labarai
Wani binciken asibiti ya nuna cewa yana da hadari a yi amfani da kariyar isoflavone Genistein tare da haɗarin chemotherapy FOLFOX a cikin kula da masu cutar kansar ƙwayar ƙwayar ƙwayar cuta. Haɗa haɗin abinci na Genistein tare da ilimin jiyya yana da yuwuwar haɓaka sakamakon jiyya na FOLFOX chemotherapy a cikin marasa lafiya masu cutar kansa.
Ciwon Cutar Kansa na Metastatic
Metastatic Colorectal Cancer (mCRC) yana da mummunan tsinkaya tare da rayuwa na shekaru 2 kasa da 40% kuma rayuwa ta shekaru 5 tana ƙasa da 10%, duk da zaɓin zaɓin magani na chemotherapy mai tsanani. (AJCC Staging Handbook, 8th Edn).
Metastatic Colorectal Cancer Regimen Chemotherapy
Magungunan ciwon daji na Metastatic Colorectal sun haɗa da 5-Fluorouracil tare da maganin platinum Oxaliplatin, tare da ko ba tare da antiangiogenic (yana hana samuwar jini zuwa ƙwayar cuta) wakili Bevacizumab (Avastin). Sabbin tsarin da suka hada da FOLFIRI (fluorouracil, leucovorin, irinotecan), FOLFOX (5-Fuorouracil, oxaliplatin), CAPOX (capecitabine, oxaliplatin) da FOLFOXIRI (fluorouracil, oxaliplatin, leucovorin, irinotecan) sun kuma nuna sakamakon sakamako na mCRCsing.
Anan, zamu tattauna fitattun tsarin tsarin mCRC waɗanda ke cikin gwaje-gwajen asibiti kuma ana ɗaukar tasiri akan Ciwon Ciwon Ciwon Jiki (mCRC).
Ingancin FOLFOXIRI a cikin Majiyoyin Ciwon Kankara na Metastatic
Yawancin karatu sun mayar da hankali kan launi na metastatic daban-daban ciwon daji tsarin mulki da ingancin su a cikin marasa lafiya na mCRC. FOLFOXIRI shine haɗin haɗin layin farko na mCRC wanda ya haɗa da fluorouracil, oxaliplatin, leucovorin da haɗin magungunan irinotecan. A cikin gwajin TRIBE, wanda aka buga kwanan nan a cikin 2020, sake dawo da FOLFOXIRI tare da bevacizumab ya haifar da sakamako mafi kyau fiye da FOLFIRI da bevacizumab amma tare da damar haɓaka mafi girma yayin da ake buƙatar ƙarin tsawon lokaci na chemotherapy kuma an sami sakamako mai yawa a cikin irin waɗannan marasa lafiya. (Glynne-Jones R, et al. Lancet Oncology, 2020). Wannan dabarar hada magunguna masu tasiri amma cytotoxic tare da magungunan antiangiogenic ya tayar da wasu damuwa ga masu ilimin likitanci game da aminci da guba.
Cikakkun bayanai na Meta-Analysis: XELOX vs. FOLFOX a cikin Ciwon Kankara na Metastatic Colorectal
Nazarin a cikin 2016 ta Guo Y, et al. idan aka kwatanta ingancin capecitabine da fluorouracil, kowannensu yana hade da oxaliplatin, a cikin marasa lafiya na mCRC a hade tare da chemotherapy.Guo, Yu et al. Binciken ciwon daji, 2016).
- An yi amfani da gwaje-gwajen da bazuwar bazuwar guda takwas (RCTs) don bincike wanda ya ƙunshi marasa lafiya 4,363 gabaɗaya.
- Babban mahimmanci na binciken shine kimanta aminci da ingancin tsarin maganin chemotherapy XELOX (capecitabine da oxaliplatin) vs. FOLFOX (fluorouracil da oxaliplatin) a cikin marasa lafiya na ciwon daji na metastatic.
- An bi da marasa lafiya 2,194 tare da tsarin XELOX yayin da marasa lafiya 2,169 aka bi da su tare da tsarin FOLFOX.
Sakamakon Meta-Analysis: XELOX vs. FOLFOX a cikin Ciwon Kankara na Metastatic Colorectal
- Ƙungiyar XELOX ta sami mafi girma na ciwon ƙafar ƙafar hannu, zawo da thrombocytopenia yayin da ƙungiyar FOLFOX ta sami mafi girma na neutropenia kawai.
- Bayanan bayanan guba da aka samu daga binciken da aka tattara don ƙungiyoyin biyu sun bambanta amma ana buƙatar ƙarin bincike akan wannan batu.
- Amfanin XELOX ga marasa lafiya na mCRC yayi kama da ingancin FOLFOX.
Abincin da Zai Ci Bayan Bayanan Ciwon Cutar Kansa!
Babu cutar kansa guda biyu iri daya. Wuce ka'idojin abinci mai gina jiki na kowa don kowa kuma yanke hukunci na musamman game da abinci da kari tare da ƙarfin gwiwa.
Ƙarin Genistein don Ciwon daji
Genistein isoflavone ne da ake samu a cikin abinci kamar waken soya da kayan waken soya. Samarin Hakanan yana samuwa a cikin nau'i na kayan abinci na abinci kuma an san cewa yana da fa'idodin kiwon lafiya da yawa saboda abubuwan da ke cikin antioxidant, anti-inflammatory da anti-cancer Properties. Wasu fa'idodin kiwon lafiya na gabaɗaya na abubuwan da ake amfani da su na genistein (ban da abubuwan hana cutar kansa) sun haɗa da:
- Zai iya taimakawa rage matakan sukarin jini
- Zai iya taimakawa rage alamun cutar menopause
- Zai iya taimakawa inganta lafiyar zuciya
- Zai iya inganta lafiyar kashi da kwakwalwa
A cikin wannan shafin za mu tattauna ko amfani da kari na Genistein yana da fa'idodi a cikin launi na metastatic ciwon daji marasa lafiya.
Amfani da Ƙarin Genistein a Ciwon Daji
Yawancin karatu sun nuna haɗarin ƙananan haɗarin cututtukan cututtukan kai tsaye a cikin gabashin Asiya waɗanda ke cin abinci mai yalwar abinci. Akwai karatun gwaji da yawa wadanda suka nuna abubuwan da suka shafi cutar kansa na soy isoflavone Genistein, da ikon ta na rage juriya a cikin kwayoyin sankara. Saboda haka, masu bincike a Makarantar Magunguna ta Icahn a Dutsen Sinai, a New York, sun gwada aminci da ingancin amfani da soy isoflavone Genistein tare da daidaitaccen kulawar hadewar chemotherapy a cikin binciken likita mai zuwa a cikin marasa lafiya masu fama da cutar sankarau. (NCT01985763) (Pintova S et al, Ciwon daji Chemotherapy & Pharmacol., 2019)
Cikakkun bayanai game da Nazarin Asibiti akan Amfani da Ƙarin Genistein a Ciwon Kanjamau
- Akwai marasa lafiya 13 tare da mCRC ba tare da magani na farko ba wanda aka bi da su tare da haɗin FOLFOX da Genistein (N = 10) da FOLFOX + Bevacizumab + Genistein (N = 3).
- Matsayi na farko na binciken shine don tantance aminci da juriya na amfani da Genistein tare da haɗuwa da ƙwayar cuta. Arshen ƙarshe shine don tantance mafi kyawun amsawa (BOR) bayan hawan keke 6 na chemotherapy.
- Genistein a cikin kashi 60 mg / day, ana bashi baki na tsawon kwanaki 7 kowane sati 2, yana farawa kwanaki 4 kafin chemo kuma yana ci gaba har zuwa kwanaki 1-3 na yaduwar chemo. Wannan ya ba masu binciken damar tantance tasirin-tasirin tare da Genistein shi kaɗai kuma a gaban chemo.
Sakamakon Nazarin Clinical akan Amfani da Ƙarin Genistein a Ciwon Kanjamau
- Haɗin Genistein tare da chemotherapy an sami lafiya da haƙurin.
- Mummunan al'amuran da aka ruwaito tare da Genistein kadai sun kasance masu laushi ƙwarai, kamar ciwon kai, tashin zuciya da walƙiya mai zafi.
- Abubuwa masu rikitarwa da aka ruwaito lokacin da aka ba Genistein tare da chemotherapy suna da alaƙa da sakamako masu illa na chemotherapy, kamar neuropathy, gajiya, gudawa, duk da haka, babu ɗayan marasa lafiya da ya sami mummunar mummunan sakamako na 4.
- Akwai ci gaba a cikin mafi kyawun amsawa (BOR) a cikin waɗannan marasa lafiya na mCRC da ke shan maganin tare da Genistein, idan aka kwatanta da waɗanda aka ba da rahoto game da maganin ƙwaƙwalwar a cikin binciken farko. BOR ya kasance 61.5% a cikin wannan binciken vs. 38-49% a cikin binciken da ya gabata tare da wannan maganin cutar sankara. (Saltz LB et al, J Clin Oncol, 2008)
- Ko da tsarin ci gaba na rayuwa kyauta, wannan yana nuna adadin lokacin da cutar ba ta ci gaba ba tare da maganin, ya kasance tsaka-tsakin watanni 11.5 tare da haɗin Genistein da na watanni 8 don ilimin kimiyyar magani shi kaɗai bisa ga binciken da ya gabata. (Saltz LB et al, J Clin Oncol., 2008)
Kammalawa
Wannan binciken, kodayake akan ƙananan marasa lafiya, yana nuna amfani da shi waken soya isoflavone Genistein kari tare da hadewar chemotherapy ya kasance amintacce kuma bai kara yawan cutar cutar sanadiyyar cutar sankara ba a cikin Cancer na Colorectal. Bugu da ƙari, yin amfani da Genistein a hade tare da FOLFOX yana da damar haɓaka ingancin magani kuma wataƙila rage abubuwan da ke tattare da chemotherapy. Wadannan binciken, kodayake suna da alamar rahama, suna buƙatar a kimanta su kuma a tabbatar da su a cikin manyan karatun asibiti.
Abin da abinci kuke ci, da kuma abin da kari kuke dauka shine shawarar da kuka yanke. Ya kamata shawararku ta haɗa da la'akari da maye gurbi na ƙwayar cutar kansa, wanda kansar, jiyya mai gudana da kari, duk wani rashin lafiyar jiki, bayanin salon rayuwa, nauyi, tsayi da halaye.
Tsarin abinci mai gina jiki don ciwon daji daga addon baya dogara ne akan binciken intanet ba. Yana sarrafa yanke shawara akan ku dangane da kimiyyar ƙwayoyin cuta waɗanda masana kimiyya da injiniyoyinmu suka aiwatar. Ba tare da la'akari da ko kuna kula da fahimtar hanyoyin ƙwayoyin ƙwayoyin cuta ba ko a'a - don shirin abinci mai gina jiki don ciwon daji ana buƙatar fahimta.
Fara NOW tare da shirin abinci mai gina jiki ta hanyar amsa tambayoyi kan sunan cutar kansa, maye gurbi, jiyya mai gudana da kari, duk wani rashin lafiyan, halaye, salon rayuwa, ƙungiyar shekaru da jinsi.
Abincin da kuke ci kuma wanne kari kuke ɗauka shine yanke shawara. Ya kamata shawararku ta haɗa da la'akari da maye gurbi na ciwon daji, wanda cutar kansa, jiyya da ci gaba da gudana, duk wani rashin lafiyan, bayanin salon rayuwa, nauyi, tsayi da halaye.
Tsarin abinci mai gina jiki don cutar kansa daga addon baya dogara ne akan binciken intanet. Yana sarrafa muku yanke shawara ta atomatik dangane da kimiyyar kwayoyin da masana kimiyya da injiniyoyin software suka aiwatar. Ba tare da la’akari da ko kuna kula da fahimtar hanyoyin hanyoyin kwayoyin halittar biochemical ko a'a - don shirin abinci mai gina jiki don cutar kansa wanda ake buƙatar fahimta.
Fara NOW tare da shirin abinci mai gina jiki ta hanyar amsa tambayoyi kan sunan cutar kansa, maye gurbi, jiyya mai gudana da kari, duk wani rashin lafiyan, halaye, salon rayuwa, ƙungiyar shekaru da jinsi.
Keɓaɓɓen Abinci don Ciwon daji!
Ciwon daji yana canzawa da lokaci. Keɓancewa da canza abincin ku dangane da alamun cutar kansa, jiyya, salon rayuwa, abubuwan da ake so abinci, alerji da sauran dalilai.
Marasa lafiya masu cutar kansa sau da yawa dole su magance daban-daban illar illa na chemotherapy wanda ke shafar ingancin rayuwarsu da kuma neman wasu hanyoyin magance cutar kansa. Shan da madaidaicin abinci mai gina jiki da kari bisa la'akari na kimiyya (gujewa zato da zabin bazata) shine mafi kyawun maganin halitta don cutar kansa da cututtukan da suka shafi jiyya.