Ndi khansa iti yomwe ingapindule ndi kuphatikiza Andrographis muzakudya zawo?

Mfundo

Andrographis imadziwika kwambiri chifukwa cha thanzi lake ndipo imagwiritsidwa ntchito pafupipafupi ndi odwala khansa komanso omwe ali pachiwopsezo cha majini. Komabe, chitetezo ndi mphamvu ya Andrographis kwa odwala khansa zimadalira zinthu zambiri monga kuwonetsa khansa, chemotherapy, chithandizo china, ndi chibadwa cha chotupacho. Kudziwa kuti zakudya zina ndi zowonjezera, monga manyumwa ndi sipinachi, zimatha kugwirizana bwino ndi mankhwala a khansa ndipo zimayambitsa zovuta ndizofunikira.

Zakudya ndizofunikira kwambiri pochiza khansa chifukwa zingakhudze zotsatira za chithandizo. Odwala khansa ayenera kusankha mosamala komanso kuphatikiza zakudya zoyenera ndi zowonjezera m'zakudya zawo. Mwachitsanzo, Andrographis ikhoza kupindulitsa iwo omwe ali ndi Primary Glioblastoma omwe akudwala Temozolomide, koma sizingakhale zabwino kwa odwala omwe akulandira Carmustine for Primary Pineoblastoma. Kuphatikiza apo, ngakhale Andrographis ikhoza kuthandiza anthu omwe ali ndi chiwopsezo chamtundu wa "CDKN2A", sizingaganizidwe kwa omwe ali ndi chiwopsezo chosiyana. Kusankha zakudya zoyenera malinga ndi thanzi, chithandizo, ndi majini ndikofunikira.

Kumvetsetsa kuti kupanga chisankho pakuyenera kwa Andrographis kwa wodwala khansa kuyenera kukhala payekha ndikofunikira. Zinthu zovuta monga mtundu wa khansa, njira zothandizira, mapangidwe a majini, kuopsa kwa majini, zaka, kulemera kwa thupi, ndi moyo ndizofunika kwambiri posankha ngati Andrographis ndi chisankho choyenera. Genetics ndi genomics, makamaka, ndizofunikira kwambiri. Chifukwa chakuti zinthuzi zimatha kusinthika, ndikofunikira kuyang'ana pafupipafupi ndikusintha zosankha zazakudya kuti zigwirizane ndi kusintha kwaumoyo ndi chithandizo.

Pomaliza, njira yokwanira yosankha zakudya ndiyofunikira, kuyang'ana kwambiri zotsatira za zigawo zonse zomwe zimagwira ntchito muzakudya / zowonjezera monga Andrographis m'malo mowunika chilichonse chomwe chimagwira padera kapena kunyalanyaza kwathunthu. Kuwona kwakukulu uku kumalimbikitsa njira yomveka komanso yasayansi yokonzekera zakudya za khansa.

Mwachidule

Kugwiritsiridwa ntchito kwa zakudya za zomera ndi zowonjezera, monga mavitamini, zitsamba, mchere, ma probiotics, ndi zina zapadera zowonjezera, zikuwonjezeka pakati pa odwala khansa. Zowonjezera izi zidapangidwa kuti zipereke kuchuluka kwazinthu zomwe zimagwira ntchito, zambiri zomwe zimakhalanso muzakudya zosiyanasiyana. Kusakanizika ndi kusiyanasiyana kwazinthu zogwira ntchito kumasiyana pakati pazakudya zonse ndi zowonjezera. Zakudya nthawi zambiri zimapereka zinthu zingapo zogwira ntchito koma zotsika kwambiri, pomwe zowonjezera zimapereka kuchuluka kwazinthu zinazake.

Poganizira ntchito zosiyanasiyana zasayansi ndi zachilengedwe za chinthu chilichonse chomwe chimagwiritsidwa ntchito pamlingo wa mamolekyulu, ndikofunikira kuwerengera zotsatira zophatikizana za zigawozi posankha zakudya ndi zowonjezera zomwe mungadye kapena ayi.

Funso lofunikira limabuka: Kodi muyenera kuphatikiza Andrographis muzakudya zanu ngati chakudya kapena chowonjezera? Kodi ndizoyenera kudya Andrographis ngati muli ndi chibadwa cha khansa yokhudzana ndi jini ya CDKN2A? Nanga bwanji ngati m'malo mwake chiopsezo chanu cha chibadwa chimachokera ku jini ina? Kodi ndizothandiza kuphatikiza Andrographis muzakudya zanu ngati mwapezeka ndi Primary Pineoblastoma, kapena ngati matenda anu ndi Primary Glioblastoma? Komanso, momwe mungagwiritsire ntchito Andrographis ziyenera kusinthidwa bwanji ngati mukulandira chithandizo cha Temozolomide kapena ngati dongosolo lanu la mankhwala likusintha kuchokera ku Temozolomide kupita ku Carmustine? Ndikofunika kuzindikira kuti zonena zosavuta monga 'Andrographis ndi zachilengedwe, choncho zimakhala zopindulitsa nthawi zonse' kapena 'Andrographis imalimbitsa chitetezo cha mthupi' ndizosakwanira pa zosankha za chakudya / zowonjezera.

Kuphatikiza apo, ndikofunikira kuwonanso kuyenera kwa kuphatikiza Andrographis muzakudya zanu ngati pali kusintha kwamankhwala anu. Mwachidule, popanga zisankho zophatikizira zakudya kapena zowonjezera monga Andrographis muzakudya zanu chifukwa cha zopindulitsa zake, muyenera kuganizira zachilengedwe chonse chazinthu zonse, poganizira zinthu monga mtundu wa khansa, chithandizo chamankhwala chomwe mukukumana nacho, ma genetic predispositions. , ndi zosankha za moyo.

Cancer

Khansara imakhalabe vuto lalikulu m'zachipatala, zomwe nthawi zambiri zimayambitsa nkhawa. Komabe, kupita patsogolo kwaposachedwa kwasintha zotsatira za chithandizo, makamaka kudzera mu njira zochizira makonda, njira zowunikira zosasokoneza pogwiritsa ntchito zitsanzo zamagazi ndi malovu, komanso chitukuko cha immunotherapy. Kuzindikira koyambirira komanso kuchitapo kanthu pa nthawi yake kwakhala kofunika kwambiri pakulimbikitsa zotsatira za chithandizo chonse.

Kuyeza kwa ma genetic kumapereka chiyembekezo chachikulu pakuwunika chiopsezo cha khansa komanso kutengeka koyambirira. Komabe, kwa anthu ambiri omwe ali ndi matenda am'banja komanso chibadwa ku khansa, njira zothandizira chithandizo, ngakhale kuyang'anitsitsa nthawi zonse, nthawi zambiri zimakhala zochepa kapena palibe. Akapezeka ndi mtundu wina wa khansa, monga Primary Glioblastoma kapena Primary Pineoblastoma, njira zothandizira zimayenera kusinthidwa malinga ndi chibadwa cha chotupa cha munthu, siteji ya matendawa, komanso zinthu monga zaka ndi jenda.

Pambuyo pa chithandizo, kuyang'anira kosalekeza ndikofunikira kuti muwone zizindikiro zilizonse zakuyambiranso kwa khansa ndikudziwitsanso zisankho zotsatila. Odwala ambiri omwe ali ndi khansa komanso omwe ali pachiwopsezo nthawi zambiri amafunsira upangiri wophatikizira zakudya zina ndi zowonjezera m'zakudya zawo, zomwe zimathandiza kwambiri popanga zisankho pazaumoyo.

Funso lofunika kwambiri ndilakuti mungakhale ndi chiwopsezo cha majini ndi matenda enaake a khansa posankha zakudya, monga Andrographis. Kodi chiwopsezo cha chibadwa cha khansa yobwera chifukwa cha kusintha kwa CDKN2A chimakhala ndi zotsatira zofanana ndi zakusintha kwa jini? Kuchokera pazakudya, kodi chiopsezo chokhudzana ndi Primary Glioblastoma chikufanana ndi Primary Pineoblastoma? Komanso, kodi kulingalira kwa zakudya kumakhala kofanana kwa omwe akudwala Carmustine monga omwe amalandira Temozolomide? Izi ndizofunikira pakusankha zakudya mwanzeru kwa anthu omwe ali ndi ziwopsezo zamitundu yosiyanasiyana komanso chithandizo cha khansa.

Andrographis - Chowonjezera Chakudya

Andrographis yowonjezera imaphatikizapo zinthu zingapo zogwira ntchito, kuphatikizapo Andrographolide, iliyonse yomwe ilipo mosiyanasiyana. Zosakaniza izi zimakhudza njira zama cell, makamaka Cell Cycle ndi Oncogenic Cancer Epigenetics, zomwe zimayang'anira zovuta za khansa pama cell, monga kukula kwa chotupa, kufalikira, ndi kufa kwa cell. Chifukwa cha kukhudzidwa kwachilengedwechi, kusankha zowonjezera zowonjezera monga Andrographis, zokha kapena zophatikizana, zimakhala chisankho chofunikira pazakudya za khansa. Poganizira kugwiritsa ntchito Andrographis kwa khansa, ndikofunikira kuganizira izi ndi njira zosiyanasiyana. Izi zili choncho chifukwa, mofanana ndi chithandizo cha khansa, kugwiritsa ntchito Andrographis si chisankho chapadziko lonse choyenera makhansa onse koma chiyenera kukhala chamunthu.

Kusankha Andrographis Zowonjezera

Kuyankha funso loti 'Ndiyenera kupewa liti Andrographis pankhani ya Cancer' ndizovuta chifukwa yankho limakhala lamunthu payekhapayekha - limangoti 'Zimadalira!'. Mofanana ndi momwe chithandizo chilichonse cha khansa sichingakhale chothandiza kwa wodwala aliyense, kufunika ndi chitetezo kapena ubwino wa Andrographis zimasiyana malinga ndi momwe munthu alili. Zinthu monga mtundu weniweni wa khansa, ma genetic predispositions, chithandizo chamakono, zowonjezera zowonjezera zomwe zikumwedwa, zizolowezi za moyo, BMI, ndi ziwengo zilizonse zimathandizira kudziwa ngati Andrographis ndi yoyenera kapena iyenera kupewedwa, ndikugogomezera kufunikira kwa kudziganizira payekha. zisankho zotere.

1. Kodi Andrographis Supplements idzapindula Odwala a Primary Pineoblastoma omwe akulandira chithandizo cha Carmustine?

Primary Pineoblastoma imadziwika ndi kusintha kwa majini, komwe ndi ATR, ATM ndi CREBBP, zomwe zimatsogolera ku kusintha kwa njira zama biochemical, makamaka Oncogenic Cancer Epigenetics, Kukonzanso kwa DNA, Ma cell Cycle Checkpoints, G-protein-coupled Receptor Signaling ndi Immune Evasion Signaling. Kuchita bwino kwa chithandizo cha khansa, monga Carmustine, kumadalira momwe amachitira panjira izi. Njira yabwino imaphatikizapo kugwirizanitsa machitidwe a chithandizo ndi njira zoyendetsera khansara, potero kuwonetsetsa kuti munthu ali ndi njira yoyenera komanso yothandiza. Muzochitika zotere, kupewa zakudya kapena zakudya zopatsa thanzi zomwe zitha kuthana ndi zotsatira za mankhwalawa kapena kuchepetsa kusamvana kumeneku ndikofunikira. Mwachitsanzo, chowonjezera cha Andrographis, chomwe chimakhudza Oncogenic Cancer Epigenetics, sichingakhale chisankho choyenera pa nkhani ya Primary Pineoblastoma pamene akukumana ndi Carmustine. Izi ndichifukwa choti zitha kukulitsa kukula kwa matendawa kapena kusokoneza chithandizo chamankhwala. Posankha dongosolo lazakudya, ndikofunikira kuganizira zinthu monga mtundu wa khansa, chithandizo chopitilira, zaka, jenda, BMI, moyo, ndi kusintha kulikonse komwe kumadziwika.

2. Kodi Andrographis Supplements idzapindulitsa Odwala a Glioblastoma omwe akulandira chithandizo cha Temozolomide?

Primary Glioblastoma imadziwika ndi kusintha kwa majini, monga TRBV7-7, TAS2R46 ndi TP53, zomwe zimabweretsa kusintha kwa biochemical pathways, makamaka Cell Cycle, Cell Cycle Checkpoints ndi Apoptosis. Kuchita bwino kwa chithandizo cha khansa, monga Temozolomide, kumatsimikiziridwa ndi kuyanjana kwake ndi njira izi. Cholinga chake ndikuwonetsetsa kuti chithandizocho chikugwirizana bwino ndi njira zomwe zimayendetsa khansara, ndikupangitsa njira yochizira payekha. M'nkhaniyi, zakudya kapena zowonjezera zomwe zimagwirizana ndi chithandizo kapena kupititsa patsogolo kugwirizanitsa kumeneku ziyenera kuganiziridwa. Mwachitsanzo, chowonjezera cha Andrographis ndi njira yabwino kwa iwo omwe ali ndi Primary Glioblastoma akukumana ndi Temozolomide. Izi zili choncho chifukwa Andrographis imakhudza njira monga Cell Cycle, zomwe zingathe kulepheretsa zinthu zomwe zimayendetsa Primary Glioblastoma kapena kupindula ndi mphamvu ya Temozolomide.

3. Kodi Andrographis Supplements Ndi Yotetezeka kwa Anthu Athanzi Amene Ali ndi CDKN2A Mutation Associated Genetic Risk?

CDKN2A imatenga gawo lofunikira pakuwunika chiopsezo cha khansa. Kusintha kwa CDKN2A kumatha kusokoneza njira zama biochemical, kuphatikiza ma Cell Cycle Checkpoints ndi Cell Cycle, zomwe zimakhudza kukula kwa khansa. Ngati chibadwa chanu chikuwonetsa masinthidwe a CDKN2A okhudzana ndi Khansa Yapakhungu, lingalirani zophatikiza zowonjezera za Andrographis muzakudya zanu. Zowonjezera izi zitha kukhudzanso njira ngati Cell Cycle, kupindula popereka chithandizo choyenera kwa anthu omwe ali ndi masinthidwe a CDKN2A ndi nkhawa zokhudzana ndi thanzi.

Pomaliza

Zinthu ziwiri zofunika kwambiri kukumbukira ndikuti chithandizo cha khansa ndi zakudya sizikhala zofanana kwa aliyense. Zakudya zopatsa thanzi, kuphatikiza zakudya ndi zowonjezera monga Andrographis, ndi chida chothandiza chomwe chingathe kuwongoleredwa ndi inu mukukumana ndi khansa.

"Ndidye chiyani?" ndi funso lomwe limafunsidwa kwambiri ndi odwala khansa komanso omwe ali pachiwopsezo cha khansa. Yankho lolondola ndiloti zimatengera zinthu monga mtundu wa khansa, chibadwa cha chotupa, chithandizo chamakono, ziwengo, moyo, ndi BMI.

Pezani makonda anu a khansa kuchokera ku addon podina ulalo womwe uli pansipa ndikuyankha mafunso okhudza mtundu wa khansa yanu, chithandizo, moyo, ziwengo, zaka, komanso jenda.

Zothandizira

• Kusindikiza zala zamitundu yosiyanasiyana ndi ma probe a DNA opangidwa kuchokera ku ma tempuleti a DNA osasunthika.
• cBioPortal ya Cancer Genomics
• Andrographolide imatsutsana ndi kusintha kwa epithelial-mesenchymal komwe kumayambitsa utsi wa ndudu ndi kusagwira ntchito kwa pulmonary kudzera mu anti-inflammatory inhibiting HOTAIR.
• Kusintha kwa IDH1/2 ndi chizindikiro chodziwikiratu kuti munthu apulumuke ndipo amalosera kuyankha kwa chemotherapy kwa ma glioma a giredi II omwe amathandizidwa nthawi yomweyo ndi ma radiation.
• cBioPortal ya Cancer Genomics
• Chithandizo cha khansa chimapanga mawonekedwe olimba a clonal hematopoiesis.
• MGMT-inhibitor yophatikiza ndi TGF-βRI inhibitor kapena CDK 4/6 inhibitor imawonjezera chidwi cha temozolomide m'maselo a temozolomide-resistant glioblastoma.
• Mawonekedwe a somatic genomic a glioblastoma.