarara dzinoda ruzivo rwegomarara biology, sainzi yechikafu uye kunzwisisa kweakasiyana chemotherapy marapirwo. Chekupedzisira kana paine shanduko yekurapa kana nyowani genomics inoonekwa - iyo inovaka muviri inoda kuongororwazve.

Iyo addon nutrition personalization solution inoita kuti sarudzo ive nyore uye inobvisa fungidziro yese mukupindura mubvunzo, "Ndezvipi zvekudya zvandinofanira kusarudza kana kusasarudzira Breast Carcinoma?". Iyo addon yakawanda-yekuranga timu inosanganisira varapi vegomarara, masayendisiti ekiriniki, mainjiniya esoftware uye masayendisiti edata.

References

• Zamu Msk 2018
• Pan-cancer kuongororwa kweiyo genomes yakazara.
• The Natural Compound Myricetin Zvinobudirira Kudzvinyirira Kukura Kwakashata kweCancer Prostate neKudzivisa PIM1 uye Kuvhiringidza PIM1 / CXCR4 Kudyidzana.
• Modulation yeHER2 kutaura neferulic acid pagomarara rezamu remunhu MCF7 masero.
• Chlorogenic acid inhibits kuwanda uye induces apoptosis muA498 masero ekenza yeitsvo yemunhu kuburikidza nekusaita PI3K/Akt/mTOR nzira yekusaina.
• Tsvagiridzo inofambira mberi pane anticancer mhedzisiro yevhitamini K2.
• L-Ascorbic Acid Inhibits Breast Cancer Growth neInducing IRE / JNK / CHOP-Inoenderana Endoplasmic Reticulum Stress-Mediated p62 / SQSTM1 Kuunganidza muNucleus.
• Negative regulation ye signal transducer uye activator ye transcription-3 signing cascade ne lupeol inhibits kukura uye induces apoptosis muhepatocellular carcinoma masero.
• Iyo antitumor mhedzisiro yegeraniol: Modulation yegomarara hallmark nzira (Ongororo).
• https://www.who.int/news-room/fact-sheets/detail/breast-cancer;
• https://www.cancer.gov/types/breast/hp/breast-treatment-pdq#_551_toc
• https://www.ncbi.nlm.nih.gov/books/NBK482286/#:~:text=Stage%200%20and%20stage%20I,survive%20their%20next%205%20years.