Metastatic Breast Cancer: Iyakance Amfanin Clinical na Irinotecan da Etoposide a cikin Jiyya na Mara lafiya

labarai

Metastatic nono cancer, wanda kuma aka sani da mataki IV ciwon nono, wani ci-gaba nau'i ne na cutar da ciwon daji ya yadu zuwa wasu sassa na jiki, kamar kashi, huhu, hanta, ko kwakwalwa. Kashi kaɗan (6%) na mata ne aka fara gano ciwon nono ciwon daji, tare da mafi yawan lokuta da ke faruwa a sakamakon sake dawowa bayan maganin da aka rigaya da kuma lokacin gafara.

Akwai babban bambanci tsakanin ciwon nono da kuma ciwon nono na metastatic; kansar nono laima ce ga kowane nau'i da matakai na carcinoma wanda ya samo asali a cikin nono. A daya hannun kuma, Cibiyar Ciwon daji ta kasa (NCI) ta kuma bayar da bayanai game da ciwon daji na nono da kuma matakan ciwon nono daban-daban, ciki har da ma'anar ciwon daji na nono a matsayin mataki na IV na cutar, inda kwayoyin cutar kansa suka yadu zuwa wasu sassan jiki. .

Yayin da cutar sankarar nono ta zama mafi yawanci ana samunta a cikin mata, hakanan yana shafar ƙananan adadin maza. Dangane da Facts and Figures na Cibiyar Ciwon daji ta Amurka daga shekarar 2019, yawan rayuwa na shekaru 5 don ciwon daji na nono bai wuce 30% ba.
Segar, Jennifer M et al. "Nazarin Mataki na II na Irinotecan da Etoposide a matsayin Jiyya don Ciwon Ciwon Ciwon Ciwon Nono." Likitan oncologist vol. 24,12 (2019): 1512-e1267. doi:10.1634/theoncologist.2019-0516

Gwajin Clinical (NCT00693719): Irinotecan da Etoposide a cikin Ciwon Ciwon Nono Metastatic

• Akwai mata 31 da suka yi rajista a cikin wannan hannu guda, gwajin gwaji na II, tsakanin shekaru 36-84.
• 64% na waɗannan matan suna da kwayar cutar mai tabbatacce kuma HER2 mummunan nau'in ciwon nono.
• Matan sun kasance tare da medial na aƙalla hanyoyin shan magani 5 kuma sun riga sun yi tsayayya da maganin anthracycline, taxane da maganin kafecitabine.

Dalilin kimiyya don Nazarin

• Dalilin da ya sa aka yi gwajin shi ne a gwada wani sabon salo na magungunan da ke nuna cutar sankara wanda duka sun nuna aiki a rubuce a cikin masu cutar sankarar mama kuma an tabbatar da hadewar daidai.
• Dukansu Irinotecan da Etoposide na halitta ne, sunadaran da suka samo asali daga tsire-tsire waɗanda suke masu daidaita yanayin haɓakar enzyme na topoisomerase (TOP). Ana buƙatar enzymes TOP don kwafin DNA da kwafin rubutu, duka matakai masu mahimmanci don ƙwayar ƙwayar daji mai saurin girma. Tsoma baki tare da aikin TOP yana haifar da raunin DNA, lalacewar DNA kuma yana haifar da mutuwar kwayar halitta.
• Irinotecan shine TOP1 kuma Etoposide shine mai modulator TOP2. Dalilin hada duka masu hana TOP1 da TOP2 shine don magance ragin kunnawa dayan masu rarrabuwa lokacinda aka murkushe daya daga cikin abubuwan da aka kera.

Sakamakon Gwajin Clinical

• Akwai marasa lafiya 24 da za a iya kimantawa don ingancin wannan tsarin haɗin gwiwar na Irinotecan da Etoposide. 17% suna da amsa na ɓangare kuma 38% suna da cutar barga.
• Dukkanin marasa lafiya 31 an kimanta su don cutar mai guba kuma 22 na 31 (71%) sun sami goyan baya game da aji 3 da 4 abubuwan da suka faru. Mafi yawan cutar guba ita ce rashin nutsuwa, wanda shine kasancewar ƙananan matakan ƙananan ƙwayoyin cuta a cikin jini wanda zai iya ƙara saurin kamuwa da cututtuka.
• An dakatar da karatu tun da wuri tunda nauyi mai guba yayi tsanani kuma ya fi ingancin haɗin gwiwa nauyi.

Alamomin Ciwon Kan Nono Metastatic

• Ciwon kashi ko taushi: Yana iya yadawa zuwa kashi, yana haifar da ciwo ko taushi a wuraren da abin ya shafa.
• Gajiya: Maganin ciwon daji da ciwon daji na iya haifar da gajiya, wanda zai iya zama mai tsanani kuma mai tsayi.
• Karancin numfashi: Ciwon daji da ke yaduwa zuwa huhu na iya haifar da karancin numfashi.
• Alamun Neurological: Ciwon daji wanda ya yadu zuwa kwakwalwa na iya haifar da alamun cututtuka kamar ciwon kai, ciwon kai, ko canje-canje a aikin tunani.
• Rashin ci da asarar nauyi: Ciwon daji da maganin ciwon daji na iya haifar da asarar ci da asarar nauyi.
• Jaundice ko kumburi a cikin ciki lokacin da ciwon daji ya yadu zuwa hanta.

Tsawon rayuwar mutumin da ke da ciwon nono mai ƙazanta zai iya bambanta dangane da abubuwa da yawa kamar wurin da yaduwar ƙwayar cuta.

A cewar wani bincike, adadin tsira na shekaru 5 shine ma'auni na yawan mutanen da ke da irin wannan ciwon daji har yanzu suna raye a cikin shekaru 5 da suka gabata bayan an gano cutar kansa. An bayyana shi azaman kashi, ma'ana adadin mutane cikin 100 masu rai bayan shekaru 5. A cewar Ƙungiyar Ciwon daji ta Amirka, yawan shekarun rayuwa na shekaru 5 ga mata masu ciwon nono na nono shine 29%, yayin da shekaru 5 na rayuwa na maza da kashi 22%. Yana da mahimmanci a lura cewa waɗannan ƙididdiga ne na gaba ɗaya kuma shari'o'in mutum ɗaya na iya bambanta.

Maganin Ciwon Kankara Na Metastatic Breast

Maganin yana da rikitarwa amma haɗin chemotherapy tare da takamaiman magungunan chemo yana da wasu fa'idodi a cikin sarrafa kansa. Ba za a iya amfani da shi da yawa da kuma dogon lokaci ba saboda tsananin bayaninsa mai guba da tasirin rayuwa akan mai haƙuri. Immunotherapy wani zaɓi ne wanda za'a iya la'akari da shi ga marasa lafiya da ciwon nono na metastatic; wannan tsarin kulawa zai iya taimakawa tsarin garkuwar jiki ya gane da kuma kai hari ga kwayoyin cutar kansa.

Ƙididdiga bayanin martabar maye gurbi na ƙwayar ƙwayar ƙwayar cuta zai iya taimakawa wajen gano haɗuwar ƙarin hanyoyin da aka yi niyya tare da ƙananan illa. Hadarin yin amfani da takamaiman haɗin topoisomerase inhibitors Irinotecan da Etoposide ya fi fa'ida kuma maiyuwa ba za a yi amfani da su ba wajen magance ƙwayar ƙwayar cuta. cancers.  

Tunda kowane ciwon nono na metastatic na musamman ne tare da tsarin sa na bambance-bambancen kwayoyin halitta, zaɓuɓɓukan jiyya sun keɓanta daidai da masu ilimin oncologists. Har yanzu akwai sauran aikin da za a yi wajen nemo ingantattun zaɓuɓɓukan magani masu aminci. Kowace shekara, a ranar 13 ga Oktoba, ana bikin ranar wayar da kan jama'a game da cutar kansar nono don ba da tallafi ga masu fama da cutar da kuma tara kudade don bincike don samar da ingantattun hanyoyin magance cutar.

Abincin da kuke ci kuma wanne kari kuke ɗauka shine yanke shawara. Ya kamata shawararku ta haɗa da la'akari da maye gurbi na ciwon daji, wanda cutar kansa, jiyya da ci gaba da gudana, duk wani rashin lafiyan, bayanin salon rayuwa, nauyi, tsayi da halaye.

Tsarin abinci mai gina jiki don cutar kansa daga addon baya dogara ne akan binciken intanet. Yana sarrafa muku yanke shawara ta atomatik dangane da kimiyyar kwayoyin da masana kimiyya da injiniyoyin software suka aiwatar. Ba tare da la’akari da ko kuna kula da fahimtar hanyoyin hanyoyin kwayoyin halittar biochemical ko a'a - don shirin abinci mai gina jiki don cutar kansa wanda ake buƙatar fahimta.

Fara NOW tare da shirin abinci mai gina jiki ta hanyar amsa tambayoyi kan sunan cutar kansa, maye gurbi, jiyya mai gudana da kari, duk wani rashin lafiyan, halaye, salon rayuwa, ƙungiyar shekaru da jinsi.

Marasa lafiya masu cutar kansa sau da yawa dole su magance daban-daban illar illa na chemotherapy wanda ke shafar ingancin rayuwarsu da kuma neman wasu hanyoyin magance cutar kansa. Shan da madaidaicin abinci mai gina jiki da kari bisa la'akari na kimiyya (gujewa zato da zabin bazata) shine mafi kyawun maganin halitta don cutar kansa da cututtukan da suka shafi jiyya.

References:

• Cancer.net (2022). Ciwon nono – Metastatic: Kididdiga.
• Cibiyar Ciwon daji ta Kasa. (nd). Ciwon Nono.
• American Cancer Society. (2021). Metastatic Breast Cancer.
• Cibiyar Ciwon daji ta Kasa. (2021). Metastatic Breast Cancer.
• Cancer.net. (2022). Ciwon nono – Metastatic: Kididdiga.

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