o ka Naauao
ʻO Curcumin ka mea hana nui o ka mea ʻala maʻamau Turmeric. ʻO Piperine, ka mea nui o ka pepa ʻEleʻele i hoʻokomo pinepine ʻia i loko o nā curcumin formulate e hoʻomaikaʻi ai i kona bioavailability. Hoʻomaʻamaʻa ʻia nā mea maʻi maʻi umauma me ka hae o ka mālama hormonal therapy i kapa ʻia ʻo Tamoxifen. Me nā kūlana maʻamau o ka mālama mālama ʻana, nānā pinepine nā mea maʻi kanesa o ka umauma i nā mea kōkua kūlohelohe e like me Curcumin (mai Turmeric) me nā anti-inflammatory, antioxidant a me nā anti-cancer waiwai e hoʻomaikaʻi ai i kā lākou palekana, pono pono, maikaʻi o ke ola a i ʻole. hoʻemi i nā hopena ʻaoʻao i ka lāʻau. Eia nō naʻe, hiki i kekahi o kēia mau mea hoʻopihapiha ke hoʻopau i ka hōʻino ʻana i ka lāʻau. Ua loaʻa kahi noiʻi hoʻokolohua i kūkākūkā ʻia ma kēia blog i kahi pilina i makemake ʻole ʻia ma waena o ka lāʻau lapaʻau ʻo Tamoxifen a me Curcumin i lawe ʻia mai Turmeric mai. Lawe i ka hoʻopihapiha Curcumin ʻoiai ma Tamoxifen therapy hiki ke hōʻemi i nā pae o ka metabolite hana o Tamoxifen a hoʻopilikia i ka hopena therapeutic o ka lāʻau i nā maʻi maʻi ʻaʻai umauma. No laila, e hōʻalo kekahi i ka hoʻopili ʻana iā Curcumin i ʻāpana o ka umauma maʻiʻai o nā maʻi ʻaʻai inā e mālama ʻia ana ʻo Tamoxifen. Eia kekahi, he mea nui e hoʻopilikino i ka meaʻai i ka mea kikoʻī Ka maʻi 'aʻai a me ka lāʻau lapaʻau e ʻohi ai i nā pōmaikaʻi nui mai ka meaʻai a palekana.
ʻO Tamoxifen No ka maʻi ʻaʻai umauma
ʻO ka maʻi ʻaʻai umauma ka maʻi ʻaʻai ʻike pinepine ʻia a ʻo kekahi o nā kumu kumu o ka make ʻana e pili ana i ka maʻi ʻaʻai i nā wahine ma ka honua holoʻokoʻa. ʻO kekahi o nā subtypes maʻamau o ka maʻi ʻaʻai umauma ka mea pili i ka hormone sex, estrogen (ER) a me ka progesterone (PR) reseptor maikaʻi a me nā mea ulu ulu epidermal kanaka 2 (ERBB2, i kapa ʻia ʻo HER2) maikaʻi ʻole - (ER + / PR + / HER2- subtype) . Loaʻa i ka subtype maikaʻi o ka maʻi ʻaʻai umauma kahi wānana maikaʻi me kahi helu ola 5-makahiki kiʻekiʻe loa o 94-99% (ʻO Waks a me Lanakila, JAMA, 2019). Hoʻomaʻamaʻa ʻia nā maʻi i loaʻa i ka maʻi maʻi maʻi maʻi maʻi hormone me ka endocrine therapy e like me Tamoxifen no ka pale ʻana i ka maʻi kanesa a me ka hoʻi hou ʻana, ma hope o kā lākou ʻoki ʻana a me nā lāʻau chemo-radiation. Hana ʻo Tamoxifen ma ke ʻano he estrogen receptor modulator (SERM), kahi e kāohi ai i nā mea hoʻokipa hormone i loko o ka ʻiʻo maʻi maʻi umauma e hōʻemi i ke ola o ka maʻi kanesa. Ka maʻi 'aʻai nā pūnaewele a hoʻemi i ka pilikia o ka hoʻi hou ʻana.
ʻO Curcumin- ka mea hana o Turmeric
Lawe kahi maʻi ʻaʻai i nā hoʻololi o ka nohona nui i kēlā me kēia kanaka e pili ana i ke ʻano i ka hoʻohana ʻana i nā mea kanu maoli i loaʻa i nā mea kanu i ʻike ʻia he anti-cancer waiwai, hoʻonui i ka palekana a me ke olakino maikaʻi. Ua hōʻike ʻia nā hopena o nā noiʻi hou loa ma mua o 80% o nā maʻi maʻi ʻaʻai e hoʻohana ana i nā mea hoʻohui e like me ka mea kōkua a me nā lāʻau ʻē aʻe (Richardson MA et al, J Clin Oncol., 2000). ʻO Curcumin, ka mea hana mai ka curry spice turmeric, kahi mea hoʻohui kūlohelohe i kaulana i waena o nā mea maʻi ʻaʻai a me nā mea ola no kāna kūʻē i ke kanesa a Anati-hoʻoʻino waiwai. No laila, ʻo ka likelihood o nā maʻi maʻi ʻaʻai umauma e lawe ana i nā mea kōkua Curcumin (lawe ʻia mai Turmeric) ʻoiai ma Tamoxifen therapy kiʻekiʻe. ʻIke ʻia ʻo Curcumin i ka loaʻa ʻole o ke komo maikaʻi ʻole i loko o ke kino a no laila hoʻohana mau ʻia ia i loko o kahi formulate me piperine, kahi ʻāpana o ka pepa ʻeleʻele, e kōkua i ka hoʻonui ʻana i kāna bioavailability (ʻO Shoba G et al, Planta Med, 1998).
Nā Mea ʻai e ʻAi ai Ma hope o ka ʻike maʻi ʻaʻai!
ʻAʻohe ʻelua maʻi ʻaʻai. E hele i waho o nā kulekele meaʻai maʻamau no kēlā me kēia kanaka a hoʻoholo i nā koho pilikino e pili ana i ka meaʻai a me nā mea hoʻopihapiha me ka hilinaʻi.
ʻO Curcumin (mai Turmeric) & Tamoxifen Nā Hana Lāʻau i ka maʻi ʻaʻai umauma
Hoʻopili ʻia ka lāʻau oral Tamoxifen i loko o ke kino i loko o nā metabolite hana lāʻau ma o ka cytochrome P450 enzymes i ke akepaʻa. ʻO Endoxifen ka metabolite hana ʻo Tamoxifen, ʻo ia ka mea nui waena o ka pono o tamoxifen therapy (Del Re M et al, Pharmacol Res., 2016). Ua hōʻike ʻia kekahi mau noiʻi ma mua ma nā ʻiole aia kahi launa lāʻau lāʻau ma waena o Curcumin (mai Turmeric) a me Tamoxifen no ka mea ua kāohi ʻo Curcumin i ka cytochrome P450 mediated metabolism o ka tamoxifen hoʻololi i kāna ʻano hana (ʻO Cho YA et al, Pharmazie, 2012). Ua hōʻike ʻia kahi noiʻi noiʻi prospective prospective (EudraCT 2016-004008-71 / NTR6149) mai ka Erasmus MC Cancer Institute ma Netherlands, ua hoʻāʻo i kēia pilina ma waena o Curcumin a me Tamoxifen i nā maʻi maʻi maʻi hānai (Hussaarts KGAM et al, Nā maʻi ʻaʻai (Basel), 2019).
I loko o kēia noiʻi ʻana ua hoʻāʻo lākou i ka hopena o Curcumin wale nō a me Curcumin me kāna bio-enhancer Piperine i ka wā i lawe pū ʻia me Tamoxifen i 16 umauma loiloi. Ka maʻi 'aʻai nā maʻi. Hāʻawi ʻia nā mea maʻi iā Tamoxifen no 28 mau lā ma mua o ke aʻo ʻana e hōʻoia i ka pae paʻa o Tamoxifen i nā kumuhana āpau. A laila, lawelawe 'ia ka po'e ma'i i nā pō'ai 3 i loko o 2 mau pū'ulu ho'oka'awale 'ole me ke ka'ina like 'ole o nā pō'ai. Hāʻawi ʻia ʻo Tamoxifen ma kahi maʻa mau o 20-30 mg i ka wā o 3 mau manawa. ʻO nā pōʻai 3 ʻo Tamoxifen wale nō, ʻo Tamoxifen me 1200 mg Curcumin i lawe ʻia ʻekolu manawa i kēlā me kēia lā, a i ʻole Tamoxifen me 1200 mg Curcumin a me 10 mg Piperine i lawe ʻia ʻekolu manawa i kēlā me kēia lā. Ua hoʻohālikelike ʻia nā pae o Tamoxifen a me Endoxifen me ka Curcumin wale nō a me ka hoʻohui ʻana o ka bio-enhancer Piperine.
Ua hōʻike kēia noiʻi i ka hoʻoliʻiliʻi o ka metabolite hana Endoxifen i hoʻemi ʻia me Curcumin a ua emi hou me Curcumin a me Piperine i hui pū ʻia. ʻO kēia emi ʻana o Endoxifen he helu nui.
Panina
I ka hōʻuluʻulu manaʻo, inā lawe ʻia ka mea kōkua Curcumin me Tamoxifen therapy, hiki iā ia ke hoʻohaʻahaʻa i ka nui o ka lāʻau lapaʻau ma lalo o kona paepae no ka pono a e hoʻopilikia paha i ka hopena therapeutic o ka lāʻau. ʻAʻole hiki ke nānā ʻole ʻia nā haʻawina e like me kēia, ʻoiai i loko o kahi helu liʻiliʻi o nā maʻi ʻaʻai umauma, a hāʻawi i ke akahele no nā wahine e lawe ana i ka tamoxifen e koho i nā mea hoʻopono kūlohelohe a lākou e mālama pono ai, ʻaʻole ia e hoʻopilikia i ka pono o ka lāʻau ʻaʻai (ka hopena therapeutic) i kekahi. ala. Ma muli o kēia hōʻike, ʻaʻole ʻo Curcumin kahi mea hoʻopiha kūpono e lawe pū ʻia me Tamoxifen ʻoiai ke keʻakeʻa nei i ka pono therapeutic.
He aha nā meaʻai āu e ʻai ai a me nā mea hoʻopihapiha āu e lawe ai i hoʻoholo. Pono e hoʻoholo i kāu hoʻoholo ʻana e pili ana i ka hoʻololi ʻana i nā ʻāpana o ka maʻi ʻaʻai, ka maʻi ʻaʻai, nā lāʻau e hoʻomau nei a me nā mea hoʻopihapiha, nā maʻi āpau, nā ʻike nohona, ke kaupaona, ke kiʻekiʻe a me nā ʻano.
ʻAʻole hoʻokumu ʻia ka hoʻolālā meaʻai no ka maʻi ʻaʻai mai addon ma ka ʻimi pūnaewele. Hoʻokele ia i ka hoʻoholo ʻana iā ʻoe ma muli o ka ʻepekema molekole i hoʻokō ʻia e ko mākou ʻepekema a me nā ʻenekini polokalamu. Nānā ʻole inā ʻoe e noʻonoʻo e hoʻomaopopo i ke ʻano o nā ʻolaola biōmika kumu a i ʻole ʻole - no ka hoʻolālā meaʻai no ka maʻi ʻaʻai e pono ai ka ʻike.
E hoʻomaka I K NOWIA manawa me kāu hoʻolālā meaʻai e ka pane ʻana i nā nīnau e pili ana i ka inoa o ka maʻi ʻaʻai, ka hoʻololi ʻana o nā kūpuna, nā mālama ʻana a me nā mea hoʻopihapiha mau, nā maʻi āpau, nā ʻano, ka nohona, nā makahiki a me nā kāne.
Mea 'ai pilikino no ka ma'i 'a'ai!
Hoʻololi ka maʻi kanesa me ka manawa. Hoʻopilikino a hoʻololi i kāu meaʻai e pili ana i ka hōʻailona maʻi maʻi, ka mālama ʻana, ke ʻano o ka nohona, nā makemake meaʻai, nā allergies a me nā mea ʻē aʻe.
ʻO nā mea maʻi maʻi maʻi e hana pinepine me nā mea ʻokoʻa nā hopena ʻaoʻao chemotherapy kahi e hoʻopili ai i ko lākou ola o ke ola a nānā i nā hoʻoponopono ʻokoʻa no ka maʻi ʻaʻai. Lawe ana i ka ka meaʻai kūpono a me nā mea hoʻopihapiha e pili ana i nā noʻonoʻo ʻepekema (ka hōʻalo ʻana i ka wānana a me ke koho wale ʻana) ʻo ia ka lāʻau kūlohelohe maikaʻi loa no ka maʻi ʻaʻai a me nā lāʻau e pili ana i nā hopena ʻaoʻao.