Isi
Nnyocha ụlọ ọgwụ egosila na ọ dị mma iji mgbakwunye soy isoflavone Genistein yana njikọ kemoterapi FOLFOX n'ịgwọ ndị ọrịa cancer agba agba metastatic. Ijikọta ihe mgbakwunye Genistein na kemoterapi nwere ike ịkwalite nsonaazụ ọgwụgwọ kemoterapi FOLFOX na ndị ọrịa cancer colorectal metastatic.
Ọrịa Metastatic Colorectal
Metastatic Colorectal Cancer (mCRC) nwere amụma na-adịghị mma yana ndụ afọ 2 na-erughị 40% yana ndụ afọ ise na-erughị 5%, n'agbanyeghị nhọrọ ọgwụgwọ chemotherapy na-akpa ike. ( Akwụkwọ ntuziaka AJCC Cancer Staging, 10th Edn).
Metastatic Colorectal Cancer Usoro Chemotherapy
Usoro ọrịa cancer nke Metastatic Colorectal gụnyere 5-Fluorouracil yana ọgwụ platinum Oxaliplatin, yana ma ọ bụ na-enweghị antiangiogenic (na-egbochi nhazi arịa ọbara na tumor) Bevacizumab (Avastin). Usoro ọhụrụ gụnyere FOLFIRI (fluorouracil, leucovorin, irinotecan), FOLFOX (5-Fuorouracil, oxaliplatin), CAPOX (capecitabine, oxaliplatin) na FOLFOXIRI (fluorouracil, oxaliplatin, leucovorin, irinotecan) egosiwokwa ndị ọrịa mCRCsing .
N'ebe a, anyị ga-atụle usoro mCRC ama ama nke dị na ule ụlọ ọgwụ ma na-ewere dị irè megide Metastatic Colorectal Cancer (mCRC).
Ịrụ ọrụ FOLFOXIRI n'ime Ndị Ọrịa Cancer Metastatic Colorectal
Ọtụtụ ọmụmụ lekwasịrị anya na colorectal metastatic dị iche iche cancer usoro na arụmọrụ ha na ndị ọrịa mCRC. FOLFOXIRI bụ usoro ọgwụgwọ nchikota nke mbụ mCRC nke gụnyere fluorouracil, oxaliplatin, leucovorin na ngwakọta ọgwụ irinotecan. N'ime nnwale TRIBE, nke ebipụtara n'oge na-adịbeghị anya na 2020, mweghachi nke FOLFOXIRI na bevacizumab rụpụtara nsonaazụ kacha mma karịa FOLFIRI gbakwunyere bevacizumab mana enwere ohere nke nsi dị elu dị ka ogologo oge chemotherapy ka achọrọ yana enwere ọtụtụ mmetụta ọjọọ na ndị ọrịa dị otú ahụ. (Glynne-Jones R, et al. Lancet Oncology, 2020). Usoro a nke ijikọta ọgwụ ndị dị irè mana cytotoxic na ọgwụ antiangiogenic ewelitela ụfọdụ nchegbu maka ndị ọkà mmụta banyere oncology n'ihe gbasara nchekwa na nsi.
Nkọwa nke Meta-analysis: XELOX vs. FOLFOX na Metastatic Colorectal Cancer
Ọmụmụ ihe na 2016 site na Guo Y, et al. ma e jiri ya tụnyere ịdị irè nke capecitabine na fluorouracil, nke ọ bụla jikọtara ya na oxaliplatin, na ndị ọrịa mCRC na-ejikọta ya na chemotherapy.Guo, Yu et al. Nnyocha ọrịa kansa, 2016).
- A na-eji ule asatọ a na-achịkwa (RCT) maka nyocha nke metụtara ndị ọrịa 4,363 na mkpokọta.
- Isi njedebe nke ọmụmụ ihe ahụ bụ iji nyochaa nchekwa na ịdị irè nke usoro ọgwụgwọ chemotherapy XELOX (capecitabine plus oxaliplatin) vs. FOLFOX (fluorouracil plus oxaliplatin) na ndị ọrịa ọrịa cancer metastatic colorectal.
- A na-agwọ ndị ọrịa 2,194 na usoro XELOX ebe ndị ọrịa 2,169 na-eji usoro FOLFOX.
Nsonaazụ nke meta-analysis: XELOX vs. FOLFOX na Metastatic Colorectal Cancer
- Otu XELOX nwere mmụba dị elu nke ọrịa ụkwụ ụkwụ aka, afọ ọsịsa na thrombocytopenia ebe FOLFOX otu nwere nnukwu neutropenia naanị.
- Profaịlụ toxicity enwetara site na nchịkọta ọnụ maka otu abụọ ahụ dị iche iche mana nyocha ọzọ gbasara okwu a chọrọ.
- Mmetụta nke XELOX maka ndị ọrịa mCRC yiri arụmọrụ FOLFOX.
Ihe oriri iji rie mgbe nyochachara ọrịa kansa!
Onweghi oria abuo abuo. Gaa na ntuziaka na-edozi ahụ maka onye ọ bụla ma mee mkpebi nke onwe banyere nri na mgbakwunye na obi ike.
Ihe mgbakwunye Genistein maka ọrịa kansa
Genistein bụ isoflavone nke a na-ahụkarị na nri dị ka soy na ngwaahịa soybean. Ezigbo ihe dịkwa n'ụdị ihe mgbakwunye nri ma mara na ọ nwere ọtụtụ uru ahụike duets ya antioxidant, mgbochi mkpali na mgbochi ọrịa cancer. Ụfọdụ n'ime uru ahụike izugbe ndị ọzọ nke mgbakwunye genistein (na mgbakwunye na ihe mgbochi ọrịa cancer) gụnyere:
- Nwere ike inye aka belata ogo shuga dị n'ọbara
- Nwere ike nyere aka belata mgbaàmà menopause
- Nwere ike inye aka melite ahụike obi
- Nwere ike ịkwalite ahụike ọkpụkpụ na ụbụrụ
Na blọọgụ a, anyị ga-atụle ma iji mgbakwunye Genistein nwere uru na colorectal metastatic cancer ndị ọrịa.
Eji Mgbakwunye Genistein na Ọrịa Cancer
Otutu ihe omumu egosiputala nmekorita nke oria ojoo ojoo nke ndi no n'Eshia nke n'eri nri Soy. Enwere otutu ihe omumu ihe omumu nke gosiputara ihe na-egbochi kansa cancer nke soy isoflavone Genistein, na ikike ya iji belata mgbochi ogwu na sel cancer. N'ihi ya, ndị na-eme nchọpụta na clọ Akwụkwọ Nkà Mmụta Ọgwụ nke Icahn na Ugwu Saịnaị, na New York, nwalere nchekwa na nrụpụta ọrụ nke iji soy isoflavone Genistein yana usoro nlekọta ọgwụ chemotherapy na ọmụmụ ihe gbasara ahụike na-arịa ọrịa cancer na-egbu egbu. (NCT01985763) (Pintova S et al, Ọrịa Cancer Chemotherapy & Pharmacol., 2019)
Nkọwapụta nke Clinical Study na ojiji mgbakwunye Genistein na Ọrịa Cancer
- Enwere ndị ọrịa 13 nwere mCRC na-enweghị ọgwụgwọ mbụ bụ ndị a na-emeso FOLFOX na Genistein (N = 10) na FOLFOX + Bevacizumab + Genistein (N = 3).
- Ebumnuche bụ isi nke ọmụmụ ihe a bụ iji nyochaa nchekwa na ndidi nke iji Genistein na ọgwụ ọgwụ. Isi njedebe nke abụọ bụ iji chọpụta nzaghachi kachasị mma (BOR) mgbe usoro 6 nke chemotherapy.
- Genistein na ọgwụ nke 60 mg / ụbọchị, ka e nyere ọnụ maka ụbọchị 7 kwa izu abụọ ọ bụla, bido ụbọchị 2 tupu chemo ma gaa n'ihu ụbọchị 4-1 nke ịmị mkpụrụ. Nke a mere ka ndị nyocha ahụ nyochaa mmetụta-mmetụta naanị Genistein na ọnụnọ nke chemo.
Nsonaazụ nke Clinical Study na ojiji mgbakwunye Genistein na Ọrịa Cancer
- Nchikota nke Genistein na chemotherapy ka achoputara ma di nma.
- Ihe omume ojoo emere na Genistein naanị nwere nwayọ nwayọ, dịka isi ọwụwa, ọgbụgbọ na ọkụ ọkụ.
- Ihe omume ojoo kọrọ mgbe enyere Genistein yana kemoterapi metụtara chemotherapy akụkụ-mmetụta, dị ka neuropathy, ike ọgwụgwụ, afọ ọsịsa, agbanyeghị, ọ dịghị onye ọrịa ahụ nwere nnukwu nsogbu 4 ọjọọ.
- Enwere ọganihu na nzaghachi kachasị mma (BOR) na ndị ọrịa mCRC ndị a na-ewere chemotherapy tinyere Genistein, ma e jiri ya tụnyere ndị a kọrọ maka ọgwụgwọ chemotherapy naanị na ọmụmụ ndị gara aga. BOR bụ 61.5% n'ọmụmụ ihe a vs. 38-49% na ọmụmụ ihe gara aga na otu usoro ọgwụgwọ chemotherapy. (Saltz LB et al, J Ọgwụ Oncol, 2008)
- Ọbụna usoro ọnya na-enweghị nnwere onwe na-aga n'ihu, nke na-egosi oge ole etuto ahụ enwebeghị ọganihu na ọgwụgwọ, bụ etiti nke ọnwa 11.5 na ngwakọta Genistein vs. ọnwa 8 maka chemotherapy naanị dabere na ọmụmụ ihe tupu. (Saltz LB et al, J Ọgwụ Oncol., 2008)
mmechi
Ọmụmụ ihe a, ọ bụ ezie na ọnụ ọgụgụ dị nta nke ndị ọrịa, na-egosi na iji ya Soy isoflavone Genistein emeju yana ngwakọta chemotherapy dị mma ma ghara ịbawanye nsị nke chemotherapy na Colorectal Cancer. Na mgbakwunye, iji Genistein yana FOLFOX nwere ikike iji melite nrụpụta ọgwụgwọ yana ike belata mmetụta-nke chemotherapy. Ihe nchoputa ndia, obu ezie na ha kwere nkwa, odi nkpa ka enyocha ma gosiputa ya na ihe omumu ogwu.
Ihe oriri ị na-eri, na ihe mgbakwunye ị na-ewere bụ mkpebi ị na-eme. Mkpebi gị kwesịrị ịgụnye nleba anya maka mmụgharị mkpụrụ ndụ cancer, nke ọrịa kansa, ọgwụgwọ na-aga n'ihu na mgbakwunye, ihe ọ bụla allergies, ozi ndụ, ịdị arọ, ịdị elu na àgwà.
Atụmatụ nri maka ọrịa kansa sitere na addon adabereghị na ọchụchọ ịntanetị. Ọ na-emezi mkpebi gị dabere na sayensị molekụla nke ndị sayensị sayensị na ndị injinia sọftụwia mebere. N'agbanyeghị ma ị nwere mmasị ịghọta ụzọ molekul biochemical dị n'okpuru ma ọ bụ na ọ bụghị - maka atụmatụ nri maka ọrịa kansa na nghọta dị mkpa.
Bido ugbu a na atụmatụ nri gị site na ịza ajụjụ n'aha ọrịa kansa, mmụba mkpụrụ ndụ ihe nketa, ọgwụgwọ na mgbakwunye na -aga n'ihu, nfụkasị ọ bụla, omume, ụdị ndụ, otu afọ na okike.
Ihe oriri ị na -eri na nke mgbakwunye ị na -ewere bụ mkpebi ị na -eme. Mkpebi gị kwesịrị ịgụnye ịtụle mmụba mkpụrụ ndụ nke ọrịa kansa, ọrịa kansa, ọgwụgwọ na mgbakwunye na -aga n'ihu, ihe ọ bụla nke na -emetụta ahụ, ozi ndụ, ịdị arọ, ịdị elu na omume.
Atụmatụ nri maka kansa site na addon esiteghị na nchọta ịntanetị. Ọ na -emere gị mkpebi onwe gị dabere na sayensị molekụla nke ndị sayensị anyị na ndị injinia sọftụwia mejuputara. Na agbanyeghị ma ọ bụrụ na ị na -eche ịghọta ụzọ ihe omimi nke biochemical dị n'okpuru ma ọ bụ na ọ bụghị - maka nhazi nri maka ọrịa kansa nke nghọta dị mkpa.
Bido ugbu a na atụmatụ nri gị site na ịza ajụjụ n'aha ọrịa kansa, mmụba mkpụrụ ndụ ihe nketa, ọgwụgwọ na mgbakwunye na -aga n'ihu, nfụkasị ọ bụla, omume, ụdị ndụ, otu afọ na okike.
Nri nkeonwe maka Ọrịa Cancer!
Ọrịa cancer na-agbanwe ka oge na-aga. Hazie ma gbanwee nri gị dabere na ihe ngosi ọrịa kansa, ọgwụgwọ, ụdị ndụ, mmasị nri, allergies na ihe ndị ọzọ.
Ndị na-arịa ọrịa cancer na-enwekarị nsogbu dị iche iche ọgwụ na-emetụta ọgwụ nke na-emetụta ụdị ndụ ha ma na-ele anya maka ọgwụgwọ ọzọ maka kansa. Na-ewere nri oriri na mgbakwunye na-adabere n'echiche sayensị (na-ezere ịkọ nkọ na nhọrọ aghara) bụ ihe kachasị mma maka ọgwụgwọ ọrịa kansa na ọgwụgwọ metụtara nsonaazụ.