Foods for Hodgkin Lymphoma!

Introduction

Foods for Hodgkin Lymphoma should be personalized for each individual and also must adapt when cancer treatment or tumor genetic change. The personalization and adaptation must consider all the active ingredients or bioactives contained in different foods with respect to cancer tissue biology, genetics, treatments, lifestyle conditions and diet preferences. Hence while nutrition is one of the very important decisions for a cancer patient and individual at risk of cancer to make – how to choose foods to eat is not an easy task.

For Hodgkin Lymphoma does it matter what vegetables, fruits, nuts, seeds one eats?

A very common nutrition question asked by cancer patients and individuals at-genetic risk of cancer is – for cancers like Hodgkin Lymphoma does it matter what foods I eat and which I do not? Or if I follow a plant-based diet is that enough for cancer like Hodgkin Lymphoma?

For example does it matter if vegetable Celery Stalks is consumed more compared to Oyster Mushroom? Does it make any difference if fruit {food_fruit1_nr1} is preferred over Arctic Blackberry? Also if similar choices are made for nuts/seeds like Chestnut over {food_nut1_nr1} and for pulses like Yellow Wax Bean over {food_pulse1_nr1}. And if what I eat matters – then how does one identify foods which are recommended for Hodgkin Lymphoma and is it the same answer for everyone with the same diagnosis or genetic risk?

Yes! Foods you eat matters for Hodgkin Lymphoma!

Food recommendations may not be the same for everyone and can be different even for the same diagnosis and genetic risk.

All foods (vegetables, fruits, nuts, seeds, pulses, oils etc.) and nutritional supplements are made up of more than one active molecular ingredient or bio-actives in different proportions and quantities. Each active ingredient has a unique mechanism of action – which can be activation or inhibition of different biochemical pathways. Simply stated foods and supplements which are recommended are those which do not cause an increase of molecular drivers of cancer but reduce them. Else those foods should not be recommended. Foods contain multiple active ingredients – hence when evaluating foods and supplements you need to consider the impact of all active ingredients cumulatively rather than individually.

For example {food_fruit1_nr1} contains active ingredients {food_fruit1_nr1_ing}. And Arctic Blackberry contains active ingredients Ellagic Acid, Curcumin, Apigenin, Phloretin, Formononetin and possibly others.

A common mistake made when deciding and choosing foods to eat for Hodgkin Lymphoma – is to evaluate only selected active ingredients contained in foods and ignore the rest. Because different active ingredients contained in foods may have opposing effects on cancer drivers – you cannot cherry pick active ingredients in foods and supplements for making a nutrition decision for Hodgkin Lymphoma.

YES – FOOD CHOICES MATTER FOR CANCER. NUTRITION DECISIONS MUST CONSIDER ALL ACTIVE INGREDIENTS OF FOODS.

Skills Needed for Nutrition Personalization for Hodgkin Lymphoma?

Personalized nutrition for cancers like Hodgkin Lymphoma consists of recommended foods / supplements; not recommended foods / supplements with example recipes which prioritize use of recommended foods. An example of personalized nutrition can be seen at this link.

Deciding which foods are recommended or not is extremely complicated, requiring expertise in Hodgkin Lymphoma biology, food science, genetics, biochemistry along with good understanding of how cancer treatments work and associated vulnerabilities by which the treatments could stop being effective.

MINIMUM KNOWLEDGE EXPERTISE NEEDED FOR NUTRITION PERSONALIZATION FOR CANCER ARE: CANCER BIOLOGY, FOOD SCIENCE, CANCER TREATMENTS AND GENETICS.

Characteristics of cancers like Hodgkin Lymphoma

All cancers like Hodgkin Lymphoma can be characterized by a unique set of biochemical pathways – the signature pathways of Hodgkin Lymphoma. Biochemical pathways like Apoptosis, Chromatin Remodeling, Cell Cycle Checkpoints, Epithelial to Mesenchymal Transition are part of the signature definition of Hodgkin Lymphoma. Each individual’s cancer genetics can be different and hence their specific cancer signature could be unique.

The treatments which are effective for Hodgkin Lymphoma need to be cognizant of the associated signature biochemical pathways for each cancer patient and individual at genetic risk. Therefore different treatments with different mechanisms of actions are effective for different patients. Similarly and for the same reasons foods and supplements need to be personalized for each individual. Hence some foods and supplements are recommended for Hodgkin Lymphoma when taking cancer treatment Vinblastine, and some foods and supplements are not recommended.

Sources like cBioPortal and many others provide population representative patient anonymized data from clinical trials for all cancer indications. This data consists of clinical trial study details like sample size / number of patients, age groups, gender, ethnicity, treatments, tumor site and any genetic mutations.

ARID1A, ARID5B, B2M, CD79A and CTCF are the top ranked reported genes for Hodgkin Lymphoma. ARID1A is reported in 25.0 % of the representative patients across all clinical trials. And ARID5B is reported in 25.0 %. The combined population patient data cover ages from to . 60.0 % of the patient data are identified as men. The Hodgkin Lymphoma biology along with reported genetics together define the population represented signature biochemical pathways for this cancer. If the individual cancer tumor genetics or genes contributing to the risk are also known then that should also be used for nutrition personalization.

NUTRITION CHOICES SHOULD MATCH WITH EACH INDIVIDUAL’S CANCER SIGNATURE.

Food and Supplements for Hodgkin Lymphoma

For Cancer Patients

Cancer patients on treatment or on palliative care need to make decisions on food and supplements – for the needed dietary calories, for managing any treatment side effects and also for improved cancer management. All plant-based foods are not equal and choosing and prioritizing foods which are personalized and customized to ongoing cancer treatment is important and complicated. Here are some examples providing guidelines for making nutrition decisions.

Choose Vegetable CELERY STALKS or OYSTER MUSHROOM

Vegetable Celery Stalks contains many active ingredients or bioactives such as Curcumin, Apigenin, Phloretin, Formononetin, Rosmarinic Acid. These active ingredients manipulate various biochemical pathways like Apoptosis and Cell Survival and others. Celery Stalks is recommended for Hodgkin Lymphoma when ongoing cancer treatment is Vinblastine. This is because Celery Stalks modifies those biochemical pathways which have been scientifically reported to sensitize the effect of Vinblastine.

Some of the active ingredients or bioactives in vegetable Oyster Mushroom are Curcumin, Apigenin, Phloretin, Formononetin, Rosmarinic Acid. These active ingredients manipulate various biochemical pathways like Apoptosis and others. Oyster Mushroom is not recommended for Hodgkin Lymphoma when ongoing cancer treatment is Vinblastine because it modifies those biochemical pathways which make the cancer treatment resistant or less responsive.

VEGETABLE CELERY STALKS IS RECOMMENDED OVER OYSTER MUSHROOM FOR Hodgkin Lymphoma AND TREATMENT Vinblastine.

Choose Fruit ARCTIC BLACKBERRY

Fruit Arctic Blackberry contains many active ingredients or bioactives such as Ellagic Acid, Curcumin, Apigenin, Phloretin, Formononetin. These active ingredients manipulate various biochemical pathways like Apoptosis and Cell Survival and others. Arctic Blackberry is recommended for Hodgkin Lymphoma when ongoing cancer treatment is Vinblastine. This is because Arctic Blackberry modifies those biochemical pathways which have been scientifically reported to sensitize the effect of Vinblastine.

FRUIT ARCTIC BLACKBERRY IS RECOMMENDED FOR Hodgkin Lymphoma AND TREATMENT Vinblastine.

Choose Nut CHESTNUT

Chestnut contains many active ingredients or bioactives such as Ellagic Acid, Curcumin, Apigenin, Phloretin, Formononetin. These active ingredients manipulate various biochemical pathways like Apoptosis and Cell Survival and others. Chestnut is recommended for Hodgkin Lymphoma when ongoing cancer treatment is Vinblastine. This is because Chestnut modifies those biochemical pathways which have been scientifically reported to sensitize the effect of Vinblastine.

CHESTNUT IS RECOMMENDED FOR Hodgkin Lymphoma AND TREATMENT Vinblastine.

For Individuals with Genetic Risk of Cancer

The question asked by individuals who have genetic risk of Hodgkin Lymphoma or familial history is “What Should I Eat Differently from Before?” and how they should choose foods and supplements to manage risks of the disease. Since for cancer risk there is nothing actionable in terms of treatment – decisions of foods and supplements become important and one of the very few actionable things which can be done. All plant-based foods are not equal and based on identified genetics and pathway signature – the choices of food and supplements should be personalized.

Choose Vegetable GIANT BUTTERBUR or MOUNTAIN YAM

Vegetable Giant Butterbur contains many active ingredients or bioactives such as Curcumin, Apigenin, Lupeol, Beta-sitosterol, Phloretin. These active ingredients manipulate various biochemical pathways like Cell Cycle Checkpoints, Cell Cycle, Apoptosis and PI3K-AKT-MTOR Signaling and others. Giant Butterbur is recommended for risk of Hodgkin Lymphoma when associated genetic risk is ARID1A. This is because Giant Butterbur increases those biochemical pathways which counteract the signature drivers of it.

Some of the active ingredients or bioactives in vegetable Mountain Yam are Curcumin, Apigenin, Lupeol, Beta-sitosterol, Phloretin. These active ingredients manipulate various biochemical pathways like Cell Cycle Checkpoints, DNA Repair and WNT Beta Catenin Signaling and others. Mountain Yam is not recommended when risk of Hodgkin Lymphoma when associated genetic risk is ARID1A because it increases the signature pathways of it.

VEGETABLE GIANT BUTTERBUR IS RECOMMENDED OVER MOUNTAIN YAM FOR ARID1A GENETIC RISK OF CANCER.

Choose Fruit JAVA PLUM or HALF-HIGHBUSH BLUEBERRY

Fruit Java Plum contains many active ingredients or bioactives such as Curcumin, Apigenin, Lupeol, Beta-sitosterol, Phloretin. These active ingredients manipulate various biochemical pathways like Cell Cycle Checkpoints, Cell Cycle, Apoptosis and PI3K-AKT-MTOR Signaling and others. Java Plum is recommended for risk of Hodgkin Lymphoma when associated genetic risk is ARID1A. This is because Java Plum increases those biochemical pathways which counteract the signature drivers of it.

Some of the active ingredients or bioactives in fruit Half-highbush Blueberry are Curcumin, Apigenin, Lupeol, Beta-sitosterol, Phloretin. These active ingredients manipulate various biochemical pathways like DNA Repair and Suppressive Histone Methylation and others. Half-highbush Blueberry is not recommended when risk of Hodgkin Lymphoma when associated genetic risk is ARID1A because it increases the signature pathways of it.

FRUIT JAVA PLUM IS RECOMMENDED OVER HALF-HIGHBUSH BLUEBERRY FOR ARID1A GENETIC RISK OF CANCER.

Choose Nut BUTTERNUT or JAPANESE WALNUT

Butternut contains many active ingredients or bioactives such as Curcumin, Apigenin, Lupeol, Beta-sitosterol, Phloretin. These active ingredients manipulate various biochemical pathways like DNA Repair, Cell Cycle, MYC Signaling and PI3K-AKT-MTOR Signaling and others. Butternut is recommended for risk of Hodgkin Lymphoma when associated genetic risk is ARID1A. This is because Butternut increases those biochemical pathways which counteract the signature drivers of it.

Some of the active ingredients or bioactives in Japanese Walnut are Curcumin, Apigenin, Lupeol, Beta-sitosterol, Phloretin. These active ingredients manipulate various biochemical pathways like Cell Cycle Checkpoints, DNA Repair and Suppressive Histone Methylation and others. Japanese Walnut is not recommended when risk of Hodgkin Lymphoma when associated genetic risk is ARID1A because it increases the signature pathways of it.

BUTTERNUT IS RECOMMENDED OVER JAPANESE WALNUT FOR ARID1A GENETIC RISK OF CANCER.

In Conclusion

Foods and Supplements chosen are important decisions for cancers like Hodgkin Lymphoma. Hodgkin Lymphoma patients and individuals with genetic-risk always have this question: “What foods and nutritional supplements are recommended for me and which are not?” There is a common belief which is a misconception that all plant-based foods could be beneficial or not but would not be harmful. Certain foods and supplements can interfere with cancer treatments or promote molecular pathway drivers of cancer.

There are different types of cancer indications like Hodgkin Lymphoma, each with different tumor genetics with further genomic variations across each individual. Further every cancer treatment and chemotherapy has a unique mechanism of action. Each food like Celery Stalks contains various bioactives in different quantities, which have an impact on different and distinct sets of biochemical pathways. The definition of personalized nutrition is individualized food recommendations for the cancer indication, treatments, genetics, lifestyle and other factors. Nutrition personalization decisions for cancer require knowledge of cancer biology, food science and an understanding of different chemotherapy treatments. Finally when there are treatment changes or new genomics is identified – the nutrition personalization needs re-evaluation.

The addon nutrition personalization solution makes the decision making easy and removes all the guesswork in answering the question, “What foods should I choose or not choose for Hodgkin Lymphoma?”. The addon multi-disciplinary team includes cancer physicians, clinical scientists, software engineers and data scientists.

References

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