Zakudya za Melanoma!

Introduction

Zakudya za Melanoma ziyenera kukhala zamunthu aliyense payekhapayekha komanso zimayenera kusintha ngati chithandizo cha khansa kapena chotupa chikusintha. Kusintha kwamunthu ndikusintha kuyenera kuganizira zonse zomwe zimagwira ntchito kapena ma bioactive omwe ali muzakudya zosiyanasiyana molingana ndi biology ya khansa, majini, chithandizo, moyo komanso zomwe amakonda. Chifukwa chake ngakhale zakudya ndi chimodzi mwazosankha zofunika kwambiri kwa wodwala khansa komanso munthu yemwe ali pachiwopsezo cha khansa - momwe angasankhire zakudya zomwe angadye si ntchito yophweka.

Melanoma ndi mtundu wa khansa yapakhungu yomwe imachokera ku melanocytes, maselo omwe amapanga pigment. Ndi khansa yapakhungu yoopsa kwambiri ndipo imatha kufalikira mofulumira ku ziwalo zina za thupi ngati isiyanitsidwa. Matenda a melanoma amathanso kupanga m'diso lotchedwa ocular melanoma komanso mkati mwa mphuno, mkamwa, mmero, kumaliseche kapena kumatako komwe kumadziwika kuti mucosal melanoma. Zizindikiro za melanoma zingaphatikizepo kusintha kwa mawonekedwe, mtundu, kapena kukula kwa ma moles omwe alipo, maonekedwe a ma moles atsopano, kapena kukula kwa zilonda zomwe sizichira. Chithandizo cha melanoma chimadalira pa siteji ndipo chitha kuphatikizira opaleshoni, chithandizo cha radiation, chemotherapy, kapena chithandizo chomwe mukufuna. Ndikofunikira kudziwa zinthu zomwe zimayambitsa khansa ya melanoma, kuphatikizapo chibadwa komanso kutenthedwa ndi dzuwa, komanso kusamala monga kuvala zodzitetezera ku dzuwa ndi zovala zoteteza. Kudzifufuza nthawi zonse, komanso kudzifufuza nthawi zonse ndi dermatologist, kungathandize kuti azindikire msanga komanso kusintha moyo wa melanoma.

Kwa Melanoma kodi zili ndi masamba, zipatso, mtedza, mbewu zomwe munthu amadya?

Funso lodziwika bwino lazakudya lomwe limafunsidwa ndi odwala khansa komanso anthu omwe ali pachiwopsezo cha khansa ndi - la khansa ngati Melanoma, kodi zilibe kanthu kuti ndi zakudya ziti zomwe ndimadya komanso zomwe sindidya? Kapena ngati nditsatira zakudya zochokera ku zomera ndizokwanira khansa ngati Melanoma?

Mwachitsanzo, kodi zilibe kanthu ngati Kolifulawa wamasamba amadyedwa kwambiri poyerekeza ndi American Pokeweed? Kodi pali kusiyana kulikonse ngati zipatso za Malabar Plum zimakonda kuposa Black Mulberry? Komanso ngati kusankha kofananako kumapangidwira mtedza/mbewu monga Butternut pa European Chestnut komanso zamasamba monga Broad Bean over Pigeon Pea. Ndipo ngati zomwe ndimadya zili ndi vuto - ndiye kuti munthu angadziwe bwanji zakudya zomwe zimalimbikitsidwa ku Melanoma ndipo ndi yankho lomwelo kwa aliyense yemwe ali ndi matenda omwewo kapena chiwopsezo cha chibadwa?

Inde! Zakudya zomwe mumadya ndizofunikira pa Melanoma!

Malingaliro a zakudya sangakhale ofanana kwa aliyense ndipo akhoza kukhala osiyana ngakhale pa matenda omwewo komanso chiopsezo cha majini.

Zakudya zonse (masamba, zipatso, mtedza, mbewu, phala, mafuta ndi zina) ndi zakudya zopatsa thanzi zimapangidwa ndi mamolekyulu opitilira imodzi kapena zogwira ntchito mosiyanasiyana komanso kuchuluka kwake. Chilichonse chogwiritsidwa ntchito chimakhala ndi njira yapadera yochitirapo kanthu - yomwe imatha kuyambitsa kapena kuletsa njira zosiyanasiyana zama biochemical. Zakudya zongotchulidwa mwachidule ndi zowonjezera zomwe zimalimbikitsidwa ndizomwe sizimayambitsa kuchuluka kwa maselo oyambitsa khansa koma zimawachepetsa. Apo ayi zakudya zimenezo siziyenera kuvomerezedwa. Zakudya zimakhala ndi zosakaniza zingapo zomwe zimagwira ntchito - chifukwa chake powunika zakudya ndi zowonjezera, muyenera kuganizira momwe zosakaniza zonse zimakhudzira thupi limodzi osati payekhapayekha.

Mwachitsanzo Malabar Plum ili ndi zinthu zogwira ntchito Myricetin, Lycopene, Curcumin, Isoliquiritigenin, Cinnamaldehyde. Ndipo Black Mulberry imakhala ndi zinthu zomwe zimagwira ntchito monga Quercetin, Myricetin, Curcumin, Isoliquiritigenin, Cinnamaldehyde ndipo mwina ena.

Kulakwitsa kofala komwe kumachitika posankha ndikusankha zakudya zoyenera kudya chifukwa cha Melanoma - ndikuwunika zomwe zasankhidwa zokha zomwe zili muzakudya ndikunyalanyaza zina. Chifukwa zosakaniza zosiyanasiyana zomwe zili muzakudya zitha kukhala ndi zotsatira zotsutsana ndi oyendetsa khansa - simungathe kusankha zosakaniza muzakudya ndi zowonjezera kuti mupange chisankho chazakudya cha Melanoma.

INDE - ZOSANKHA CHAKUDYA NDINKHANI PA KANSA. ZINSINSI ZA KALERE ZIYENERA KUGANIZIRA ZONSE ZONSE ZOKHUDZA ZOKHUDZA ZAKUDYA.

Maluso Ofunika Pakukonza Chakudya Chake cha Melanoma?

Zakudya zokometsera zamakhansa ngati Melanoma zimakhala ndi zakudya / zowonjezera; zakudya zosavomerezeka / zowonjezera zomwe zili ndi maphikidwe achitsanzo omwe amaika patsogolo kugwiritsa ntchito zakudya zoyenera. Chitsanzo cha kadyedwe kake kamakonda kuwoneka pa izi kugwirizana.

Kusankha zakudya zomwe zikulimbikitsidwa kapena ayi ndizovuta kwambiri, zomwe zimafuna ukadaulo wa Melanoma biology, sayansi yazakudya, majini, biochemistry komanso kumvetsetsa bwino momwe chithandizo cha khansa chimagwirira ntchito komanso zovuta zina zomwe chithandizocho chingasiye kugwira ntchito.

ZOCHEPA ZODZIWA ZOCHEPA ZOFUNIKA KUTI MUZITHANDIZA KUKHALA KWA MANKHWALA A KANSA NDI: CANCER BIOLOGY, FOOD SAYANSI, MANKHWALA A KANSA NDI MA GENETICS.

Makhalidwe a khansa ngati Melanoma

Makhansa onse ngati Melanoma amatha kudziwika ndi njira zapadera zama biochemical - njira zosainira za Melanoma. Njira zama biochemical monga RAS-RAF Signaling, Inositol Phosphate Signaling, Extracellular Matrix Remodelling, Focal Adhesion ndi gawo la siginecha ya Melanoma. Mitundu ya khansa ya munthu aliyense imatha kukhala yosiyana chifukwa chake siginecha yawo yeniyeni ya khansa imatha kukhala yapadera.

Chithandizo chomwe chili chothandiza kwa Melanoma chikuyenera kuzindikirika ndi ma signature a biochemical omwe amalumikizana nawo kwa wodwala khansa aliyense komanso munthu yemwe ali pachiwopsezo cha majini. Choncho mankhwala osiyanasiyana omwe ali ndi njira zosiyanasiyana zochitira zinthu ndi othandiza kwa odwala osiyanasiyana. Momwemonso komanso pazifukwa zomwezo zakudya ndi zowonjezera ziyenera kukhala zamunthu aliyense payekhapayekha. Chifukwa chake zakudya zina ndi zowonjezera zimalimbikitsidwa ku Melanoma mukamamwa mankhwala a khansa ya Dabrafenib, ndipo zakudya zina ndi zowonjezera sizovomerezeka.

Magwero ngati cBioPortal ndipo ena ambiri amapereka deta yosadziwika ya odwala omwe ali ndi chiwerengero cha anthu omwe amachokera ku mayesero a zachipatala pa zizindikiro zonse za khansa. Izi zili ndi tsatanetsatane wa kafukufuku wazachipatala monga kukula kwa zitsanzo / kuchuluka kwa odwala, magulu azaka, jenda, fuko, chithandizo, malo otupa ndi masinthidwe aliwonse.

MUC16, BRAF, APOB, MGAM ndi NRAS ndi omwe ali pamwamba pa jini za melanoma. MUC16 imanenedwa mu 7.5 % ya odwala oyimira m'mayesero onse azachipatala. Ndipo BRAF imanenedwa mu 4.9%. Deta yophatikizidwa ya odwala imaphimba zaka kuyambira 5 mpaka 90. 62.8 % ya data ya odwala amadziwika kuti ndi amuna. Biology ya Melanoma pamodzi ndi ma genetics omwe adanenedwa palimodzi amafotokozera kuchuluka kwazomwe zimayimiridwa ndi njira zama biochemical za khansa iyi. Ngati chibadwa cha khansa ya munthu kapena majini omwe amathandizira pachiwopsezo amadziwikanso ndiye kuti ayenera kugwiritsidwanso ntchito pakusintha zakudya.

ZOSANKHA ZA KALERE ZIYENERA KUGWIRITSA NTCHITO NDI SIZINI YA KANSA YA MUNTHU ALIYENSE.

Zakudya ndi Zowonjezera za Melanoma

Kwa Odwala Khansa

Odwala khansa omwe ali ndi chithandizo chamankhwala kapena ochepetsa chithandizo chamankhwala amayenera kupanga zisankho pazakudya ndi zowonjezera - pazakudya zopatsa thanzi, kuthana ndi zovuta zilizonse komanso kuwongolera kasamalidwe ka khansa. Zakudya zonse zozikidwa pamasamba sizofanana ndipo kusankha ndikuyika patsogolo zakudya zomwe zimasankhidwa payekhapayekha komanso zomwe zimasinthidwa kuti zigwiritsidwe ntchito ndi khansa ndizofunikira komanso zovuta. Nazi zitsanzo zopereka malangizo opangira zisankho za kadyedwe.

Sankhani Masamba a CAULIFLOWER kapena AMERICAN POKEWEED?

Kolifulawa wamasamba ali ndi zinthu zambiri zogwira ntchito kapena bioactives monga Curcumin, Isoliquiritigenin, Cinnamaldehyde, Formononetin, Phloretin. Zosakaniza zogwira izi zimagwiritsa ntchito njira zosiyanasiyana zama biochemical monga MAPK Signaling, RAS-RAF Signaling, Amino Acid Metabolism ndi PI3K-AKT-MTOR Signaling ndi ena. Kolifulawa amalangizidwa ku Melanoma pamene chithandizo cha khansa chopitilira ndi Dabrafenib. Izi zili choncho chifukwa Kolifulawa amasintha njira za biochemical zomwe zanenedwa mwasayansi kuti zidziwitse zotsatira za Dabrafenib.

Zina mwazinthu zomwe zimagwira ntchito kapena bioactives mu masamba a American Pokeweed ndi Quercetin, Myricetin, Curcumin, Isoliquiritigenin, Cinnamaldehyde. Zosakaniza zogwira izi zimagwiritsa ntchito njira zosiyanasiyana zama biochemical monga DNA Repair ndi Oxidative Stress ndi zina. American Pokeweed siyovomerezeka kwa Melanoma pamene chithandizo cha khansa chikupitirirabe ndi Dabrafenib chifukwa chimasintha njira za biochemical zomwe zimapangitsa kuti chithandizo cha khansa zisawonongeke kapena kuti chisamayankhe.

KAULIFWA WA MASOMPHENYA NDI MANKHWALALA PA POKEWEED YA AMERICAN PA Matenda a Melanoma NDI MALANGIZO A Dabrafenib.

Sankhani Zipatso BLACK MULBERRY kapena MALABAR PLUM?

Zipatso za Black Mabulosi zimakhala ndi zinthu zambiri zogwira ntchito kapena bioactives monga Quercetin, Myricetin, Curcumin, Isoliquiritigenin, Cinnamaldehyde. Zosakaniza zogwira izi zimagwiritsa ntchito njira zosiyanasiyana zama biochemical monga MAPK Signaling, DNA Repair, Growth Factor Signaling ndi Epithelial to Mesenchymal Transition ndi ena. Black Mabulosi amalimbikitsidwa ku Melanoma pamene chithandizo cha khansa chopitilira ndi Dabrafenib. Izi zili choncho chifukwa Black Mulberry imasintha njira za biochemical zomwe zanenedwa mwasayansi kuti zidziwitse zotsatira za Dabrafenib.

Zina mwazinthu zomwe zimagwira ntchito kapena bioactives mu zipatso Malabar Plum ndi Myricetin, Lycopene, Curcumin, Isoliquiritigenin, Cinnamaldehyde. Zosakaniza zogwira izi zimagwiritsa ntchito njira zosiyanasiyana zama biochemical monga DNA Repair ndi Oxidative Stress ndi zina. Malabar Plum ndiyosavomerezeka kwa Melanoma pamene chithandizo cha khansa chikupitilira ndi Dabrafenib chifukwa chimasintha njira zama biochemical zomwe zimapangitsa kuti chithandizo cha khansa zisamve kapena kuyankha.

MALABAR PLUM WA CHIPATSO WAKUDA WA CHIPATSO NDI MALANGIZO OTHANDIZA Dabrafenib.

Sankhani Nut BUTTERNUT kapena EUROPEAN CHESTNUT?

Butternut imakhala ndi zinthu zambiri zogwira ntchito kapena bioactives monga Myricetin, Lycopene, Curcumin, Isoliquiritigenin, Cinnamaldehyde. Zosakaniza zogwira izi zimagwiritsa ntchito njira zosiyanasiyana zama biochemical monga MAPK Signaling, DNA Repair ndi Insulin Signaling ndi ena. Butternut akulimbikitsidwa ku Melanoma pamene chithandizo cha khansa chopitilira ndi Dabrafenib. Izi zili choncho chifukwa Butternut amasintha njira za biochemical zomwe zanenedwa mwasayansi kuti zidziwitse zotsatira za Dabrafenib.

Zina mwazinthu zomwe zimagwira ntchito kapena bioactives mu European Chestnut ndi Quercetin, Ellagic Acid, Myricetin, Curcumin, Isoliquiritigenin. Zosakaniza zogwira izi zimagwiritsa ntchito njira zosiyanasiyana zama biochemical monga kukonza DNA, WNT Beta Catenin Signaling, Epithelial to Mesenchymal Transition ndi Oxidative Stress ndi ena. European Chestnut sivomerezedwa ku Melanoma pamene chithandizo cha khansa chikupitirirabe ndi Dabrafenib chifukwa chimasintha njira za biochemical zomwe zimapangitsa kuti chithandizo cha khansa chisamve kapena kuyankha.

BUTTERNUT AMADALITSIDWA PA CHESTNUT YA KU ULAYA PA MANKHWALA A MANKHWALA NDI MANKHWALA A Dabrafenib.

Kwa Anthu Amene Ali ndi Genetic Risk of Cancer

Funso lofunsidwa ndi anthu omwe ali ndi chiopsezo cha chibadwa cha melanoma kapena mbiri ya banja ndi "Kodi Ndiyenera Kudya Chiyani Mosiyana ndi Kale?" ndi momwe angasankhire zakudya ndi zowonjezera kuti athe kuthana ndi kuopsa kwa matendawa. Popeza pachiwopsezo cha khansa palibe chomwe chingachitike pankhani ya chithandizo - zosankha zazakudya ndi zowonjezera zimakhala zofunika komanso chimodzi mwazinthu zochepa zomwe zingatheke. Zakudya zonse zochokera ku zomera sizofanana ndipo zimatengera chibadwa chodziwika ndi siginecha ya njira - zosankha za zakudya ndi zowonjezera ziyenera kukhala zaumwini.

Sankhani Masamba GIANT BUTTERBUR kapena TURNIP?

Masamba a Giant Butterbur ali ndi zinthu zambiri zogwira ntchito kapena bioactives monga Apigenin, Curcumin, Myricetin, Lycopene, Lupeol. Zosakaniza zogwira izi zimagwiritsa ntchito njira zosiyanasiyana zama biochemical monga Kuzindikiritsa kwa MAPK, Kuwonetsa kwa RAS-RAF, Kuyika kwa MYC ndi PI3K-AKT-MTOR Signaling ndi ena. Giant Butterbur ikulimbikitsidwa kuti ikhale pachiwopsezo cha Melanoma pomwe chiwopsezo chokhudzana ndi majini ndi APOB. Izi ndichifukwa choti Giant Butterbur imakulitsa njira za biochemical zomwe zimatsutsana ndi oyendetsa siginecha ake.

Zina mwazinthu zomwe zimagwira ntchito kapena bioactives mu Turnip ya masamba ndi Ellagic Acid, Curcumin, Quercetin, Lupeol, Daidzein. Zosakaniza zogwira izi zimagwiritsa ntchito njira zosiyanasiyana zama biochemical monga MAPK Signaling, Cell Cycle ndi PI3K-AKT-MTOR Signaling ndi ena. Turnip sivomerezedwa ngati chiwopsezo cha melanoma chikugwirizana ndi chiwopsezo cha chibadwa cha APOB chifukwa chimawonjezera njira zake.

MANKHWALA WABWINO WABWINO KWAMBIRI AKUKONZEDWA PAMENE NTCHITO YA APOB GENETIC RISK OF CANCER.

Sankhani Chipatso RED RASPBERRY kapena PUMMELO?

Chipatso Chofiira cha Rasipiberi chili ndi zinthu zambiri zogwira ntchito kapena bioactives monga Ellagic Acid, Curcumin, Quercetin, Lupeol, Daidzein. Zosakaniza zogwira izi zimagwiritsa ntchito njira zosiyanasiyana zama biochemical monga MAPK Signaling, RAS-RAF Signaling, Growth Factor Signaling ndi PI3K-AKT-MTOR Signaling ndi ena. Rasipiberi Wofiyira akulimbikitsidwa pachiwopsezo cha Melanoma pomwe chiwopsezo chokhudzana ndi majini ndi APOB. Izi ndichifukwa choti Red Rasipiberi imawonjezera njira zama biochemical zomwe zimatsutsana ndi oyendetsa siginecha ake.

Zina mwazinthu zomwe zimagwira ntchito kapena bioactives mu chipatso Pummelo ndi Apigenin, Curcumin, Quercetin, Lycopene, Lupeol. Zosakaniza zogwira izi zimagwiritsa ntchito njira zosiyanasiyana zama biochemical monga Cell Cycle Checkpoints ndi Extracellular Matrix Remodeling ndi ena. Pummelo sivomerezedwa ngati chiwopsezo cha melanoma chikugwirizana ndi chiwopsezo cha chibadwa cha APOB chifukwa chimawonjezera njira zake.

FRUIT RED RASPBERRY NDIKONDIKONZEDWA PA PUMMELO PA APOB GENETIC RISK OF CANCER.

Sankhani Mtedza COMMON HAZELNUT kapena MACADAMIA NUT?

Hazelnut Wamba imakhala ndi zinthu zambiri zogwira ntchito kapena bioactives monga Curcumin, Quercetin, Myricetin, Lycopene, Lupeol. Zosakaniza zogwira izi zimagwiritsa ntchito njira zosiyanasiyana zama biochemical monga MAPK Signaling, RAS-RAF Signaling, Growth Factor Signaling ndi PI3K-AKT-MTOR Signaling ndi ena. Mtedza Wamba wa Hazelnut umalimbikitsidwa kuti ukhale pachiwopsezo cha Melanoma pomwe chiwopsezo cha chibadwa ndi APOB. Izi ndichifukwa choti Common Hazelnut imachulukitsa njira zama biochemical zomwe zimatsutsana ndi madalaivala ake.

Zina mwazinthu zomwe zimagwira ntchito kapena bioactives mu Macadamia Nut ndi Apigenin, Curcumin, Myricetin, Lupeol, Daidzein. Zosakaniza zogwira izi zimagwiritsa ntchito njira zosiyanasiyana zama biochemical monga MAPK Signaling ndi PI3K-AKT-MTOR Signaling ndi ena. Mtedza wa Macadamia ndi wosavomerezeka ngati chiopsezo cha melanoma pamene chiwopsezo cha chibadwa ndi APOB chifukwa chimawonjezera njira zake.

COMMON HAZELNUT IKUKONZEDWA PA MACADAMIA NUT PA APOB GENETIC RISK OF CANCER.

Pomaliza

Zakudya ndi Zowonjezera zomwe zasankhidwa ndizofunikira kwambiri pa khansa ngati Melanoma. Odwala a melanoma komanso anthu omwe ali pachiwopsezo cha majini nthawi zonse amakhala ndi funso ili: "Ndi zakudya ziti ndi zakudya zowonjezera zomwe zimandilimbikitsa komanso zomwe sizili?" Pali chikhulupiliro chofala chomwe ndi lingaliro lolakwika kuti zakudya zonse zokhala ndi mbewu zitha kukhala zopindulitsa kapena ayi koma sizingakhale zovulaza. Zakudya zina ndi zowonjezera zimatha kusokoneza chithandizo cha khansa kapena kulimbikitsa madalaivala a khansa.

Pali mitundu yosiyanasiyana yazizindikiro za khansa monga Melanoma, iliyonse ili ndi chibadwa chosiyana cha chotupa chokhala ndi ma genomic osiyanasiyana pamunthu aliyense. Kuphatikiza apo, chithandizo chilichonse cha khansa ndi chemotherapy chili ndi njira yapadera yochitira. Chakudya chilichonse monga Kolifulawa chimakhala ndi ma bioactive osiyanasiyana mosiyanasiyana, omwe amakhudza njira zosiyanasiyana zama biochemical. Tanthauzo la zakudya zamunthu payekhapayekha ndi malingaliro amunthu payekhapayekha pazowonetsa khansa, machiritso, ma genetic, moyo ndi zina. Zosankha zokhudzana ndi thanzi la khansa zimafuna kudziwa za biology ya khansa, sayansi yazakudya komanso kumvetsetsa kwamankhwala osiyanasiyana a chemotherapy. Pomaliza pakakhala kusintha kwamankhwala kapena ma genomics atsopano azindikirika - kusintha kwa zakudya kumafunika kuunikanso.

Njira yothetsera makonda a addon imapangitsa kupanga zisankho kukhala kosavuta ndikuchotsa zongoganiza poyankha funso, "Ndi zakudya ziti zomwe ndiyenera kusankha kapena kusasankha Melanoma?". Gulu la addon lamitundu yambiri limaphatikizapo madokotala a khansa, asayansi azachipatala, akatswiri opanga mapulogalamu ndi asayansi a data.

Zothandizira

• Msonkhano wa 2018
• Curcuminoids Imapangitsa Mitundu Yogwira Ntchito ya Oxygen ndi Autophagy Kupititsa patsogolo Apoptosis mu Maselo a Khansa ya M'kamwa.
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• Kudya mabulosi 1-deoxynojirimycin kumateteza khansa yapakhungu mu mbewa.
• Brassinin Imapondereza Kuthekera Kwa Ma cell a Lung Carcinoma Kupyolera mu Kutsekedwa kwa PI3K/Akt/mTOR Signaling Cascade.
• Vitamini C amapha maselo a khansa ya chithokomiro kudzera mu kuletsa kwa ROS kwa MAPK/ERK ndi PI3K/AKT njira kudzera munjira zosiyanasiyana.
• Kupewa kwa butyric acid, nicotinamide, calcium glucarate yokha kapena kuphatikiza pa 7, 12-dimethylbenz (a) anthracene induced mouse skin tumorigenesis kudzera modulation of K-Ras-PI3K-AKTpathway and related micro RNAs.
• Kulimbikitsa kukula kwa maselo amtundu wa pulmonary adenocarcinoma ndi maselo ang'onoang'ono a epithelial airway ndi beta-carotene kudzera mu activation ya cAMP, PKA, CREB ndi ERK1/2.
• https://www.ncbi.nlm.nih.gov/books/NBK470409
• https://www.cancer.org/cancer/types/melanoma-skin-cancer/about/what-is-melanoma.html