Which Foods are Recommended for Anaplastic Oligoastrocytoma?

Highlights

No two cancers are the same, nor are they treated the same, and neither should nutrition be the same for everyone. Nutrition includes foods like pulses, vegetables, fruits, nuts, oils, herbs and spices. Also nutrition includes supplements which are high concentrations of foods or high concentrations of individual ingredients found in foods. For cancers like Anaplastic Oligoastrocytoma when undergoing chemotherapy or when you determine you have a genetic risk for developing Anaplastic Oligoastrocytoma because of NOTCH2 and IDH1 gene mutations, a very important question is “What foods should I avoid and what foods are recommended specifically for me?”. The other related question is “What nutritional supplements should I avoid?”.

There is no one answer to this question for cancers such as Anaplastic Oligoastrocytoma which can be found through internet searches. The answer to the question is “It Depends” because the nutrition plan needs to be personalized for you. Nutrition should depend on the cancer indication, genetic information, adult or pediatric, staging, primary or secondary, advanced, metastatic, relapsed or refractory, ongoing treatments if any, nutritional supplements being taken, age and factors like gender, weight, height, lifestyle, allergies and food preferences.

In short – the process to answer questions like “Should I Avoid eating fruit Cranberry” or “Include fruit Pomegranate in my diet” or “Should I reduce consumption of vegetable Lotus” or “Can I take Tangerine and Dim supplements” is not as simple as internet searches. The process is very complex and answers are based on knowhow of genetics, action of treatments, active ingredients in foods and their associated biological action. Finally the answer to the nutrition question needs to be personalized for you.

RECOMMENDATION: PERSONALIZE YOUR FOODS AND SUPPLEMENTS TO ANAPLASTIC OLIGOASTROCYTOMA, TREATMENTS, GENETIC INFORMATION, AND OTHER CONDITIONS.

The overall objective of personalized nutrition for Anaplastic Oligoastrocytoma is to minimize foods and nutritional supplements which have adverse interactions with cancer molecular drivers and ongoing treatments. And identify those foods and supplements which have a beneficial action. Whenever there are changes in treatments or diagnosis – it is important to remember that your foods and supplements need re-evaluation. And the answers to the nutrition question could be different based on the new context.

RECOMMENDATION: UPDATE YOUR NUTRITION FOR ANAPLASTIC OLIGOASTROCYTOMA, WHEN TREATMENTS, DISEASE STATUS AND OTHER CONDITIONS CHANGE.

About Anaplastic Oligoastrocytoma

cBioPortal is one source of collection of cancer patient data from clinical trials across 350 plus cancer indications. The data from each clinical trial includes the clinical trial name and study details like number of patients, ages, gender, ethnicity, treatments, tumor site, genetic aberrations found and analysis of all the data. The cBioPortal for Cancer Genomics was originally developed at Memorial Sloan Kettering Cancer Center (MSK). The public cBioPortal site is hosted by the Center for Molecular Oncology at MSK – https://www.cbioportal.org/about.

Following key highlights are derived from clinical data for Anaplastic Oligoastrocytoma from cBioPortal. The patients enrolled in the studies for Anaplastic Oligoastrocytoma are in ages between 30 to 56 with an average age of 46. 58.8% of males and 41.2% of females were the distribution of gender in these clinical studies. From a patient sample size of 18; the top genes with mutations and other abnormalities for Anaplastic Oligoastrocytoma include genes TP53, TERT, NOTCH2, IDH1 and EIF1AX. The occurrence frequency distribution for these genes respectively is 64.7%, 17.6%, 11.8%, 11.8% and 5.9%. These tumor genetic details of Anaplastic Oligoastrocytoma are mapped to molecular biochemical pathway drivers of cancer thereby providing definition of characteristic features of Anaplastic Oligoastrocytoma.

Significance of Nutrition for Anaplastic Oligoastrocytoma

All foods and nutritional supplements consist of a collection of one or more active chemical ingredients in different proportions and quantities. The action of some active ingredients in a food can have adverse interactions while other active ingredients in the same food may be supportive from the context of Anaplastic Oligoastrocytoma. Hence the same food has good and not-so-good actions and analysis of combined effect will be needed to come up with a personalized nutrition plan.

For example Cranberry includes active ingredients Quercetin, Ellagic Acid, Vitamin C, Hyperoside, P-coumaric Acid and others. And Pomegranate contains active ingredients Apigenin, Ellagic Acid, Vitamin C, Corilagin, Beta-sitosterol and others. It is likely that some of these active ingredients of the same food could have opposing effects and hence it is recommended to identify recommended foods based on analysis of all high quantity ingredients contained in foods.

For cancers like Anaplastic Oligoastrocytoma, activation or inhibition of selected biochemical pathways like DNA Repair, Hypoxia, Apoptosis, Cell Cycle Checkpoints plays an important role in driving cancer growth. Similarly different treatments work via different molecular actions which should never be canceled out by your foods and supplements. The foods and nutritional supplements contain different active ingredients each of which have a specific molecular action on different biochemical pathways. Hence, eating some foods and nutritional supplements would be recommended with a specific treatment of Anaplastic Oligoastrocytoma, while eating some other foods and supplements may not be recommended.

One common mistake when finding foods to eat or not – is to consider only a few active ingredients contained in foods based on internet searches and ignore the rest. Because different active ingredients contained in foods may have opposing effects on relevant biochemical pathways – it is recommended to consider all the high quantity active ingredients that are present in significant and much larger than trace amounts in the food.

RECOMMENDATION: TO FIND RECOMMENDED AND NON-RECOMMENDED FOODS FOR ANAPLASTIC OLIGOASTROCYTOMA – CONSIDER HIGH QUANTITY ACTIVE INGREDIENTS CONTAINED IN FOODS.

Foods for Anaplastic Oligoastrocytoma undergoing chemotherapy treatment

In Anaplastic Oligoastrocytoma – the genes TP53, TERT, NOTCH2, IDH1 and EIF1AX have high occurrences of genomic abnormalities. Not all of these genes necessarily are relevant for cancer – though they have been reported. Some of these genes directly or indirectly end up manipulating different cancer related biochemical biological pathways. Some of the pathways which are relevant drivers for Anaplastic Oligoastrocytoma are DNA Repair, Hypoxia, RUNX Signaling and others. Temozolomide is one of the chemotherapies used for cancer treatment. The intent of treatment is to negate or cancel out effects of biochemical pathway drivers DNA Repair, Hypoxia, RUNX Signaling so as to reduce disease progression and inhibit growth. Those foods whose combined action of active ingredients support treatment action and do not enhance disease drivers are recommended foods and supplements which will be included in personalized nutrition. And similarly – those foods whose combined action of active ingredients is not supportive of treatment action but end up promoting disease drives will not be recommended in your personalized nutrition plan.

RECOMMENDATION: AVOID SUPPLEMENTS AND FOODS WHICH ARE NOT SUPPORTIVE OF CANCER TREATMENT ACTION AND RATHER ENHANCE DISEASE DRIVERS.

Eat more pulses, Scarlet Bean or Common Bean?

Pulses are an important part of many diets. The active ingredients contained in Scarlet Bean are Vitamin C, Beta-sitosterol, Linolenic Acid, Oleic Acid, Stigmasterol among others. While the active ingredients contained in Common Bean are Apigenin, Esculin, Vitamin C, Ferulic Acid, P-coumaric Acid and others.

Vitamin C can manipulate biochemical pathways Growth Factor Signaling, Cell Cycle and MYC Signaling. Beta-sitosterol has biological action on biochemical pathways P53 Signaling, RUNX Signaling and PI3K-AKT-MTOR Signaling.

Apigenin can manipulate biochemical pathways DNA Repair. Esculin has biological action on biochemical pathways DNA Repair. And so on.

When treating Anaplastic Oligoastrocytoma with chemotherapy Temozolomide – Foods like Scarlet Bean are recommended compared to Common Bean. This is because the active ingredients Apigenin and Esculin in Common Bean interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Vitamin C and Beta-sitosterol contained in Scarlet Bean support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.

RECOMMENDATION: SCARLET BEAN IS RECOMMENDED OVER COMMON BEAN FOR ANAPLASTIC OLIGOASTROCYTOMA ON TREATMENT WITH CHEMOTHERAPY TEMOZOLOMIDE FOR SOME CONDITIONS.

Eat more vegetables, Lettuce or Lotus?

Vegetables are an important part of many diets. The active ingredients contained in Lettuce are Quercetin, Vitamin C, Beta-sitosterol, Linolenic Acid, Oleic Acid among others. While the active ingredients contained in Lotus are Quercetin, Fisetin, Vitamin C, Beta-sitosterol, Linolenic Acid and others.

Vitamin A can manipulate biochemical pathways MYC Signaling, Cell Cycle and PI3K-AKT-MTOR Signaling. Vitamin K has biological action on biochemical pathways MYC Signaling, Cell Cycle and PI3K-AKT-MTOR Signaling.

Fisetin can manipulate biochemical pathways MYC Signaling. Linoleic Acid has biological action on biochemical pathways Growth Factor Signaling. And so on.

When treating Anaplastic Oligoastrocytoma with chemotherapy Temozolomide – Foods like Lettuce are recommended compared to Lotus. This is because the active ingredients Fisetin and Linoleic Acid in Lotus interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Vitamin A and Vitamin K contained in Lettuce support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.

RECOMMENDATION: LETTUCE IS RECOMMENDED OVER LOTUS FOR ANAPLASTIC OLIGOASTROCYTOMA ON TREATMENT WITH CHEMOTHERAPY TEMOZOLOMIDE FOR SOME CONDITIONS.

Eat more fruits, Pomegranate or Cranberry?

Fruits are an important part of many diets. The active ingredients contained in Pomegranate are Apigenin, Ellagic Acid, Vitamin C, Corilagin, Beta-sitosterol among others. While the active ingredients contained in Cranberry are Quercetin, Ellagic Acid, Vitamin C, Hyperoside, P-coumaric Acid and others.

Betulinic Acid can manipulate biochemical pathways DNA Repair, Cell Cycle and MYC Signaling. Gallic Acid has biological action on biochemical pathways Growth Factor Signaling, PI3K-AKT-MTOR Signaling and Hypoxia.

Ellagic Acid can manipulate biochemical pathways MYC Signaling. Resveratrol has biological action on biochemical pathways P53 Signaling and DNA Repair. And so on.

When treating Anaplastic Oligoastrocytoma with chemotherapy Temozolomide – Foods like Pomegranate are recommended compared to Cranberry. This is because the active ingredients Ellagic Acid and Resveratrol in Cranberry interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Betulinic Acid and Gallic Acid contained in Pomegranate support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.

RECOMMENDATION: POMEGRANATE IS RECOMMENDED OVER CRANBERRY FOR ANAPLASTIC OLIGOASTROCYTOMA ON TREATMENT WITH CHEMOTHERAPY TEMOZOLOMIDE FOR SOME CONDITIONS.

Eat more nuts, Pecan Nut or Chestnut?

Nuts are an important part of many diets. The active ingredients contained in Pecan Nut are Vitamin E, Linolenic Acid, Oleic Acid, Cianidanol, Vitamin A among others. While the active ingredients contained in Chestnut are Quercetin, Ellagic Acid, Vitamin C, Linolenic Acid, Gallic Acid and others.

Vitamin E can manipulate biochemical pathways DNA Repair, Cell Cycle and Growth Factor Signaling. Cianidanol has biological action on biochemical pathways MYC Signaling, P53 Signaling and RUNX Signaling.

Ellagic Acid can manipulate biochemical pathways MYC Signaling. Linoleic Acid has biological action on biochemical pathways Growth Factor Signaling. And so on.

When treating Anaplastic Oligoastrocytoma with chemotherapy Temozolomide – Foods like Pecan Nut are recommended compared to Chestnut. This is because the active ingredients Ellagic Acid and Linoleic Acid in Chestnut interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Vitamin E and Cianidanol contained in Pecan Nut support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.

RECOMMENDATION: PECAN NUT IS RECOMMENDED OVER CHESTNUT FOR ANAPLASTIC OLIGOASTROCYTOMA ON TREATMENT WITH CHEMOTHERAPY TEMOZOLOMIDE FOR SOME CONDITIONS.

Foods for Genetic Risk of Anaplastic Oligoastrocytoma

One of the ways to assess risk of cancer is by checking for presence of genetic abnormalities in a set of genes. There is prior information on a list of genes whose mutations and other aberrations can play a role in risk to different cancers. NOTCH2 and IDH1 are two genes whose abnormalities are risk factors for Anaplastic Oligoastrocytoma. In such a cancer risk situation – while there are typically no treatments which a physician can prescribe – the various biochemical pathways which are potentially molecular drivers of Anaplastic Oligoastrocytoma can be used as a guide for coming up with a recommended personalized nutrition plan. For Anaplastic Oligoastrocytoma gene NOTCH2 has causative impact on biological pathways like Notch Signaling and Thyroid Hormone Signaling. And IDH1 has a causative impact on biological pathways like Oncogenic Cancer Epigenetics, Glutathione Metabolism and Hypoxia. Foods and nutritional supplements which have molecular action to cancel out biochemical pathways effects of genes like NOTCH2 and IDH1 should be included in a personalized nutrition plan. And those foods and supplements which promote the effects of genes NOTCH2 and IDH1 should be avoided.

Eat more pulses, Common Pea or Soy Bean?

The active ingredients contained in Common Pea are Vitamin C, Lupeol, Beta-sitosterol, Daidzein, Linolenic Acid among others. While the active ingredients contained in Soy Bean are Vitamin C, Lupeol, Vitamin E, Quercetin, Beta-sitosterol and others.

Vitamin C can manipulate biochemical pathways Apoptosis, MYC Signaling and P53 Signaling. Beta-sitosterol has biological action on biochemical pathways Cell Cycle Checkpoints, Oncogenic Cancer Epigenetics and Hypoxia.

Aescin can manipulate biochemical pathways Cell Cycle Checkpoints. Lecithin has biological action on biochemical pathways MYC Signaling. And so on.

For genetic risk of Anaplastic Oligoastrocytoma due to abnormalities in genes NOTCH2 and IDH1 – Foods like Common Pea are recommended compared to Soy Bean. This is because the active ingredients Aescin and Lecithin in Soy Bean further promote the effects of genes on the biochemical pathways. While the active ingredients Vitamin C and Beta-sitosterol contained in Common Pea together have a canceling effect of genes on the biochemical pathways.

RECOMMENDATION: COMMON PEA IS RECOMMENDED OVER SOY BEAN FOR REDUCING THE GENETIC RISK OF ANAPLASTIC OLIGOASTROCYTOMA DUE TO GENES NOTCH2 AND IDH1

Eat more vegetables, Giant Butterbur or Heart Of Palm?

The active ingredients contained in Giant Butterbur are Vitamin C, Beta-sitosterol, Vitamin B3, Melatonin, Kaempferol among others. While the active ingredients contained in Heart Of Palm are Vitamin C, Palmitic Acid, Vitamin A, Folic Acid and others.

Vitamin C can manipulate biochemical pathways Apoptosis, MYC Signaling and P53 Signaling. Beta-sitosterol has biological action on biochemical pathways Cell Cycle Checkpoints, Oncogenic Cancer Epigenetics and Hypoxia.

Palmitic Acid can manipulate biochemical pathways Oncogenic Cancer Epigenetics and Energy Metabolism. Folic Acid has biological action on biochemical pathways MYC Signaling, P53 Signaling and Cell Cycle Checkpoints. And so on.

For genetic risk of Anaplastic Oligoastrocytoma due to abnormalities in genes NOTCH2 and IDH1 – Foods like Giant Butterbur are recommended compared to Heart Of Palm. This is because the active ingredients Palmitic Acid and Folic Acid in Heart Of Palm further promote the effects of genes on the biochemical pathways. While the active ingredients Vitamin C and Beta-sitosterol contained in Giant Butterbur together have a canceling effect of genes on the biochemical pathways.

RECOMMENDATION: GIANT BUTTERBUR IS RECOMMENDED OVER HEART OF PALM FOR REDUCING THE GENETIC RISK OF ANAPLASTIC OLIGOASTROCYTOMA DUE TO GENES NOTCH2 AND IDH1

Eat more fruits, Feijoa or Raspberry?

The active ingredients contained in Feijoa are Vitamin C, Lycopene, Casuarinin, Folic Acid among others. While the active ingredients contained in Raspberry are Vitamin C, Quercetin, Resveratrol, Ellagic Acid, Gallic Acid and others.

Vitamin C can manipulate biochemical pathways Apoptosis, MYC Signaling and P53 Signaling. Lycopene has biological action on biochemical pathways Cell Cycle Checkpoints, Hypoxia and Apoptosis.

Ellagic Acid can manipulate biochemical pathways MYC Signaling. Resveratrol has biological action on biochemical pathways P53 Signaling. And so on.

For genetic risk of Anaplastic Oligoastrocytoma due to abnormalities in genes NOTCH2 and IDH1 – Foods like Feijoa are recommended compared to Raspberry. This is because the active ingredients Ellagic Acid and Resveratrol in Raspberry further promote the effects of genes on the biochemical pathways. While the active ingredients Vitamin C and Lycopene contained in Feijoa together have a canceling effect of genes on the biochemical pathways.

RECOMMENDATION: FEIJOA IS RECOMMENDED OVER RASPBERRY FOR REDUCING THE GENETIC RISK OF ANAPLASTIC OLIGOASTROCYTOMA DUE TO GENES NOTCH2 AND IDH1

Eat more nuts, Pine Nut or Acorn?

The active ingredients contained in Pine Nut are Vitamin E, Beta-sitosterol, Linolenic Acid, Oleic Acid, Linoleic Acid among others. While the active ingredients contained in Acorn are Vitamin C, Quercetin, Beta-sitosterol, Beta-carotene, Quercitrin and others.

Beta-sitosterol can manipulate biochemical pathways Apoptosis, MYC Signaling and P53 Signaling. Vitamin K has biological action on biochemical pathways Cell Cycle Checkpoints and MYC Signaling.

Vitamin B2 can manipulate biochemical pathways Oncogenic Cancer Epigenetics. Folic Acid has biological action on biochemical pathways MYC Signaling, P53 Signaling and Cell Cycle Checkpoints. And so on.

For genetic risk of Anaplastic Oligoastrocytoma due to abnormalities in genes NOTCH2 and IDH1 – Foods like Pine Nut are recommended compared to Acorn. This is because the active ingredients Vitamin B2 and Folic Acid in Acorn further promote the effects of genes on the biochemical pathways. While the active ingredients Beta-sitosterol and Vitamin K contained in Pine Nut together have a canceling effect of genes on the biochemical pathways.

RECOMMENDATION: PINE NUT IS RECOMMENDED OVER ACORN FOR REDUCING THE GENETIC RISK OF ANAPLASTIC OLIGOASTROCYTOMA DUE TO GENES NOTCH2 AND IDH1

In Summary

An important thing to remember is that cancer treatments may not be the same for everyone – and neither should your nutrition be. Nutrition which includes food and nutritional supplements is a very effective tool controlled by you.

“What should I eat?” is the most frequently asked question in the context of cancer. The answer calculation is complex and depends upon cancer type, underlying genomics, current treatments, any allergies, lifestyle information, and factors like BMI.

The addon personalized nutrition plan recommends foods and supplements which minimizes adverse nutrition interactions and encourages support to treatments.

You can get started NOW and design a personalized nutrition plan for Anaplastic Oligoastrocytoma by answering questions on type of cancer, current treatments, supplements, allergies, age group, gender, and lifestyle information.

What food you eat and which supplements you take is a decision you make. Your decision should include consideration of the cancer gene mutations, which cancer, ongoing treatments and supplements, any allergies, lifestyle information, weight, height and habits.

The nutrition planning for cancer from addon is not based on internet searches. It automates the decision making for you based on molecular science implemented by our scientists and software engineers. Irrespective of whether you care to understand the underlying biochemical molecular pathways or not - for nutrition planning for cancer that understanding is needed.

Get started NOW with your nutrition planning by answering questions on the name of cancer, genetic mutations, ongoing treatments and supplements, any allergies, habits, lifestyle, age group and gender.

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