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What Foods are Recommended for Cancer?
is a very common question. Personalized Nutrition Plans are foods and supplements which are personalized to a cancer indication, genes, any treatments and lifestyle conditions.

Which Foods are Recommended for Hepatocellular Carcinoma Plus Intrahepatic Cholangiocarcinoma?

Aug 23, 2022

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Highlights

No two cancers are the same, nor are they treated the same, and neither should nutrition be the same for everyone. Nutrition includes foods like pulses, vegetables, fruits, nuts, oils, herbs and spices. Also nutrition includes supplements which are high concentrations of foods or high concentrations of individual ingredients found in foods. For cancers like Hepatocellular Carcinoma Plus Intrahepatic Cholangiocarcinoma when undergoing chemotherapy or when you determine you have a genetic risk for developing Hepatocellular Carcinoma Plus Intrahepatic Cholangiocarcinoma because of COL6A6 and BIRC6 gene mutations, a very important question is “What foods should I avoid and what foods are recommended specifically for me?”. The other related question is “What nutritional supplements should I avoid?”.

There is no one answer to this question for cancers such as Hepatocellular Carcinoma Plus Intrahepatic Cholangiocarcinoma which can be found through internet searches. The answer to the question is “It Depends” because the nutrition plan needs to be personalized for you. Nutrition should depend on the cancer indication, genetic information, adult or pediatric, staging, primary or secondary, advanced, metastatic, relapsed or refractory, ongoing treatments if any, nutritional supplements being taken, age and factors like gender, weight, height, lifestyle, allergies and food preferences.

In short – the process to answer questions like “Should I Avoid eating fruit Malus (crab Apple)” or “Include fruit Cherimoya in my diet” or “Should I reduce consumption of vegetable Lotus” or “Can I take Dim and Alpha Lipoic Acid supplements” is not as simple as internet searches. The process is very complex and answers are based on knowhow of genetics, action of treatments, active ingredients in foods and their associated biological action. Finally the answer to the nutrition question needs to be personalized for you.

RECOMMENDATION: PERSONALIZE YOUR FOODS AND SUPPLEMENTS TO HEPATOCELLULAR CARCINOMA PLUS INTRAHEPATIC CHOLANGIOCARCINOMA, TREATMENTS, GENETIC INFORMATION, AND OTHER CONDITIONS.

The overall objective of personalized nutrition for Hepatocellular Carcinoma Plus Intrahepatic Cholangiocarcinoma is to minimize foods and nutritional supplements which have adverse interactions with cancer molecular drivers and ongoing treatments. And identify those foods and supplements which have a beneficial action. Whenever there are changes in treatments or diagnosis – it is important to remember that your foods and supplements need re-evaluation. And the answers to the nutrition question could be different based on the new context.

RECOMMENDATION: UPDATE YOUR NUTRITION FOR HEPATOCELLULAR CARCINOMA PLUS INTRAHEPATIC CHOLANGIOCARCINOMA, WHEN TREATMENTS, DISEASE STATUS AND OTHER CONDITIONS CHANGE.



About Hepatocellular Carcinoma Plus Intrahepatic Cholangiocarcinoma

cBioPortal is one source of collection of cancer patient data from clinical trials across 350 plus cancer indications. The data from each clinical trial includes the clinical trial name and study details like number of patients, ages, gender, ethnicity, treatments, tumor site, genetic aberrations found and analysis of all the data. The cBioPortal for Cancer Genomics was originally developed at Memorial Sloan Kettering Cancer Center (MSK). The public cBioPortal site is hosted by the Center for Molecular Oncology at MSK – https://www.cbioportal.org/about.

Following key highlights are derived from clinical data for Hepatocellular Carcinoma Plus Intrahepatic Cholangiocarcinoma from cBioPortal. The patients enrolled in the studies for Hepatocellular Carcinoma Plus Intrahepatic Cholangiocarcinoma are in ages between 28 to 75 with an average age of 50. 80.8% of males and 19.2% of females were the distribution of gender in these clinical studies. From a patient sample size of 131; the top genes with mutations and other abnormalities for Hepatocellular Carcinoma Plus Intrahepatic Cholangiocarcinoma include genes TP53, MUC16, TERT, COL6A6 and BIRC6. The occurrence frequency distribution for these genes respectively is 15.8%, 11.5%, 11.5%, 5.5% and 3.6%. These tumor genetic details of Hepatocellular Carcinoma Plus Intrahepatic Cholangiocarcinoma are mapped to molecular biochemical pathway drivers of cancer thereby providing definition of characteristic features of Hepatocellular Carcinoma Plus Intrahepatic Cholangiocarcinoma.

Significance of Nutrition for Hepatocellular Carcinoma Plus Intrahepatic Cholangiocarcinoma

All foods and nutritional supplements consist of a collection of one or more active chemical ingredients in different proportions and quantities. The action of some active ingredients in a food can have adverse interactions while other active ingredients in the same food may be supportive from the context of Hepatocellular Carcinoma Plus Intrahepatic Cholangiocarcinoma. Hence the same food has good and not-so-good actions and analysis of combined effect will be needed to come up with a personalized nutrition plan.

For example Malus (crab Apple) includes active ingredients Linolenic Acid, Vitamin C, Oleic Acid, Linoleic Acid, 7-4′-dihydroxyflavone and others. And Cherimoya contains active ingredients Beta-sitosterol, Linolenic Acid, Vitamin C, Oleic Acid, Stigmasterol and others. It is likely that some of these active ingredients of the same food could have opposing effects and hence it is recommended to identify recommended foods based on analysis of all high quantity ingredients contained in foods.

For cancers like Hepatocellular Carcinoma Plus Intrahepatic Cholangiocarcinoma, activation or inhibition of selected biochemical pathways like RAS-RAF Signaling, mRNA Splicing, Focal Adhesion, Small Molecule Transport plays an important role in driving cancer growth. Similarly different treatments work via different molecular actions which should never be canceled out by your foods and supplements. The foods and nutritional supplements contain different active ingredients each of which have a specific molecular action on different biochemical pathways. Hence, eating some foods and nutritional supplements would be recommended with a specific treatment of Hepatocellular Carcinoma Plus Intrahepatic Cholangiocarcinoma, while eating some other foods and supplements may not be recommended.

One common mistake when finding foods to eat or not – is to consider only a few active ingredients contained in foods based on internet searches and ignore the rest. Because different active ingredients contained in foods may have opposing effects on relevant biochemical pathways – it is recommended to consider all the high quantity active ingredients that are present in significant and much larger than trace amounts in the food.

For cancers like Hepatocellular Carcinoma Plus Intrahepatic Cholangiocarcinoma, activation or inhibition of selected biochemical pathways like RAS-RAF Signaling, mRNA Splicing, Focal Adhesion, Small Molecule Transport plays an important role in driving cancer growth.

RECOMMENDATION: TO FIND RECOMMENDED AND NON-RECOMMENDED FOODS FOR HEPATOCELLULAR CARCINOMA PLUS INTRAHEPATIC CHOLANGIOCARCINOMA – CONSIDER HIGH QUANTITY ACTIVE INGREDIENTS CONTAINED IN FOODS.

Foods for Hepatocellular Carcinoma Plus Intrahepatic Cholangiocarcinoma undergoing chemotherapy treatment

In Hepatocellular Carcinoma Plus Intrahepatic Cholangiocarcinoma – the genes TP53, MUC16, TERT, COL6A6 and BIRC6 have high occurrences of genomic abnormalities. Not all of these genes necessarily are relevant for cancer – though they have been reported. Some of these genes directly or indirectly end up manipulating different cancer related biochemical biological pathways. Some of the pathways which are relevant drivers for Hepatocellular Carcinoma Plus Intrahepatic Cholangiocarcinoma are RAS-RAF Signaling, mRNA Splicing, Cell Cycle and others. Radiation is one of the chemotherapies used for cancer treatment. The intent of treatment is to negate or cancel out effects of biochemical pathway drivers RAS-RAF Signaling, mRNA Splicing, Cell Cycle so as to reduce disease progression and inhibit growth. Those foods whose combined action of active ingredients support treatment action and do not enhance disease drivers are recommended foods and supplements which will be included in personalized nutrition. And similarly – those foods whose combined action of active ingredients is not supportive of treatment action but end up promoting disease drives will not be recommended in your personalized nutrition plan.

RECOMMENDATION: AVOID SUPPLEMENTS AND FOODS WHICH ARE NOT SUPPORTIVE OF CANCER TREATMENT ACTION AND RATHER ENHANCE DISEASE DRIVERS.

Eat more pulses, Common Pea or Fava Bean?

Pulses are an important part of many diets. The active ingredients contained in Common Pea are Lupeol, Beta-sitosterol, Daidzein, Linolenic Acid, Genistein among others. While the active ingredients contained in Fava Bean are Quercetin, Caffeic Acid, Beta-sitosterol, P-coumaric Acid, Daidzein and others.

Beta-sitosterol can manipulate biochemical pathways Epithelial to Mesenchymal Transition, NFKB Signaling and Glucocorticoid Signaling. Vitamin C has biological action on biochemical pathways Cell Cycle, MYC Signaling and MAPK Signaling.

Quercetin can manipulate biochemical pathways Oxidative Stress. Caffeic Acid has biological action on biochemical pathways Heat Stress Response and TGFB Signaling. And so on.

When treating Hepatocellular Carcinoma Plus Intrahepatic Cholangiocarcinoma with chemotherapy Radiation – Foods like Common Pea are recommended compared to Fava Bean. This is because the active ingredients Quercetin and Caffeic Acid in Fava Bean interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Beta-sitosterol and Vitamin C contained in Common Pea support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.

RECOMMENDATION: COMMON PEA IS RECOMMENDED OVER FAVA BEAN FOR HEPATOCELLULAR CARCINOMA PLUS INTRAHEPATIC CHOLANGIOCARCINOMA ON TREATMENT WITH CHEMOTHERAPY RADIATION FOR SOME CONDITIONS.

Eat more vegetables, Giant Butterbur or Lotus?

Vegetables are an important part of many diets. The active ingredients contained in Giant Butterbur are Beta-sitosterol, Kaempferol, Vitamin C, Vitamin B3, Melatonin among others. While the active ingredients contained in Lotus are Quercetin, Beta-sitosterol, Linolenic Acid, Fisetin, Kaempferol and others.

Vitamin C can manipulate biochemical pathways Epithelial to Mesenchymal Transition, Cell Cycle and MYC Signaling. Beta-sitosterol has biological action on biochemical pathways NFKB Signaling, Glucocorticoid Signaling and Oxidative Stress.

Citric Acid can manipulate biochemical pathways Oxidative Stress. Quercetin has biological action on biochemical pathways Oxidative Stress. And so on.

When treating Hepatocellular Carcinoma Plus Intrahepatic Cholangiocarcinoma with chemotherapy Radiation – Foods like Giant Butterbur are recommended compared to Lotus. This is because the active ingredients Citric Acid and Quercetin in Lotus interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Vitamin C and Beta-sitosterol contained in Giant Butterbur support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.

RECOMMENDATION: GIANT BUTTERBUR IS RECOMMENDED OVER LOTUS FOR HEPATOCELLULAR CARCINOMA PLUS INTRAHEPATIC CHOLANGIOCARCINOMA ON TREATMENT WITH CHEMOTHERAPY RADIATION FOR SOME CONDITIONS.

Which Foods are Recommended for Hepatocellular Carcinoma Plus Intrahepatic Cholangiocarcinoma?

Eat more fruits, Cherimoya or Malus (crab Apple)?

Fruits are an important part of many diets. The active ingredients contained in Cherimoya are Beta-sitosterol, Linolenic Acid, Vitamin C, Oleic Acid, Stigmasterol among others. While the active ingredients contained in Malus (crab Apple) are Linolenic Acid, Vitamin C, Oleic Acid, Linoleic Acid, 7-4′-dihydroxyflavone and others.

Beta-sitosterol can manipulate biochemical pathways Epithelial to Mesenchymal Transition, NFKB Signaling and Glucocorticoid Signaling. Stigmasterol has biological action on biochemical pathways DNA Repair, JAK-STAT Signaling and Cell Cycle.

7-4′-dihydroxyflavone can manipulate biochemical pathways Chromatin Remodeling and Oncogenic Cancer Epigenetics. Linolenic Acid has biological action on biochemical pathways Oxidative Stress. And so on.

When treating Hepatocellular Carcinoma Plus Intrahepatic Cholangiocarcinoma with chemotherapy Radiation – Foods like Cherimoya are recommended compared to Malus (crab Apple). This is because the active ingredients 7-4′-dihydroxyflavone and Linolenic Acid in Malus (crab Apple) interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Beta-sitosterol and Stigmasterol contained in Cherimoya support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.

RECOMMENDATION: CHERIMOYA IS RECOMMENDED OVER MALUS (CRAB APPLE) FOR HEPATOCELLULAR CARCINOMA PLUS INTRAHEPATIC CHOLANGIOCARCINOMA ON TREATMENT WITH CHEMOTHERAPY RADIATION FOR SOME CONDITIONS.

Eat more nuts, Walnut or Peanut?

Nuts are an important part of many diets. The active ingredients contained in Walnut are Quercetin, Ellagic Acid, Myricetin, Beta-sitosterol, P-coumaric Acid among others. While the active ingredients contained in Peanut are Quercetin, Beta-sitosterol, Vitamin E, Linolenic Acid, Rhamnetin and others.

Ellagic Acid can manipulate biochemical pathways NFKB Signaling, Glucocorticoid Signaling and Oxidative Stress. Myricetin has biological action on biochemical pathways Microtubule Dynamics, DNA Repair and Growth Factor Signaling.

Quercetin can manipulate biochemical pathways Oxidative Stress. Vitamin A has biological action on biochemical pathways Extracellular Matrix Remodelling, Notch Signaling and Focal Adhesion. And so on.

When treating Hepatocellular Carcinoma Plus Intrahepatic Cholangiocarcinoma with chemotherapy Radiation – Foods like Walnut are recommended compared to Peanut. This is because the active ingredients Quercetin and Vitamin A in Peanut interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Ellagic Acid and Myricetin contained in Walnut support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.

RECOMMENDATION: WALNUT IS RECOMMENDED OVER PEANUT FOR HEPATOCELLULAR CARCINOMA PLUS INTRAHEPATIC CHOLANGIOCARCINOMA ON TREATMENT WITH CHEMOTHERAPY RADIATION FOR SOME CONDITIONS.

Foods for Genetic Risk of Hepatocellular Carcinoma Plus Intrahepatic Cholangiocarcinoma

One of the ways to assess risk of cancer is by checking for presence of genetic abnormalities in a set of genes. There is prior information on a list of genes whose mutations and other aberrations can play a role in risk to different cancers. COL6A6 and BIRC6 are two genes whose abnormalities are risk factors for Hepatocellular Carcinoma Plus Intrahepatic Cholangiocarcinoma. In such a cancer risk situation – while there are typically no treatments which a physician can prescribe – the various biochemical pathways which are potentially molecular drivers of Hepatocellular Carcinoma Plus Intrahepatic Cholangiocarcinoma can be used as a guide for coming up with a recommended personalized nutrition plan. For Hepatocellular Carcinoma Plus Intrahepatic Cholangiocarcinoma gene COL6A6 has causative impact on biological pathways like Extracellular Matrix Remodelling, Focal Adhesion and Growth Factor Signaling. And BIRC6 has a causative impact on biological pathways like . Foods and nutritional supplements which have molecular action to cancel out biochemical pathways effects of genes like COL6A6 and BIRC6 should be included in a personalized nutrition plan. And those foods and supplements which promote the effects of genes COL6A6 and BIRC6 should be avoided.

Eat more pulses, Mung Bean or Soy Bean?

The active ingredients contained in Mung Bean are Vitexin, Quercetin, Oleic Acid, Vitamin C, Linolenic Acid among others. While the active ingredients contained in Soy Bean are Daidzein, Lupeol, Quercetin, Vitamin E, Oleic Acid and others.

Vitexin can manipulate biochemical pathways Small Molecule Transport, MYC Signaling and Calcium Signaling. Vitamin C has biological action on biochemical pathways RAS-RAF Signaling, Cell Cycle Checkpoints and PI3K-AKT-MTOR Signaling.

Aescin can manipulate biochemical pathways Cell Cycle Checkpoints. Lecithin has biological action on biochemical pathways MYC Signaling and PI3K-AKT-MTOR Signaling. And so on.

For genetic risk of Hepatocellular Carcinoma Plus Intrahepatic Cholangiocarcinoma due to abnormalities in genes COL6A6 and BIRC6 – Foods like Mung Bean are recommended compared to Soy Bean. This is because the active ingredients Aescin and Lecithin in Soy Bean further promote the effects of genes on the biochemical pathways. While the active ingredients Vitexin and Vitamin C contained in Mung Bean together have a canceling effect of genes on the biochemical pathways.

RECOMMENDATION: MUNG BEAN IS RECOMMENDED OVER SOY BEAN FOR REDUCING THE GENETIC RISK OF HEPATOCELLULAR CARCINOMA PLUS INTRAHEPATIC CHOLANGIOCARCINOMA DUE TO GENES COL6A6 AND BIRC6

Eat more vegetables, Arrowroot or Squash?

The active ingredients contained in Arrowroot are Protocatechuic Acid, Quercetin, Vitamin C, Beta-carotene, Chlorogenic Acid among others. While the active ingredients contained in Squash are Ellagic Acid, Vitamin E, Oleic Acid, Beta-sitosterol, Vitamin C and others.

Protocatechuic Acid can manipulate biochemical pathways MYC Signaling, RAS-RAF Signaling and Cell Cycle Checkpoints. Vitamin C has biological action on biochemical pathways PI3K-AKT-MTOR Signaling, MYC Signaling and RAS-RAF Signaling.

Linoleic Acid can manipulate biochemical pathways Extracellular Matrix Remodelling. Folic Acid has biological action on biochemical pathways MYC Signaling, RAS-RAF Signaling and Cell Cycle Checkpoints. And so on.

For genetic risk of Hepatocellular Carcinoma Plus Intrahepatic Cholangiocarcinoma due to abnormalities in genes COL6A6 and BIRC6 – Foods like Arrowroot are recommended compared to Squash. This is because the active ingredients Linoleic Acid and Folic Acid in Squash further promote the effects of genes on the biochemical pathways. While the active ingredients Protocatechuic Acid and Vitamin C contained in Arrowroot together have a canceling effect of genes on the biochemical pathways.

RECOMMENDATION: ARROWROOT IS RECOMMENDED OVER SQUASH FOR REDUCING THE GENETIC RISK OF HEPATOCELLULAR CARCINOMA PLUS INTRAHEPATIC CHOLANGIOCARCINOMA DUE TO GENES COL6A6 AND BIRC6

Foods to Eat After Cancer Diagnosis!

No two cancers are the same. Go beyond the common nutrition guidelines for everyone and make personalized decisions about food and supplements with confidence.

Eat more fruits, Bilberry or Elderberry?

The active ingredients contained in Bilberry are Resveratrol, Quercetin, P-coumaric Acid, Chlorogenic Acid, Asperuloside among others. While the active ingredients contained in Elderberry are Lupeol, Quercetin, Betulinic Acid, Oleic Acid, Vitamin C and others.

Chlorogenic Acid can manipulate biochemical pathways MYC Signaling, PI3K-AKT-MTOR Signaling and Extracellular Matrix Remodelling. Delphinidin has biological action on biochemical pathways RAS-RAF Signaling, MYC Signaling and PI3K-AKT-MTOR Signaling.

Rutin can manipulate biochemical pathways Extracellular Matrix Remodelling. Isorhamnetin has biological action on biochemical pathways Small Molecule Transport and Calcium Signaling. And so on.

For genetic risk of Hepatocellular Carcinoma Plus Intrahepatic Cholangiocarcinoma due to abnormalities in genes COL6A6 and BIRC6 – Foods like Bilberry are recommended compared to Elderberry. This is because the active ingredients Rutin and Isorhamnetin in Elderberry further promote the effects of genes on the biochemical pathways. While the active ingredients Chlorogenic Acid and Delphinidin contained in Bilberry together have a canceling effect of genes on the biochemical pathways.

RECOMMENDATION: BILBERRY IS RECOMMENDED OVER ELDERBERRY FOR REDUCING THE GENETIC RISK OF HEPATOCELLULAR CARCINOMA PLUS INTRAHEPATIC CHOLANGIOCARCINOMA DUE TO GENES COL6A6 AND BIRC6

Eat more nuts, Pecan Nut or Cashew Nut?

The active ingredients contained in Pecan Nut are Vitamin E, Oleic Acid, Cianidanol, Linolenic Acid, Delphinidin among others. While the active ingredients contained in Cashew Nut are Beta-sitosterol, Vitamin C, Palmitic Acid, Butyric Acid, Gallic Acid and others.

Vitamin E can manipulate biochemical pathways MYC Signaling, Calcium Signaling and Cell Cycle Checkpoints. Cianidanol has biological action on biochemical pathways PI3K-AKT-MTOR Signaling, MYC Signaling and Cell Cycle Checkpoints.

Palmitic Acid can manipulate biochemical pathways PI3K-AKT-MTOR Signaling. Lauric Acid has biological action on biochemical pathways MYC Signaling and PI3K-AKT-MTOR Signaling. And so on.

For genetic risk of Hepatocellular Carcinoma Plus Intrahepatic Cholangiocarcinoma due to abnormalities in genes COL6A6 and BIRC6 – Foods like Pecan Nut are recommended compared to Cashew Nut. This is because the active ingredients Palmitic Acid and Lauric Acid in Cashew Nut further promote the effects of genes on the biochemical pathways. While the active ingredients Vitamin E and Cianidanol contained in Pecan Nut together have a canceling effect of genes on the biochemical pathways.

RECOMMENDATION: PECAN NUT IS RECOMMENDED OVER CASHEW NUT FOR REDUCING THE GENETIC RISK OF HEPATOCELLULAR CARCINOMA PLUS INTRAHEPATIC CHOLANGIOCARCINOMA DUE TO GENES COL6A6 AND BIRC6


In Summary

An important thing to remember is that cancer treatments may not be the same for everyone – and neither should your nutrition be. Nutrition which includes food and nutritional supplements is a very effective tool controlled by you.

“What should I eat?” is the most frequently asked question in the context of cancer. The answer calculation is complex and depends upon cancer type, underlying genomics, current treatments, any allergies, lifestyle information, and factors like BMI.

The addon personalized nutrition plan recommends foods and supplements which minimizes adverse nutrition interactions and encourages support to treatments.

You can get started NOW and design a personalized nutrition plan for Hepatocellular Carcinoma Plus Intrahepatic Cholangiocarcinoma by answering questions on type of cancer, current treatments, supplements, allergies, age group, gender, and lifestyle information.

What food you eat and which supplements you take is a decision you make. Your decision should include consideration of the cancer gene mutations, which cancer, ongoing treatments and supplements, any allergies, lifestyle information, weight, height and habits.

The nutrition planning for cancer from addon is not based on internet searches. It automates the decision making for you based on molecular science implemented by our scientists and software engineers. Irrespective of whether you care to understand the underlying biochemical molecular pathways or not - for nutrition planning for cancer that understanding is needed.

Get started NOW with your nutrition planning by answering questions on the name of cancer, genetic mutations, ongoing treatments and supplements, any allergies, habits, lifestyle, age group and gender.

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References

Personalized Nutrition for Cancer!

Cancer changes with time. Customize and modify your nutrition based on cancer indication, treatments, lifestyle, food preferences, allergies and other factors.


Scientifically Reviewed by: Dr. Cogle

Christopher R. Cogle, M.D. is a tenured professor at the University of Florida, Chief Medical Officer of Florida Medicaid, and Director of the Florida Health Policy Leadership Academy at the Bob Graham Center for Public Service.

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