Ndi khansa iti yomwe ingapindule pophatikiza Amla muzakudya zawo?

Mfundo

Amla amadziwika kwambiri chifukwa cha thanzi lake ndipo amagwiritsidwa ntchito kawirikawiri ndi odwala khansa komanso omwe ali pachiopsezo cha majini. Komabe, chitetezo ndi mphamvu ya Amla kwa odwala khansa zimadalira zinthu zambiri monga kuwonetsa khansa, chemotherapy, chithandizo china, ndi chibadwa cha chotupacho. Kudziwa kuti zakudya zina ndi zowonjezera, monga manyumwa ndi sipinachi, zimatha kugwirizana bwino ndi mankhwala a khansa ndipo zimayambitsa zovuta ndizofunikira.

Zakudya ndizofunikira kwambiri pochiza khansa chifukwa zingakhudze zotsatira za chithandizo. Odwala khansa ayenera kusankha mosamala komanso kuphatikiza zakudya zoyenera ndi zowonjezera m'zakudya zawo. Mwachitsanzo, Amla akhoza kupindulitsa omwe ali ndi Primary Penile Squamous Cell Carcinoma omwe akudwala Mitomycin, koma sizingakhale zabwino kwa odwala omwe akulandira Radiation for Primary Adamantinoma. Kuphatikiza apo, ngakhale Amla atha kuthandiza anthu omwe ali ndi chiwopsezo chamtundu wa "ERBB2", sizingaganizidwe kwa omwe ali ndi chiwopsezo chosiyana "ASXL1". Kusankha zakudya zoyenera malinga ndi thanzi, chithandizo, ndi majini ndikofunikira.

Kumvetsetsa kuti kupanga chisankho pakuyenera kwa Amla kwa wodwala khansa kuyenera kukhala payekha ndikofunikira. Zinthu zovuta monga mtundu wa khansa, njira zothandizira, mapangidwe a majini, kuopsa kwa majini, zaka, kulemera kwa thupi, ndi moyo ndizofunika kwambiri posankha ngati Amla ndiye chisankho choyenera. Genetics ndi genomics, makamaka, ndizofunikira kwambiri. Chifukwa chakuti zinthuzi zimatha kusinthika, ndikofunikira kuyang'ana pafupipafupi ndikusinthira zakudya kuti zigwirizane ndi kusintha kwaumoyo ndi chithandizo.

Pomaliza, njira yokwanira yosankha zakudya ndiyofunikira, kuyang'ana pa zotsatira zonse zomwe zimagwira ntchito muzakudya / zowonjezera monga Amla m'malo mowunika chilichonse chogwira ntchito padera kapena kunyalanyaza kwathunthu. Kuwona kwakukulu uku kumalimbikitsa njira yomveka komanso yasayansi yokonzekera zakudya za khansa.

Mwachidule

Kugwiritsiridwa ntchito kwa zakudya za zomera ndi zowonjezera, monga mavitamini, zitsamba, mchere, ma probiotics, ndi zina zapadera zowonjezera, zikuwonjezeka pakati pa odwala khansa. Zowonjezera izi zidapangidwa kuti zipereke kuchuluka kwazinthu zomwe zimagwira ntchito, zambiri zomwe zimakhalanso muzakudya zosiyanasiyana. Kusakanizika ndi kusiyanasiyana kwazinthu zogwira ntchito kumasiyana pakati pazakudya zonse ndi zowonjezera. Zakudya nthawi zambiri zimapereka zinthu zingapo zogwira ntchito koma zotsika kwambiri, pomwe zowonjezera zimapereka kuchuluka kwazinthu zinazake.

Poganizira ntchito zosiyanasiyana zasayansi ndi zachilengedwe za chinthu chilichonse chomwe chimagwiritsidwa ntchito pamlingo wa mamolekyulu, ndikofunikira kuwerengera zotsatira zophatikizana za zigawozi posankha zakudya ndi zowonjezera zomwe mungadye kapena ayi.

Funso lofunikira limabuka: Kodi muyenera kuphatikiza Amla muzakudya zanu ngati chakudya kapena chowonjezera? Kodi ndi bwino kudya Amla ngati muli ndi chibadwa cha khansa yokhudzana ndi jini ya ERBB2? Nanga bwanji ngati m'malo mwake chiwopsezo chanu cha chibadwa chimachokera ku jini ya ASXL1? Kodi ndizopindulitsa kuphatikiza Amla muzakudya zanu ngati mwapezeka ndi Primary Adamantinoma, kapena ngati matenda anu ndi Primary Penile Squamous Cell Carcinoma? Komanso, kodi kumwa kwanu kwa Amla kukuyenera kusinthidwa bwanji ngati mukulandira chithandizo cha Mitomycin kapena ngati dongosolo lanu lamankhwala likuchoka ku Mitomycin kupita ku Radiation? Ndikofunika kuzindikira kuti zonena zosavuta monga 'Amla ndi zachilengedwe, choncho zimakhala zopindulitsa' kapena 'Amla amalimbitsa chitetezo cha mthupi' ndizosakwanira kusankha zakudya / zowonjezera.

Kuphatikiza apo, ndikofunikira kuwunikanso kuyenera kwa kuphatikiza Amla muzakudya zanu ngati pali kusintha kwamankhwala anu. Mwachidule, popanga zisankho zophatikizira zakudya kapena zowonjezera monga Amla muzakudya zanu chifukwa cha zopindulitsa zake, muyenera kuganizira zachilengedwe chonse chazinthu zonse, poganizira zinthu monga mtundu wa khansa, chithandizo chamankhwala chomwe mukukumana nacho, ma genetic predispositions. , ndi zosankha za moyo.

Cancer

Khansara imakhalabe vuto lalikulu m'zachipatala, zomwe nthawi zambiri zimayambitsa nkhawa. Komabe, kupita patsogolo kwaposachedwa kwasintha zotsatira za chithandizo, makamaka kudzera mu njira zochizira makonda, njira zowunikira zosasokoneza pogwiritsa ntchito zitsanzo zamagazi ndi malovu, komanso chitukuko cha immunotherapy. Kuzindikira koyambirira komanso kuchitapo kanthu pa nthawi yake kwakhala kofunika kwambiri pakulimbikitsa zotsatira za chithandizo chonse.

Kuyeza kwa ma genetic kumapereka chiyembekezo chachikulu pakuwunika chiopsezo cha khansa komanso kutengeka koyambirira. Komabe, kwa anthu ambiri omwe ali ndi matenda am'banja komanso chibadwa ku khansa, njira zothandizira chithandizo, ngakhale kuyang'anitsitsa nthawi zonse, nthawi zambiri zimakhala zochepa kapena palibe. Mukapezeka ndi mtundu wina wa khansa, monga Primary Penile Squamous Cell Carcinoma kapena Primary Adamantinoma, njira zothandizira ziyenera kusinthidwa malinga ndi chibadwa cha chotupa cha munthu, siteji ya matendawa, komanso zinthu monga zaka ndi jenda. "

Pambuyo pa chithandizo, kuyang'anira kosalekeza ndikofunikira kuti muwone zizindikiro zilizonse zakuyambiranso kwa khansa ndikudziwitsanso zisankho zotsatila. Odwala ambiri omwe ali ndi khansa komanso omwe ali pachiwopsezo nthawi zambiri amafunsira upangiri wophatikizira zakudya zina ndi zowonjezera m'zakudya zawo, zomwe zimathandiza kwambiri popanga zisankho pazaumoyo.

Funso lofunika kwambiri ndilakuti mungakhale ndi chiwopsezo cha majini ndi matenda enaake a khansa posankha zakudya, monga Amla. Kodi chiwopsezo cha chibadwa cha khansa chomwe chimachokera ku kusintha kwa ERBB2 chimakhala ndi zotsatira zofanana ndi kusintha kwa ASXL1? Kuchokera pazakudya, kodi chiopsezo chokhudzana ndi Primary Penile Squamous Cell Carcinoma chikufanana ndi Primary Adamantinoma? Kuonjezera apo, kodi kulingalira kwa zakudya kumakhalabe komweko kwa omwe akudwala Radiation monga omwe amalandira Mitomycin? Izi ndizofunikira pakusankha zakudya mwanzeru kwa anthu omwe ali ndi ziwopsezo zamitundu yosiyanasiyana komanso chithandizo cha khansa.

Amla - Chowonjezera Chakudya

Amla yowonjezera imaphatikizapo zinthu zambiri zogwira ntchito, kuphatikizapo Emblicanin B, Emblicanin A, Pyrogallol, Ellagic Acid ndi Gallic Acid, iliyonse yomwe ilipo pazigawo zosiyanasiyana. Zosakaniza izi zimakhudza njira zama cell, makamaka Extracellular Matrix Remodelling, Epithelial to Mesenchymal Transition, Oncogenic Cancer Epigenetics ndi PI3K-AKT-MTOR Signaling, yomwe imayang'anira zovuta za khansa pama cell, monga kukula kwa chotupa, kufalikira, ndi kufa kwa cell. Chifukwa cha kukhudzidwa kwachilengedwechi, kusankha zowonjezera zowonjezera monga Amla, yekha kapena kuphatikiza, kumakhala chisankho chofunikira pazakudya za khansa. Mukaganizira kugwiritsa ntchito Amla pa khansa, ndikofunikira kuganizira izi ndi njira zosiyanasiyana. Izi zili choncho chifukwa, mofanana ndi chithandizo cha khansa, kugwiritsa ntchito Amla sichigamulo chapadziko lonse choyenera makhansa onse koma chiyenera kukhala chamunthu.

Kusankha Zowonjezera za Amla

Kuyankha funso loti 'Ndiyenera kupewa liti Amla pankhani ya Khansa' ndizovuta chifukwa yankho limakhala lamunthu payekhapayekha - limangoti 'Zimadalira!'. Mofanana ndi momwe chithandizo chilichonse cha khansa sichingakhale chothandiza kwa wodwala aliyense, kufunika ndi chitetezo kapena ubwino wa Amla zimasiyana malinga ndi momwe zinthu zilili. Zinthu monga mtundu wa khansa, ma genetic predispositions, chithandizo chamakono, zowonjezera zina zomwe zikumwedwa, zizolowezi za moyo, BMI, ndi ziwengo zilizonse zimathandizira kudziwa ngati Amla ndi woyenera kapena ayenera kupewedwa, ndikugogomezera kufunikira koganizira za munthu payekha. zisankho zotere.

1. Kodi Amla Supplements angathandize Odwala a Adamantinoma omwe akulandira chithandizo cha radiation?

Adamantinoma yoyambirira imadziwika ndi kusintha kwa majini, komwe ndi ARHGAP45, PI4KB ndi SDSL, zomwe zimabweretsa kusintha kwa njira zam'magazi, makamaka Epithelial to Mesenchymal Transition ndi Inositol Phosphate Signaling. Kuchita bwino kwa chithandizo cha khansa, monga Radiation, kumadalira momwe amachitira panjira izi. Njira yabwino imaphatikizapo kugwirizanitsa machitidwe a chithandizo ndi njira zoyendetsera khansara, potero kuwonetsetsa kuti munthu ali ndi njira yoyenera komanso yothandiza. Muzochitika zotere, kupewa zakudya kapena zakudya zopatsa thanzi zomwe zitha kuthana ndi zotsatira za mankhwalawa kapena kuchepetsa kusamvana kumeneku ndikofunikira. Mwachitsanzo, chowonjezera cha Amla, chomwe chimakhudza Epithelial to Mesenchymal Transition, sichingakhale chisankho choyenera pa nkhani ya Primary Adamantinoma pamene akudutsa Radiation. Izi ndichifukwa choti zitha kukulitsa kukula kwa matendawa kapena kusokoneza chithandizo chamankhwala. Posankha dongosolo lazakudya, ndikofunikira kuganizira zinthu monga mtundu wa khansa, chithandizo chopitilira, zaka, jenda, BMI, moyo, ndi kusintha kulikonse komwe kumadziwika.

2. Kodi Amla Supplements angathandize Odwala a Primary Penile Squamous Cell Carcinoma omwe akulandira Chithandizo cha Mitomycin?

Primary Penile Squamous Cell Carcinoma imadziwika ndi kusintha kwa majini, monga ABRAXAS1, PIK3CB ndi NUP93, zomwe zimabweretsa kusintha kwa biochemical pathways, makamaka Extracellular Matrix Remodelling, Hematopoiesis ndi Inositol Phosphate Signaling. Kuchita bwino kwa chithandizo cha khansa, monga Mitomycin, kumatsimikiziridwa ndi kuyanjana kwake ndi njira izi. Cholinga chake ndikuwonetsetsa kuti chithandizocho chikugwirizana bwino ndi njira zomwe zimayendetsa khansara, ndikupangitsa njira yochizira payekha. M'nkhaniyi, zakudya kapena zowonjezera zomwe zimagwirizana ndi chithandizo kapena kupititsa patsogolo kugwirizanitsa kumeneku ziyenera kuganiziridwa. Mwachitsanzo, chowonjezera cha Amla ndi njira yabwino kwa iwo omwe ali ndi Primary Penile Squamous Cell Carcinoma akukumana ndi Mitomycin. Izi zili choncho chifukwa Amla amakhudza njira monga Extracellular Matrix Remodelling, zomwe zingathe kulepheretsa zinthu zomwe zimayendetsa Primary Penile Squamous Cell Carcinoma kapena kupindula ndi mphamvu ya Mitomycin.

3. Kodi Amla Supplements Ndi Otetezeka kwa Anthu Athanzi Amene Ali ndi ASXL1 Mutation Associated Genetic Risk?

Makampani osiyanasiyana amapereka magulu a majini kuti awone kuopsa kwa ma genetic a mitundu yosiyanasiyana ya khansa. Maguluwa amaphatikizapo majini okhudzana ndi khansa ya m'mawere, ovarian, chiberekero, prostate, ndi khansa ya m'mimba. Kuyesa majiniwa kumatha kutsimikizira matenda ndikudziwitsa njira zamankhwala ndi kasamalidwe. Kuzindikira kusiyanasiyana komwe kumayambitsa matenda kungathandizenso kuyesa ndikuzindikira achibale omwe ali pachiwopsezo. Jini la ASXL1 nthawi zambiri limaphatikizidwa m'magawo awa pakuwunika chiopsezo cha khansa.

Kusintha kwa jini ya ASXL1 kumakhudza njira zama biochemical kapena njira, monga Oncogenic Cancer Epigenetics ndi Suppressive Histone Methylation, zomwe zimakhudzidwa mwachindunji kapena mosalunjika pakuyendetsa khansa pamlingo wa maselo. Pamene gulu la majini likuwonetsa kusintha kwa ASXL1 komwe kumakhudzana ndi chiwopsezo chowonjezereka cha Chronic Myelomonocytic Leukemia, malingaliro asayansi akuwonetsa kupeŵa kugwiritsa ntchito Amla yowonjezera. Izi ndichifukwa choti chowonjezera cha Amla chimakhudza njira ngati Oncogenic Cancer Epigenetics, zomwe zitha kubweretsa zovuta pakusintha kwa ASXL1 ndi zovuta zina za khansa.

4. Kodi Amla Supplements Ndiotetezeka kwa Anthu Athanzi Amene Ali ndi ERBB2 Mutation Associated Genetic Risk?

ERBB2 imagwira ntchito yofunika kwambiri pakuwunika chiopsezo cha khansa. Kusintha kwa ERBB2 kungathe kusokoneza njira zowonongeka zowonongeka, kuphatikizapo Kukula kwa Factor Signaling ndi PI3K-AKT-MTOR Signaling, zomwe zimakhudza kukula kwa khansa. Ngati gulu lanu la majini likuwonetsa masinthidwe mu ERBB2 okhudzana ndi Esophageal Adenocarcinoma, lingalirani zophatikiza zowonjezera za Amla mu dongosolo lanu lazakudya. Zowonjezera izi zimatha kukhudza njira monga PI3K-AKT-MTOR Signaling, kupindula popereka chithandizo choyenera kwa anthu omwe ali ndi kusintha kwa ERBB2 ndi nkhawa zokhudzana ndi thanzi.

Pomaliza

Zinthu ziwiri zofunika kwambiri kukumbukira ndikuti chithandizo cha khansa ndi zakudya sizikhala zofanana kwa aliyense. Zakudya zopatsa thanzi, kuphatikiza zakudya ndi zowonjezera monga Amla, ndi chida chothandiza chomwe chitha kuwongoleredwa ndi inu mukukumana ndi khansa.

"Ndidye chiyani?" ndi funso lomwe limafunsidwa kwambiri ndi odwala khansa komanso omwe ali pachiwopsezo cha khansa. Yankho lolondola ndiloti zimatengera zinthu monga mtundu wa khansa, chibadwa cha chotupa, chithandizo chamakono, ziwengo, moyo, ndi BMI.

Pezani makonda anu a khansa kuchokera ku addon podina ulalo womwe uli pansipa ndikuyankha mafunso okhudza mtundu wa khansa yanu, chithandizo, moyo, ziwengo, zaka, komanso jenda.

Zothandizira

• Kufunika Kogwira Ntchito ndi Nutraceutical kwa Amla (Phyllanthus emblica L.): Ndemanga.
• cBioPortal ya Cancer Genomics
• cBioPortal ya Cancer Genomics
• Kugwirizana kwa integrinβ1 kumapangitsa kukana kwa ma cell a khansa ya chikhodzodzo ku mitomycin-C.
• Pan-cancer kusanthula ma genomes onse.
• Chithandizo cha khansa chimapanga mawonekedwe olimba a clonal hematopoiesis.
• Kuzindikiritsa ellagic acid ngati inhibitor yamphamvu ya protein kinase CK2: chitsanzo chopambana cha pulogalamu yowonera.
• Kukana kwawayilesi m'maselo a khansa ya m'mawere kumalumikizidwa kudzera mu chizindikiro cha TGF-β, hybrid epithelial-mesenchymal phenotype ndi ma cell stem cell.
• Indeno [1,2-b] zotengera za indole monga gulu lamphamvu la anthu amphamvu protein kinase CK2 inhibitors.