Isi
Nnukwu ọgwụ Ascorbic Acid (Vitamin C) nke e nyere intravenously yana ọgwụ chemotherapy dịka FOLFOX na FOLFIRI, na metastatic colorectal ma ọ bụ ndị ọrịa kansa na-arịa ọrịa, nwere ike jikwaa n'enweghị nsogbu ọ bụla. Inye nnukwu ọgwụ vitamin C ma ọ bụ tinyere vitamin C bara ọgaranya dị ka akụkụ nke nri ndị ọrịa cancer yana chemotherapy nwere ike melite nzaghachi n'ozuzu yana ibelata mmetụta akụkụ chemotherapy metụtara ọrịa cancer colorectal ma ọ bụ gastric. cancer.
Vitamin C / Ascorbic Acid
Ascorbic acid (Vitamin C) bụ ihe na-eme ka ọ bụrụ ihe na-eme ka ọ bụrụ ihe na-eme ka ọ bụrụ ihe na-eme ka ọ dịkwuo mma. Agbanyeghị, ọrụ ya na cancer mgbochi na ọgwụgwọ abụrụla arụmụka. Ọ bụ ezie na ụfọdụ ihe akaebe na-egosi na iri nri bara ụba nke vitamin C belatara ohere nke ọrịa kansa, ihe akaebe sitere na ntinye aka, nnwale ụlọ ọgwụ na-enweghị usoro na ascorbate ọnụ egosighi uru ọ bụla. Ma na-adịbeghị anya preclinical ọmụmụ na nnọọ elu dose ascorbic acid ikpughe na intravenous infusion selectively gburu cancer mkpụrụ ndụ, na gosiri synergistic mmetụta na cytotoxic ọgwụ. Enwere ike nweta ọgwụ ascorbic acid dị elu naanị site na infusion intravenous na na nke a, ascorbic acid nwere ike inwe mmetụta pro-oxidant, na-akpata mmebi DNA na-abawanye, na n'aka nke ya nwere ike ịkpata ọrịa cancer. Na mgbakwunye, enwere ihe akaebe izizi ụlọ ọgwụ na-agbakọta na-egosi na enwere ike inye ọgwụ ascorbic acid dị elu yana ọgwụ cytotoxic dị ka gemcitabine, paclitaxel na carboplatin.Ma Y et al, Sci. Ntughari. Ahụike., 2014; Welsh JL et al, Ọrịa Cancer Chemother Pharmacol, 2013)
Ihe oriri iji rie mgbe nyochachara ọrịa kansa!
Onweghi oria abuo abuo. Gaa na ntuziaka na-edozi ahụ maka onye ọ bụla ma mee mkpebi nke onwe banyere nri na mgbakwunye na obi ike.
Iji Vitamin C / Ascorbic Acid tinyere Chemotherapy na Metastatic Colorectal na Gastric Cancer
Iji nyochaa nchekwa na oke anabatara dose (MTD) nke ascorbic acid / Vitamin C nke enwere ike inye ya na usoro ọgwụgwọ cytotoxic chemotherapy dị ka FOLFOX na FOLFIRI, ndị nyocha sitere na Collaborative Innovation Center for Cancer Medicine, Mahadum Sun Yat-sen na China. mere nnwale ụlọ ọgwụ na-atụ anya na nke 1 (NCT02969681) na colorectal metastatic (mCRC) ma ọ bụ gastric cancer (mGC) ndị ọrịa. FOLFOX bụ chemotherapy ngwakọta nke nwere ọgwụ atọ: leucovorin (Folinic acid), Fluorouracil na oxaliplatin. Na usoro FOLFIRI, a na-eji ọgwụ 3 cytotoxic - Folinic acid, Fluorouracil, Irinotecan na Cetuximab. (Wang F et al, BMC Ọrịa, 2019)
A nwalere ndị ọrịa 36 nọ na China site na nha mbuli elu nke ascorbic acid intravenous site na 0.2-1.5 g / kg maka ntinye nke 3, otu ugboro kwa ụbọchị, maka ụbọchị 1-3, yana FOLFOX ma ọ bụ FOLFIRI na ụbọchị iri na anọ, ruo mgbe enwetara MTD. N'ime ndị ọrịa 14 debanyere aha, 36 (24 na mCRC na 23 na mGC) enyocha maka nzaghachi tumo. Ihe nzaghachi kachasị mma gụnyere gụnyere nzaghachi elebara anya na ndị ọrịa iri na anọ (1%), ọrịa siri ike na itoolu (58.35%), yana njikwa njikwa ọrịa nke 37.5%. Ndị nnyocha ahụ kwuru na ọ nweghị MTD ruru na ha ahụghị ọgwụ ndị na-egbochi ọgwụ na-achọpụta na mmụba ọgwụ. Mmetụta ndị kachasị emetụta bụ nke ascorbic acid dị elu gụnyere isi ọwụwa, isi ọkụ, ọnụ akọrọ na ụfọdụ nsị nke eriri afọ n'ihi nsị nsị. Ọmụmụ ihe a gosikwara mbelata nke ụmị ọkpụkpụ na-egbu egbu na nsị nke eriri afọ nke metụtara usoro ọgwụgwọ chemotherapy mgbe e nyere ọgwụ dị elu ascorbic acid yana chemotherapy.
Ihe nchoputa nke ihe omumu a kwuru na "ascorbic acid / Vitamin C na 1.5 g / kg otu ugbo kwa ubochi maka ubochi ato nke ozo nwere ike ijiko aka na FOLFOX ma obu FOLFIRI chemotherapy n'ime ubochi 14." (Wang F et al, BMC Ọrịa, 2019)
mmechi
Vitamin C dị elu na / ma ọ bụ nri / nri na-edozi ahụ na vitamin C na-enye yana chemotherapy nwere ike imezi nzaghachi n'ozuzu ya ma belata mmetụta nke chemotherapy metụtara ọrịa cancer colorectal ma ọ bụ gastric. cancer.
Ihe oriri ị na -eri na nke mgbakwunye ị na -ewere bụ mkpebi ị na -eme. Mkpebi gị kwesịrị ịgụnye ịtụle mmụba mkpụrụ ndụ nke ọrịa kansa, ọrịa kansa, ọgwụgwọ na mgbakwunye na -aga n'ihu, ihe ọ bụla nke na -emetụta ahụ, ozi ndụ, ịdị arọ, ịdị elu na omume.
Atụmatụ nri maka kansa site na addon esiteghị na nchọta ịntanetị. Ọ na -emere gị mkpebi onwe gị dabere na sayensị molekụla nke ndị sayensị anyị na ndị injinia sọftụwia mejuputara. Na agbanyeghị ma ọ bụrụ na ị na -eche ịghọta ụzọ ihe omimi nke biochemical dị n'okpuru ma ọ bụ na ọ bụghị - maka nhazi nri maka ọrịa kansa nke nghọta dị mkpa.
Bido ugbu a na atụmatụ nri gị site na ịza ajụjụ n'aha ọrịa kansa, mmụba mkpụrụ ndụ ihe nketa, ọgwụgwọ na mgbakwunye na -aga n'ihu, nfụkasị ọ bụla, omume, ụdị ndụ, otu afọ na okike.
Nri nkeonwe maka Ọrịa Cancer!
Ọrịa cancer na-agbanwe ka oge na-aga. Hazie ma gbanwee nri gị dabere na ihe ngosi ọrịa kansa, ọgwụgwọ, ụdị ndụ, mmasị nri, allergies na ihe ndị ọzọ.
Ndị na-arịa ọrịa cancer na-enwekarị nsogbu dị iche iche ọgwụ na-emetụta ọgwụ nke na-emetụta ụdị ndụ ha ma na-ele anya maka ọgwụgwọ ọzọ maka kansa. Na-ewere nri oriri na mgbakwunye na-adabere n'echiche sayensị (na-ezere ịkọ nkọ na nhọrọ enweghị usoro) bụ ọgwụgwọ okike kacha mma maka cancer na ọgwụgwọ metụtara akụkụ-mmetụta.