Nā Kākoʻo Glutamine ʻallelo no nā mea paʻakikī e hoʻoulu ʻia e ka radiation i nā maʻi maʻi ʻaʻai pūpū

o ka Naauao

Ninaninau ʻia nā noiʻi lapaʻau e nā pūʻulu noiʻi like ʻole i ka hopena o ka lawe waha ʻana o nā mea hoʻopiha glutamine, kahi amino acid pono ʻole, ma ka helu o ka esophagitis a i ʻole ka ʻai ʻana i nā pilikia a me ka emi ʻana o ke kaumaha ma nā maʻi maʻi maʻi maʻi maʻi. Ua hōʻike ʻia nā hopena o kēia mau haʻawina e hiki i ka hoʻonui ʻana i ka glutamine oral supplementation ke pōmaikaʻi i ka māmā Ka maʻi 'aʻai nā poʻe maʻi ma o ka hoʻemi ʻana i ka maʻi o ka esophagus, ka ʻai ʻana i nā pilikia/pilikia a me ka pohō kaumaha e pili ana.

ʻO Esophagitis i nā maʻi maʻi ʻaʻai pūpū

ʻO ka maʻi kanesa ke kumu nui o ka make e pili ana i ka maʻi kanesa i nā kāne a me nā wahine ma ka honua holoʻokoʻa a ʻoi aku ma mua o 18% o ka nui o ka make maʻi kanesa (GLOBOCAN, 2018). Me nā holomua lapaʻau hou loa, ʻo ka helu o nā māmā hou Ka maʻi 'aʻai Ua hōʻemi ʻia nā hihia i nā makahiki i hala iho nei (American Cancer Society, 2020). Ma muli o ke ʻano a me ka pae o ka maʻi kanesa, ka hana ʻana o ka māmā a me ke olakino holoʻokoʻa o ka mea maʻi, ua hoʻoholo ʻia ka mālama ʻana no ka mea maʻi maʻi maʻi maʻi maʻi mai nā koho like ʻole me ka radiotherapy, chemotherapy, immunotherapy, targeted therapy and surgery. Eia nō naʻe, pili ka nui o kēia mau lāʻau lapaʻau me nā hopena ʻaoʻao lōʻihi a pōkole. ʻO kekahi o nā hopena maʻamau, ʻoluʻolu a ʻeha hoʻi i ʻike ʻia i nā poʻe maʻi maʻi maʻi maʻi i loaʻa i ka radiation therapy ma ka ʻāpana o ka umauma he esophagitis. 

ʻO ka esophagitis ka pehu o ka esophagus, kahi puʻupuʻu puʻupuʻu muscular e hoʻopili i ka puʻu me ka ʻōpū. ʻO ka mea maʻamau, hoʻomaka ka hoʻomaka ʻana o ka esophagitis i hoʻokomo ʻia e ka radiation radiation (ARIE) ma waena o 3 mau mahina ma hope o ka radiotherapy a hiki ke alakaʻi pinepine i nā pilikia ale nui. No laila, ua lawe ʻia kahi noiʻi ākea e ʻimi i nā ala e pale a mālama ai i ka esophagitis i hoʻokomo ʻia i ka radiation i nā mea maʻi maʻi maʻi. Ua hōʻike nui ʻia nā noiʻi i paʻi ʻia i ka hoʻohana ʻana o nā mea hoʻopihapiha e like me glutamine e pale ai a hoʻopaneʻe ai paha i ka esophagitis induced radiation. ʻO L-Glutamine, i kapa ʻia ʻo Glutamine kahi amino acid pono ʻole i hana ʻia e ke kino a hiki ke kiʻi ʻia mai nā ʻano meaʻai like ʻole e pili pū me nā kumu holoholona e like me ka waiū, nā huahana waiū, nā hua a me nā ʻiʻo, a me nā kumuwaiwai e like me e like me ke kāpeti, nā pīni, ka milo, ka pāhiri a me nā greets beet. Eia nō naʻe, ʻo ka glutamine, ʻo ia ka 60% o nā aminoacids i loaʻa i ko mākou kino iwi, hoʻopau pinepine ʻia i nā mea maʻi maʻi ʻaʻai e alakaʻi ana i ka pohō kaumaha a me ka luhi. 

Nā noiʻi e pili pū ana me ka Oral Glutamine Supplement & Radiation-Induced Swallowing Difflicies in Lung Cancer

Ke aʻo ʻia e ka Haukapila Hoʻohanohano ʻo Far Eastern, Taiwan

I loko o kahi noiʻi hoʻokolohua hou i mālama ʻia e nā mea noiʻi ma Far Hospital Memorial Hospital, Taiwan ma waena o Kepakemapa 2014 a Sepatemaba 2015, ua loiloi ʻia nā hōʻike mai 60 mau maʻi maʻi ʻaʻai liʻiliʻi liʻiliʻi me nā kāne 42 a me 18 wahine, me ka makahiki he 60.3 mau makahiki. . (Chang SC et al, Medicine (Baltimore), 2019) Loaʻa i kēia mau maʻi i nā regimens a me nā radiotherapy ma muli o ka platinum, me ka ʻole a me ka ʻole o ka glutamine waha i hoʻohui ʻia no 1 makahiki. Ua ʻike nā kānaka noiʻi ma hope o ka hala ʻana o ka manawa he 26.4 mau mahina, ua hoʻemi ka glutamine supplementation i ka nui o ka papa 2/3 esophagitis i hoʻoulu ʻia e ka pāhawewe / e loaʻa ana nā pilikia i ka 6.7% i ka hoʻohālikelike ʻia me 53.4% ​​i nā maʻi i loaʻa ʻole nā ​​pāʻina glutamine. Ua ʻike ʻia nō hoʻi ka hōʻemi hanana o ka pohō kaumaha i hōʻemi ʻia i 20% i nā glutamine i lawelawe ʻia i nā maʻi e hoʻohālikelike ʻia me 73.3% i nā maʻi i loaʻa ʻole ka glutamine. Ua hoʻopaneʻe hoʻi ka hoʻohui ʻana o Glutamine i ka hoʻomaka ʻana o ka esophagitis i hoʻokomo ʻia e radiation radiation no nā lā 5.8 (Chang SC et al, Medicine (Baltimore), 2019).

Ke aʻo ʻia e Necmettin Erbakan University Meram Medicine School, Turkey

Ma kahi noiʻi lapaʻau ʻē aʻe i mālama ʻia e nā mea noiʻi mai ke kula ʻo Necmettin Erbakan University Meram Medicine School, Turkey, ma waena o 2010 a me 2014, ʻikepili mai 122 Stage 3 ʻaʻole liʻiliʻi cell lung. Ka maʻi 'aʻai ua kālailai ʻia nā maʻi (Kanyilmaz Gul et al, ʻO Nutr Clin., 2017). Loaʻa kēia mau mea maʻi i ka chemotherapy concurrent (me Cisplatin / carboplatin + pactitaxel a i ʻole Cisplatin + Etoposide, a i ʻole Cisplatin + Vinorelbine) a me radiotherapy, me a i ʻole me ka ʻole o ka hoʻopuka glutamine waha. ʻO 56 mau maʻi (46%) i kākoʻo ʻia me ka glutamine waha. Ua ʻike nā kānaka noiʻi ma hope o ka awelika o ka manawa o ka 13.14 mau mahina, ua hoʻemi ka glutamine supplementation i ka helu o ka papa 2-3 esophagitis i hoʻokomo ʻia i loko o ka radiation radiation / 30 mau pilikia i hoʻohālikelike ʻia me 70% i ka poʻe i loaʻa ʻole nā ​​pāʻina glutamine. Ua nānā lākou i ka nui o ka hōʻemi o ke kaumaha i hoʻemi ʻia i 53% i ka poʻe glutamine i lawelawe ʻia i nā maʻi e hoʻohālikelike ʻia me 86% i nā maʻi i loaʻa ʻole ka glutamine. Ua hōʻike pū ʻia ka noiʻi ʻaʻohe hopena maikaʻi ʻole o ka suplement glutamine i ka hopena tumo a me nā hopena ola (Kanyilmaz Gul et al, Clin Nutr., 2017).

Hiki i ka Oral Glutamine supplementation ke hoʻoliʻiliʻi i ka Esophagitis a i ʻole ke ale ʻana i nā paʻakikī i nā maʻi maʻi maʻi lepa?

I ka hōʻuluʻulu ʻana, hōʻike kēia mau haʻawina e hiki ke hoʻopōmaikaʻi i ka lawe ʻana i nā mea hoʻohui waha glutamine i ka poʻe maʻi maʻi maʻi maʻi ʻaʻai liʻiliʻi liʻiliʻi ma o ka hōʻemi ʻana i ka nui o ka esophagitis i hoʻoiho ʻia e ka radiation-induced esophagitis a me ka poho kaumaha, a laila e hoʻomaikaʻi ai i ko lākou ola. Eia nō naʻe, ʻoiai ua ʻōlelo ʻia nā haʻawina in vitro ma mua e hiki i ka glutamine ke kākoʻo i ka ulu ʻana o ka maʻi maʻi maʻi, ʻaʻole makemake nā oncologists e lawelawe i ka glutamine i loko. Ka maʻi 'aʻai nā mea maʻi i mea e pale aku ai i nā pilikia (Kanyilmaz Gul et al, Asian Pacific Journal of Cancer Prevention, 2015), ʻoiai ʻaʻole i hōʻike ʻia nā haʻawina hauʻoli hou i ka hopena maikaʻi ʻole i ka mālama ʻana i ka tumo a me nā hopena ola me ka glutamine supplementation. (Kanyilmaz Gul et al, Clin Nutr., 2017) No laila, ʻoiai nā haʻawina i hōʻuluʻulu ʻia ma kēia blog e hōʻike ana i nā pono o ka glutamine i ka maʻi maʻi ʻāʻī, pono e kūkākūkā mau nā mea maʻi me kā lākou kauka ma mua o ka lawe ʻana i nā mea hoʻohui no ko lākou maʻi kanesa.

He aha nā meaʻai āu e ʻai ai a me nā mea hoʻopihapiha āu e lawe ai i hoʻoholo. Pono e hoʻoholo i kāu hoʻoholo ʻana e pili ana i ka hoʻololi ʻana i nā ʻāpana o ka maʻi ʻaʻai, ka maʻi ʻaʻai, nā lāʻau e hoʻomau nei a me nā mea hoʻopihapiha, nā maʻi āpau, nā ʻike nohona, ke kaupaona, ke kiʻekiʻe a me nā ʻano.

ʻAʻole hoʻokumu ʻia ka hoʻolālā meaʻai no ka maʻi ʻaʻai mai addon ma ka ʻimi pūnaewele. Hoʻokele ia i ka hoʻoholo ʻana iā ʻoe ma muli o ka ʻepekema molekole i hoʻokō ʻia e ko mākou ʻepekema a me nā ʻenekini polokalamu. Nānā ʻole inā ʻoe e noʻonoʻo e hoʻomaopopo i ke ʻano o nā ʻolaola biōmika kumu a i ʻole ʻole - no ka hoʻolālā meaʻai no ka maʻi ʻaʻai e pono ai ka ʻike.

E hoʻomaka I K NOWIA manawa me kāu hoʻolālā meaʻai e ka pane ʻana i nā nīnau e pili ana i ka inoa o ka maʻi ʻaʻai, ka hoʻololi ʻana o nā kūpuna, nā mālama ʻana a me nā mea hoʻopihapiha mau, nā maʻi āpau, nā ʻano, ka nohona, nā makahiki a me nā kāne.

ʻO nā mea maʻi maʻi maʻi e hana pinepine me nā mea ʻokoʻa nā hopena ʻaoʻao chemotherapy kahi e hoʻopili ai i ko lākou ola o ke ola a nānā i nā hoʻoponopono ʻokoʻa no ka maʻi ʻaʻai. Lawe ana i ka ka meaʻai kūpono a me nā mea hoʻopihapiha e pili ana i nā noʻonoʻo ʻepekema (ka hōʻalo ʻana i ka wānana a me ke koho wale ʻana) ʻo ia ka lāʻau kūlohelohe maikaʻi loa no ka maʻi ʻaʻai a me nā lāʻau e pili ana i nā hopena ʻaoʻao.

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