Zakudya za Medulloblastoma!

Introduction

Zakudya za Medulloblastoma ziyenera kukhala zamunthu aliyense payekhapayekha komanso zimayenera kusintha ngati chithandizo cha khansa kapena chotupa chikusintha. Kusintha kwamunthu ndikusintha kuyenera kuganizira zonse zomwe zimagwira ntchito kapena ma bioactive omwe ali muzakudya zosiyanasiyana molingana ndi biology ya khansa, majini, chithandizo, moyo komanso zomwe amakonda. Chifukwa chake ngakhale zakudya ndi chimodzi mwazosankha zofunika kwambiri kwa wodwala khansa komanso munthu yemwe ali pachiwopsezo cha khansa - momwe angasankhire zakudya zomwe angadye si ntchito yophweka.

Medulloblastoma ndi mtundu wa chotupa cha ubongo chosowa, chomwe chimapezeka mu cerebellum (tsinde laubongo), ndipo chimafala kwambiri mwa ana kuposa akuluakulu. Chotupacho chikukula mofulumira ndipo chimatha kufalikira kumadera ena a ubongo ndi msana. Zizindikiro za medulloblastoma ndi mutu, chizungulire, nseru ndi kusanza, kutopa, kusakhazikika bwino, kusintha kwa masomphenya, kuyenda movutikira, kupweteka kwa msana, mkodzo kapena matumbo. Zomwe zimayambitsa medulloblastoma sizimamveka bwino, koma kusintha kwa majini monga BRCA1 ndi BRCA2 kungathandize. Njira zochizira za medulloblastoma zimaphatikizapo opaleshoni, chithandizo cha radiation, ndi chemotherapy, zogwirizana ndi vuto la munthu. Zomwe zikuyembekezeredwa komanso kupulumuka kwa akuluakulu omwe ali ndi medulloblastoma zimasiyana ndi za ana. Zaka zisanu zamoyo za medulloblastoma ndizoposa 5%. Moyo pambuyo pa medulloblastoma umafunika kuyang'anitsitsa ndi kutsata chisamaliro

Kwa Medulloblastoma, kodi zili ndi masamba, zipatso, mtedza, mbewu zomwe munthu amadya?

Funso lodziwika bwino lazakudya lomwe limafunsidwa ndi odwala khansa komanso anthu omwe ali pachiwopsezo cha khansa ndi - la khansa ngati Medulloblastoma kodi zilibe kanthu kuti ndi zakudya ziti zomwe ndimadya komanso zomwe sindidya? Kapena ngati nditsatira zakudya zochokera ku zomera ndizokwanira khansa ngati Medulloblastoma?

Mwachitsanzo, kodi zilibe kanthu ngati masamba a New Zealand Sipinachi amadyedwa kwambiri poyerekeza ndi Jerusalem Artichoke? Kodi zimapanga kusiyana kulikonse ngati Pummelo imakondedwa kuposa Red Raspberry? Komanso ngati kusankha kofananako kumapangidwa pa mtedza/mbewu monga Butternut pa European Chestnut ndi nsonga monga Broad Bean pa Hyacinth Bean. Ndipo ngati zomwe ndimadya zili ndi vuto - ndiye kuti munthu angadziwe bwanji zakudya zomwe zimalimbikitsidwa ku Medulloblastoma ndipo ndi yankho lomwelo kwa aliyense yemwe ali ndi matenda omwewo kapena chiwopsezo cha chibadwa?

Inde! Zakudya zomwe mumadya ndizofunikira za Medulloblastoma!

Malingaliro a zakudya sangakhale ofanana kwa aliyense ndipo akhoza kukhala osiyana ngakhale pa matenda omwewo komanso chiopsezo cha majini.

Zakudya zonse (masamba, zipatso, mtedza, mbewu, phala, mafuta ndi zina) ndi zakudya zopatsa thanzi zimapangidwa ndi mamolekyulu opitilira imodzi kapena zogwira ntchito mosiyanasiyana komanso kuchuluka kwake. Chilichonse chogwiritsidwa ntchito chimakhala ndi njira yapadera yochitirapo kanthu - yomwe imatha kuyambitsa kapena kuletsa njira zosiyanasiyana zama biochemical. Zakudya zongotchulidwa mwachidule ndi zowonjezera zomwe zimalimbikitsidwa ndizomwe sizimayambitsa kuchuluka kwa maselo oyambitsa khansa koma zimawachepetsa. Apo ayi zakudya zimenezo siziyenera kuvomerezedwa. Zakudya zimakhala ndi zosakaniza zingapo zomwe zimagwira ntchito - chifukwa chake powunika zakudya ndi zowonjezera, muyenera kuganizira momwe zosakaniza zonse zimakhudzira thupi limodzi osati payekhapayekha.

Mwachitsanzo Pummelo ili ndi zinthu zogwira ntchito monga Quercetin, Curcumin, Isoliquiritigenin, Apigenin, Lycopene. Ndipo Rasipiberi Wofiira ali ndi zinthu zomwe zimagwira ntchito monga Quercetin, Ellagic Acid, Curcumin, Isoliquiritigenin, Formononetin ndi ena.

Kulakwitsa kofala komwe kumachitika posankha ndikusankha zakudya zodyera Medulloblastoma - ndikuwunika zosakaniza zosankhidwa zokha zomwe zili muzakudya ndikunyalanyaza zina zonse. Chifukwa zosakaniza zosiyanasiyana zomwe zili muzakudya zitha kukhala ndi zotsatira zotsutsana ndi oyendetsa khansa - simungathe kusankha zosakaniza muzakudya ndi zowonjezera kuti mupange chisankho chazakudya cha Medulloblastoma.

INDE - ZOSANKHA CHAKUDYA NDINKHANI PA KANSA. ZINSINSI ZA KALERE ZIYENERA KUGANIZIRA ZONSE ZONSE ZOKHUDZA ZOKHUDZA ZAKUDYA.

Maluso Ofunika Pakukonda Chakudya Chakudya cha Medulloblastoma?

Zakudya zamakhansa ngati Medulloblastoma zimakhala ndi zakudya / zowonjezera; zakudya zosavomerezeka / zowonjezera zomwe zili ndi maphikidwe achitsanzo omwe amaika patsogolo kugwiritsa ntchito zakudya zoyenera. Chitsanzo cha kadyedwe kake kamakonda kuwoneka pa izi kugwirizana.

Kusankha zakudya zomwe zimalangizidwa kapena ayi ndizovuta kwambiri, zomwe zimafuna ukadaulo wa Medulloblastoma biology, sayansi yazakudya, majini, biochemistry komanso kumvetsetsa bwino momwe chithandizo cha khansa chimagwirira ntchito komanso zovuta zina zomwe mankhwalawo angasiye kugwira ntchito.

ZOCHEPA ZODZIWA ZOCHEPA ZOFUNIKA KUTI MUZITHANDIZA KUKHALA KWA MANKHWALA A KANSA NDI: CANCER BIOLOGY, FOOD SAYANSI, MANKHWALA A KANSA NDI MA GENETICS.

Makhalidwe a khansa monga Medulloblastoma

Makhansa onse monga Medulloblastoma amatha kudziwika ndi njira zapadera za biochemical - njira zosayina za Medulloblastoma. Njira zama biochemical monga kukonza kwa DNA, Angiogenesis, Oncogenic Histone Methylation, Epithelial to Mesenchymal Transition ndi gawo la tanthauzo la siginecha ya Medulloblastoma. Mitundu ya khansa ya munthu aliyense imatha kukhala yosiyana chifukwa chake siginecha yawo yeniyeni ya khansa imatha kukhala yapadera.

Chithandizo chomwe chili chothandiza pa Medulloblastoma chikuyenera kuzindikirika ndi ma signature a biochemical omwe amagwirizana nawo kwa wodwala khansa aliyense komanso munthu yemwe ali pachiwopsezo cha majini. Choncho mankhwala osiyanasiyana omwe ali ndi njira zosiyanasiyana zochitira zinthu ndi othandiza kwa odwala osiyanasiyana. Momwemonso komanso pazifukwa zomwezo zakudya ndi zowonjezera ziyenera kukhala zamunthu aliyense payekhapayekha. Chifukwa chake zakudya zina ndi zowonjezera zimalimbikitsidwa kwa Medulloblastoma mukamamwa mankhwala a khansa ya Temozolomide, ndipo zakudya zina ndi zowonjezera sizovomerezeka.

Magwero ngati cBioPortal ndipo ena ambiri amapereka deta yosadziwika ya odwala omwe ali ndi chiwerengero cha anthu omwe amachokera ku mayesero a zachipatala pa zizindikiro zonse za khansa. Izi zili ndi tsatanetsatane wa kafukufuku wazachipatala monga kukula kwa zitsanzo / kuchuluka kwa odwala, magulu azaka, jenda, fuko, chithandizo, malo otupa ndi masinthidwe aliwonse.

PTCH1, TERT, DDX3X, KMT2D ndi CTNNB1 ndi majini omwe ali pamwamba pa Medulloblastoma. PTCH1 imanenedwa mu 6.3 % ya odwala oyimira m'mayesero onse azachipatala. Ndipo TERT imanenedwa mu 6.2%. Deta yophatikizidwa ya odwala imaphimba zaka kuyambira 1 mpaka 50. 62.3 % ya data ya odwala amadziwika kuti ndi amuna. Biology ya Medulloblastoma pamodzi ndi ma genetics omwe adanenedwa palimodzi amafotokozera kuchuluka kwazomwe zimayimiridwa ndi njira zama biochemical za khansa iyi. Ngati chibadwa cha khansa ya munthu kapena majini omwe amathandizira pachiwopsezo amadziwikanso ndiye kuti ayenera kugwiritsidwanso ntchito pakusintha zakudya.

ZOSANKHA ZA KALERE ZIYENERA KUGWIRITSA NTCHITO NDI SIZINI YA KANSA YA MUNTHU ALIYENSE.

Zakudya ndi Zowonjezera za Medulloblastoma

Kwa Odwala Khansa

Odwala khansa omwe ali ndi chithandizo chamankhwala kapena ochepetsa chithandizo chamankhwala amayenera kupanga zisankho pazakudya ndi zowonjezera - pazakudya zopatsa thanzi, kuthana ndi zovuta zilizonse komanso kuwongolera kasamalidwe ka khansa. Zakudya zonse zozikidwa pamasamba sizofanana ndipo kusankha ndikuyika patsogolo zakudya zomwe zimasankhidwa payekhapayekha komanso zomwe zimasinthidwa kuti zigwiritsidwe ntchito ndi khansa ndizofunikira komanso zovuta. Nazi zitsanzo zopereka malangizo opangira zisankho za kadyedwe.

Sankhani Masamba NEW ZEALAND SPINACH kapena JERUSALEM ARTICHOKE?

Masamba a New Zealand Sipinachi ali ndi zinthu zambiri zogwira ntchito kapena bioactives monga Quercetin, Curcumin, Isoliquiritigenin, Apigenin, Lycopene. Zosakaniza zogwira izi zimagwiritsa ntchito njira zosiyanasiyana zama biochemical monga Kukula kwa Factor Signaling, Hypoxia, NFKB Signaling ndi Focal Adhesion ndi ena. Sipinachi ya ku New Zealand imalimbikitsidwa kuti ikhale ya Medulloblastoma pamene chithandizo cha khansa chopitirira ndi Temozolomide. Izi ndichifukwa chakuti Sipinachi ya New Zealand imasintha njira za biochemical zomwe zanenedwa mwasayansi kuti zidziwitse zotsatira za Temozolomide.

Zina mwazinthu zomwe zimagwira ntchito kapena bioactives mu masamba a Jerusalem Artichoke ndi Curcumin, Isoliquiritigenin, Apigenin, Formononetin, Phloretin. Zosakaniza zogwira izi zimagwiritsa ntchito njira zosiyanasiyana zama biochemical monga kukonza DNA ndi TGFB Signaling ndi ena. Jerusalem Artichoke siyovomerezeka kwa Medulloblastoma pamene chithandizo cha khansa chikupitirirabe ndi Temozolomide chifukwa chimasintha njira za biochemical zomwe zimapangitsa kuti chithandizo cha khansa zisawonongeke kapena kuti chisamayankhe.

MASANGALA NEW ZEALAND SPINACH AMAKONZEDWA PA YERUSALEM ARTICHOKE PA Medulloblastoma NDI Mchiritsi wa Temozolomide.

Sankhani Chipatso RED RASPBERRY kapena PUMMELO?

Chipatso Chofiira Rasipiberi chili ndi zinthu zambiri zogwira ntchito kapena bioactives monga Quercetin, Ellagic Acid, Curcumin, Isoliquiritigenin, Formononetin. Zosakaniza zogwira izi zimagwiritsa ntchito njira zosiyanasiyana zama biochemical monga MAPK Signaling, NFKB Signaling, Focal Adhesion ndi Oxidative Stress ndi ena. Red Rasipiberi akulimbikitsidwa Medulloblastoma pamene chithandizo cha khansa chopitirira ndi Temozolomide. Izi ndichifukwa choti Rasipiberi Wofiira amasintha njira zama biochemical zomwe zanenedwa mwasayansi kuti zidziwitse zotsatira za Temozolomide.

Zina mwazinthu zogwira ntchito kapena bioactives mu zipatso Pummelo ndi Quercetin, Curcumin, Isoliquiritigenin, Apigenin, Lycopene. Zosakaniza zogwira izi zimagwiritsa ntchito njira zosiyanasiyana zama biochemical monga DNA Repair ndi Oxidative Stress ndi zina. Pummelo sivomerezedwa kwa Medulloblastoma pamene chithandizo cha khansa chikupitirirabe ndi Temozolomide chifukwa chimasintha njira za biochemical zomwe zimapangitsa kuti chithandizo cha khansa chisagwirizane kapena chisamayankhe.

CHIPATSO CHOFIIRA RASPBERRY AMAKONZEDWA PA PUMMELO KWA Medulloblastoma NDI MACHIRITSO Temozolomide.

Sankhani Nut BUTTERNUT kapena EUROPEAN CHESTNUT?

Butternut imakhala ndi zinthu zambiri zogwira ntchito kapena bioactives monga Curcumin, Isoliquiritigenin, Apigenin, Lycopene, Formononetin. Zosakaniza zogwira izi zimagwiritsa ntchito njira zosiyanasiyana zama biochemical monga MAPK Signaling, DNA Repair, NFKB Signaling ndi Focal Adhesion ndi ena. Butternut akulimbikitsidwa Medulloblastoma pamene chithandizo cha khansa chopitirira ndi Temozolomide. Izi ndichifukwa choti Butternut imasintha njira zama biochemical zomwe zanenedwa mwasayansi kuti zidziwitse zotsatira za Temozolomide.

Zina mwazinthu zomwe zimagwira ntchito kapena bioactives mu European Chestnut ndi Quercetin, Ellagic Acid, Curcumin, Isoliquiritigenin, Apigenin. Zosakaniza zogwira izi zimagwiritsa ntchito njira zosiyanasiyana zama biochemical monga kukonza DNA ndi TGFB Signaling ndi ena. European Chestnut siyovomerezeka kwa Medulloblastoma pamene chithandizo cha khansa chikupitirirabe ndi Temozolomide chifukwa chimasintha njira za biochemical zomwe zimapangitsa kuti chithandizo cha khansa zisawonongeke kapena kuti chisamayankhe.

BUTTERNUT AMAKONZEDWA PA CHESTNUT YA KU ULAYA PA Medulloblastoma NDI Mchiritsi wa Temozolomide.

Kwa Anthu Amene Ali ndi Genetic Risk of Cancer

Funso lofunsidwa ndi anthu omwe ali ndi chiopsezo cha chibadwa cha Medulloblastoma kapena mbiri ya banja ndi "Kodi Ndiyenera Kudya Chiyani Mosiyana ndi Kale?" ndi momwe angasankhire zakudya ndi zowonjezera kuti athe kuthana ndi kuopsa kwa matendawa. Popeza pachiwopsezo cha khansa palibe chomwe chingachitike pankhani ya chithandizo - zisankho zazakudya ndi zowonjezera zimakhala zofunika komanso chimodzi mwazinthu zochepa zomwe zingatheke. Zakudya zonse zochokera ku zomera sizofanana ndipo zimatengera chibadwa chodziwika ndi siginecha ya njira - zosankha za zakudya ndi zowonjezera ziyenera kukhala zaumwini.

Sankhani Masamba GIANT BUTTERBUR kapena OSTRICH FERN?

Masamba a Giant Butterbur ali ndi zinthu zambiri zogwira ntchito kapena bioactives monga Curcumin, Apigenin, Formononetin, Lupeol, Beta-sitosterol. Zosakaniza zogwira izi zimagwiritsa ntchito njira zosiyanasiyana zama biochemical monga RAS-RAF Signaling, JAK-STAT Signaling, Oncogenic Cancer Epigenetics ndi PI3K-AKT-MTOR Signaling ndi ena. Giant Butterbur ikulimbikitsidwa kuti ikhale pachiwopsezo cha Medulloblastoma pomwe chiwopsezo chokhudzana ndi majini ndi CTNNB1. Izi ndichifukwa choti Giant Butterbur imakulitsa njira za biochemical zomwe zimatsutsana ndi oyendetsa siginecha ake.

Zina mwazinthu zomwe zimagwira ntchito kapena bioactives mu masamba a Nthiwatiwa Fern ndi Curcumin, Apigenin, Formononetin, Lupeol, Beta-sitosterol. Zosakaniza zogwira izi zimagwiritsa ntchito njira zosiyanasiyana zama biochemical monga Oncogenic Cancer Epigenetics, WNT Beta Catenin Signaling ndi Stem Cell Signaling ndi ena. Nthiwatiwa Fern ali osavomerezeka pamene chiopsezo cha Medulloblastoma pamene kugwirizana chibadwa chiopsezo ndi CTNNB1 chifukwa kumawonjezera siginecha njira zake.

MANKHWALA WABWINO WA MASOMBE AKUTHANDIZANI KUPANDA NTWACHITO FERN PA CTNNB1 GENETIC RISK OF CANCER.

Sankhani Zipatso NANCE kapena SUMMER GRAPE?

Zipatso za Nance zili ndi zinthu zambiri zogwira ntchito kapena bioactives monga Curcumin, Apigenin, Formononetin, Betulinic Acid, Lupeol. Zosakaniza zogwira izi zimagwiritsa ntchito njira zosiyanasiyana zama biochemical monga RAS-RAF Signaling, JAK-STAT Signaling, Oncogenic Cancer Epigenetics ndi PI3K-AKT-MTOR Signaling ndi ena. Nance akulimbikitsidwa pa chiopsezo cha Medulloblastoma pamene chiopsezo cha majini ndi CTNNB1. Izi ndichifukwa choti Nance amawonjezera njira za biochemical zomwe zimatsutsana ndi oyendetsa siginecha ake.

Zina mwazinthu zomwe zimagwira ntchito kapena bioactives mu zipatso za Chilimwe Mphesa ndi Curcumin, Apigenin, Formononetin, Lupeol, Beta-sitosterol. Zosakaniza zogwira izi zimagwiritsa ntchito njira zosiyanasiyana zama biochemical monga Oncogenic Cancer Epigenetics, WNT Beta Catenin Signaling ndi Stem Cell Signaling ndi ena. Mphesa za Chilimwe ndizosavomerezeka ngati chiopsezo cha Medulloblastoma chikugwirizana ndi chiwopsezo cha chibadwa ndi CTNNB1 chifukwa chimawonjezera njira zake.

FRUIT NANCE AKUKONZEDWA PA MPHESA WA CHILIMWE PA CTNNB1 GENETIC RISK OF CANCER.

Sankhani Nut CHIA kapena JAPANESE WALNUT?

Chia ili ndi zinthu zambiri zogwira ntchito kapena bioactives monga Curcumin, Apigenin, Formononetin, Lupeol, Beta-sitosterol. Zosakaniza zogwira izi zimagwiritsa ntchito njira zosiyanasiyana zama biochemical monga Cell Cycle Checkpoints, RAS-RAF Signaling, Oncogenic Cancer Epigenetics ndi PI3K-AKT-MTOR Signaling ndi ena. Chia akulimbikitsidwa pangozi ya Medulloblastoma pamene chiopsezo cha majini ndi CTNNB1. Izi ndichifukwa choti Chia imawonjezera njira zama biochemical zomwe zimatsutsana ndi oyendetsa siginecha ake.

Zina mwazinthu zomwe zimagwira ntchito kapena bioactives mu Walnut waku Japan ndi Curcumin, Apigenin, Formononetin, Lupeol, Beta-sitosterol. Zosakaniza zogwira izi zimagwiritsa ntchito njira zosiyanasiyana zama biochemical monga Oncogenic Cancer Epigenetics, WNT Beta Catenin Signaling ndi Stem Cell Signaling ndi ena. Walnut waku Japan sizovomerezeka ngati chiwopsezo cha Medulloblastoma chikugwirizana ndi chiwopsezo cha chibadwa ndi CTNNB1 chifukwa chimawonjezera ma signature awo.

CHIA AKUYAMBIRA PA WALNUT WA KU JAPANESE PA CTNNB1 GENETIC RISK OF CANCER.

Pomaliza

Zakudya ndi Zowonjezera zomwe zasankhidwa ndizofunikira pa khansa monga Medulloblastoma. Odwala a Medulloblastoma komanso anthu omwe ali pachiwopsezo cha majini nthawi zonse amakhala ndi funso ili: "Ndi zakudya ziti ndi zakudya zowonjezera zomwe zimandilimbikitsa komanso zomwe sizili?" Pali chikhulupiliro chofala chomwe ndi lingaliro lolakwika kuti zakudya zonse zokhala ndi mbewu zitha kukhala zopindulitsa kapena ayi koma sizingakhale zovulaza. Zakudya zina ndi zowonjezera zimatha kusokoneza chithandizo cha khansa kapena kulimbikitsa madalaivala a khansa.

Pali mitundu yosiyanasiyana yazizindikiro za khansa monga Medulloblastoma, iliyonse ili ndi ma genetic chotupa chosiyana ndi ma genomic osiyanasiyana pamunthu aliyense. Kuphatikiza apo, chithandizo chilichonse cha khansa ndi chemotherapy chili ndi njira yapadera yochitira. Chakudya chilichonse monga New Zealand Sipinachi chimakhala ndi ma bioactive osiyanasiyana mosiyanasiyana, omwe amakhudza njira zosiyanasiyana zama biochemical. Tanthauzo la zakudya zamunthu payekhapayekha ndi malingaliro amunthu payekhapayekha pazowonetsa khansa, machiritso, ma genetic, moyo ndi zina. Zosankha zokhudzana ndi thanzi la khansa zimafuna kudziwa za biology ya khansa, sayansi yazakudya komanso kumvetsetsa kwamankhwala osiyanasiyana a chemotherapy. Pomaliza pakakhala kusintha kwamankhwala kapena ma genomics atsopano azindikirika - kusintha kwa zakudya kumafunika kuunikanso.

Njira yothetsera makonda a addon imapangitsa kupanga chisankho kukhala kosavuta ndikuchotsa zongoyerekeza poyankha funso, "Ndi zakudya ziti zomwe ndiyenera kusankha kapena kusasankha Medulloblastoma?". Gulu la addon lamitundu yambiri limaphatikizapo madokotala a khansa, asayansi azachipatala, akatswiri opanga mapulogalamu ndi asayansi a data.

Zothandizira

• Brain Cptac 2020
• Pan-cancer kusanthula ma genomes onse.
• Zotsatira za isoliquiritigenin pama cell a khansa ya ovarian.
• Citrus flavonoid naringenin imathandizira kukonza DNA m'maselo a khansa ya prostate.
• Daidzein imakhudzanso khansa ya prostate ya refractory mu vitro komanso mu vivo poyerekeza ndi genistein ndi soya: kuthekera kwa radiotherapy.
• Retinol imachepetsa kuchuluka kwa mapuloteni a beta-catenin mu cell cell retinoic acid-resistant colon cancer cell.
• https://www.cancer.gov/rare-brain-spine-tumor/tumors/medulloblastoma
• Eibl T et al, Kukalamba (Albany NY), 2021
• https://my.clevelandclinic.org/health/diseases/22591-medulloblastoma
• https://www.cancer.gov/rare-brain-spine-tumor/tumors/medulloblastoma#:~:text=Medulloblastoma%20Prognosis,how%20they%20respond%20to%20treatment