Isi
Curcumin, nke ewepụtara site na mgbọrọgwụ turmeric, ka enyochala nke ọma maka ihe na-egbochi ọrịa cancer ya na nghọta na usoro ekwentị nke otu ọ ga-esi nyere aka mekọrịta na chemotherapy kpọmkwem. Curcumin sitere na turmeric kwalitere nzaghachi nke FOLFOX chemotherapy ọgwụgwọ n'ime ndị ọrịa cancer colorectal dị ka nke a na-eme ka ọ pụta ìhè site na nnwale ụlọ ọgwụ nke II. Agbanyeghị, cancer Ndị ọrịa kwesịrị ịnara ihe mgbakwunye Curcumin (curcumin gbadoro anya nke a na-amịpụta na turmeric) naanị n'okpuru nduzi nke onye na-ahụ maka ahụike ka ọ nwere ike ịmekọrịta ọgwụgwọ ndị ọzọ dị ka Tamoxifen.
Nri ose nke Turmeric
Turmeric bụ ihe eji eme ihe kemgbe ọtụtụ narị afọ na Asia ọ bụghị naanị dị ka isi ihe dị na nri ndị India kamakwa na ọgwụ ndị China ọdịnala na ọgwụgwọ Ayurvedic ndị India, iji gwọọ nsogbu ahụike dị iche iche. Na nso nso a enweela nyocha dị ukwuu banyere ihe ndị na-egbochi ọrịa cancer nke ihe na-arụ ọrụ bụ Curcumin, nke dị na turmeric (curcuma longa). A na-ewepụta curcumin site na mgbọrọgwụ nke Turmeric ma jiri odo odo oroma mara ya. Enwere otutu ihe omumu na nlebara anya nke edeputara na otutu akwukwo akwukwo ndi ozo banyere ihe omuma nke Curcumin.
Curcumin sitere na ihe na-esi ísì ụtọ Turmeric bụ phytochemical nwere mmetụta dịgasị iche iche n'ọtụtụ usoro cellular, ụzọ, protein na mkpụrụ ndụ ihe nketa gụnyere iche iche kinases, cytokines, enzymes na ihe transcription. N'ihi ya Curcumin nwere ọtụtụ ahụ ike-echebe Njirimara tinyere antioxidant, mgbochi cancer, mgbochi mkpali, antimicrobial, immunomodulatory, neuroprotective, na a nabatara umu nchebe ọtụtụ akụkụ na ngwa usoro tinyere imeju, akụrụ, anụ wdg (Kocaadam B et al, Crit. Rev. Food Sci. Nutr., 2015)
Na blog a, anyị ga-achikota ihe omumu na ihe omuma banyere ihe omimi na ogwu ogwu nke Curcumin, ihe di omimi nke ogwu Turmeric. Ọ bụ ihe na-adị mfe inweta, ala na-eri na ala toxicity, eke phytochemical, họọrọ dị ka otu n'ime ihe ndị pụrụ na-ekwe nkwa bekee a na-anwale na-adakarị ọnwụnwa site US National Cancer Institute.
N'agbanyeghị nnwale siri ike na nyocha nke usoro ọgwụgwọ nke ọgwụ ọgwụ nke Curcumin, ọ nwere nsogbu na-adịghị mma na obere bioavailability na ahụ, n'ụdị ya. Enwere ike ilebara nke a anya site na usoro nke na - eme ka bioavailability dị na ya. Ọzọkwa, site na ya na mmekọrịta ya na ọgwụ n'ịgbari enzymes na ọgwụ ụgbọala, o nwere elu nwere na-emekọ ihe ndị ọzọ ọgwụ ọjọọ. N'ihi ya, ọ dị mkpa ka e mekwuo ọmụmụ ihe ọmụmụ nke ọma maka ịkọwa kpọmkwem ọnọdụ na njikọta nke Curcumin nwere ike iji mee ihe. (Unlu A et al, JBUON, 2016)
Mgbochi mkpali Properties nke Curcumin / turmeric Nye Anti-Cancer Uru
Characteristicsdị njirimara ọrịa cancer bụ Curcumin / Turmeric bụ n'ihi ihe ndị na-egbochi mgbochi mkpali na nke immunomodulatory.
Ọrịa cancer na-apụta mgbe mkpụrụ ndụ anyị gbanwere n'ihi ngbanwe na ntụpọ kpatara ọtụtụ ihe kpatara kpatara gụnyere ibi ndụ, nri, nrụgide, gburugburu ebe obibi na ihe mkpụrụ ndụ ihe nketa. Emere aru anyị na ndị nche na usoro nchekwa na usoro sistemụ na selula. Anyị dịghịzi usoro e mere na-mata ihe ọ bụla na mba ọzọ (a nje na ma ọ bụ malitere ịrịa ọrịa) ma ọ bụ ihe ọ bụla n'ime ahu na bụ ndiiche, na nwere usoro na ndu workflows anya ka ndị nhata. Ọbụna na cellular larịị dị ka mkpụrụ ndụ na-eke maka ibu, ọhụrụ, ọnya na-agwọ ọrịa na ndị ọzọ na-eme ahụ ịrụ ọrụ, anyị nwere akwụkwọ ndọrọ ego ọ bụla larịị malite na ịlele izi ezi nke ndị nna ha ukwu ozi anyị genome, na DNA. Enwere DNA zuru oke na-arụ ọrụ yana ihe nrụzi na-arụ ọrụ mgbe niile maka usoro a.
Mgbe ọrịa kansa na-eme, ọmụmụ ahụ egosila na enwere ntụpọ na ọkwa cellular yana igwe nrụzi DNA na-eme ka mmebi cellular na adịghị njọ, yana usoro ntụpọ n'usoro mgbochi ndị uwe ojii nke eleghara anya na enweghị ike ịmata ma kpochapụ nhata. N'ihi ya, ọrịa ntutu ịdapụsị mkpụrụ ndụ na-ekwe ka na-adị ndụ na rogue mkpụrụ ndụ mgbe weghara usoro na-eme nke ọma na-ama pokopoko dị ka ọrịa na-aga n'ihu.
Mbufụt bụ usoro mgbe ahụ apụtụghị ghotara a ntụpọ ma ọ bụ nhata na Isonye ahụ ji alụso ọrịa chebe onwe mee ndị nke na-ewepụsị nsogbu. Karịsịa, nsogbu niile gụnyere nsogbu autoimmune, nsogbu degenerative na ọbụna ọrịa kansa bụ n'ihi nrụrụ dị iche iche nke usoro ahụ ji alụso ọrịa ọgụ. N'ihe banyere ọrịa kansa, a na-apụnara usoro ahụ ji alụso ọrịa ọgụ ka ọ ghara ịmata ma kwado mkpụrụ ndụ ndị na-adịghị ahụkebe ma nyere aka na uto ha.
E nwere ọtụtụ ọmụmụ na kpebisiri ike na cellular usoro maka mgbochi mkpali omume nke Curcumin amịpụtara si turmeric na-enye isi mgbochi cancer uru. Curcumin na-akpa ya mgbochi mkpali Njirimara site mmekọrịta na ọtụtụ dịghịzi ogbugbo dị ka inhibiting pro mkpali transcription ihe ndị dị ka Nuclear akpata kappa B (NFKB), na-egbochi pro mkpali cytokines, chemokines, prostaglandins na ọbụna reactive oxygen umu (ros). Ọtụtụ n'ime ndị ogbugbo a na-etinye aka n'ọtụtụ ụzọ mgbaàmà sel nke metụtara ọrịa kansa dị ka uto oke kansa (mmụba), belata mkpụrụ ndụ cell (apoptosis), iwepụta oke ọbara ọhụrụ (angiogenesis) ma na-akwado mgbasa nke mkpụrụ ndụ kansa kansa. akụkụ ndị ọzọ nke ahụ (metastasis). The immunomodulatory Njirimara nke Curcumin na-abụghị nanị n'ihi na mgbochi nke cellular molekụla zaa ma ọ bụ ike n'ụzọ dị irè modulate dịghịzi mkpụrụ ndụ ndị dị otú ahụ dị ka macrophages, dendritic sel, T-sel B-lymphocytes, ahụ na-agbachitere usoro. (Giordano A na Tommonaro G, Nri, 2019)
Ihe omumu ihe omumu banyere oria cancer nke Turmeric / Curcumin Na Cancer
Enyochala ọrịa cancer nke Curcumin / Turmeric n'ọtụtụ nyocha mkpụrụ ndụ cancer na ụdị anụmanụ. Curcumin egosiputa mmetụta bara uru nke mbenata uto cell cancer na ụdị nke ọrịa prostate, ọrịa ara ara gụnyere okpukpu atọ na-egbu ara ara, ọrịa esophageal na isi na n'olu, ọrịa kansa na ọtụtụ ndị ọzọ. (Unlu A et al, JBUON, 2016)
Tụkwasị na nke a, enwere ọmụmụ ihe na-enyocha ma ọ bụrụ na Curcumin nwere ike ime ka uche nke ọgwụ chemotherapy na ọgwụ radiation.
- E gosipụtara Curcumin ịbawanye uche nke 5-fluorouracil na ahịhịa mkpụrụ ndụ cancer. (Shakibaei M et al, PLoS Otu, 2014)
- Curcumin amịpụtara na Turmeric na-eme ka nrụpụta cisplatin dị na isi na n'olu na mkpụrụ ndụ cancer cancer nke ovarian dịkwuo irè. (Kumar B et al, PLoS One, 2014; Selvendiran K et al, Cancer Biol. Id., 2011)
- E kwuru na Curcumin na-eme ka paclitaxel dịkwuo elu na mkpụrụ ndụ kansa cancer. (Sreekanth CN et al, Oncogene, 2011)
- Na lymphoma, egosiri Curcumin iji mee ka uche dị na ọgwụgwọ radieshon. (Qiao Q et al, Ọgwụ Anticancer, 2012)
- Na squamous cell ọrịa cancer akpa ume na mkpụrụ ndụ, Curcumin si turmeric e kọrọ na-synergistic na ọgwụ ọgwụ vinorelbine. (Sen S et al, Biochem Biophys Res. Obodo., 2005)
Ihe oriri iji rie mgbe nyochachara ọrịa kansa!
Onweghi oria abuo abuo. Gaa na ntuziaka na-edozi ahụ maka onye ọ bụla ma mee mkpebi nke onwe banyere nri na mgbakwunye na obi ike.
Clinical Studies na Mmetụta nke Curcumin na Cancer
A na-enyocha Curcumin n'ọtụtụ nyocha mmụta ahụike na-aga n'ihu, ma dịka monotherapy yana yana ọgwụ ndị ọzọ.
- Na a eriri cancer na-adakarị ọmụmụ, ntụgharị ọnụ Nwa nke curcumin e inyocha. Enweghi egbu egbu na Curcumin, ebe mmadụ 2 n'ime ndị ọrịa 15 gosipụtara ọrịa kwụsiri ike mgbe ọnwa 2 gachara ọgwụgwọ Curcumin. (Sharma RA et al, Clin Cancer Res., 2004) Na nyocha nke abụọ nke abụọ nke ndị ọrịa 44 nwere ọnya cancer, na-akọ Curcumin maka ụbọchị 30 iji belata ọnụ ọgụgụ ọnya ahụ site na 40%. (Carroll RE et al, Cancer Na Mbụ. Nchapụta. (Phila), 2011)
- N'ime usoro nke abụọ nke usoro curcumin na 25 ọrịa kansa na-arịa ọrịa pancreatic, ndị ọrịa abụọ gosipụtara usoro ọgwụgwọ ndụ na otu onye ọrịa kwuru na ya nwere ọrịa siri ike maka> ọnwa 18 na onye ọzọ nwere mkpụmkpụ mkpụmkpụ ma dị oke mkpa. (Dhillon N et al, Ọrịa Cancer Res., 2008)
- A na-enyocha ọmụmụ ihe ọmụmụ na ọrịa ndị na-arịa ọrịa leukemia (CML) na-adịghị ala ala, mmetụta ọgwụgwọ nke nchikota Curcumin yana Imatinib (usoro ọgwụgwọ ọgwụ maka CML) enyocha. Ngwakọta ahụ gosipụtara nrụpụta ka mma karịa Imatinib naanị. (Ghalaut VS et al, J Oncol. Pharm Pract., 2012)
- N'ime ndị ọrịa kansa ara, Curcumin na-enyocha na monotherapy (NCT03980509) yana yana paclitaxel (NCT03072992). A na-enyocha ya n'ọmụmụ ihe ọmụmụ ndị ọzọ maka ọrịa cancer prostate dị ala, ọrịa cancer cervical, ọrịa endometrial, sarcoma uterine na ndị ọzọ. (Giordano A na Tommonaro G, Nri, 2019)
- A na-adịbeghị anya na-adọ II adakarị ọmụmụ ọrịa na metastatic eriri cancer (NCT01490996) tụnyere n'ozuzu lanarị nke ọrịa na-anata Nchikota ọgwụ FOLFOX (folinic acid / 5-fluorouracil / oxaliplatin ọgwụgwọ) na na-enweghị Curcumin Mmeju (site turmeric). Mgbakwunye Curcumin na FOLFOX achọpụtara dị mma ma nwee ndidi maka ndị ọrịa kansa na-emeghị ka ọ ka njọ na mmetụta nke chemo. Na usoro nke nzaghachi udu, na Curcumin + FOLFOX otu nwere a ka mma lanarị pụta na progression free lanarị ịbụ 120 ụbọchị ogologo karịa FOLFOX otu na mkpokọta lanarị a karịa okpukpu abụọ. (Howells LM et al, J Nutr, 2019) tinyere Curcumin dị ka akụkụ nke eriri nri ndị ọrịa cancer mgbe na-ewere FOLFOX ọgwụ nwere ike ịba uru.
Mmekọrịta nke Curcumin na ọgwụ ndị ọzọ
Curcumin, n'agbanyeghị na FDA (Nchịkwa nri na ọgwụ ọjọọ ghọtara dị ka ihe na-adịghị ize ndụ), nwere ihe akaebe na ọ na-emetụta ọgwụ na-eme ka cytochrome P450 enzymes metabolizing. Ya mere, ọ nwere ikike iji ọgwụ ụfọdụ na-emekọrịta ihe ma gbochie ịdị irè ọgwụ ahụ. Enwere ọmụmụ banyere mmekọrịta ya na ọgwụ gụnyere ọgwụ antiplatelet, na ndị ọzọ cancer na ọgwụ chemotherapy gụnyere Tamoxifen, doxorubicin, cyclophosphamide, tacrolimus na ndị ọzọ. (Unlu A et al, JBUON, 2016)
Ngwongwo antiplatelet Curcumin nwere ike ime ka ọnya ọgbụgba ma ọ bụrụ na ejiri ya na ndị na-egbochi ọgwụ mgbochi. Ihe onwunwe ya nwere ike igbochi usoro nke usoro ọgwụ chemotherapy dị ka cyclophosphamide na doxorubicin. (Yeung KS et al, Oncology J, Integrative Oncol., 2018)
Curcumin sitere na Turmeric na mmekọrịta Tamoxifen, Nlekọta Nlekọta Maka Ọrịa Cancer Na-eme Ọrịa ara
A na-etinye ọgwụ ọgwụ Tamoxifen n'ime ahụ n'ime ọgwụ ndị na-arụ ọrụ na ọgwụ na-edozi ahụ site na cytochrome P450 enzymes n'ime imeju. Endoxifen bụ clinically ifịk metabolite nke Tamoxifen, nke ahụ bụ isi onye ogbugbo nke nrụpụta ọrụ nke tamoxifen ọgwụ (Del Re M et al, Pharmacol nchapụta., 2016). Fọdụ nnyocha ndị emere na mbu mere na ụmụ oke gosiri na enwere mmekọrịta ọgwụ na ọgwụ n'etiti Curcumin na Tamoxifen. Curcumin gbochiri cytochrome P450 nke mgbasa ozi nke mgbanwe nke tamoxifen na ụdị ọrụ ya (Cho YA et al, Pharmazie, 2012). A bipụtara na nso nso gaje adakarị ọmụmụ (EudraCT 2016-004008-71 / NTR6149) si Erasmus MC Cancer Institute na Netherlands, na-anwale a na mmekọrịta dị n'etiti Curcumin si turmeric (na ma ọ bụ na-enweghị piperine) na Tamoxifen ọgwụgwọ na ara cancer ọrịa (Hussaarts KGAM et al, Ọrịa (Basel), 2019). Ndị nnyocha ahụ nyochare ogo nke Tamoxifen na Endoxifen n'ihu Curcumin.
Nsonaazụ gosiri na ịta ahụhụ nke metabolite nọ n'ọrụ Endoxifen belatara na Curcumin. Mbelata a na Endoxifen bụ ihe ndekọ ọnụ ọgụgụ. Ya mere, ọ bụrụ na Curcumin emeju (site turmeric)-e tinyere Tamoxifen ọgwụgwọ maka ọrịa ara ure, ọ nwere ike belata ịta nke nọ n'ọrụ ọgwụ n'okpuru ya fọrọ maka nrụpụta na nwere igbochi ya na ọgwụgwọ mmetụta nke ọgwụ ahụ.
mmechi
Turmeric, oroma-acha odo odo ose, anọwo na-eji ọtụtụ narị afọ, ọbụna tupu ya n'ọrụ mgwa Curcumin e kwuru na n'ihi na ya na ọtụtụ ike uru. A na-eji ya dị ka mgbochi mkpali na ọbụna tinye ya na ọnya iji mee ka ọnya ọnya. A tuo nke turmeric na-ekpo ọkụ mmiri ara ehi nwere kemgbe ihe afọ ochie antibacterial na dịghịzi boosting usọbọ eji na ezinụlọ taa, dị ka kwa omenala amamihe. Ọ bụ ihe na mgwa nke Curry ntụ ntụ na a na-ewerekarị na ọtụtụ-eji dị ka akụkụ nke Indian na Asian esi nri. Otu ngaji nke mgbọrọgwụ raw na grated turmeric tinyere ose ojii na lemon bụ ngwakọta ọzọ a na-ejikarị eme ihe maka usoro ọgwụgwọ maka ọrịa shuga, ọrịa ogbu na nkwonkwo, nke na-eme ka ọ ghara ịmalite. N'ihi ya, dị ka ihe oriri na ose, a na-eri turmeric n'ọtụtụ ebe.
Taa, e nwere ihe nile di iche iche nke turmeric na Curcumin extracts, mbadamba, capsules, dị iche iche formulations-ere n'ahịa, n'elu ọma mara ike uru. Agbanyeghị, Curcumin maara na ọ nweghị nsị na bioavailability na ahụ. Mgbe ugbu a na Nchikota na nwa ose ma ọ bụ piperine ma ọ bụ bioperine, o nwere mma bioavailability. Curcumin ngwaahịa na-nkewa dị ka herbals na botanicals na-adịghị erube nnọọ usoro dị ka ọgwụ ọjọọ. Yabụ, n'agbanyeghị ọtụtụ ngwaahịa Curcumin dị n'ahịa, ọ dị mkpa ka mmadụ mara maka ịhọrọ ngwaahịa a na usoro ziri ezi yana mgbakwunye aha njirimara sitere na USP, NSF wdg, iji mesie ngwaahịa a ka mma.
Dika akowaputara na blog ahu, otutu otutu ihe omumu omumu di iche iche di iche iche di iche iche di iche iche di iche iche di iche iche na umu anumanu nke gosiputara na Curcumin abughi nani na o nwere ike igbochi uto kansa na ihe ndi ozo banyere oria kansa, kama o mekwara ihe ndi mmadu ji eme ihe banyere uzo Curcumin na-arụ ọrụ na-enye mgbochi cancer uru. Enwere ụfọdụ ọmụmụ gbasara ahụike egosiputala obere uru ma gosipụta mmelite na ọgwụ ọgwụ ụfọdụ ọgwụgwọ ọrịa kansa gụnyere chemotherapy na ọgwụgwọ radieshon, yana Curcumin (site na Turmeric).
Otú ọ dị, n'adịghị ka ihe siri ike chọrọ maka ọmụmụ ọgwụ ọgwụ, iji usoro Curcumin na ntinye uche adịghị agbanwe agbanwe na nhazi n'ọtụtụ ọmụmụ ụlọ ọgwụ. Na mgbakwunye, n'ihi okwu dị ala bioavailability nke Curcumin sitere n'okike, nsonaazụ ọmụmụ ụlọ ọgwụ adịchaghị mma ma kwenye. Ọzọkwa enwere data gbasara mmekọrịta nke Curcumin na ọgwụgwọ ndị ọzọ nwere ike imetụta ịdị mma nke ọgwụ ahụ. N'ihi ya, n'ihi na ihe niile dị n'elu, e wezụga iji turmeric na nri na nri anyị na ma eleghị anya, a ruru eru curcumin formulation maka ya dịghịzi boosting Njirimara, ojiji nke Curcumin site. cancer A naghị atụ aro ndị ọrịa ọ gwụla ma n'okpuru nduzi nke onye na-ahụ maka ahụike.
Ihe oriri ị na -eri na nke mgbakwunye ị na -ewere bụ mkpebi ị na -eme. Mkpebi gị kwesịrị ịgụnye ịtụle mmụba mkpụrụ ndụ nke ọrịa kansa, ọrịa kansa, ọgwụgwọ na mgbakwunye na -aga n'ihu, ihe ọ bụla nke na -emetụta ahụ, ozi ndụ, ịdị arọ, ịdị elu na omume.
Atụmatụ nri maka kansa site na addon esiteghị na nchọta ịntanetị. Ọ na -emere gị mkpebi onwe gị dabere na sayensị molekụla nke ndị sayensị anyị na ndị injinia sọftụwia mejuputara. Na agbanyeghị ma ọ bụrụ na ị na -eche ịghọta ụzọ ihe omimi nke biochemical dị n'okpuru ma ọ bụ na ọ bụghị - maka nhazi nri maka ọrịa kansa nke nghọta dị mkpa.
Bido ugbu a na atụmatụ nri gị site na ịza ajụjụ n'aha ọrịa kansa, mmụba mkpụrụ ndụ ihe nketa, ọgwụgwọ na mgbakwunye na -aga n'ihu, nfụkasị ọ bụla, omume, ụdị ndụ, otu afọ na okike.
Nri nkeonwe maka Ọrịa Cancer!
Ọrịa cancer na-agbanwe ka oge na-aga. Hazie ma gbanwee nri gị dabere na ihe ngosi ọrịa kansa, ọgwụgwọ, ụdị ndụ, mmasị nri, allergies na ihe ndị ọzọ.
Ndị na-arịa ọrịa cancer na-enwekarị nsogbu dị iche iche ọgwụ na-emetụta ọgwụ nke na-emetụta ụdị ndụ ha ma na-ele anya maka ọgwụgwọ ọzọ maka kansa. Na-ewere nri oriri na mgbakwunye na-adabere n'echiche sayensị (na-ezere ịkọ nkọ na nhọrọ aghara) bụ usoro ọgwụgwọ kachasị mma maka ọrịa kansa na ọgwụgwọ metụtara nsonaazụ.