faatumutumuga
Maualuga vailaʻau Ascorbic Acid (Vitamini C) tuʻuina intravenously faʻatasi ai ma le tuʻufaʻatasia chemotherapy pei o FOLFOX ma FOLFIRI, i metastatic colorectal poʻo gastric kanesa kanesa, mafai ona faʻatautaia saogalemu e aunoa ma se faaopoopo faʻaopoopoga oona. Aveina o fualaʻau maualuga Vitamini C pe aofia ai Vitamini C mauoa meaʻai o se vaega o le kanesa 'ai fa'atasi ai ma le chemotherapy e mafai ona fa'aleleia atili le tali atu ma fa'aitiitia le chemotherapy e a'afia ai a'afiaga i le kanesa colorectal po'o le gastric kanesa.
Vitamini C / Ascorbic oʻona
Ascorbic Acid (Vitamin C) ose fa'aoga masani ma lautele fa'aoga antioxidant ma fa'aola fa'anatura. Ae peitai, o lana matafaioi i kanesa puipuia ma togafitiga sa finauina. E ui o nisi faʻamatalaga faʻamatalaga na faʻaalia ai o le taumafaina o meaʻai e tele Vitamin C e faʻaitiitia ai le lamatiaga o le kanesa, o faʻamaoniga mai faʻalavelave faʻafuaseʻi, faʻataʻitaʻiga faʻataʻitaʻiga faʻataʻitaʻiga faʻatasi ai ma le ascorbate tautala e leai se aoga. Ae i suʻesuʻega faʻapitoa talu ai nei ma le maualuga tele o le fua o le ascorbic acid faʻaalia ma le tui toto na faʻaumatia ai sela o le kanesa, ma faʻaalia ai aafiaga synergistic ma vailaʻau cytotoxic. Ole fua maualuga ole acid ascorbic e mafai ona maua ile tui toto ma i lenei fua, ole acid ascorbic e mafai ona i ai aʻafiaga faʻamaʻi faʻamaʻi, mafua ai le faʻaleagaina o DNA, ma mafua ai le oti o le kanesa. E le gata i lea, o loʻo i ai faʻamaoniga faʻapitoa faʻapitoa o loʻo faʻaputuina e faʻaalia ai e mafai ona tuʻuina atu ma le saogalemu le acid ascorbic faʻatasi ma vailaʻau cytotoxic e pei o gemcitabine, paclitaxel ma carboplatin (Ma Y et al, Sci. Faaliliu. Med., 2014; Welsh JL et al, Kanesa Chemother Pharmacol, 2013)
Meaʻai e 'ai Ina ua maeʻa faʻamaʻi kanesa!
Leai lua kanesa e tutusa. Alu i talaatu o le masani taʻiala taiala mo tagata uma ma faia filifiliga faʻapitoa e uiga i meaʻai ma faʻaopopoga ma le mautinoa.
Faʻaaogaina o Vaitamini C / Ascorbic Acid faʻatasi ai ma Chemotherapy i Metastatic Colorectal ma Gastric Cancer
Ina ia iloilo le saogalemu ma le maualuga o le toleted dose (MTD) o le ascorbic acid/Vitamin C e mafai ona tuʻuina faʻatasi ma le tuʻufaʻatasia o le cytotoxic chemotherapy regimens e pei ole FOLFOX ma FOLFIRI, tagata suʻesuʻe mai le Collaborative Innovation Center for Cancer Medicine, Sun Yat-sen University i Saina. faia se fa'ata'ita'iga fa'apitoa ole Vaega 1 ile falema'i (NCT02969681) ile metastatic colorectal (mCRC) po'o le gastric. kanesa (mGC) gasegase. FOLFOX o se vaila'au tu'ufa'atasi e aofia ai vaila'au e 3: leucovorin (Folinic acid), Fluorouracil ma le oxaliplatin. I le FOLFIRI regimen, 4 vailaʻau cytotoxic - Folinic acid, Fluorouracil, Irinotecan ma Cetuximab o loʻo faʻaaogaina. (Wang F et al, BMC Kanesa, 2019)
36 tagata gasegase Saina na faʻataʻitaʻia ma le faʻateleina o vailaʻau oona ascorbic acid mai le 0.2-1.5 g / kg mo le 3 itula faʻasusuina, tasi aso i aso uma, mo aso 1-3, faʻatasi ai ma FOLFOX poʻo le FOLFIRI i le 14 aso taʻamilosaga, seʻia ausia MTD. Mai le 36 gasegase na lesitalaina, 24 (23 ma le mCRC ma le 1 ma le mGC) na iloiloina mo le tali atu o le patu. O le tali sili ona lelei na aofia ai se vaega o tali i le sefulu ma le fa o tagata mamaʻi (58.35%), maʻi tumau i le iva (37.5%), ma le faʻatonutonuina o faʻamaʻi 95.8%. Na lipotia mai e le au suʻesuʻe e leai se MTD na oʻo atu ma latou te leʻi mauaina ni vailaʻau faʻatapulaʻaina o vailaʻau na iloa ile faʻateleina o fualaʻau. O le masani taatele itu-aafiaga mafua mai i maualuga-inumaga ascorbic acid aofia ai tiga ulu, malamalama-ulu, mago gutu ma nisi gastrointestinal oona ona o le loloto tui. O lenei suʻesuʻega na faʻaalia ai foi le faʻaititia o le leaga o ponaivi o le ponaivi ma gastrointestinal oona e fesoʻotaʻi ma le chemotherapy regimens pe a fai o le maualuga o le ascorbic acid na tuʻuina atu faʻatasi ma le chemotherapy.
O mea na maua i lenei suʻesuʻega na fautuaina ai le "ascorbic acid / Vitamini C i le 1.5 g / kg tasi aso i aso uma mo le tolu aso sosoʻo e mafai ona saogalemu ona faʻatautaia ma le FOLFOX poʻo le FOLFIRI chemotherapy i le 14-aso taʻamilosaga." (Wang F et al, BMC Kanesa, 2019)
iʻuga
Ole fua maualuga ole Vitamini C ma/po'o se mea'ai/mea'ai e tele ile Vitamini C e tu'uina atu fa'atasi ma le chemotherapy e mafai ona fa'aleleia atili le tali atu ma fa'aitiitia ai a'afiaga e a'afia ile chemotherapy ile kanesa colorectal po'o le gastric. kanesa.
O a meaʻai e te 'ai ma poʻo fea mea faʻaopopo e te aveina o se filifiliga e te faia. Lau filifiliga e tatau ona aofia ai le iloiloina o le kanesa gafa fesuiaʻiga, o le kanesa, faifai pea togafitiga ma faʻaopopoga, soʻo se allies, olaga faʻamatalaga, mamafa, maualuga ma masani.
O le fuafuaina meaʻai mo kanesa mai le addon e le faʻavae luga o initaneti sailiga. E otometi lava le faia o faʻaiuga mo oe faʻavae i luga o molemole faʻasaienisi faʻatinoina e o tatou saienitisi ma inisinia polokalama. Tusa lava pe e te popole e malamalama i le faʻavaeina o meaola niniʻi o le biochemical pe leai - mo le fuafuaina o meaʻai mo le kanesa e manaʻomia le malamalama.
Amata NEI i lau taumafataga fuafuaina e ala i le taliina o fesili i le igoa o le kanesa, fesuiaʻiga o gafa, togafitiga faifai pea ma supa, soʻo se allergy, masani, ituaiga olaga, tausaga kulupu ma itupa.
Mea'ai Fa'apitoa mo Kanesa!
E suia le kanesa i le taimi. Fa'asinomaga ma fesuia'i au mea'ai e fa'atatau i fa'ailoga o le kanesa, togafitiga, ituaiga olaga, mea'ai e fiafia i ai, allergies ma isi mea.
Kanesa gasegase masani ona feagai ma le eseʻese aafiaga o le chemotherapy lea e afaina ai lo latou tulaga lelei o le olaga ma vaavaai mo isi togafitiga mo kanesa. Aveina o le saʻo meaʻai ma mea faʻaopopo e faʻavae i mafaufauga faasaienitisi (aloese mai taumatematega ma filifiliga fa'afuase'i) ole fofo fa'anatura sili lea mo kanesa ma a'afiaga e fa'atatau i togafitiga.