Highlights
No two cancers are the same, nor are they treated the same, and neither should nutrition be the same for everyone. Nutrition includes foods like pulses, vegetables, fruits, nuts, oils, herbs and spices. Also nutrition includes supplements which are high concentrations of foods or high concentrations of individual ingredients found in foods. For cancers like Collecting Duct Renal Cell Carcinoma when undergoing chemotherapy or when you determine you have a genetic risk for developing Collecting Duct Renal Cell Carcinoma because of SMARCB1 and ACADVL gene mutations, a very important question is “What foods should I avoid and what foods are recommended specifically for me?”. The other related question is “What nutritional supplements should I avoid?”.
There is no one answer to this question for cancers such as Collecting Duct Renal Cell Carcinoma which can be found through internet searches. The answer to the question is “It Depends” because the nutrition plan needs to be personalized for you. Nutrition should depend on the cancer indication, genetic information, adult or pediatric, staging, primary or secondary, advanced, metastatic, relapsed or refractory, ongoing treatments if any, nutritional supplements being taken, age and factors like gender, weight, height, lifestyle, allergies and food preferences.
In short – the process to answer questions like “Should I Avoid eating fruit Coconut” or “Include fruit Grape in my diet” or “Should I reduce consumption of vegetable Celery” or “Can I take Echinacea and Apigenin supplements” is not as simple as internet searches. The process is very complex and answers are based on knowhow of genetics, action of treatments, active ingredients in foods and their associated biological action. Finally the answer to the nutrition question needs to be personalized for you.
RECOMMENDATION: PERSONALIZE YOUR FOODS AND SUPPLEMENTS TO COLLECTING DUCT RENAL CELL CARCINOMA, TREATMENTS, GENETIC INFORMATION, AND OTHER CONDITIONS.
The overall objective of personalized nutrition for Collecting Duct Renal Cell Carcinoma is to minimize foods and nutritional supplements which have adverse interactions with cancer molecular drivers and ongoing treatments. And identify those foods and supplements which have a beneficial action. Whenever there are changes in treatments or diagnosis – it is important to remember that your foods and supplements need re-evaluation. And the answers to the nutrition question could be different based on the new context.
RECOMMENDATION: UPDATE YOUR NUTRITION FOR COLLECTING DUCT RENAL CELL CARCINOMA, WHEN TREATMENTS, DISEASE STATUS AND OTHER CONDITIONS CHANGE.
About Collecting Duct Renal Cell Carcinoma
cBioPortal is one source of collection of cancer patient data from clinical trials across 350 plus cancer indications. The data from each clinical trial includes the clinical trial name and study details like number of patients, ages, gender, ethnicity, treatments, tumor site, genetic aberrations found and analysis of all the data. The cBioPortal for Cancer Genomics was originally developed at Memorial Sloan Kettering Cancer Center (MSK). The public cBioPortal site is hosted by the Center for Molecular Oncology at MSK – https://www.cbioportal.org/about.
Following key highlights are derived from clinical data for Collecting Duct Renal Cell Carcinoma from cBioPortal. The patients enrolled in the studies for Collecting Duct Renal Cell Carcinoma are in ages between 66 to 66 with an average age of 66.From a patient sample size of 2; the top genes with mutations and other abnormalities for Collecting Duct Renal Cell Carcinoma include genes SMARCB1, ACADVL, ADRB3, ARHGAP5 and CDC42BPA. The occurrence frequency distribution for these genes respectively is 50.0%, 50.0%, 50.0%, 50.0% and 50.0%. These tumor genetic details of Collecting Duct Renal Cell Carcinoma are mapped to molecular biochemical pathway drivers of cancer thereby providing definition of characteristic features of Collecting Duct Renal Cell Carcinoma.
Significance of Nutrition for Collecting Duct Renal Cell Carcinoma
All foods and nutritional supplements consist of a collection of one or more active chemical ingredients in different proportions and quantities. The action of some active ingredients in a food can have adverse interactions while other active ingredients in the same food may be supportive from the context of Collecting Duct Renal Cell Carcinoma. Hence the same food has good and not-so-good actions and analysis of combined effect will be needed to come up with a personalized nutrition plan.
For example Coconut includes active ingredients Vitamin E, Beta-sitosterol, Palmitic Acid, Capric Acid, Lauric Acid and others. And Grape contains active ingredients Resveratrol, Lupeol, Vitamin E, Pterostilbene, Beta-sitosterol and others. It is likely that some of these active ingredients of the same food could have opposing effects and hence it is recommended to identify recommended foods based on analysis of all high quantity ingredients contained in foods.
For cancers like Collecting Duct Renal Cell Carcinoma, activation or inhibition of selected biochemical pathways like Chromatin Remodeling, PI3K-AKT-MTOR Signaling, Cell Cycle, Cell Cycle Checkpoints plays an important role in driving cancer growth. Similarly different treatments work via different molecular actions which should never be canceled out by your foods and supplements. The foods and nutritional supplements contain different active ingredients each of which have a specific molecular action on different biochemical pathways. Hence, eating some foods and nutritional supplements would be recommended with a specific treatment of Collecting Duct Renal Cell Carcinoma, while eating some other foods and supplements may not be recommended.
One common mistake when finding foods to eat or not – is to consider only a few active ingredients contained in foods based on internet searches and ignore the rest. Because different active ingredients contained in foods may have opposing effects on relevant biochemical pathways – it is recommended to consider all the high quantity active ingredients that are present in significant and much larger than trace amounts in the food.
RECOMMENDATION: TO FIND RECOMMENDED AND NON-RECOMMENDED FOODS FOR COLLECTING DUCT RENAL CELL CARCINOMA – CONSIDER HIGH QUANTITY ACTIVE INGREDIENTS CONTAINED IN FOODS.
Foods for Collecting Duct Renal Cell Carcinoma undergoing chemotherapy treatment
In Collecting Duct Renal Cell Carcinoma – the genes SMARCB1, ACADVL, ADRB3, ARHGAP5 and CDC42BPA have high occurrences of genomic abnormalities. Not all of these genes necessarily are relevant for cancer – though they have been reported. Some of these genes directly or indirectly end up manipulating different cancer related biochemical biological pathways. Some of the pathways which are relevant drivers for Collecting Duct Renal Cell Carcinoma are Chromatin Remodeling, PI3K-AKT-MTOR Signaling and others. Pembrolizumab is one of the chemotherapies used for cancer treatment. The intent of treatment is to negate or cancel out effects of biochemical pathway drivers Chromatin Remodeling, PI3K-AKT-MTOR Signaling so as to reduce disease progression and inhibit growth. Those foods whose combined action of active ingredients support treatment action and do not enhance disease drivers are recommended foods and supplements which will be included in personalized nutrition. And similarly – those foods whose combined action of active ingredients is not supportive of treatment action but end up promoting disease drives will not be recommended in your personalized nutrition plan.
RECOMMENDATION: AVOID SUPPLEMENTS AND FOODS WHICH ARE NOT SUPPORTIVE OF CANCER TREATMENT ACTION AND RATHER ENHANCE DISEASE DRIVERS.
Eat more pulses, Mung Bean or Fava Bean?
Pulses are an important part of many diets. The active ingredients contained in Mung Bean are Oleic Acid, Vitamin C, Linolenic Acid, Vitexin, Stigmasterol among others. While the active ingredients contained in Fava Bean are Daidzein, Beta-sitosterol, Oleic Acid, Vitamin C, Linolenic Acid and others.
Vitamin C can manipulate biochemical pathways MYC Signaling and PI3K-AKT-MTOR Signaling. Vitexin has biological action on biochemical pathways MYC Signaling and PI3K-AKT-MTOR Signaling.
Genistein can manipulate biochemical pathways Chromatin Remodeling. Folic Acid has biological action on biochemical pathways MYC Signaling and PI3K-AKT-MTOR Signaling. And so on.
When treating Collecting Duct Renal Cell Carcinoma with chemotherapy Pembrolizumab – Foods like Mung Bean are recommended compared to Fava Bean. This is because the active ingredients Genistein and Folic Acid in Fava Bean interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Vitamin C and Vitexin contained in Mung Bean support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.
RECOMMENDATION: MUNG BEAN IS RECOMMENDED OVER FAVA BEAN FOR COLLECTING DUCT RENAL CELL CARCINOMA ON TREATMENT WITH CHEMOTHERAPY PEMBROLIZUMAB FOR SOME CONDITIONS.
Eat more vegetables, Arugula or Celery?
Vegetables are an important part of many diets. The active ingredients contained in Arugula are Esculin, Kaempferol, Vitamin A, Vitamin K, Erysolin among others. While the active ingredients contained in Celery are Apigenin, Oleic Acid, Vitamin C, Linolenic Acid, Cynaroside and others.
Kaempferol can manipulate biochemical pathways PI3K-AKT-MTOR Signaling. Vitamin A has biological action on biochemical pathways MYC Signaling and PI3K-AKT-MTOR Signaling.
Luteolin can manipulate biochemical pathways MYC Signaling. Chrysin has biological action on biochemical pathways Chromatin Remodeling and MYC Signaling. And so on.
When treating Collecting Duct Renal Cell Carcinoma with chemotherapy Pembrolizumab – Foods like Arugula are recommended compared to Celery. This is because the active ingredients Luteolin and Chrysin in Celery interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Kaempferol and Vitamin A contained in Arugula support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.
RECOMMENDATION: ARUGULA IS RECOMMENDED OVER CELERY FOR COLLECTING DUCT RENAL CELL CARCINOMA ON TREATMENT WITH CHEMOTHERAPY PEMBROLIZUMAB FOR SOME CONDITIONS.
Eat more fruits, Grape or Coconut?
Fruits are an important part of many diets. The active ingredients contained in Grape are Resveratrol, Lupeol, Vitamin E, Pterostilbene, Beta-sitosterol among others. While the active ingredients contained in Coconut are Vitamin E, Beta-sitosterol, Palmitic Acid, Capric Acid, Lauric Acid and others.
Resveratrol can manipulate biochemical pathways MYC Signaling and PI3K-AKT-MTOR Signaling. Vitamin C has biological action on biochemical pathways MYC Signaling and PI3K-AKT-MTOR Signaling.
Lauric Acid can manipulate biochemical pathways MYC Signaling and PI3K-AKT-MTOR Signaling. Myristic Acid has biological action on biochemical pathways MYC Signaling. And so on.
When treating Collecting Duct Renal Cell Carcinoma with chemotherapy Pembrolizumab – Foods like Grape are recommended compared to Coconut. This is because the active ingredients Lauric Acid and Myristic Acid in Coconut interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Resveratrol and Vitamin C contained in Grape support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.
RECOMMENDATION: GRAPE IS RECOMMENDED OVER COCONUT FOR COLLECTING DUCT RENAL CELL CARCINOMA ON TREATMENT WITH CHEMOTHERAPY PEMBROLIZUMAB FOR SOME CONDITIONS.
Eat more nuts, Pecan Nut or Brazil Nut?
Nuts are an important part of many diets. The active ingredients contained in Pecan Nut are Vitamin E, Oleic Acid, Linolenic Acid, Cianidanol, Delphinidin among others. While the active ingredients contained in Brazil Nut are Vitamin E, Oleic Acid, Linolenic Acid, Lecithin, Folic Acid and others.
Vitamin E can manipulate biochemical pathways MYC Signaling and PI3K-AKT-MTOR Signaling. Cianidanol has biological action on biochemical pathways MYC Signaling and PI3K-AKT-MTOR Signaling.
Lecithin can manipulate biochemical pathways MYC Signaling and PI3K-AKT-MTOR Signaling. Folic Acid has biological action on biochemical pathways MYC Signaling and PI3K-AKT-MTOR Signaling. And so on.
When treating Collecting Duct Renal Cell Carcinoma with chemotherapy Pembrolizumab – Foods like Pecan Nut are recommended compared to Brazil Nut. This is because the active ingredients Lecithin and Folic Acid in Brazil Nut interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Vitamin E and Cianidanol contained in Pecan Nut support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.
RECOMMENDATION: PECAN NUT IS RECOMMENDED OVER BRAZIL NUT FOR COLLECTING DUCT RENAL CELL CARCINOMA ON TREATMENT WITH CHEMOTHERAPY PEMBROLIZUMAB FOR SOME CONDITIONS.
Foods for Genetic Risk of Collecting Duct Renal Cell Carcinoma
One of the ways to assess risk of cancer is by checking for presence of genetic abnormalities in a set of genes. There is prior information on a list of genes whose mutations and other aberrations can play a role in risk to different cancers. SMARCB1 and ACADVL are two genes whose abnormalities are risk factors for Collecting Duct Renal Cell Carcinoma. In such a cancer risk situation – while there are typically no treatments which a physician can prescribe – the various biochemical pathways which are potentially molecular drivers of Collecting Duct Renal Cell Carcinoma can be used as a guide for coming up with a recommended personalized nutrition plan. For Collecting Duct Renal Cell Carcinoma gene SMARCB1 has causative impact on biological pathways like Androgen Signaling, Chromatin Remodeling and Epithelial to Mesenchymal Transition. And ACADVL has a causative impact on biological pathways like Lipid Metabolism. Foods and nutritional supplements which have molecular action to cancel out biochemical pathways effects of genes like SMARCB1 and ACADVL should be included in a personalized nutrition plan. And those foods and supplements which promote the effects of genes SMARCB1 and ACADVL should be avoided.
Eat more pulses, Winged Bean or Moth Bean?
The active ingredients contained in Winged Bean are Betulinic Acid, Oleic Acid, Vitamin C, Linolenic Acid, Linoleic Acid among others. While the active ingredients contained in Moth Bean are Oleic Acid, Beta-sitosterol, Linolenic Acid, Stigmasterol, Linoleic Acid and others.
Betulinic Acid can manipulate biochemical pathways Apoptosis, MYC Signaling and P53 Signaling. Vitamin C has biological action on biochemical pathways Growth Factor Signaling, Cell Cycle Checkpoints and PI3K-AKT-MTOR Signaling.
Linolenic Acid can manipulate biochemical pathways Lipid Metabolism. Linoleic Acid has biological action on biochemical pathways Growth Factor Signaling. And so on.
For genetic risk of Collecting Duct Renal Cell Carcinoma due to abnormalities in genes SMARCB1 and ACADVL – Foods like Winged Bean are recommended compared to Moth Bean. This is because the active ingredients Linolenic Acid and Linoleic Acid in Moth Bean further promote the effects of genes on the biochemical pathways. While the active ingredients Betulinic Acid and Vitamin C contained in Winged Bean together have a canceling effect of genes on the biochemical pathways.
RECOMMENDATION: WINGED BEAN IS RECOMMENDED OVER MOTH BEAN FOR REDUCING THE GENETIC RISK OF COLLECTING DUCT RENAL CELL CARCINOMA DUE TO GENES SMARCB1 AND ACADVL
Eat more vegetables, Giant Butterbur or Bell Pepper?
The active ingredients contained in Giant Butterbur are Vitamin C, Beta-sitosterol, Melatonin, Vitamin B3, Kaempferol among others. While the active ingredients contained in Bell Pepper are Vitamin E, Oleic Acid, Capsaicin, Vitamin C, Linolenic Acid and others.
Vitamin C can manipulate biochemical pathways Apoptosis, Growth Factor Signaling and MYC Signaling. Beta-sitosterol has biological action on biochemical pathways P53 Signaling, Cell Cycle Checkpoints and PI3K-AKT-MTOR Signaling.
Capsaicin can manipulate biochemical pathways Lipid Metabolism and Small Molecule Transport. Isorhamnetin has biological action on biochemical pathways Small Molecule Transport. And so on.
For genetic risk of Collecting Duct Renal Cell Carcinoma due to abnormalities in genes SMARCB1 and ACADVL – Foods like Giant Butterbur are recommended compared to Bell Pepper. This is because the active ingredients Capsaicin and Isorhamnetin in Bell Pepper further promote the effects of genes on the biochemical pathways. While the active ingredients Vitamin C and Beta-sitosterol contained in Giant Butterbur together have a canceling effect of genes on the biochemical pathways.
RECOMMENDATION: GIANT BUTTERBUR IS RECOMMENDED OVER BELL PEPPER FOR REDUCING THE GENETIC RISK OF COLLECTING DUCT RENAL CELL CARCINOMA DUE TO GENES SMARCB1 AND ACADVL
Foods to Eat After Cancer Diagnosis!
No two cancers are the same. Go beyond the common nutrition guidelines for everyone and make personalized decisions about food and supplements with confidence.
Eat more fruits, Feijoa or Sea Buckthorn?
The active ingredients contained in Feijoa are Lycopene, Vitamin C, Casuarinin, Folic Acid among others. While the active ingredients contained in Sea Buckthorn are Oleic Acid, Vitamin C, Beta-sitosterol, Linolenic Acid, Isorhamnetin and others.
Vitamin C can manipulate biochemical pathways Apoptosis, Growth Factor Signaling and MYC Signaling. Lycopene has biological action on biochemical pathways P53 Signaling, Cell Cycle Checkpoints and PI3K-AKT-MTOR Signaling.
Isorhamnetin can manipulate biochemical pathways Small Molecule Transport. Linolenic Acid has biological action on biochemical pathways Lipid Metabolism. And so on.
For genetic risk of Collecting Duct Renal Cell Carcinoma due to abnormalities in genes SMARCB1 and ACADVL – Foods like Feijoa are recommended compared to Sea Buckthorn. This is because the active ingredients Isorhamnetin and Linolenic Acid in Sea Buckthorn further promote the effects of genes on the biochemical pathways. While the active ingredients Vitamin C and Lycopene contained in Feijoa together have a canceling effect of genes on the biochemical pathways.
RECOMMENDATION: FEIJOA IS RECOMMENDED OVER SEA BUCKTHORN FOR REDUCING THE GENETIC RISK OF COLLECTING DUCT RENAL CELL CARCINOMA DUE TO GENES SMARCB1 AND ACADVL
Eat more nuts, Pine Nut or Acorn?
The active ingredients contained in Pine Nut are Vitamin E, Oleic Acid, Beta-sitosterol, Linolenic Acid, Linoleic Acid among others. While the active ingredients contained in Acorn are Quercetin, Vitamin C, Beta-sitosterol, Vitamin B3, Quercitrin and others.
Beta-sitosterol can manipulate biochemical pathways Apoptosis, MYC Signaling and P53 Signaling. Vitamin K has biological action on biochemical pathways Cell Cycle Checkpoints, PI3K-AKT-MTOR Signaling and MYC Signaling.
Vitamin B3 can manipulate biochemical pathways PI3K-AKT-MTOR Signaling. Folic Acid has biological action on biochemical pathways Apoptosis, MYC Signaling and P53 Signaling. And so on.
For genetic risk of Collecting Duct Renal Cell Carcinoma due to abnormalities in genes SMARCB1 and ACADVL – Foods like Pine Nut are recommended compared to Acorn. This is because the active ingredients Vitamin B3 and Folic Acid in Acorn further promote the effects of genes on the biochemical pathways. While the active ingredients Beta-sitosterol and Vitamin K contained in Pine Nut together have a canceling effect of genes on the biochemical pathways.
RECOMMENDATION: PINE NUT IS RECOMMENDED OVER ACORN FOR REDUCING THE GENETIC RISK OF COLLECTING DUCT RENAL CELL CARCINOMA DUE TO GENES SMARCB1 AND ACADVL
In Summary
An important thing to remember is that cancer treatments may not be the same for everyone – and neither should your nutrition be. Nutrition which includes food and nutritional supplements is a very effective tool controlled by you.
“What should I eat?” is the most frequently asked question in the context of cancer. The answer calculation is complex and depends upon cancer type, underlying genomics, current treatments, any allergies, lifestyle information, and factors like BMI.
The addon personalized nutrition plan recommends foods and supplements which minimizes adverse nutrition interactions and encourages support to treatments.
You can get started NOW and design a personalized nutrition plan for Collecting Duct Renal Cell Carcinoma by answering questions on type of cancer, current treatments, supplements, allergies, age group, gender, and lifestyle information.
What food you eat and which supplements you take is a decision you make. Your decision should include consideration of the cancer gene mutations, which cancer, ongoing treatments and supplements, any allergies, lifestyle information, weight, height and habits.
The nutrition planning for cancer from addon is not based on internet searches. It automates the decision making for you based on molecular science implemented by our scientists and software engineers. Irrespective of whether you care to understand the underlying biochemical molecular pathways or not - for nutrition planning for cancer that understanding is needed.
Get started NOW with your nutrition planning by answering questions on the name of cancer, genetic mutations, ongoing treatments and supplements, any allergies, habits, lifestyle, age group and gender.
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Personalized Nutrition for Cancer!
Cancer changes with time. Customize and modify your nutrition based on cancer indication, treatments, lifestyle, food preferences, allergies and other factors.