Isi
Silymarin bioactive sitere na ahịhịa-mmiri ara ehi thistle, bụ ihe antioxidant na egosiri na ọ nwere uru ụfọdụ. cancer ndị ọrịa dị ka cardio-echebe mmetụta site n'ibelata nrụgide oxidative. Iji mmiri ara ehi Thistle na-arụ ọrụ Silymarin yana Doxorubicin na-erite uru ụmụaka nwere ọrịa leukemia site na ibelata cardiotoxicity nke Doxorubicin kpatara dị ka egosipụtara na nyocha ụlọ ọgwụ na ụmụaka nwere nnukwu leukemia lymphoblastic.
Doxorubicin Chemotherapy & Cardiotoxicity na-arịa ọrịa leukemia
Doxorubicin bụ ọgwụ chemotherapy nke akwadoro maka iji dị ka ọkọlọtọ nlekọta n'ọtụtụ ihe ngosi ọrịa kansa gụnyere nnukwu ọrịa leukemia lymphoblastic (ALL), nnukwu myeloblastic leukemia (AML), neuroblastoma, sarcomas, ara, ovarian, eriri afo, thyroid, gastric na ọtụtụ. ọrịa cancer ndị ọzọ. Doxorubicin nwere ike igbu ndị na-eto ngwa ngwa na-adịghị mma cancer mkpụrụ ndụ site n'imebi DNA gabiga ókè yana nrụgide oxidative nke na-ebutekwa ọnwụ cell. Otú ọ dị, mmetụta a nke Doxorubicin na-ebutekwa mmebi dị ukwuu na sel ahụ dị mma, yana cardiotoxicity dị ka otu n'ime mmetụta kachasị njọ nke nwere ike ịkpata nkụchi obi na-egbu egbu, nke nwere ike ime ma n'oge ọgwụgwọ ma ọ bụ ọnwa ma ọ bụ afọ mgbe ọgwụgwọ ahụ gasịrị. . Mmụba ohere nke cardiotoxicity, dị ka a na-enyocha site na akara na akara dị iche iche gụnyere mbelata nke ọrụ obi ma ọ bụ mgbanwe n'ogo nke ihe nrịbama enzyme cardiotoxicity, na-abawanye na mkpokọta mkpokọta Doxorubicin.
Ọdịdị a nke iwepu ọrịa cancer na nsogbu metụtara oke mmetụta na mgbe ụfọdụ a na - agaghị agbanwe agbanwe bụ nsogbu na - aga n'ihu na obodo kansa. N'ihi ya, a na-agbasi mbọ ike ịchọta ụzọ nke nwere ike inyere aka belata ma ọ bụ chebe onye ọrịa ahụ site na mmetụta dị egwu. Ndị na-eme nchọpụta amụọla mmetụta dị iche iche sitere na osisi sitere na mgbakwunye mgbe ejiri ya na Doxorubicin na njedebe obi na mkpụrụ ndụ kansa na ụdị ọrịa anụmanụ, nke yiri nke a na-eji usoro mmepe ọgwụ maka ọgwụ ndị akwadoro. Otu osisi dị otú ahụ sitere na Silymarin na-arụ ọrụ site na osisi Milk thistle a nwalere n'ọtụtụ nyocha ọmụmụ ma gosipụta mmetụta nchekwa na obi.
Milk Thistle na Silymarin na-arụ ọrụ
Mmiri ara ehi thistle bụ osisi ejirila kemgbe ọtụtụ narị afọ ọgwụgwọ ọrịa imeju na bile na Europe. Ọ dịkwa dị ka mgbakwunye nri. Mmiri ara ehi na-enweta aha ya site na mmiri ara ehi milki nke ewepụtara mgbe epupụta agbaji. Isi ihe na-akpata bioactive nke Milk Thistle mkpụrụ gụnyere Silibinin (silybin), Isosilybin, Silychristin na Silydianin nke a na-akpọ Silymarin.
Ihe oriri iji rie mgbe nyochachara ọrịa kansa!
Onweghi oria abuo abuo. Gaa na ntuziaka na-edozi ahụ maka onye ọ bụla ma mee mkpebi nke onwe banyere nri na mgbakwunye na obi ike.
Ojiji nke Milk Thistle na-arụsi ọrụ ike Silymarin maka Doxorubicin na-ebute Cardiotoxicity na Leukemia
E gosipụtara Silymarin na nnwale iji nwee mmetụta nke cardioprotective mgbe enyere ya yana Doxorubicin (na-ebelata Doxorubicin na-ebute cardiotoxicity). Silymarin nwere ike ibelata nrụgide oxidative, ihe kpatara akpata cardiotoxicity. Ọ bụ antioxidant ma nwee ike belata mmebi nke membranes na protein site na ụdị mmeghachi omume, nke e kere dị ka akụkụ nke usoro Doxorubicin, site na igbochi mmebi nke akụrụngwa antioxidant dị na mkpụrụ ndụ siri ike (Roskovic A et al, Molecules 2011) .
Ọmụmụ Clinical na Silymarin Jiri & Doxorubicin na-emetụta Cardiotoxicity
Otu nnyocha ọmụmụ na Mahadum Tanta dị n'Ijipt nwalere uru / nchedo nchedo nke Silymarin si Milk Thistle na ụmụaka nwere ọrịa leukemia lymphoblastic buru ibu (ALL), ndị a na-agwọ Doxorubicin (Hagag AA et al, Ebumnuche Nsogbu Ọgwụ Ọrịa. 2019). N'ime ọmụmụ ihe a na ụmụaka 80 nwere ALL, 40 n'ime ha na Doxorubicin na Silymarin na 420 mg / ụbọchị (Group I - nyocha) na ndị fọdụrụ na 40 ka a na-agwọ naanị Doxorubicin na-enweghị Silymarin (Otu 2 - placebo). Nyocha nke ọrụ obi n'ime ụmụaka ndị a mere site na usoro nkuzi mgbanaka-Doppler nke systolic na ọrụ diastolic. Ha chọpụtara na n'ime otu Silymarin, enwere 'mbelata nke mbido Doxorubicin na-akpata systolic ventricular disturbances (cardiotoxicity)' maka otu placebo.
mmechi
Ọmụmụ ihe na-egosi na Milk Thistle na-arụ ọrụ Silymarin nwere ike ịba uru na ndị ọrịa cancer dịka ibelata Doxorubicin na-akpata Cardiotoxicity na ụmụaka nwere ọrịa leukemia. Ọmụmụ ụlọ ọgwụ a, ọ bụ ezie na ọ nwere ọnụ ọgụgụ dị nta nke ụmụaka leukemia, na-enye ụfọdụ nkwenye nke mmetụta cardioprotective (uru) nke Milk thistle na-arụ ọrụ Silymarin dị ka a hụrụ na ụdị ọrịa nyocha. N'agbanyeghị mmetụta bara uru nke ihe mgbakwunye eke sitere na nnwale na obere ụlọ ọgwụ, ndị ọrịa cancer ga-akpachara anya na-ewere mgbakwunye ndị a yana ha. cancer ọgwụgwọ. Ihe mgbakwunye okike ndị a agafebeghị nnwale na nnabata nke iwu na ebughị n'uche ịgwọ, gbochie ma ọ bụ gwọọ ọrịa ahụ. Ọzọkwa, e nwere ohere nke mgbakwunye ihe ọkụkụ na mmekọrịta ọgwụ nwere ike igbochi ọgwụgwọ ahụ ma nwee ike ịdị ize ndụ n'ọnọdụ ụfọdụ. N'ihi ya, ndị ọrịa kansa kwesịrị ịgakwuru dọkịta ha mgbe niile tupu ha ejiri mgbakwunye eke ọ bụla.
Ihe oriri ị na -eri na nke mgbakwunye ị na -ewere bụ mkpebi ị na -eme. Mkpebi gị kwesịrị ịgụnye ịtụle mmụba mkpụrụ ndụ nke ọrịa kansa, ọrịa kansa, ọgwụgwọ na mgbakwunye na -aga n'ihu, ihe ọ bụla nke na -emetụta ahụ, ozi ndụ, ịdị arọ, ịdị elu na omume.
Atụmatụ nri maka kansa site na addon esiteghị na nchọta ịntanetị. Ọ na -emere gị mkpebi onwe gị dabere na sayensị molekụla nke ndị sayensị anyị na ndị injinia sọftụwia mejuputara. Na agbanyeghị ma ọ bụrụ na ị na -eche ịghọta ụzọ ihe omimi nke biochemical dị n'okpuru ma ọ bụ na ọ bụghị - maka nhazi nri maka ọrịa kansa nke nghọta dị mkpa.
Bido ugbu a na atụmatụ nri gị site na ịza ajụjụ n'aha ọrịa kansa, mmụba mkpụrụ ndụ ihe nketa, ọgwụgwọ na mgbakwunye na -aga n'ihu, nfụkasị ọ bụla, omume, ụdị ndụ, otu afọ na okike.
Nri nkeonwe maka Ọrịa Cancer!
Ọrịa cancer na-agbanwe ka oge na-aga. Hazie ma gbanwee nri gị dabere na ihe ngosi ọrịa kansa, ọgwụgwọ, ụdị ndụ, mmasị nri, allergies na ihe ndị ọzọ.
Ndị na-arịa ọrịa cancer na-enwekarị nsogbu dị iche iche ọgwụ na-emetụta ọgwụ nke na-emetụta ụdị ndụ ha ma na-ele anya maka ọgwụgwọ ọzọ maka kansa. Na-ewere nri oriri na mgbakwunye na-adabere n'echiche sayensị (na-ezere ịkọ nkọ na nhọrọ aghara) bụ ihe kachasị mma maka ọgwụgwọ ọrịa kansa na ọgwụgwọ metụtara nsonaazụ.