Nlekọta Ahụike nke Milk Thistle / Silymarin na Ọrịa Cancer

Isi

Mmiri ara ehi Thistle Extract/Silymarin na akụkụ ya bụ isi Silibinin nwere ọtụtụ uru ahụike dị egwu n'ihi ihe antioxidant, mgbochi mkpali na mgbochi ọrịa cancer. Dị iche iche na vitro / in vivo na ọmụmụ anụmanụ enyochala uru ahụike nke mmiri ara ehi thistle wepụ na ikike ya igbochi ọrịa cancer dị iche iche wee chọpụta ihe ndị na-ekwe nkwa. Ọnwụnwa mmadụ ole na ole tụkwara aro na thistle mmiri ara ehi na ihe ndị na-arụ ọrụ ya nwere ike ịba uru n'ibelata ụfọdụ mmetụta dị ize ndụ nke chemotherapy na ọgwụgwọ redio dị ka cardiotoxicity, hepatotoxicity na ụbụrụ edema n'ụfọdụ. cancer ụdị chemo a kapịrị ọnụ na-agwọ ya.

Kedu ihe bụ Milk Thistle?

Mmiri ara ehi bụ osisi ifuru nke ejiriworo ọtụtụ narị afọ mee ihe dị ka ọgwụgwọ si n'okike ịgwọ ọrịa imeju na bile ọkachasị na mba Europe. A na-enwetakwa mmiri ara ehi dị ka ihe mgbakwunye nri. Mmiri ara ehi nwere aha ya site na mmiri ara ehi ara ehi nke na-apụta site na epupụta mgbe agbajiri ha. 

Igodo ndị dị mkpa nke Milk Thistle

Isi ihe dị mkpa nke mmiri mkpụrụ osisi mịrị amị bụ flavonolignans (ihe okike sitere n'okike nke flavonoid na akụkụ lignan) gụnyere:

• Silibin (silybin)
• Isosilybin
• Silychristin
• Silydian.

A na-akpọ ngwakọta nke flavonolignans ndị amịpụtara site na mkpụrụ osisi thistle mmiri ara ehi dịka Silymarin. Silibinin nke a makwaara dị ka silybin, bụ isi ihe na-arụ ọrụ nke silymarin. Silymarin nwere antioxidant, antiviral na mgbochi mkpali Njirimara. Milk Thistle / Silymarin dị ka mgbakwunye nri nri ma na-ejikarị ya maka uru bara uru n'ịgwọ ọrịa imeju. A na-ahazikwa ọtụtụ ihe mgbakwunye dabere na ọdịnaya silibinin ha. Enwekwara usoro pụrụ iche nke silymarin ma ọ bụ silibinin nke nwere ike ịbawanye bioavailability ha site na ijikọta na phosphatidylcholine.

General Health Uru nke Milk Thistle

Ọtụtụ anụmanụ ọmụmụ na ole na ole na-adakarị ọmụmụ e rụrụ inwale uru nke mmiri ara ehi thistle. Fọdụ n'ime aro ahụike bara uru nke mmiri ara ehi thistle bụ:

1. Nwere ike inyere aka na nsogbu imeju gụnyere ọrịa imeju, ịba ọcha n'anya, ịba ọcha n'anya
2. Nwere ike inyere aka na nsogbu eriri afọ
3. Mgbe ejiri ya na ọgwụgwọ ọdịnala, ọ nwere ike meziwanye ọrịa shuga
4. Nwere ike inyere aka melite ogo kọlesterol na ndị ọrịa mamịrị
5. Nwere ike inye aka na nrekasi obi na afọ mgbu
6. Nwere ike inyere aka igbochi kansa

Uru Milk Thistle na Ọrịa Cancer

N'ime afọ iri abụọ gara aga, enweela mmasị na-arịwanye elu n'ịghọta uru ọgwụgwọ nke ogwu ogwu mmiri ara ehi na ọrịa kansa. Ụfọdụ ihe ọmụmụ in vitro/in vivo/anụmanụ/mmadụ nke tụlere ngwa/mmetụta nke thistle mmiri ara ehi dị na ya. cancer A na-achịkọta n'okpuru:

Na Vitro / Na Vivo / Nnyocha anụmanụ

1. May Inhibit Pancreatic Cancer Growth & Belata Pancreatic Ọrịa Cancer-Etinyere Cachexia / Adịghị Ike

In vitro ọmụmụ gosiri na mmiri ara ehi thistle nọ n'ọrụ silibinin nwere ike iji gbochie pancreatic cancer cell uto na a dose-ndabere n'ụzọ. Ihe ọmụmụ ndị ọzọ dị na vivo na-atụkwa aro na silibinin na-ebelata uto tumọ yana ịba ụba nke ọrịa cancer na-egbu egbu ma nwee ike inye aka igbochi ọnwụ nke ahụ na akwara. (Shukla SK et al, Oncotarget., 2015)

Na nkenke, in vitro na ọmụmụ anụmanụ na-egosi na mmiri ara ehi thistle / silibinin nwere ike irite uru na mbenata uto kansa cancer na ọrịa pancreatic-Nsogbu cachexia / adịghị ike. Nlere ogwu di iche iche choro iji guzobe otu ihe na mmadu. 

2. Mee Ka Ọgba Ọrịa Cancer Na-eto

In vitro ọmụmụ gosiri na silibinin gbochiri uto cell cancer na-ebute apoptosis / cell ọnwụ na mkpụrụ ndụ kansa kansa. Nchọpụta sitere n’ọmụmụ dị iche iche na-egosi na silibinin nwere ezigbo ihe na-egbochi ọria ara ure. (Tiwari P et al, Ọrịa Cancer., 2011)

3. Mee Na-egbochi Ọganihu Ọrịa Cancer

N'ọmụmụ ihe ọzọ, a tụlere mmetụta nke ọrịa kansa nke Silibinin na usoro ọgwụgwọ yana DOX / Adriamycin. N'ime ọmụmụ ihe a, a na-eji silibinin na DOX jikọtara mkpụrụ ndụ carcinoma prostate na mkpụrụ ndụ. Nchoputa gosipụtara na ngwakọta silibinin-DOX rụpụtara igbochi 62-69% nke uto na sel ndị a gwọrọ. (Prabha Tiwari na Kaushala Prasad Mishra, Researchlọ Ọgwụ Ọrịa Cancer., 2015)

4. Ka Na-egbochi Ọrịa Skin

Enweela ọtụtụ ọmụmụ iji nyochaa mmetụta Milk Thistle na-arụsi ọrụ ike na Silibinin na ọrịa kansa. Nchọpụta sitere na nchọpụta in vitro ndị a gosiri na ọgwụgwọ Silibinin nwere ike ịnwe mgbochi na mkpụrụ ndụ kansa nke mmadụ. Nnyocha n'ime vivo chọpụtara na Silibinin nwekwara ike igbochi ọrịa kansa UVB na-akpata kansa anụ ahụ ma nwee ike inye aka na ndozi mmebi DNA kpatara UV na anụ ahụ. (Prabha Tiwari na Kaushala Prasad Mishra, Cancer Research Frontiers., 2015)

Ọmụmụ ihe ndị a na-ekwe nkwa ma na-atụ aro na thistle/silibinin mmiri ara ehi nwere ike ịdị mma ma baara anụ ahụ uru cancer.

5. Mee Na-egbochi Ọrịa Cancer

Fọdụ n'ime ihe ọmụmụ in vitro gosiri na Silibinin nwere ike ịkpalite ọnwụ cell na mkpụrụ ndụ kansa cancer nke mmadụ. Nnyocha in vitro chọpụtakwara na ọgwụgwọ Silibinin maka 24h nwere ike belata uto nke mkpụrụ ndụ cancer site na 30-49%. (Prabha Tiwari na Kaushala Prasad Mishra, Nchọpụta Ọrịa Cancer., 2015)

A tụlekwara elele nke mmiri ara ehi na Silibinin yana ọgwụgwọ ndị ọzọ dịka ndị na-eme ihe nkiri histone-deacetylase (HDAC). Ngwakọta ahụ gosipụtara mmetụta mmekọrịta na sel colorectal.

6. Nwere ike igbochi Ọrịa Cancer

Nnyocha in vitro gosiri na Silibinin nwere ike ịnwe nsonaazụ mgbochi na usoro mkpụrụ ndụ akwara mmadụ. Nnyocha gosikwara na Silibinin yana DOX gbochiri uto cell cancer cancer na vitro. Silibinin yana indole-3-carbinol mekwara ka mmetụta mgbochi antiproliferative dị ike karịa ndị ọrụ nke ọ bụla. (Prabha Tiwari na Kaushala Prasad Mishra, Nchọpụta Ọrịa Cancer., 2015)

Nchọpụta ndị a na-egosi na Silibinin Milk Thistle na-arụ ọrụ nwekwara ike ịnwe uru ọgwụgwọ megide ọrịa cancer akpa ume.

7. Nwere ike igbochi kansa eriri afọ

In vitro ọmụmụ gosiri na Silibinin butere ọnwụ apoptosis / cell nke mkpụrụ ndụ kansa eriri afọ mmadụ. Nnyocha gosikwara na Silibinin nwekwara ike igbochi mbugharị na mgbasa nke mkpụrụ ndụ kansa cancer. (Prabha Tiwari na Kaushala Prasad Mishra, Nchọpụta Ọrịa Cancer., 2015)

8. Nwere ike igbochi Ovarian Cancer

Nnyocha in vitro gosipụtara na silibinin nwere ike igbochi uto nke mkpụrụ ndụ kansa nke ụmụ nwoke, wee bute ọnwụ apoptosis / cell. Nnyocha achọpụtakwara na Silibinin nwere ike ime ka PWX (Onxal) nwee mmetụta nke mkpụrụ ndụ kansa mkpụrụ ndụ. Silibinin mgbe ejiri ya na PTX (Onxal) nwekwara ike ịkwalite apoptosis / cell ọnwụ. (Prabha Tiwari na Kaushala Prasad Mishra, Researchlọ Ọgwụ Ọrịa Cancer., 2015)

Nchọpụta ndị a na-egosi na enwere ike iji silibinin mee ihe dịka akụkụ nke usoro ọgwụgwọ jikọrọ aka megide ọrịa kansa nke ovarian.

9. Nwere ike igbochi Ọrịa Cancer

Nnyocha na-egosi na Silibinin nwere ike igbochi ịba ụba nke mkpụrụ ndụ ụmụ nwoke. Na mgbakwunye, silibinin yana MET, onye ọrụ amaara ama na-egbochi ọrịa shuga, na-egosi nsonaazụ synergistic na mgbochi nke mkpụrụ ndụ kansa mkpụrụ ndụ na ọnwu sel. Yabụ, silibinin nwere ike ịdị irè dị ka onye na-egbochi ọrịa cancer akpa nwa. Ọmụmụ ihe ọzọ kwesịrị ịchọpụta ohere nke ịmepụta usoro ọgwụgwọ kachasị mma megide cancer cancer.

Ọmụmụ Clinical na ansmụ mmadụ

Ka anyị nwere a lee anya na dị iche iche na-adakarị ọmụmụ ịghọta ma gụnyere mmiri ara ehi thistle dị ka akụkụ nke nri ndị ọrịa cancer bara uru ma ọ bụ na ọ bụghị.

1. Uru nke mmiri ara ehi na-ebelata Cardiotoxicity na Nnukwu Lymphoblastic Leukemia Treatmụaka ejiri DOX (Adriamycin)

E gosipụtara Silymarin, otu n'ime ihe ndị dị mkpa na-arụ ọrụ nke mmiri ara ehi thistle, ka o gosipụtara iji nweta mmetụta nke cardioprotective mgbe enyere ya yana DOX Silymarin nwere ike belata nrụgide oxidative, ihe kpatara akpata cardiotoxicity. Ọ bụ antioxidant ma nwee ike belata mmebi nke membranes na protein site na ụdị mmeghachi omume, nke e kere dị ka akụkụ nke usoro DOX, site na igbochi mmebi nke akụrụngwa antioxidant dị na mkpụrụ ndụ ahụike. (Roskovic A et al, Mkpụrụ osisi 2011)

Otu nnyocha ọmụmụ na Mahadum Tanta dị na Egypt tụlere mmetụta cardioprotective nke Silymarin si Milk Thistle na ụmụaka nwere Nnukwu Lymphoblastic Leukemia (ALL), bụ ndị e mesoro DOX. Ọmụmụ ihe ahụ jiri data sitere na ụmụaka 80 nwere ALL, nke ndị ọrịa 40 mesoro ya na DOX yana Silymarin na 420 mg / ụbọchị ma ndị fọdụrụ na 40 ka a na-emeso naanị DOX (otu placebo). Ọmụmụ ihe ahụ chọpụtara na n'ime otu Silymarin, enwere 'mbelata nke mbido DOX nke kpatara ọrụ systolic nke aka ekpe' n'elu otu placebo. Ọmụmụ ihe ọmụmụ a, ọ bụ ezie na ọnụ ọgụgụ dị nta nke ụmụaka niile, na-enye ụfọdụ nkwenye nke mmetụta cardioprotective nke Silymarin dị ka a hụrụ na ụdị ọrịa nnwale. (Adel A Hagag et al, Ebumnuche Ọgwụ Ọrịa., 2019)

2. Uru nke Mmiri ara ehi na-ebelata nsị nke Imeju na Nnukwu Lymphoblastic Leukemia Treatmụaka ejiri Chemotherapy

A na-egbochi ọgwụgwọ ụmụaka nke nwere ọrịa leukemia nke lymphoblastic (ALL) site na iji ọgwụ ọgwụ ọgwụ na-akwụsịkarị n'ihi ọrịa hepatotoxicity / liver na-akpata site na ọgwụ ọgwụ chemotherapy. Nkọwa a nke iwepu ọrịa kansa site na iji ọgwụ chemotherapy na-emetụta nsogbu dị egwu na mgbe ụfọdụ a na-apụghị ịgbagha agbagha nke ọgwụ ndị a bụ nsogbu na-aga n'ihu na obodo kansa. N'ihi ya, a na-agbasi mbọ ike ịchọta ụzọ nke nwere ike inyere aka belata ma ọ bụ chebe onye ọrịa ahụ site na mmetụta dị egwu.

N'ime nnyocha ọmụmụ, a na-agwọ ụmụaka lymphoblastic leukemia (ALL) nwere ọrịa ọgwụ na-agwọ ọrịa naanị ya (placebo) ma ọ bụ ngwakọta nke mmiri ara ehi nwere 80 mg nke silibinin yana chemotherapy (MTX / 6-MP / VCR) ọnụ ( Milk Thistle Group) maka ụbọchị 28. E debanyere ụmụaka 50 site na Mee 2002 ruo August 2005 maka ọmụmụ ihe a, yana isiokwu 26 na otu placebo yana 24 na Milk Thistle Group. 49 n'ime ụmụaka 50 bụ ndị nyocha maka ọmụmụ ihe ahụ. A na-enyocha ọrịa na-egbu umeji n'oge ọgwụgwọ. (EJ Ladas et al, Ọrịa Cancer., 2010)

Ihe nchoputa nke ihe omumu a kwuru na iburu Milk Thistle tinyere chemotherapy nke ndi mmadu nile nwere ike jikọta ya na oke mbelata nke imeju imeju. Nnyocha ahụ achọpụtaghị nsí na-atụghị anya ya, mkpa maka mbenata usoro ọgwụgwọ ọgwụ, ma ọ bụ igbu oge ọ bụla na ọgwụgwọ n'oge oge mgbakwunye mmiri ara ehi. Nnyocha ahụ gosikwara na ogwu mmiri ara ehi adịghị emetụta nrụpụta ọrụ nke ndị na-agwọ ọrịa ọgwụ eji eme ihe maka ọgwụgwọ niile. 

Otú ọ dị, ndị nchọpụta ahụ tụrụ aro n'ọmụmụ ihe n'ọdịnihu iji chọpụta ọgwụ kachasị dị irè nke Milk Thistle na mmetụta ya na hepatotoxicity / liver toxicity na ọrịa leukemia na-enweghị ndụ.

3. Uru nke mmiri ara ehi na-arụsi ọrụ ike nke Silibinin maka ibelata ụbụrụ edema na ndị ọrịa na-arịa Ọrịa Ure

Nnyocha na-egosi na iji thistle mmiri ara ehi na-arụ ọrụ silibinin na-edozi ahụ nke aha ya bụ Legasil® nwere ike imeziwanye ụbụrụ Metastasis sitere na NSCLC/ọrịa cancer akpa ume nke gara n'ihu na ọgwụgwọ redio na chemotherapy. Nchọpụta nke ọmụmụ ndị a na-egosikwa na nchịkwa silibinin nwere ike ibelata edema ụbụrụ nke ọma. Otú ọ dị, mmetụta ndị a na-egbochi silibinin na ụbụrụ metastasis nwere ike ọ gaghị emetụta ụbụrụ ụbụrụ mbụ na ngụgụ. cancer ndị ọrịa. (Bosch-Barrera J et al, Oncotarget., 2016)

4. Uru nke mmiri ara ehi na-ebelata nsị nke Imeju na Onye Ọrịa Ọrịa ara

E bipụtara ọmụmụ ihe banyere onye ọrịa kansa ara ya bụ onye ejiri ọgwụgwọ 5 dị iche iche gwọọ ọrịa ma nwee ọrịa imeju na-aga n'ihu. Akụkọ ahụ kwuru na nsonaazụ imeju na-akawanye njọ ruo ogo ndụ mgbe usoro ọgwụgwọ chemotherapy anọ gachara. Mgbe ahụ, onye ọrịa ahụ jiri ihe oriri na-edozi ahụ nke Silibinin aha ya bụ Legasil® tinye ya bụ nke a chọpụtara ọgwụ na imeju imeju, nke nyeere onye ọrịa ahụ aka ịga n'ihu na-agwọ ọrịa ọgwụ. (Bosch-Barrera J et al, Anticancer Res., 2014)

Ọmụmụ ihe a gosipụtara uru silibinin nwere ike ịbelata nsị nke imeju na ndị ọrịa kansa ara na-agwọ na chemotherapy.

5. Uru nke mmiri ara ehi na imeziwanye nlanarị nsonaazụ na Brain Metastatic Pati mesoo na Radiotherapy

Nnyocha na-egosi na ahịhịa Milkist nwere ike ịbara ndị ọrịa na-arịa ọrịa ụbụrụ na-enweta ọgwụgwọ redio. Ọmụmụ ihe ọmụmụ gụnyere data sitere n'aka ndị ọrịa nwere ụbụrụ metastases ndị a na-agwọ ma ọ bụ naanị rediotherapy naanị ma ọ bụ rediotherapy tinyere omega 3 fatty acids na silymarin. Nnyocha ahụ chọpụtara na ndị ọrịa na-ewere omega 3 fatty acids na silymarin nwere ogologo oge lanarị yana belata radionecrosis. (Gramaglia A et al, Anticancer Res., 1999)

mmechi

Milk Thistle wepụ / Silymarin na isi ihe mejupụtara Silibinin nwere ọtụtụ uru ahụike n'ihi antioxidant, mgbochi mkpali na mgbochi kansa. Mmiri ara ehi na-ewepụta / Silymarin na-enweghịkarị ọtụtụ nsogbu mgbe ọnụ na-ewere ya nke ọma. Agbanyeghị, na ụfọdụ ndị mmadụ, ịmịpụta mmiri ogwu na-amịpụta nwere ike ibute afọ ọsịsa, ọgbụgbọ, ikuku afọ, afọ ojuju, nju afọ ma ọ bụ ihe mgbu, na enweghị agụụ. Ọzọkwa, ebe ọ bụ na mmiri ara ehi thistle nwere ike belata shuga shuga dị n'ọbara ndị nwere ọrịa shuga, enwere ike ịgbazigharị ọtụtụ ọgwụ ndị na-arịa ọrịa shuga. Mmiri ara ehi na-amịpụta mmiri nwekwara ike inwe mmetụta nke estrogenic nke nwere ike ịka njọ ọnọdụ ọnọdụ hormone, gụnyere ụfọdụ ụdị ọrịa kansa ara.

Invitro/invivo dị iche iche na ọmụmụ anụmanụ enyochala uru ahụike nke mmiri ara ehi thistle wepụ na ikike ya igbochi ọrịa cancer dị iche iche. Ọtụtụ n'ime ọmụmụ ihe ndị a akọpụtala nsonaazụ na-ekwe nkwa mmetụta nchebe nke thistle mmiri ara ehi na ụfọdụ ụdị ọrịa kansa. Ọnwụnwa mmadụ ole na ole na-akwadokwa na thistle mmiri ara ehi na ihe ndị na-arụ ọrụ ya nwere ike ịba uru n'ibelata ụfọdụ mmetụta dị ize ndụ nke chemotherapy na radiotherapy dị ka cardiotoxicity, hepatotoxicity na ụbụrụ edema na ụfọdụ ụdị ọrịa cancer na-agwọ ya na chemo. Otú ọ dị, na-ewere ihe mgbakwunye eke dị ka mmiri ara ehi thistle wepụ na-enweghị usoro na chemotherapy ọ bụla cancer A naghị atụ aro ya n'ihi na ọ nwere ike ịkpata mmekọrịta dị njọ nke ahịhịa na ọgwụ. N'ihi ya, mmadụ kwesịrị ịgakwuru dọkịta ya mgbe ọ bụla tupu ya ewere ihe mgbakwunye eke ọ bụla yana chemotherapy.

Ihe oriri ị na -eri na nke mgbakwunye ị na -ewere bụ mkpebi ị na -eme. Mkpebi gị kwesịrị ịgụnye ịtụle mmụba mkpụrụ ndụ nke ọrịa kansa, ọrịa kansa, ọgwụgwọ na mgbakwunye na -aga n'ihu, ihe ọ bụla nke na -emetụta ahụ, ozi ndụ, ịdị arọ, ịdị elu na omume.

Atụmatụ nri maka kansa site na addon esiteghị na nchọta ịntanetị. Ọ na -emere gị mkpebi onwe gị dabere na sayensị molekụla nke ndị sayensị anyị na ndị injinia sọftụwia mejuputara. Na agbanyeghị ma ọ bụrụ na ị na -eche ịghọta ụzọ ihe omimi nke biochemical dị n'okpuru ma ọ bụ na ọ bụghị - maka nhazi nri maka ọrịa kansa nke nghọta dị mkpa.

Bido ugbu a na atụmatụ nri gị site na ịza ajụjụ n'aha ọrịa kansa, mmụba mkpụrụ ndụ ihe nketa, ọgwụgwọ na mgbakwunye na -aga n'ihu, nfụkasị ọ bụla, omume, ụdị ndụ, otu afọ na okike.

Ndị na-arịa ọrịa cancer na-enwekarị nsogbu dị iche iche ọgwụ na-emetụta ọgwụ nke na-emetụta ụdị ndụ ha ma na-ele anya maka ọgwụgwọ ọzọ maka kansa. Na-ewere nri oriri na mgbakwunye na-adabere n'echiche sayensị (na-ezere ịkọ nkọ na nhọrọ aghara) bụ usoro ọgwụgwọ kachasị mma maka ọrịa kansa na ọgwụgwọ metụtara nsonaazụ.

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