o ka Naauao
Hoʻohana ka hoʻohana ʻana o ka waikawa folic ma ke ʻano he mahele o nā mea kōkua multivitamin, akā aia kahi ʻike hilahila e pili ana i ka folic acid supplementation a me ka hui pū ʻana me ka pilikia o ka maʻi ʻaʻai. Inā loaʻa nā maʻi maʻi maʻi ʻaʻa liʻiliʻi liʻiliʻi, ua ʻōlelo pono ʻia ʻo Folic acid e hoʻohana pū ʻia me Kemetrexed (Alimta) chemotherapy, no ka mea e hoʻoliʻiliʻi ia i ka toxet i hoʻoulu ʻia ʻo Kemetrexed chemo (ʻaoʻao-hopena), i kākoʻo ʻia e nā noiʻi maʻi.
He aha ka Fid Acid?
ʻO Folic acid, i kapa ʻia ʻo folate a i ʻole Vitamin B9 aia kūlohelohe i nā meaʻai he nui e like me nā lau lau ʻōmaʻomaʻo, asparagus, broccoli, Brussel sprouts, nā kīʻaha āpau a me nā mea hou aku. ʻO ia kahi ʻāpana o multivitamin a me B-complex supplement i hoʻohana ʻia e nā poʻe noʻonoʻo olakino he nui. Hiki i ka hemahema folate ke kumu i ka anemia a me ke kaumaha, a i nā wahine hāpai, hiki iā ia ke kumu i nā kīnā neural fetal; no laila he mea nui a pono no ko mākou olakino.
Ka Hui o Folic Acid Supplementation a me ka maʻi ʻaʻai
He nui ka ambiguity a me ka huikau ma ka hui o ka folic acid supplementation a Ka maʻi 'aʻai a inā he mea pale a hoʻoikaika paha i ka maʻi kanesa. Ma kahi noiʻi a kahi hui Norewai i hana i kahi meta-analysis o 19 mau noiʻi o ka folic acid supplementation i loko o ke kanaka a me ka hoʻoponopono ʻana me ka maʻi maʻi a i ʻole ka make ʻana, ua ʻike lākou i ka 'borderline nui ka piʻi ʻana o ka nui o ka maʻi maʻi āpau i ka hui folic acid i hoʻohālikelike ʻia me nā mana. .' (Wien TN, BMJ Open., 2012) Hiki ke loaʻa nā hopena like ʻole i ka nui a me ka manawa o ka ʻai ʻana i ka waikawa folic. Ua pili ka pae haʻahaʻa a kiʻekiʻe loa o ka waikawa folic i ka maʻi kanesa. Eia kekahi, ʻo ka hoʻohui ʻana i ka waikawa folic i nā poʻe i ʻike ʻia me ka maʻi kanesa hiki ke hōʻeha akā hiki ke kōkua i ka poʻe ʻaʻole loaʻa. Ka maʻi 'aʻai. No laila, pono e hana pono ʻia ka hoʻohana ʻana i nā meaʻai meaʻai e like me ka folic acid, ʻepekema, a me ke kūkākūkā ʻana me nā loea mālama ola.
Nā Mea ʻai e ʻAi ai Ma hope o ka ʻike maʻi ʻaʻai!
ʻAʻohe ʻelua maʻi ʻaʻai. E hele i waho o nā kulekele meaʻai maʻamau no kēlā me kēia kanaka a hoʻoholo i nā koho pilikino e pili ana i ka meaʻai a me nā mea hoʻopihapiha me ka hilinaʻi.
ʻO Folic Acid no ka Chemotherapy Side-Effects / Toxicity i nā maʻi maʻi ʻaʻai pūpū
ʻOiai ka ʻikepili hilahila e pili ana i ka hoʻohana ʻana o ka supplement acid Folic i nā mea maʻi ʻaʻai, ua hōʻike ʻia nā noiʻi kikoʻī i kona hopena maikaʻi ke hoʻohana ʻia me Kemetrexed (Alimta) chemotherapy i nā mea maʻi liʻiliʻi liʻiliʻi (NSCLC). ʻO ka maʻi ʻaʻai liʻiliʻi liʻiliʻi liʻiliʻi ka mea maʻamau o ka maʻi ʻaʻai a me ke kumu nui o ka make ma ka honua holoʻokoʻa. ʻO ka puhipaka kahi mea nui pilikia no kēia maʻi. I loko o nā makahiki he XNUMX i hala iho nei, ʻo Pemetrexed, kahi lāʻau chemotherapy he mea antifolate, ua lilo i mea nui o ka mālama ʻana i nā mea maʻi me NSCLC i ka laina mua a me nā hoʻonohonoho hope (ʻO Tomasini P, Ther Adv Med Oncol., 2016). Hana ʻo Pemetrexed ma ke kāohi ʻana i ka metabolism folate a ma ia mea e hoʻopōʻino ai i ka DNA a hōʻino i nā ala hoʻoponopono DNA, e kōkua ana i ka hana Ka maʻi 'aʻai ʻoi aku ka nāwaliwali o ke kelepona ʻoiai hiki ke loaʻa ka hopena maikaʻi ʻole i nā pūnaewele puʻunaue wikiwiki i ke kino e like me nā cell immune. No laila, ʻo ka myelosuppression, ka hoʻemi ʻana i ka hana ʻana o ka iwi iwi o nā ʻili koko (RBC, WBC a me nā platelets) he mea make nui o ka pemetrexed (ʻO Kim Y, Biomarkers Ka maʻi ʻaʻai maʻi maʻi Prev. 2008).
Paipai ʻia ka supplementation acid Folic (350-1000 mg / lā) e hāʻawi pū ʻia me Kemetrexed chemotherapy a ʻo ke alakaʻi e hoʻomaka i ka waikawa folic 7 mau lā ma mua o ka hoʻomaka ʻana o Pemetrexed, hoʻomau i ka wā o ka mea maʻi ma ka lāʻau a hiki i 21 mau lā ma hope o ka ua hoʻopau ʻia ka hoʻomaʻamaʻa. ʻO kekahi mau noiʻi hou e pili ana i ka nānā hou ʻana o nā mea maʻi NSCLC i mālama ʻia me ka laina laina mua me ka cisplatin chemotherapy ua ʻike ʻia ua hoʻoliʻiliʻi ka folic acid supplement i nā pae o ka homosisteine plasma, kahi māka no ka pīpī hematological (ʻona hoʻowalewale ʻia e Pemetrexed chemo), me ka hoʻohaʻahaʻa ʻole ʻia o ka hopena. o Pemetrexed chemotherapy (Singh N et al, Am J. Clin Oncol, 2017). I kekahi hoʻokolokolo ʻē aʻe i kapa ʻia ʻo PEMVITASTART (NCT02679443), ua loiloi ʻia ka manawa o ka folic acid / wikamina B12 me Pemetrexed i ka mālama ʻana i nā maʻi NSCLC. Ua ʻike ʻia ka noiʻi ʻana i ka hoʻomaka ʻana o ka folic acid supplementation i ka manawa like me Pemetrexed ma kahi o 7 mau lā ma mua ua hoʻemi ʻia ʻo Pemetrexed induced hematologic toxicity (chemotherapy ʻaoʻao-hopena) me ka ʻole o ka hopena i ka pono o ka chemotherapy (Singh N et al, Ka maʻi ʻaʻai, 2019).
I loko o kahi noiʻi i hala iho nei, ʻo ka hoʻokolohua pae III EMPHACIS, kahi i hoʻonui ʻia ai nā mea maʻi me 350-1000 mg o ka folic acid a me 1000 μg o ka huaʻai B12, ua ʻike ʻia ua hoʻemi ʻia nā papa hematologic a me nā non-hematologic papa mai ka 3% o nā mea maʻi me ka hoʻoliʻiliʻi ʻole i 4% me ka hoʻohuihui (Bunn C et al, Proc Am Soc Clin Oncol., 37)
Panina
Ua manaʻo ka haʻawina, i ka hihia o nā maʻi maʻi maʻi ʻaʻai māmā liʻiliʻi liʻiliʻi, hiki ke hoʻohana ʻia ka Folic acid me ka Pemetrexed (Alimta) chemotherapy, e hōʻemi i ka Pemetrexed chemo induced toxicity (side-effect). No laila i ka hōʻuluʻulu ʻana, supplementation o nā huahana kūlohelohe a me nā huaora i loko Ka maʻi 'aʻai ʻO nā poʻe maʻi e hoʻomau nei a i hoʻopau paha i ka mālama ʻana he mea maikaʻi inā koho ʻia ka mea hoʻohui ma ke kumu ʻepekema. No laila e hana pono ʻia ke koho ʻana i nā mea hoʻohui a ma lalo o ke alakaʻi a me ka nānā ʻana.
He aha nā meaʻai āu e ʻai ai a me nā mea hoʻopihapiha āu e lawe ai i hoʻoholo. Pono e hoʻoholo i kāu hoʻoholo ʻana e pili ana i ka hoʻololi ʻana i nā ʻāpana o ka maʻi ʻaʻai, ka maʻi ʻaʻai, nā lāʻau e hoʻomau nei a me nā mea hoʻopihapiha, nā maʻi āpau, nā ʻike nohona, ke kaupaona, ke kiʻekiʻe a me nā ʻano.
ʻAʻole hoʻokumu ʻia ka hoʻolālā meaʻai no ka maʻi ʻaʻai mai addon ma ka ʻimi pūnaewele. Hoʻokele ia i ka hoʻoholo ʻana iā ʻoe ma muli o ka ʻepekema molekole i hoʻokō ʻia e ko mākou ʻepekema a me nā ʻenekini polokalamu. Nānā ʻole inā ʻoe e noʻonoʻo e hoʻomaopopo i ke ʻano o nā ʻolaola biōmika kumu a i ʻole ʻole - no ka hoʻolālā meaʻai no ka maʻi ʻaʻai e pono ai ka ʻike.
E hoʻomaka I K NOWIA manawa me kāu hoʻolālā meaʻai e ka pane ʻana i nā nīnau e pili ana i ka inoa o ka maʻi ʻaʻai, ka hoʻololi ʻana o nā kūpuna, nā mālama ʻana a me nā mea hoʻopihapiha mau, nā maʻi āpau, nā ʻano, ka nohona, nā makahiki a me nā kāne.
Mea 'ai pilikino no ka ma'i 'a'ai!
Hoʻololi ka maʻi kanesa me ka manawa. Hoʻopilikino a hoʻololi i kāu meaʻai e pili ana i ka hōʻailona maʻi maʻi, ka mālama ʻana, ke ʻano o ka nohona, nā makemake meaʻai, nā allergies a me nā mea ʻē aʻe.
ʻO nā mea maʻi maʻi maʻi e hana pinepine me nā mea ʻokoʻa nā hopena ʻaoʻao chemotherapy kahi e hoʻopili ai i ko lākou ola o ke ola a nānā i nā hoʻoponopono ʻokoʻa no ka maʻi ʻaʻai. Lawe ana i ka ka meaʻai kūpono a me nā mea hoʻopihapiha e pili ana i nā noʻonoʻo ʻepekema (ka hōʻalo ʻana i ka wānana a me ke koho wale ʻana) ʻo ia ka lāʻau kūlohelohe maikaʻi loa no ka maʻi ʻaʻai a me nā lāʻau e pili ana i nā hopena ʻaoʻao.