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Foods for Anaplastic Oligodendroglioma?

Aug 4, 2023

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Introduction

Foods for Anaplastic Oligodendroglioma should be personalized for each individual and also must adapt when cancer treatment or tumor genetic change. The personalization and adaptation must consider all the active ingredients or bioactives contained in different foods with respect to cancer tissue biology, genetics, treatments, lifestyle conditions and diet preferences. Hence while nutrition is one of the very important decisions for a cancer patient and individual at risk of cancer to make – how to choose foods to eat is not an easy task.



For Anaplastic Oligodendroglioma does it matter what vegetables, fruits, nuts, seeds one eats?

A very common nutrition question asked by cancer patients and individuals at-genetic risk of cancer is – for cancers like Anaplastic Oligodendroglioma does it matter what foods I eat and which I do not? Or if I follow a plant-based diet is that enough for cancer like Anaplastic Oligodendroglioma?

For example does it matter if vegetable Giant Butterbur is consumed more compared to Chinese Broccoli? Does it make any difference if fruit Lime is preferred over Red Raspberry? Also if similar choices are made for nuts/seeds like Common Hazelnut over Chestnut and for pulses like Adzuki Bean over Lentils. And if what I eat matters – then how does one identify foods which are recommended for Anaplastic Oligodendroglioma and is it the same answer for everyone with the same diagnosis or genetic risk?

Yes! Foods you eat matters for Anaplastic Oligodendroglioma!

Food recommendations may not be the same for everyone and can be different even for the same diagnosis and genetic risk.

All cancers like Anaplastic Oligodendroglioma can be characterized by a unique set of biochemical pathways - the signature pathways of Anaplastic Oligodendroglioma. Biochemical pathways like RAS-RAF Signaling, mRNA Splicing, PI3K-AKT-MTOR Signaling, MAPK Signaling are part of the signature definition of Anaplastic Oligodendroglioma.

All foods (vegetables, fruits, nuts, seeds, pulses, oils etc.) and nutritional supplements are made up of more than one active molecular ingredient or bio-actives in different proportions and quantities. Each active ingredient has a unique mechanism of action – which can be activation or inhibition of different biochemical pathways. Simply stated foods and supplements which are recommended are those which do not cause an increase of molecular drivers of cancer but reduce them. Else those foods should not be recommended. Foods contain multiple active ingredients – hence when evaluating foods and supplements you need to consider the impact of all active ingredients cumulatively rather than individually.

For example Lime contains active ingredients Curcumin, Formononetin, Isoliquiritigenin, Phloretin, Lupeol. And Red Raspberry contains active ingredients Quercetin, Ellagic Acid, Curcumin, Formononetin, Isoliquiritigenin and possibly others.

A common mistake made when deciding and choosing foods to eat for Anaplastic Oligodendroglioma – is to evaluate only selected active ingredients contained in foods and ignore the rest. Because different active ingredients contained in foods may have opposing effects on cancer drivers – you cannot cherry pick active ingredients in foods and supplements for making a nutrition decision for Anaplastic Oligodendroglioma.

YES – FOOD CHOICES MATTER FOR CANCER. NUTRITION DECISIONS MUST CONSIDER ALL ACTIVE INGREDIENTS OF FOODS.

Skills Needed for Nutrition Personalization for Anaplastic Oligodendroglioma?

Personalized nutrition for cancers like Anaplastic Oligodendroglioma consists of recommended foods / supplements; not recommended foods / supplements with example recipes which prioritize use of recommended foods. An example of personalized nutrition can be seen at this link.

Deciding which foods are recommended or not is extremely complicated, requiring expertise in Anaplastic Oligodendroglioma biology, food science, genetics, biochemistry along with good understanding of how cancer treatments work and associated vulnerabilities by which the treatments could stop being effective.

MINIMUM KNOWLEDGE EXPERTISE NEEDED FOR NUTRITION PERSONALIZATION FOR CANCER ARE: CANCER BIOLOGY, FOOD SCIENCE, CANCER TREATMENTS AND GENETICS.

Foods to Eat After Cancer Diagnosis!

No two cancers are the same. Go beyond the common nutrition guidelines for everyone and make personalized decisions about food and supplements with confidence.

Characteristics of cancers like Anaplastic Oligodendroglioma

All cancers like Anaplastic Oligodendroglioma can be characterized by a unique set of biochemical pathways – the signature pathways of Anaplastic Oligodendroglioma. Biochemical pathways like RAS-RAF Signaling, mRNA Splicing, PI3K-AKT-MTOR Signaling, MAPK Signaling are part of the signature definition of Anaplastic Oligodendroglioma. Each individual’s cancer genetics can be different and hence their specific cancer signature could be unique.

The treatments which are effective for Anaplastic Oligodendroglioma need to be cognizant of the associated signature biochemical pathways for each cancer patient and individual at genetic risk. Therefore different treatments with different mechanisms of actions are effective for different patients. Similarly and for the same reasons foods and supplements need to be personalized for each individual. Hence some foods and supplements are recommended for Anaplastic Oligodendroglioma when taking cancer treatment Radiation, and some foods and supplements are not recommended.

Sources like cBioPortal and many others provide population representative patient anonymized data from clinical trials for all cancer indications. This data consists of clinical trial study details like sample size / number of patients, age groups, gender, ethnicity, treatments, tumor site and any genetic mutations.

HLA-A, PTCH1, IDH1, TERT and ARID2 are the top ranked reported genes for Anaplastic Oligodendroglioma. HLA-A is reported in 4.3 % of the representative patients across all clinical trials. And PTCH1 is reported in 4.3 %. The combined population patient data cover ages from 19 to 81. 51.1 % of the patient data are identified as men. The Anaplastic Oligodendroglioma biology along with reported genetics together define the population represented signature biochemical pathways for this cancer. If the individual cancer tumor genetics or genes contributing to the risk are also known then that should also be used for nutrition personalization.

NUTRITION CHOICES SHOULD MATCH WITH EACH INDIVIDUAL’S CANCER SIGNATURE.

Foods for Anaplastic Oligodendroglioma!

Food and Supplements for Anaplastic Oligodendroglioma

For Cancer Patients

Cancer patients on treatment or on palliative care need to make decisions on food and supplements – for the needed dietary calories, for managing any treatment side effects and also for improved cancer management. All plant-based foods are not equal and choosing and prioritizing foods which are personalized and customized to ongoing cancer treatment is important and complicated. Here are some examples providing guidelines for making nutrition decisions.

Choose Vegetable GIANT BUTTERBUR or CHINESE BROCCOLI?

Vegetable Giant Butterbur contains many active ingredients or bioactives such as Curcumin, Myricetin, Formononetin, Isoliquiritigenin, Phloretin. These active ingredients manipulate various biochemical pathways like JAK-STAT Signaling, NFKB Signaling, Cell Cycle and Epithelial to Mesenchymal Transition and others. Giant Butterbur is recommended for Anaplastic Oligodendroglioma when ongoing cancer treatment is Radiation. This is because Giant Butterbur modifies those biochemical pathways which have been scientifically reported to sensitize the effect of Radiation.

Some of the active ingredients or bioactives in vegetable Chinese Broccoli are Curcumin, Myricetin, Formononetin, Isoliquiritigenin, Phloretin. These active ingredients manipulate various biochemical pathways like Oxidative Stress and others. Chinese Broccoli is not recommended for Anaplastic Oligodendroglioma when ongoing cancer treatment is Radiation because it modifies those biochemical pathways which make the cancer treatment resistant or less responsive.

VEGETABLE GIANT BUTTERBUR IS RECOMMENDED OVER CHINESE BROCCOLI FOR Anaplastic Oligodendroglioma AND TREATMENT Radiation.

Choose Fruit RED RASPBERRY or LIME?

Fruit Red Raspberry contains many active ingredients or bioactives such as Quercetin, Ellagic Acid, Curcumin, Formononetin, Isoliquiritigenin. These active ingredients manipulate various biochemical pathways like Extracellular Matrix Remodelling, NFKB Signaling, Cell Cycle and Epithelial to Mesenchymal Transition and others. Red Raspberry is recommended for Anaplastic Oligodendroglioma when ongoing cancer treatment is Radiation. This is because Red Raspberry modifies those biochemical pathways which have been scientifically reported to sensitize the effect of Radiation.

Some of the active ingredients or bioactives in fruit Lime are Curcumin, Formononetin, Isoliquiritigenin, Phloretin, Lupeol. These active ingredients manipulate various biochemical pathways like Oxidative Stress, Notch Signaling and Microtubule Dynamics and others. Lime is not recommended for Anaplastic Oligodendroglioma when ongoing cancer treatment is Radiation because it modifies those biochemical pathways which make the cancer treatment resistant or less responsive.

FRUIT RED RASPBERRY IS RECOMMENDED OVER LIME FOR Anaplastic Oligodendroglioma AND TREATMENT Radiation.

Choose Nut COMMON HAZELNUT or CHESTNUT?

Common Hazelnut contains many active ingredients or bioactives such as Quercetin, Curcumin, Myricetin, Formononetin, Isoliquiritigenin. These active ingredients manipulate various biochemical pathways like Extracellular Matrix Remodelling, NFKB Signaling, Epithelial to Mesenchymal Transition and PI3K-AKT-MTOR Signaling and others. Common Hazelnut is recommended for Anaplastic Oligodendroglioma when ongoing cancer treatment is Radiation. This is because Common Hazelnut modifies those biochemical pathways which have been scientifically reported to sensitize the effect of Radiation.

Some of the active ingredients or bioactives in Chestnut are Ellagic Acid, Curcumin, Myricetin, Formononetin, Isoliquiritigenin. These active ingredients manipulate various biochemical pathways like Oxidative Stress, Extracellular Matrix Remodelling and TGFB Signaling and others. Chestnut is not recommended for Anaplastic Oligodendroglioma when ongoing cancer treatment is Radiation because it modifies those biochemical pathways which make the cancer treatment resistant or less responsive.

COMMON HAZELNUT IS RECOMMENDED OVER CHESTNUT FOR Anaplastic Oligodendroglioma AND TREATMENT Radiation.

For Individuals with Genetic Risk of Cancer

The question asked by individuals who have genetic risk of Anaplastic Oligodendroglioma or familial history is “What Should I Eat Differently from Before?” and how they should choose foods and supplements to manage risks of the disease. Since for cancer risk there is nothing actionable in terms of treatment – decisions of foods and supplements become important and one of the very few actionable things which can be done. All plant-based foods are not equal and based on identified genetics and pathway signature – the choices of food and supplements should be personalized.

Choose Vegetable BITTER GOURD or SWAMP CABBAGE?

Vegetable Bitter Gourd contains many active ingredients or bioactives such as Apigenin, Curcumin, Formononetin, Lupeol, Myricetin. These active ingredients manipulate various biochemical pathways like Stem Cell Signaling, JAK-STAT Signaling, PI3K-AKT-MTOR Signaling and P53 Signaling and others. Bitter Gourd is recommended for risk of Anaplastic Oligodendroglioma when associated genetic risk is ARID2. This is because Bitter Gourd increases those biochemical pathways which counteract the signature drivers of it.

Some of the active ingredients or bioactives in vegetable Swamp Cabbage are Curcumin, Formononetin, Lupeol, Daidzein, Lycopene. These active ingredients manipulate various biochemical pathways like Cell Cycle Checkpoints and MAPK Signaling and others. Swamp Cabbage is not recommended when risk of Anaplastic Oligodendroglioma when associated genetic risk is ARID2 because it increases the signature pathways of it.

VEGETABLE BITTER GOURD IS RECOMMENDED OVER SWAMP CABBAGE FOR ARID2 GENETIC RISK OF CANCER.

Choose Fruit NANCE or PUMMELO?

Fruit Nance contains many active ingredients or bioactives such as Apigenin, Curcumin, Formononetin, Lupeol, Betulinic Acid. These active ingredients manipulate various biochemical pathways like PI3K-AKT-MTOR Signaling, Hypoxia and P53 Signaling and others. Nance is recommended for risk of Anaplastic Oligodendroglioma when associated genetic risk is ARID2. This is because Nance increases those biochemical pathways which counteract the signature drivers of it.

Some of the active ingredients or bioactives in fruit Pummelo are Apigenin, Curcumin, Quercetin, Formononetin, Lupeol. These active ingredients manipulate various biochemical pathways like Stem Cell Signaling and Cell Cycle Checkpoints and others. Pummelo is not recommended when risk of Anaplastic Oligodendroglioma when associated genetic risk is ARID2 because it increases the signature pathways of it.

FRUIT NANCE IS RECOMMENDED OVER PUMMELO FOR ARID2 GENETIC RISK OF CANCER.

Choose Nut BUTTERNUT or EUROPEAN CHESTNUT?

Butternut contains many active ingredients or bioactives such as Apigenin, Curcumin, Formononetin, Lupeol, Myricetin. These active ingredients manipulate various biochemical pathways like Angiogenesis, JAK-STAT Signaling, PI3K-AKT-MTOR Signaling and Apoptosis and others. Butternut is recommended for risk of Anaplastic Oligodendroglioma when associated genetic risk is ARID2. This is because Butternut increases those biochemical pathways which counteract the signature drivers of it.

Some of the active ingredients or bioactives in European Chestnut are Apigenin, Curcumin, Quercetin, Ellagic Acid, Formononetin. These active ingredients manipulate various biochemical pathways like Stem Cell Signaling and Oncogenic Cancer Epigenetics and others. European Chestnut is not recommended when risk of Anaplastic Oligodendroglioma when associated genetic risk is ARID2 because it increases the signature pathways of it.

BUTTERNUT IS RECOMMENDED OVER EUROPEAN CHESTNUT FOR ARID2 GENETIC RISK OF CANCER.


In Conclusion

Foods and Supplements chosen are important decisions for cancers like Anaplastic Oligodendroglioma. Anaplastic Oligodendroglioma patients and individuals with genetic-risk always have this question: “What foods and nutritional supplements are recommended for me and which are not?” There is a common belief which is a misconception that all plant-based foods could be beneficial or not but would not be harmful. Certain foods and supplements can interfere with cancer treatments or promote molecular pathway drivers of cancer.

There are different types of cancer indications like Anaplastic Oligodendroglioma, each with different tumor genetics with further genomic variations across each individual. Further every cancer treatment and chemotherapy has a unique mechanism of action. Each food like Giant Butterbur contains various bioactives in different quantities, which have an impact on different and distinct sets of biochemical pathways. The definition of personalized nutrition is individualized food recommendations for the cancer indication, treatments, genetics, lifestyle and other factors. Nutrition personalization decisions for cancer require knowledge of cancer biology, food science and an understanding of different chemotherapy treatments. Finally when there are treatment changes or new genomics is identified – the nutrition personalization needs re-evaluation.

The addon nutrition personalization solution makes the decision making easy and removes all the guesswork in answering the question, “What foods should I choose or not choose for Anaplastic Oligodendroglioma?”. The addon multi-disciplinary team includes cancer physicians, clinical scientists, software engineers and data scientists.


Personalized Nutrition for Cancer!

Cancer changes with time. Customize and modify your nutrition based on cancer indication, treatments, lifestyle, food preferences, allergies and other factors.

References

Scientifically Reviewed by: Dr. Cogle

Christopher R. Cogle, M.D. is a tenured professor at the University of Florida, Chief Medical Officer of Florida Medicaid, and Director of the Florida Health Policy Leadership Academy at the Bob Graham Center for Public Service.

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