Nā noi o Astragalus Extracts in Cancer

o ka Naauao

ʻO nā hoʻokolohua lapaʻau mua, nā noiʻi nānā a me nā meta-analyses e hōʻike ana e loaʻa paha i ka Astragalus extract nā pōmaikaʻi olakino a hiki ke kōkua i ka hōʻemi ʻana i kekahi mau hopena ʻaoʻao i hoʻokomo ʻia i ka chemotherapy e like me ka nausea, ka luaʻi ʻana, ka diarrhea, ka hoʻopau ʻana i ka iwi iwi, hoʻomaikaʻi i ka maikaʻi o ke ola. nā poʻe maʻi maʻi maʻi maʻi; hoʻomaikaʻi i ka luhi e pili ana i ka maʻi maʻi a me ka anorexia a hui pū me kekahi mau chemotherapies a hoʻomaikaʻi i ko lākou hopena therapeutic, ʻoi aku hoʻi i ka maʻi maʻi pūpū liʻiliʻi ʻole. Eia nō naʻe, hiki ke hoʻopili ʻia ka extract astragalus me kekahi mau lāʻau me nā chemotherapies no Ka maʻi 'aʻai, e alakaʻi ana i nā hanana ʻino. No laila, pono e pale ʻia ka hoʻohana ʻole ʻana i nā mea hoʻohui Astragalus.

He aha ka Astragalus?

ʻO Astragalus kahi mea kanu i hoʻohana ʻia i ka lāʻau lapaʻau Kina maʻamau no nā makahiki he haneli. ʻIke ʻia ʻo ia ʻo "waiū waiū" a i ʻole "huang qi" ʻo ia hoʻi "alakaʻi melemele", ʻoiai he melemele ke aʻa i ke kala.

ʻIke ʻia he hua lāʻau lāʻau ʻo Astragalus a hoʻohana ʻia e kākoʻo i kahi ʻōnaehana pale ola olakino. Aia ma luna o 3000 mau ʻano ʻokoʻa o Astragalus. Eia nō naʻe, ʻo nā lāhui i hoʻohana pinepine ʻia i nā astragalus supplement ʻO'Astragalus membrausus.

Nā Pōmaikaʻi Ola o Astragalus Extract

ʻO ke aʻa ka mahele lāʻau o ka mea kanu Astragalus. Hāʻawi ʻia nā pono olakino o Astragalus extract i nā ʻano hana ʻokoʻa i loaʻa i ka mea kanu me:

• ʻO Polsaccharides
• Saponins
• Flavonoids
• Linoleic acid
• 'Amino acids
• ʻAkalaloida

ʻO kēia mau mea, ʻike ʻia ʻo Astragalus polysaccharide ma ke ʻano he mea nui me nā hopena o ka lāʻau.

I ka lāʻau lapaʻau Kina kuʻuna, ua hoʻohana wale ʻia ʻo Astragalus extract a i ʻole me ka hui pū ʻana me nā mea kanu ʻē aʻe no nā ʻano olakino like ʻole. Eia aʻe kekahi o nā pono olakino a me nā lāʻau lapaʻau i koi ʻia no Astragalus.

• Loaʻa paha he mau pono antioxidant
• Loaʻa i nā antimicrobial, antiviral a me nā anti-inflammatory
• Loaʻa paha i nā hopena cardioprotective / kōkua i ka hoʻomaikaʻi ʻana i ka hana puʻuwai
• Hiki ke hoʻonui i ka ʻōnaehana Immune / i nā hopena palekana
• Hiki ke hōʻemi i ka luhi mau loa / hoʻomaikaʻi i ka ikaika a me ka ikaika
• Pale aku paha nā puʻupaʻa
• Hiki ke kōkua i ke kaohi ʻana i nā pae kō kō
• Loaʻa paha i nā hopena anticancer
• Hiki ke hōʻemi i kekahi mau hopena ʻaoʻao o ka chemotherapy
• Hiki ke kōkua i ka mālama ʻana i ke anuanu maʻamau a me nā maʻi āpau ʻē aʻe

Nā hopena ʻaoʻao a me nā hana kūpono o Astragalus me nā lāʻau ʻē aʻe

ʻOiai manaʻo ʻia ʻo astragalus he palekana, malia e hoʻopilikia i kekahi mau lāʻau a alakaʻi i kekahi mau hopena ʻaoʻao.

• No ka mea he waiwai hoʻoikaika kino ko Astragalus, hoʻohana ʻia me nā lāʻau immunosuppressant e like me prednisone, cyclosporine a me tacrolimus e hoʻemi a hōʻole paha i ka maikaʻi o kēia mau lāʻau i manaʻo ʻia e kāohi i ka hana pale.

• Loaʻa nā hopena diuretic i Astragalus. No laila, ʻo kāna hoʻohana ʻana me nā lāʻau diuretic ʻē aʻe e hoʻonui i kā lākou hopena. Hoʻohui ʻia, lawe pū paha ka astragalus i ka hopena o ke kino i ka lithium, a laila ka hopena o ka hoʻonui ʻana i nā pae lithium a me nā hopena ʻē aʻe e pili ana.

• Hiki paha i ka Astragalus ke hōʻemi i ke koko. No laila, ʻo ka hoʻohana ʻana me nā lāʻau anticoagulant ʻē aʻe e hoʻonui i ka makaʻu o ke kahe.

Ke aʻo ma Astragalus Extract Hoʻohana i ka maʻi ʻaʻai 

1. Nā Cancers Pharyngeal a i ʻole Laryngeal

Ka hopena o Astragalus Polysaccharides me ka concorent Chemoradiotherapy ma nā hanana maikaʻi ʻole a me ke ʻano o ke ola o nā maʻi maʻi maʻi.

I loko o kahi hoʻokolohua mua loa, pae II hoʻokolohua hoʻokolohua i hana ʻia e nā mea noiʻi o ke Kulanui ʻo Chang Gung ma Kina, ua aʻo lākou i ka hopena o ka hoʻopiʻi ʻana o Asparagus polysaccharides i ka chemoradiation therapy (CCRT) e pili ana i nā hanana maikaʻi ʻole i nā maʻi me nā maʻi maʻi pharyngeal a i ʻole laryngeal cancers. ʻO ka chemotherapy regimen me cisplatin, tegafur-uracil a me leucovorin. Ua hoʻokomo ʻia nā maʻi he 17 i ke aʻo ʻana. (Chia-Hsun Hsieh et al, J Cancer Res Clin Oncol., 2020)

Ua ʻike ʻia ka noiʻi ʻana ua ʻoi aku ka liʻiliʻi o nā hanana hopena e pili ana i ka lāʻau lapaʻau i ka hui o nā maʻi ʻaʻai i loaʻa i nā polagalac astragalus a me ka chemoradiation therapy (CCRT) like, hoʻohālikelike ʻia me ka hui i loaʻa iā CCRT wale nō. Ua ʻike ʻia ka noiʻi ʻana i ka liʻiliʻi o ke ʻano o ka nohona like ʻole ma astragalus a me ka hui CCRT, hoʻohālikelike ʻia i ka hui i loaʻa iā CCRT wale nō. Nui nā ʻokoʻa no nā mea QOL (ke ola o ke ola) e like me ka ʻeha, ka make ʻana o ka makemake, a me ka hana kaiāulu. 

Eia nō naʻe, ʻaʻole i loaʻa i ka noiʻi nā pōmaikaʻi hou aʻe i ka pane ʻana i ka maʻi maʻi, ke ola o ka maʻi a me ke ola holoʻokoʻa ke lawelawe ʻia me Astragalus polysaccharides i ka manawa chemoradiotherapy i ka pharyngeal a i ʻole laryngeal. Ka maʻi 'aʻai maʻi.

2. Ka maʻi ʻaʻai maʻi puʻuwai liʻiliʻi liʻiliʻi

Nā pōmaikaʻi o ka injection Astragalus i hui pū ʻia me ka Chemotherapy ma muli o Platinum i nā mea maʻi maʻi maʻi

I loko o kahi meta-analysis i hana ʻia ma 2019 e nā mea noiʻi o ka Halemai Hoʻohui o Nanjing University of Chinese Medicine, Kina, ua loiloi lākou i nā pono o ka hoʻohana ʻana i ka astragalus me ka hui pū ʻia me ka chemotherapy ma muli o ka platinum i nā poʻe maʻi maʻi ʻaʻa liʻiliʻi liʻiliʻi liʻiliʻi. No ke kālailai, ua loaʻa iā lākou ka ʻikepili ma o ka ʻimi moʻokalaleo ma PubMed, EMBASE, Kina National Infrastructure Database, ka Cochrane Library, Wanfang Database, China Biological Medicine Database, a me Chinese Scientific Journal Database a hiki i Iulai 2018. Ua komo pū ka noiʻi me 19 i hoʻonohonoho ʻia nā hoʻokolohua kaohi me 1635 mau maʻi. (Ailing Cao et al, Kauka (Baltimore)., 2019)

Ua loaʻa ka meta-analysis i ka hoʻohana ʻia ʻana o ka injection astragalus i hui pū ʻia me ka chemotherapy me ka synergistically e hoʻomaikaʻi ai i ka hopena o ka chemotherapy ma muli o ka platinum, a hoʻomaikaʻi i ka helu ola 1 mau makahiki, hoʻemi i ka nui o ka leukopenia ka luaʻi. Eia naʻe, ua haʻahaʻa ka pae o nā hōʻike. Pono ʻia nā hoʻokolohua hoʻokolohua nui e pono ai e hoʻokumu i kēia mau ʻike.

Ua hana ʻia kahi ʻano like i hana ʻia i loko o nā makahiki he 65 i hala aku nei, i hoʻopili ʻia me 4751 mau hoʻokolohua hoʻokolohua e pili ana i nā mea maʻi 2010 i hōʻike i kahi hopena maikaʻi kūpono o ka lawelawe ʻana i nā astragalus me ka chemotherapy ma muli o ka platinum. Eia naʻe, ua ʻōlelo nā kānaka noiʻi i ka pono no ka hōʻoia ʻana i kēlā mau hopena i loko o nā hoʻokolohua hoʻokele hoʻokele maikaʻi i hana ʻia ma mua o ka hele mua ʻana me nā ʻōlelo aʻoaʻo. (Jean Jacques Dugoua et al, Lung Cancer (Auckl)., XNUMX)

Nā pono o ke hoʻohana pū ʻana o Astragalus-i loaʻa nā lāʻau lapaʻau lāʻau laulā Kina a me Radiotherapy i nā maʻi maʻi maʻi maʻi

I loko o kahi loiloi ʻōnaehana i hana ʻia ma 2013 e nā mea noiʻi o ka Haukapila Affiliated o ke Kulanui ʻo Nanjing o ka lāʻau lapaʻau Kina ma Kina, ua loiloi lākou i nā pono o ka hoʻohana ʻana i nā lāʻau lāʻau lāʻau Kina i loaʻa me Astragalus me ka radiotherapy i nā mea maʻi maʻi ʻaʻa liʻiliʻi liʻiliʻi. Ua komo ka loiloi i ka huina nui o 29 mau haʻawina kūpono. (Hailang He et al, Hōʻike Hōʻikeʻike Hōʻikeʻike Alternat Med., 2013)

Ua ʻike ʻia ka noiʻi ʻana he pono paha ka hoʻohana pū ʻana o Astragalus-i loaʻa i nā lāʻau lapaʻau Kina a me ka radiotherapy no nā mea maʻi me ka maʻi ʻaʻai liʻiliʻi liʻiliʻi ma o ka hoʻonui ʻana i ka pono therapeutic a me ka hoʻemi ʻana i ka ʻawahia o radiotherapy. Eia naʻe, ua ʻōlelo ʻia e nā kānaka noiʻi ua hoʻolālā maikaʻi ʻia nā hoʻokolohua hoʻokolohua nui e hōʻoia i kēia mau hopena. 

Nā hopena o Astragalus polysaccharide injection i hui pū ʻia me Vinorelbine a me Cisplatin ma ke ʻano o ke ola a me ke ola o nā maʻi maʻi maʻi maʻi.

Ua hoʻokolokolo nā kānaka noiʻi mai ka Halemai ʻEkolu o ka Hbin Medical University, Kina e hoʻokolokolo inā loiloi ʻia ʻo Astragalus polysaccharide (APS) i hoʻohui ʻia me vinorelbine a me cisplatin (VC) i hoʻomaikaʻi i ke ola o nā mea maʻi me ka maʻi ʻaʻai liʻiliʻi liʻiliʻi liʻiliʻi liʻiliʻi (NSCLC ). Ua loiloi pū ʻia ka noiʻi ʻana i ka hopena o ka pane ʻana o ka tumo, ka ʻawahia, a me nā hopena ola e pili ana i ka ʻikepili mai ka huina o nā maʻi he 136 NSCLC i kākau inoa ʻia i ke aʻo ʻana ma waena o Mei 2008 a Malaki 2010. (Li Guo et al, Med Oncol., 2012)

Ua hoʻomaikaʻi iki ʻia ke kumu pane a me ka manawa ola (42.64% a me 10.7 mau mahina) i kēlā mau maʻi i loaʻa ka inikua Astragalus polysaccharide (APS) i hui pū ʻia me vinorelbine a me cisplatin (VC) i hoʻohālikelike ʻia me ka poʻe i loaʻa ka vinorelbine a me cisplatin (36.76% a me 10.2 mahina pakahi).

Ua ʻike ʻia ua hoʻopaʻa ʻia aia he mau hoʻomaikaʻi i ke ʻano holoʻokoʻa o ke ola o ka mea hoʻomanawanui, hana kino, luhi, nausea a me ka luaʻi, ʻeha, a me ka make o ka makemake i nā mea maʻi NSCLC i mālama ʻia me nā Astragalus polysaccharide a me VC, ke hoʻohālikelike ʻia me VC wale nō.

Ka hopena o ka lāʻau lāʻau lāʻau Astragalus-based ma nā lāʻau lapaʻau lāʻau o Docetaxel 

Ua mālama nā kānaka noiʻi mai Memorial Sloan-Kettering Cancer Center, New York, US i kahi noiʻi e loiloi i ka hopena o ka lāʻau lāʻau lāʻau Astragalus-based on the pharmacokinetics of docetaxel i nā mea maʻi me NSCLC. Nā hualoaʻa mai ke aʻo ʻana ua hōʻike ʻia ka hoʻohana ʻana o Astragalus-based herbal formula ʻaʻole i hoʻololi i nā pharmacokinetics o docetaxel a i ʻole ka hopena i ke ola o nā mea maʻi me ka maʻi ʻaʻa maʻi. (Barrie R Cassileth et al, Cancer Chemother Pharmacol., 2009)

Ka hopena ma ke kaohi ʻana o Bone Marrow ma hope o Chemotherapy

I kahi noiʻi i hana ʻia e ZHENG Zhao-peng et al. i ka 2013, ua loiloi lākou i ka hopena o ka lawe ʻana i ka astragalus polysaccharide injection i ka iwi kaomi i hoʻokomo ʻia e chemotherapy i nā mea maʻi maʻi ʻaʻa. Ua loaʻa i loko o ka noiʻi he 61 mau maʻi me ka maʻi ʻaʻai liʻiliʻi liʻiliʻi liʻiliʻi. (ZHENG Zhao-peng et al, Chin. Herbal Med., 2013)

Ua ʻike ʻia ka noiʻi ʻana o ka hōʻemi ʻia ʻana o ka iwi iwi i nā mea maʻi i loaʻa i ka astragalus polysaccharide injection me chemotherapy 31.3%, ʻoi aku ka haʻahaʻa ma mua o 58.6% o ka poʻe i loaʻa ka chemotherapy wale nō. 

Ua hoʻoholo ka poʻe noiʻi he hiki i ka Astragalus polysaccharide injection ke hoʻoliʻiliʻi i ke kaohi ʻana o ka iwi o ka iwi ma hope o ka chemotherapy.

3. Ka maʻi ʻaʻai kala

I loko o kahi meta-analysis 2019 i hana ʻia e nā mea noiʻi o Kina, ua loiloi lākou i ka palekana a me ka pono o ka hoʻohana ʻana i nā lāʻau lapaʻau Kina i hoʻokumu ʻia me Astragalus me chemotherapy ke hoʻohālikelike ʻia me ka chemotherapy wale no no ka mālama ʻana i ka maʻi ʻaʻai kala. Loaʻa he 22 mau noiʻi e pili ana i nā mea maʻi 1,409 i loaʻa ma o ka ʻimi palapala ʻana ma PubMed, EMBASE, Ovid, Pūnaewele ʻepekema, Hale Waihona Puke ʻo Cochrane, Nā ʻEpekema ʻĀina a me nā ʻĀkehana ʻĀina (CQVIP), Nā Haumāna Haumāna Haina (CNKI), a me nā waihona pūnaewele Biomedical Literature Chinese.

Ua loaʻa ka meta-analysis ke hoʻohui ʻia o nā lāʻau lapaʻau Kina i hoʻokumu ʻia me Astragalus a hoʻomaikaʻi paha i ka helu pane pane pane i nā mea maʻi maʻi Colorectal, hoʻomaikaʻi i ko lākou ola a hoʻoliʻiliʻi i nā hanana maikaʻi e like me neutropenia (haʻahaʻa haʻahaʻa o nā neutrophil - kahi ʻano o ke koko keʻokeʻo. cell) i loko o ke koko, anemia, thrombositopenia (helu platelet haʻahaʻa), nausea a me ka luaʻi, diarrhea, a me neurotoxicity. Eia nō naʻe, koi ʻia nā hoʻokolohua hoʻokolohua nui e pono ai e hoʻokumu i kēia mau ʻike (Shuang Lin et al, Front Oncol. 2019)

ʻO kekahi noiʻi ʻē aʻe i hana ʻia e ka poʻe noiʻi ma Kina i loiloi i ka hopena o ka hui pū ʻana i komo pū me Astragalus membranaceus a me Jiaozhe, ma nā hana pale ʻōpū o ka poʻe maʻi maʻi maʻi maʻi colorectal postoperative. Ua ʻike ʻia ka haʻawina ua loaʻa nā hopena pale o ka hui ʻana i ka hana ʻino o ka ʻōpū i ka colorectal postoperative Ka maʻi 'aʻai nā maʻi. (Qian-zhu Wang et al, Zhongguo Zhong Xi Yi Jie He Za Zhi., 2015)

4. Hoʻomaikaʻi ka Astragalus polysaccharide i ke ʻano o ke ola o nā mea maʻi maʻi maʻi Metastatic

I loko o kahi noiʻi i hana ʻia e nā mea noiʻi mai Taipei, Taiwan, ua loiloi lākou i nā hopena o Astragalus polysaccharides (PG2) ma nā māka lāʻau kūpikipiki e pili ana i ka maʻi ʻaʻai a me ke Koina o ke Ola.

ʻO ka noiʻi i loko o 23 mau maʻi me ka maʻi ʻaʻai metastatic a ʻike ʻia e hiki i ka hoʻohana ʻana o Astragalus polysaccharides ke hoʻemi i ka ʻeha, nausea, ka luaʻi a me ka luhi, a me ka hoʻomaikaʻi ʻana i ka makemake a me ka hiamoe. Ua ʻike ʻia ka noiʻi i hiki iā Astragalus ke hōʻemi i nā māka pro-inflammatory like ʻole. (Wen-Chien Huang et al, Cancers (Basel)., 2019)

Ua hāʻawi ʻia ka noiʻi i nā hōʻike mua no ka hui ma waena o Astragalus polysaccharides a me ke ʻano o ke ola i nā mea maʻi me nā kanesa pae kiʻekiʻe. Eia nō naʻe, pono pono i nā hoʻokolohua hoʻokolohua nui e pono ai no ka hōʻoia ʻana i kēia mau hopena

5. Ka hopena i ka luhi pili i ka maʻi ʻaʻai i nā maʻi maʻi Palliative Care

Ua ʻimi nā kānaka noiʻi mai ka Haukapila Mackay Memorial ma Taipei, Taiwan i ka hopena o ka hoʻohana ʻana iā Astragalus extract i ka lāʻau palliative no ka mālama ʻana i ka luhi e pili ana i ka maʻi ʻaʻai. Ua ʻike ʻia ka noiʻi ʻana he lāʻau lapaʻau maikaʻi a palekana paha ʻo Astragalus polysaccharides no ka hoʻomaha ʻana i ka luhi e pili ana i ka maʻi ʻaʻai ma waena o nā maʻi maʻi maʻi palliative care cancer. (Hong-Wen Chen et al, Clin Invest Med. 2012)

6. Ka hopena ma Anorexia e pili ana i ka maʻi ʻaʻai i nā maʻi me ka maʻi ʻaʻai nui

I loko o kahi hoʻokolohua hoʻokolohua pae II i mālama ʻia ma 2010 e nā mea noiʻi o ka East-West NeoMedical Center, ke Kulanui ʻo Kyung Hee ma Seoul, Korea, ua loiloi lākou i ka pono a me ka palekana o kahi decoction lāʻau lapaʻau me Astragalus extract i nā maʻi maʻi ʻaʻai me anorexia. (Jae Jin Lee et al, Integr Cancer Ther., 2010)

ʻO nā maʻi he 11 a piha me nā makahiki 59.8 mau makahiki i hōʻiliʻili ʻia ma waena o Ianuali, 2007 a Ianuali, 2009 i komo i loko o ke aʻo. Ua ʻike ʻia ua hoʻopaʻa ʻia ka hoʻohana ʻana o Astragalus decoction i ka hoʻomaikaʻi ʻana i ka makemake a me ke kaumaha o ke kino i nā mea maʻi me nā kanesa kiʻekiʻe.

Ua hoʻoholo nā kānaka noiʻi he hiki paha i ka decoction lāʻau lau me Astragalus extract ke mālama i ka anorexia e pili ana i ka maʻi ʻaʻai.

Panina

ʻO ka nui o nā hoʻokolohua lapaʻau mua, nā noiʻi heluna kanaka a me nā meta-analyses e hōʻike ana he hiki ke hōʻemi i nā hopena ʻaoʻao i hoʻokomo ʻia i ka chemotherapy e like me ka nausea, ka luaʻi, ka maʻi paʻi, ka hoʻopau ʻana i ka iwi iwi e hoʻomaikaʻi i ka maikaʻi o ke ola o nā poʻe maʻi maʻi maʻi maʻi; hoʻomaikaʻi i ka luhi pili i ke kanesa a me ka anorexia; a hoʻohui pū me kekahi mau chemotherapies a hoʻomaikaʻi i ko lākou hopena therapeutic, ʻoi aku hoʻi i loko o nā ʻōpū liʻiliʻi liʻiliʻi. Ka maʻi 'aʻai. Eia nō naʻe, hiki i ka astragalus ke launa pū me nā lāʻau ʻē aʻe e alakaʻi ana i nā hanana ʻino. No laila, pono e pale ʻia ka hoʻohana ʻole ʻana o Astragalus. E kamaʻilio me kāu mea mālama ola a me ka meaʻai meaʻai a loaʻa i nā ʻōlelo aʻoaʻo pilikino e pili ana i ka meaʻai ma mua o ka lawe ʻana i nā mea hoʻohui Astragalus extract no ka maʻi kanesa.

He aha nā meaʻai āu e ʻai ai a me nā mea hoʻopihapiha āu e lawe ai i hoʻoholo. Pono e hoʻoholo i kāu hoʻoholo ʻana e pili ana i ka hoʻololi ʻana i nā ʻāpana o ka maʻi ʻaʻai, ka maʻi ʻaʻai, nā lāʻau e hoʻomau nei a me nā mea hoʻopihapiha, nā maʻi āpau, nā ʻike nohona, ke kaupaona, ke kiʻekiʻe a me nā ʻano.

ʻAʻole hoʻokumu ʻia ka hoʻolālā meaʻai no ka maʻi ʻaʻai mai addon ma ka ʻimi pūnaewele. Hoʻokele ia i ka hoʻoholo ʻana iā ʻoe ma muli o ka ʻepekema molekole i hoʻokō ʻia e ko mākou ʻepekema a me nā ʻenekini polokalamu. Nānā ʻole inā ʻoe e noʻonoʻo e hoʻomaopopo i ke ʻano o nā ʻolaola biōmika kumu a i ʻole ʻole - no ka hoʻolālā meaʻai no ka maʻi ʻaʻai e pono ai ka ʻike.

E hoʻomaka I K NOWIA manawa me kāu hoʻolālā meaʻai e ka pane ʻana i nā nīnau e pili ana i ka inoa o ka maʻi ʻaʻai, ka hoʻololi ʻana o nā kūpuna, nā mālama ʻana a me nā mea hoʻopihapiha mau, nā maʻi āpau, nā ʻano, ka nohona, nā makahiki a me nā kāne.

ʻO nā mea maʻi maʻi maʻi e hana pinepine me nā mea ʻokoʻa nā hopena ʻaoʻao chemotherapy kahi e hoʻopili ai i ko lākou ola o ke ola a nānā i nā hoʻoponopono ʻokoʻa no ka maʻi ʻaʻai. Lawe ana i ka ka meaʻai kūpono a me nā mea hoʻopihapiha e pili ana i nā noʻonoʻo ʻepekema (ka hōʻalo ʻana i ka wānana a me ke koho wale ʻana) ʻo ia ka lāʻau kūlohelohe maikaʻi loa no ka maʻi ʻaʻai a me nā lāʻau e pili ana i nā hopena ʻaoʻao.

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