Foods for Colorectal Adenocarcinoma!

Introduction

Foods for Colorectal Adenocarcinoma should be personalized for each individual and also must adapt when cancer treatment or tumor genetic change. The personalization and adaptation must consider all the active ingredients or bioactives contained in different foods with respect to cancer tissue biology, genetics, treatments, lifestyle conditions and diet preferences. Hence while nutrition is one of the very important decisions for a cancer patient and individual at risk of cancer to make – how to choose foods to eat is not an easy task.

Colorectal adenocarcinoma is a type of cancer that originates in the cells lining the colon or rectum. Recognizing the symptoms of colorectal adenocarcinoma is crucial for early detection and includes changes in bowel habits, blood in the stool, abdominal pain, and unintended weight loss. Accurate coding of colorectal adenocarcinoma is facilitated by the ICD-10 system. Pathology outlines provide an understanding of the characteristics of this cancer. Metastasis, or the spread of the tumor to other parts of the body, is an important factor in determining prognosis and treatment options for colorectal adenocarcinoma. Treatment typically involves a combination of surgery, chemotherapy, and radiation therapy, depending on the stage and extent of the cancer. The grading of colorectal adenocarcinoma provides valuable information about the aggressiveness of the tumor. Understanding the pathophysiology of colorectal adenocarcinoma helps in identifying potential targets for therapy. The staging process assesses the extent of the cancer, facilitating appropriate treatment decisions. Accurate documentation of colorectal adenocarcinoma using the ICD-10 CM coding system is important for healthcare records. Advanced stages, such as stage 4 colorectal adenocarcinoma, may require a more aggressive treatment approach. It is important to understand the differences between colorectal carcinoma and adenocarcinoma for accurate diagnosis and management. Recognizing the causes and risk factors associated with colorectal adenocarcinoma aids in prevention and early intervention. Regular screening and timely medical care play a critical role in improving outcomes for individuals with colorectal adenocarcinoma.

For Colorectal Adenocarcinoma does it matter what vegetables, fruits, nuts, seeds one eats?

A very common nutrition question asked by cancer patients and individuals at-genetic risk of cancer is – for cancers like Colorectal Adenocarcinoma does it matter what foods I eat and which I do not? Or if I follow a plant-based diet is that enough for cancer like Colorectal Adenocarcinoma?

For example does it matter if vegetable Giant Butterbur is consumed more compared to White Cabbage? Does it make any difference if fruit Pummelo is preferred over Red Raspberry? Also if similar choices are made for nuts/seeds like Butternut over European Chestnut and for pulses like Gram Bean over Yardlong Bean. And if what I eat matters – then how does one identify foods which are recommended for Colorectal Adenocarcinoma and is it the same answer for everyone with the same diagnosis or genetic risk?

Yes! Foods you eat matters for Colorectal Adenocarcinoma!

Food recommendations may not be the same for everyone and can be different even for the same diagnosis and genetic risk.

All foods (vegetables, fruits, nuts, seeds, pulses, oils etc.) and nutritional supplements are made up of more than one active molecular ingredient or bio-actives in different proportions and quantities. Each active ingredient has a unique mechanism of action – which can be activation or inhibition of different biochemical pathways. Simply stated foods and supplements which are recommended are those which do not cause an increase of molecular drivers of cancer but reduce them. Else those foods should not be recommended. Foods contain multiple active ingredients – hence when evaluating foods and supplements you need to consider the impact of all active ingredients cumulatively rather than individually.

For example Pummelo contains active ingredients Quercetin, Curcumin, Daidzein, Caffeic Acid, Apigenin. And Red Raspberry contains active ingredients Quercetin, Curcumin, Ellagic Acid, Daidzein, Isoliquiritigenin and possibly others.

A common mistake made when deciding and choosing foods to eat for Colorectal Adenocarcinoma – is to evaluate only selected active ingredients contained in foods and ignore the rest. Because different active ingredients contained in foods may have opposing effects on cancer drivers – you cannot cherry pick active ingredients in foods and supplements for making a nutrition decision for Colorectal Adenocarcinoma.

YES – FOOD CHOICES MATTER FOR CANCER. NUTRITION DECISIONS MUST CONSIDER ALL ACTIVE INGREDIENTS OF FOODS.

Skills Needed for Nutrition Personalization for Colorectal Adenocarcinoma?

Personalized nutrition for cancers like Colorectal Adenocarcinoma consists of recommended foods / supplements; not recommended foods / supplements with example recipes which prioritize use of recommended foods. An example of personalized nutrition can be seen at this link.

Deciding which foods are recommended or not is extremely complicated, requiring expertise in Colorectal Adenocarcinoma biology, food science, genetics, biochemistry along with good understanding of how cancer treatments work and associated vulnerabilities by which the treatments could stop being effective.

MINIMUM KNOWLEDGE EXPERTISE NEEDED FOR NUTRITION PERSONALIZATION FOR CANCER ARE: CANCER BIOLOGY, FOOD SCIENCE, CANCER TREATMENTS AND GENETICS.

Characteristics of cancers like Colorectal Adenocarcinoma

All cancers like Colorectal Adenocarcinoma can be characterized by a unique set of biochemical pathways – the signature pathways of Colorectal Adenocarcinoma. Biochemical pathways like Angiogenesis, PI3K-AKT-MTOR Signaling, MAPK Signaling, RAS-RAF Signaling are part of the signature definition of Colorectal Adenocarcinoma. Each individual’s cancer genetics can be different and hence their specific cancer signature could be unique.

The treatments which are effective for Colorectal Adenocarcinoma need to be cognizant of the associated signature biochemical pathways for each cancer patient and individual at genetic risk. Therefore different treatments with different mechanisms of actions are effective for different patients. Similarly and for the same reasons foods and supplements need to be personalized for each individual. Hence some foods and supplements are recommended for Colorectal Adenocarcinoma when taking cancer treatment Fluorouracil, and some foods and supplements are not recommended.

Sources like cBioPortal and many others provide population representative patient anonymized data from clinical trials for all cancer indications. This data consists of clinical trial study details like sample size / number of patients, age groups, gender, ethnicity, treatments, tumor site and any genetic mutations.

TP53, APC, KRAS, TOP2A and FBXW7 are the top ranked reported genes for Colorectal Adenocarcinoma. TP53 is reported in 2.8 % of the representative patients across all clinical trials. And APC is reported in 2.7 %. The combined population patient data cover ages from 4 to 95. 54.9 % of the patient data are identified as men. The Colorectal Adenocarcinoma biology along with reported genetics together define the population represented signature biochemical pathways for this cancer. If the individual cancer tumor genetics or genes contributing to the risk are also known then that should also be used for nutrition personalization.

NUTRITION CHOICES SHOULD MATCH WITH EACH INDIVIDUAL’S CANCER SIGNATURE.

Food and Supplements for Colorectal Adenocarcinoma

For Cancer Patients

Cancer patients on treatment or on palliative care need to make decisions on food and supplements – for the needed dietary calories, for managing any treatment side effects and also for improved cancer management. All plant-based foods are not equal and choosing and prioritizing foods which are personalized and customized to ongoing cancer treatment is important and complicated. Here are some examples providing guidelines for making nutrition decisions.

Choose Vegetable GIANT BUTTERBUR or WHITE CABBAGE?

Vegetable Giant Butterbur contains many active ingredients or bioactives such as Curcumin, Myricetin, Daidzein, Caffeic Acid, Apigenin. These active ingredients manipulate various biochemical pathways like PI3K-AKT-MTOR Signaling, NFKB Signaling, Epithelial to Mesenchymal Transition and Netrin Signaling and others. Giant Butterbur is recommended for Colorectal Adenocarcinoma when ongoing cancer treatment is Fluorouracil. This is because Giant Butterbur modifies those biochemical pathways which have been scientifically reported to sensitize the effect of Fluorouracil.

Some of the active ingredients or bioactives in vegetable White Cabbage are Quercetin, Curcumin, Daidzein, Caffeic Acid, Isoliquiritigenin. These active ingredients manipulate various biochemical pathways like Oxidative Stress and Nucleotide metabolism and others. White Cabbage is not recommended for Colorectal Adenocarcinoma when ongoing cancer treatment is Fluorouracil because it modifies those biochemical pathways which make the cancer treatment resistant or less responsive.

VEGETABLE GIANT BUTTERBUR IS RECOMMENDED OVER WHITE CABBAGE FOR Colorectal Adenocarcinoma AND TREATMENT Fluorouracil.

Choose Fruit RED RASPBERRY or PUMMELO?

Fruit Red Raspberry contains many active ingredients or bioactives such as Quercetin, Curcumin, Ellagic Acid, Daidzein, Isoliquiritigenin. These active ingredients manipulate various biochemical pathways like NFKB Signaling, Epithelial to Mesenchymal Transition, PI3K-AKT-MTOR Signaling and P53 Signaling and others. Red Raspberry is recommended for Colorectal Adenocarcinoma when ongoing cancer treatment is Fluorouracil. This is because Red Raspberry modifies those biochemical pathways which have been scientifically reported to sensitize the effect of Fluorouracil.

Some of the active ingredients or bioactives in fruit Pummelo are Quercetin, Curcumin, Daidzein, Caffeic Acid, Apigenin. These active ingredients manipulate various biochemical pathways like Oxidative Stress and DNA Repair and others. Pummelo is not recommended for Colorectal Adenocarcinoma when ongoing cancer treatment is Fluorouracil because it modifies those biochemical pathways which make the cancer treatment resistant or less responsive.

FRUIT RED RASPBERRY IS RECOMMENDED OVER PUMMELO FOR Colorectal Adenocarcinoma AND TREATMENT Fluorouracil.

Choose Nut BUTTERNUT or EUROPEAN CHESTNUT?

Butternut contains many active ingredients or bioactives such as Curcumin, Myricetin, Daidzein, Caffeic Acid, Apigenin. These active ingredients manipulate various biochemical pathways like Angiogenesis, NFKB Signaling, Epithelial to Mesenchymal Transition and Netrin Signaling and others. Butternut is recommended for Colorectal Adenocarcinoma when ongoing cancer treatment is Fluorouracil. This is because Butternut modifies those biochemical pathways which have been scientifically reported to sensitize the effect of Fluorouracil.

Some of the active ingredients or bioactives in European Chestnut are Quercetin, Curcumin, Ellagic Acid, Myricetin, Daidzein. These active ingredients manipulate various biochemical pathways like Oxidative Stress, Nucleotide metabolism, Epithelial to Mesenchymal Transition and PI3K-AKT-MTOR Signaling and others. European Chestnut is not recommended for Colorectal Adenocarcinoma when ongoing cancer treatment is Fluorouracil because it modifies those biochemical pathways which make the cancer treatment resistant or less responsive.

BUTTERNUT IS RECOMMENDED OVER EUROPEAN CHESTNUT FOR Colorectal Adenocarcinoma AND TREATMENT Fluorouracil.

For Individuals with Genetic Risk of Cancer

The question asked by individuals who have genetic risk of Colorectal Adenocarcinoma or familial history is “What Should I Eat Differently from Before?” and how they should choose foods and supplements to manage risks of the disease. Since for cancer risk there is nothing actionable in terms of treatment – decisions of foods and supplements become important and one of the very few actionable things which can be done. All plant-based foods are not equal and based on identified genetics and pathway signature – the choices of food and supplements should be personalized.

Choose Vegetable WILD LEEK or SWEDE?

Vegetable Wild Leek contains many active ingredients or bioactives such as Curcumin, Lupeol, Daidzein, Formononetin, Isoliquiritigenin. These active ingredients manipulate various biochemical pathways like Cell Cycle, PI3K-AKT-MTOR Signaling, Cell Cycle Checkpoints and MYC Signaling and others. Wild Leek is recommended for risk of Colorectal Adenocarcinoma when associated genetic risk is APC. This is because Wild Leek increases those biochemical pathways which counteract the signature drivers of it.

Some of the active ingredients or bioactives in vegetable Swede are Curcumin, Lupeol, Daidzein, Formononetin, Isoliquiritigenin. These active ingredients manipulate various biochemical pathways like Oxidative Stress, Stem Cell Signaling, TGFB Signaling and WNT Beta Catenin Signaling and others. Swede is not recommended when risk of Colorectal Adenocarcinoma when associated genetic risk is APC because it increases the signature pathways of it.

VEGETABLE WILD LEEK IS RECOMMENDED OVER SWEDE FOR APC GENETIC RISK OF CANCER.

Choose Fruit NANCE or SAPODILLA?

Fruit Nance contains many active ingredients or bioactives such as Curcumin, Lupeol, Myricetin, Daidzein, Formononetin. These active ingredients manipulate various biochemical pathways like Oxidative Stress, Angiogenesis, Cell Cycle and PI3K-AKT-MTOR Signaling and others. Nance is recommended for risk of Colorectal Adenocarcinoma when associated genetic risk is APC. This is because Nance increases those biochemical pathways which counteract the signature drivers of it.

Some of the active ingredients or bioactives in fruit Sapodilla are Curcumin, Lupeol, Myricetin, Daidzein, Formononetin. These active ingredients manipulate various biochemical pathways like Oxidative Stress and Cell Cycle and others. Sapodilla is not recommended when risk of Colorectal Adenocarcinoma when associated genetic risk is APC because it increases the signature pathways of it.

FRUIT NANCE IS RECOMMENDED OVER SAPODILLA FOR APC GENETIC RISK OF CANCER.

Choose Nut COMMON HAZELNUT or CHESTNUT?

Common Hazelnut contains many active ingredients or bioactives such as Curcumin, Quercetin, Lupeol, Myricetin, Daidzein. These active ingredients manipulate various biochemical pathways like Oxidative Stress, Angiogenesis, Cell Cycle and PI3K-AKT-MTOR Signaling and others. Common Hazelnut is recommended for risk of Colorectal Adenocarcinoma when associated genetic risk is APC. This is because Common Hazelnut increases those biochemical pathways which counteract the signature drivers of it.

Some of the active ingredients or bioactives in Chestnut are Curcumin, Ellagic Acid, Lupeol, Myricetin, Daidzein. These active ingredients manipulate various biochemical pathways like Oxidative Stress and TGFB Signaling and others. Chestnut is not recommended when risk of Colorectal Adenocarcinoma when associated genetic risk is APC because it increases the signature pathways of it.

COMMON HAZELNUT IS RECOMMENDED OVER CHESTNUT FOR APC GENETIC RISK OF CANCER.

In Conclusion

Foods and Supplements chosen are important decisions for cancers like Colorectal Adenocarcinoma. Colorectal Adenocarcinoma patients and individuals with genetic-risk always have this question: “What foods and nutritional supplements are recommended for me and which are not?” There is a common belief which is a misconception that all plant-based foods could be beneficial or not but would not be harmful. Certain foods and supplements can interfere with cancer treatments or promote molecular pathway drivers of cancer.

There are different types of cancer indications like Colorectal Adenocarcinoma, each with different tumor genetics with further genomic variations across each individual. Further every cancer treatment and chemotherapy has a unique mechanism of action. Each food like Giant Butterbur contains various bioactives in different quantities, which have an impact on different and distinct sets of biochemical pathways. The definition of personalized nutrition is individualized food recommendations for the cancer indication, treatments, genetics, lifestyle and other factors. Nutrition personalization decisions for cancer require knowledge of cancer biology, food science and an understanding of different chemotherapy treatments. Finally when there are treatment changes or new genomics is identified – the nutrition personalization needs re-evaluation.

The addon nutrition personalization solution makes the decision making easy and removes all the guesswork in answering the question, “What foods should I choose or not choose for Colorectal Adenocarcinoma?”. The addon multi-disciplinary team includes cancer physicians, clinical scientists, software engineers and data scientists.

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