Highlights
No two cancers are the same, nor are they treated the same, and neither should nutrition be the same for everyone. Nutrition includes foods like pulses, vegetables, fruits, nuts, oils, herbs and spices. Also nutrition includes supplements which are high concentrations of foods or high concentrations of individual ingredients found in foods. For cancers like Uterine Epithelioid Leiomyosarcoma when undergoing chemotherapy or when you determine you have a genetic risk for developing Uterine Epithelioid Leiomyosarcoma because of PDGFRB and BRD4 gene mutations, a very important question is “What foods should I avoid and what foods are recommended specifically for me?”. The other related question is “What nutritional supplements should I avoid?”.
There is no one answer to this question for cancers such as Uterine Epithelioid Leiomyosarcoma which can be found through internet searches. The answer to the question is “It Depends” because the nutrition plan needs to be personalized for you. Nutrition should depend on the cancer indication, genetic information, adult or pediatric, staging, primary or secondary, advanced, metastatic, relapsed or refractory, ongoing treatments if any, nutritional supplements being taken, age and factors like gender, weight, height, lifestyle, allergies and food preferences.
In short – the process to answer questions like “Should I Avoid eating fruit Cranberry” or “Include fruit Elderberry in my diet” or “Should I reduce consumption of vegetable Yam” or “Can I take Andrographis and Alpha Lipoic Acid supplements” is not as simple as internet searches. The process is very complex and answers are based on knowhow of genetics, action of treatments, active ingredients in foods and their associated biological action. Finally the answer to the nutrition question needs to be personalized for you.
RECOMMENDATION: PERSONALIZE YOUR FOODS AND SUPPLEMENTS TO UTERINE EPITHELIOID LEIOMYOSARCOMA, TREATMENTS, GENETIC INFORMATION, AND OTHER CONDITIONS.
The overall objective of personalized nutrition for Uterine Epithelioid Leiomyosarcoma is to minimize foods and nutritional supplements which have adverse interactions with cancer molecular drivers and ongoing treatments. And identify those foods and supplements which have a beneficial action. Whenever there are changes in treatments or diagnosis – it is important to remember that your foods and supplements need re-evaluation. And the answers to the nutrition question could be different based on the new context.
RECOMMENDATION: UPDATE YOUR NUTRITION FOR UTERINE EPITHELIOID LEIOMYOSARCOMA, WHEN TREATMENTS, DISEASE STATUS AND OTHER CONDITIONS CHANGE.
About Uterine Epithelioid Leiomyosarcoma
cBioPortal is one source of collection of cancer patient data from clinical trials across 350 plus cancer indications. The data from each clinical trial includes the clinical trial name and study details like number of patients, ages, gender, ethnicity, treatments, tumor site, genetic aberrations found and analysis of all the data. The cBioPortal for Cancer Genomics was originally developed at Memorial Sloan Kettering Cancer Center (MSK). The public cBioPortal site is hosted by the Center for Molecular Oncology at MSK – https://www.cbioportal.org/about.
Following key highlights are derived from clinical data for Uterine Epithelioid Leiomyosarcoma from cBioPortal. From a patient sample size of 11; the top genes with mutations and other abnormalities for Uterine Epithelioid Leiomyosarcoma include genes TP53, PDGFRB, ATRX, MED12 and BRD4. The occurrence frequency distribution for these genes respectively is 66.7%, 33.3%, 33.3%, 33.3% and 33.3%. These tumor genetic details of Uterine Epithelioid Leiomyosarcoma are mapped to molecular biochemical pathway drivers of cancer thereby providing definition of characteristic features of Uterine Epithelioid Leiomyosarcoma.
Significance of Nutrition for Uterine Epithelioid Leiomyosarcoma
All foods and nutritional supplements consist of a collection of one or more active chemical ingredients in different proportions and quantities. The action of some active ingredients in a food can have adverse interactions while other active ingredients in the same food may be supportive from the context of Uterine Epithelioid Leiomyosarcoma. Hence the same food has good and not-so-good actions and analysis of combined effect will be needed to come up with a personalized nutrition plan.
For example Cranberry includes active ingredients Hyperoside, Ellagic Acid, Quercetin, P-coumaric Acid, Vitamin C and others. And Elderberry contains active ingredients Lupeol, Betulinic Acid, Quercetin, Linolenic Acid, Vitamin C and others. It is likely that some of these active ingredients of the same food could have opposing effects and hence it is recommended to identify recommended foods based on analysis of all high quantity ingredients contained in foods.
For cancers like Uterine Epithelioid Leiomyosarcoma, activation or inhibition of selected biochemical pathways like TGFB Signaling, Apoptosis, Cell Cycle Checkpoints, DNA Repair plays an important role in driving cancer growth. Similarly different treatments work via different molecular actions which should never be canceled out by your foods and supplements. The foods and nutritional supplements contain different active ingredients each of which have a specific molecular action on different biochemical pathways. Hence, eating some foods and nutritional supplements would be recommended with a specific treatment of Uterine Epithelioid Leiomyosarcoma, while eating some other foods and supplements may not be recommended.
One common mistake when finding foods to eat or not – is to consider only a few active ingredients contained in foods based on internet searches and ignore the rest. Because different active ingredients contained in foods may have opposing effects on relevant biochemical pathways – it is recommended to consider all the high quantity active ingredients that are present in significant and much larger than trace amounts in the food.
RECOMMENDATION: TO FIND RECOMMENDED AND NON-RECOMMENDED FOODS FOR UTERINE EPITHELIOID LEIOMYOSARCOMA – CONSIDER HIGH QUANTITY ACTIVE INGREDIENTS CONTAINED IN FOODS.
Foods for Uterine Epithelioid Leiomyosarcoma undergoing chemotherapy treatment
In Uterine Epithelioid Leiomyosarcoma – the genes TP53, PDGFRB, ATRX, MED12 and BRD4 have high occurrences of genomic abnormalities. Not all of these genes necessarily are relevant for cancer – though they have been reported. Some of these genes directly or indirectly end up manipulating different cancer related biochemical biological pathways. Some of the pathways which are relevant drivers for Uterine Epithelioid Leiomyosarcoma are TGFB Signaling, Apoptosis, Cell Cycle and others. Docetaxel is one of the chemotherapies used for cancer treatment. The intent of treatment is to negate or cancel out effects of biochemical pathway drivers TGFB Signaling, Apoptosis, Cell Cycle so as to reduce disease progression and inhibit growth. Those foods whose combined action of active ingredients support treatment action and do not enhance disease drivers are recommended foods and supplements which will be included in personalized nutrition. And similarly – those foods whose combined action of active ingredients is not supportive of treatment action but end up promoting disease drives will not be recommended in your personalized nutrition plan.
RECOMMENDATION: AVOID SUPPLEMENTS AND FOODS WHICH ARE NOT SUPPORTIVE OF CANCER TREATMENT ACTION AND RATHER ENHANCE DISEASE DRIVERS.
Eat more pulses, Mung Bean or Lentils?
Pulses are an important part of many diets. The active ingredients contained in Mung Bean are Quercetin, Stigmasterol, Linolenic Acid, Vitamin C, Vitexin among others. While the active ingredients contained in Lentils are Esculin, Daidzein, Ellagic Acid, Beta-sitosterol, Linolenic Acid and others.
Quercetin can manipulate biochemical pathways MYC Signaling, Apoptosis and Cell Cycle. Stigmasterol has biological action on biochemical pathways MYC Signaling, Apoptosis and Cell Cycle.
Esculin can manipulate biochemical pathways TGFB Signaling. Ellagic Acid has biological action on biochemical pathways MYC Signaling. And so on.
When treating Uterine Epithelioid Leiomyosarcoma with chemotherapy Docetaxel – Foods like Mung Bean are recommended compared to Lentils. This is because the active ingredients Esculin and Ellagic Acid in Lentils interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Quercetin and Stigmasterol contained in Mung Bean support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.
RECOMMENDATION: MUNG BEAN IS RECOMMENDED OVER LENTILS FOR UTERINE EPITHELIOID LEIOMYOSARCOMA ON TREATMENT WITH CHEMOTHERAPY DOCETAXEL FOR SOME CONDITIONS.
Eat more vegetables, Asparagus or Yam?
Vegetables are an important part of many diets. The active ingredients contained in Asparagus are Quercetin, Linolenic Acid, Vitamin C, Oleic Acid, Isorhamnetin among others. While the active ingredients contained in Yam are Beta-sitosterol, Dioscin, Linolenic Acid, Vitamin C, Oleic Acid and others.
Quercetin can manipulate biochemical pathways MYC Signaling, Apoptosis and Cell Cycle. Vitamin C has biological action on biochemical pathways MYC Signaling, Apoptosis and Cell Cycle.
Linoleic Acid can manipulate biochemical pathways TGFB Signaling. Folic Acid has biological action on biochemical pathways MYC Signaling and Apoptosis. And so on.
When treating Uterine Epithelioid Leiomyosarcoma with chemotherapy Docetaxel – Foods like Asparagus are recommended compared to Yam. This is because the active ingredients Linoleic Acid and Folic Acid in Yam interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Quercetin and Vitamin C contained in Asparagus support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.
RECOMMENDATION: ASPARAGUS IS RECOMMENDED OVER YAM FOR UTERINE EPITHELIOID LEIOMYOSARCOMA ON TREATMENT WITH CHEMOTHERAPY DOCETAXEL FOR SOME CONDITIONS.
Eat more fruits, Elderberry or Cranberry?
Fruits are an important part of many diets. The active ingredients contained in Elderberry are Lupeol, Betulinic Acid, Quercetin, Linolenic Acid, Vitamin C among others. While the active ingredients contained in Cranberry are Hyperoside, Ellagic Acid, Quercetin, P-coumaric Acid, Vitamin C and others.
Rutin can manipulate biochemical pathways MYC Signaling, Apoptosis and Cell Cycle. Lupeol has biological action on biochemical pathways MYC Signaling, Apoptosis and Cell Cycle.
Ellagic Acid can manipulate biochemical pathways MYC Signaling. Caffeic Acid has biological action on biochemical pathways TGFB Signaling. And so on.
When treating Uterine Epithelioid Leiomyosarcoma with chemotherapy Docetaxel – Foods like Elderberry are recommended compared to Cranberry. This is because the active ingredients Ellagic Acid and Caffeic Acid in Cranberry interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Rutin and Lupeol contained in Elderberry support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.
RECOMMENDATION: ELDERBERRY IS RECOMMENDED OVER CRANBERRY FOR UTERINE EPITHELIOID LEIOMYOSARCOMA ON TREATMENT WITH CHEMOTHERAPY DOCETAXEL FOR SOME CONDITIONS.
Eat more nuts, Almond or Peanut?
Nuts are an important part of many diets. The active ingredients contained in Almond are Vitamin E, Beta-sitosterol, Quercetin, Stigmasterol, Linolenic Acid among others. While the active ingredients contained in Peanut are Vitamin E, Ferulic Acid, Beta-sitosterol, Quercetin, Stigmasterol and others.
Beta-sitosterol can manipulate biochemical pathways MYC Signaling, Apoptosis and Cell Cycle. Vitamin E has biological action on biochemical pathways MYC Signaling, Apoptosis and Cell Cycle.
Lecithin can manipulate biochemical pathways MYC Signaling. Linoleic Acid has biological action on biochemical pathways TGFB Signaling. And so on.
When treating Uterine Epithelioid Leiomyosarcoma with chemotherapy Docetaxel – Foods like Almond are recommended compared to Peanut. This is because the active ingredients Lecithin and Linoleic Acid in Peanut interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Beta-sitosterol and Vitamin E contained in Almond support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.
RECOMMENDATION: ALMOND IS RECOMMENDED OVER PEANUT FOR UTERINE EPITHELIOID LEIOMYOSARCOMA ON TREATMENT WITH CHEMOTHERAPY DOCETAXEL FOR SOME CONDITIONS.
Foods for Genetic Risk of Uterine Epithelioid Leiomyosarcoma
One of the ways to assess risk of cancer is by checking for presence of genetic abnormalities in a set of genes. There is prior information on a list of genes whose mutations and other aberrations can play a role in risk to different cancers. PDGFRB and BRD4 are two genes whose abnormalities are risk factors for Uterine Epithelioid Leiomyosarcoma. In such a cancer risk situation – while there are typically no treatments which a physician can prescribe – the various biochemical pathways which are potentially molecular drivers of Uterine Epithelioid Leiomyosarcoma can be used as a guide for coming up with a recommended personalized nutrition plan. For Uterine Epithelioid Leiomyosarcoma gene PDGFRB has causative impact on biological pathways like MAPK Signaling, Growth Factor Signaling and PI3K-AKT-MTOR Signaling. And BRD4 has a causative impact on biological pathways like Chromatin Remodeling, DNA Repair and Epithelial to Mesenchymal Transition. Foods and nutritional supplements which have molecular action to cancel out biochemical pathways effects of genes like PDGFRB and BRD4 should be included in a personalized nutrition plan. And those foods and supplements which promote the effects of genes PDGFRB and BRD4 should be avoided.
Eat more pulses, Scarlet Bean or Soy Bean?
The active ingredients contained in Scarlet Bean are Beta-sitosterol, Linolenic Acid, Vitamin C, Stigmasterol, Oleic Acid among others. While the active ingredients contained in Soy Bean are Lupeol, Daidzein, Vitamin E, Beta-sitosterol, Ferulic Acid and others.
Beta-sitosterol can manipulate biochemical pathways Apoptosis, Cell Cycle and MYC Signaling. Vitamin C has biological action on biochemical pathways P53 Signaling, Cell Cycle Checkpoints and Apoptosis.
Aescin can manipulate biochemical pathways Cell Cycle Checkpoints. Lecithin has biological action on biochemical pathways MYC Signaling. And so on.
For genetic risk of Uterine Epithelioid Leiomyosarcoma due to abnormalities in genes PDGFRB and BRD4 – Foods like Scarlet Bean are recommended compared to Soy Bean. This is because the active ingredients Aescin and Lecithin in Soy Bean further promote the effects of genes on the biochemical pathways. While the active ingredients Beta-sitosterol and Vitamin C contained in Scarlet Bean together have a canceling effect of genes on the biochemical pathways.
RECOMMENDATION: SCARLET BEAN IS RECOMMENDED OVER SOY BEAN FOR REDUCING THE GENETIC RISK OF UTERINE EPITHELIOID LEIOMYOSARCOMA DUE TO GENES PDGFRB AND BRD4
Eat more vegetables, Jicama or Heart Of Palm?
The active ingredients contained in Jicama are Vitamin C, Beta-carotene, Vitamin B3, Vitamin A, Folic Acid among others. While the active ingredients contained in Heart Of Palm are Vitamin C, Palmitic Acid, Vitamin A, Folic Acid and others.
Vitamin C can manipulate biochemical pathways Apoptosis, Cell Cycle and MYC Signaling. Beta-carotene has biological action on biochemical pathways P53 Signaling, Cell Cycle Checkpoints and Apoptosis.
Palmitic Acid can manipulate biochemical pathways DNA Repair. Folic Acid has biological action on biochemical pathways Apoptosis, Cell Cycle and MYC Signaling. And so on.
For genetic risk of Uterine Epithelioid Leiomyosarcoma due to abnormalities in genes PDGFRB and BRD4 – Foods like Jicama are recommended compared to Heart Of Palm. This is because the active ingredients Palmitic Acid and Folic Acid in Heart Of Palm further promote the effects of genes on the biochemical pathways. While the active ingredients Vitamin C and Beta-carotene contained in Jicama together have a canceling effect of genes on the biochemical pathways.
RECOMMENDATION: JICAMA IS RECOMMENDED OVER HEART OF PALM FOR REDUCING THE GENETIC RISK OF UTERINE EPITHELIOID LEIOMYOSARCOMA DUE TO GENES PDGFRB AND BRD4
Foods to Eat After Cancer Diagnosis!
No two cancers are the same. Go beyond the common nutrition guidelines for everyone and make personalized decisions about food and supplements with confidence.
Eat more fruits, Kiwi or Grape?
The active ingredients contained in Kiwi are Vitamin C, Quercetin, Fisetin, Vitamin A, Chlorogenic Acid among others. While the active ingredients contained in Grape are Lupeol, Pterostilbene, Vitamin E, Beta-sitosterol, Linolenic Acid and others.
Vitamin C can manipulate biochemical pathways Apoptosis, Cell Cycle and MYC Signaling. Quercetin has biological action on biochemical pathways P53 Signaling, Cell Cycle Checkpoints and Apoptosis.
Resveratrol can manipulate biochemical pathways P53 Signaling. Berberine has biological action on biochemical pathways Oncogenic Histone Methylation. And so on.
For genetic risk of Uterine Epithelioid Leiomyosarcoma due to abnormalities in genes PDGFRB and BRD4 – Foods like Kiwi are recommended compared to Grape. This is because the active ingredients Resveratrol and Berberine in Grape further promote the effects of genes on the biochemical pathways. While the active ingredients Vitamin C and Quercetin contained in Kiwi together have a canceling effect of genes on the biochemical pathways.
RECOMMENDATION: KIWI IS RECOMMENDED OVER GRAPE FOR REDUCING THE GENETIC RISK OF UTERINE EPITHELIOID LEIOMYOSARCOMA DUE TO GENES PDGFRB AND BRD4
Eat more nuts, Hazelnut or Chestnut?
The active ingredients contained in Hazelnut are Vitamin E, Linolenic Acid, Quercetin, Oleic Acid, Linoleic Acid among others. While the active ingredients contained in Chestnut are Ellagic Acid, Linolenic Acid, Vitamin C, Quercetin, Oleic Acid and others.
Vitamin E can manipulate biochemical pathways Apoptosis, Cell Cycle and MYC Signaling. Quercetin has biological action on biochemical pathways P53 Signaling, Cell Cycle Checkpoints and Apoptosis.
Ellagic Acid can manipulate biochemical pathways MYC Signaling. Gallic Acid has biological action on biochemical pathways DNA Repair. And so on.
For genetic risk of Uterine Epithelioid Leiomyosarcoma due to abnormalities in genes PDGFRB and BRD4 – Foods like Hazelnut are recommended compared to Chestnut. This is because the active ingredients Ellagic Acid and Gallic Acid in Chestnut further promote the effects of genes on the biochemical pathways. While the active ingredients Vitamin E and Quercetin contained in Hazelnut together have a canceling effect of genes on the biochemical pathways.
RECOMMENDATION: HAZELNUT IS RECOMMENDED OVER CHESTNUT FOR REDUCING THE GENETIC RISK OF UTERINE EPITHELIOID LEIOMYOSARCOMA DUE TO GENES PDGFRB AND BRD4
In Summary
An important thing to remember is that cancer treatments may not be the same for everyone – and neither should your nutrition be. Nutrition which includes food and nutritional supplements is a very effective tool controlled by you.
“What should I eat?” is the most frequently asked question in the context of cancer. The answer calculation is complex and depends upon cancer type, underlying genomics, current treatments, any allergies, lifestyle information, and factors like BMI.
The addon personalized nutrition plan recommends foods and supplements which minimizes adverse nutrition interactions and encourages support to treatments.
You can get started NOW and design a personalized nutrition plan for Uterine Epithelioid Leiomyosarcoma by answering questions on type of cancer, current treatments, supplements, allergies, age group, gender, and lifestyle information.
What food you eat and which supplements you take is a decision you make. Your decision should include consideration of the cancer gene mutations, which cancer, ongoing treatments and supplements, any allergies, lifestyle information, weight, height and habits.
The nutrition planning for cancer from addon is not based on internet searches. It automates the decision making for you based on molecular science implemented by our scientists and software engineers. Irrespective of whether you care to understand the underlying biochemical molecular pathways or not - for nutrition planning for cancer that understanding is needed.
Get started NOW with your nutrition planning by answering questions on the name of cancer, genetic mutations, ongoing treatments and supplements, any allergies, habits, lifestyle, age group and gender.
References
- Msk Impact 2017
- Genomic Landscape of Uterine Sarcomas Defined Through Prospective Clinical Sequencing.
- Crystal structure of a human cyclin-dependent kinase 6 complex with a flavonol inhibitor, fisetin.
- Stigmasterol exhibits potent antitumor effects in human gastric cancer cells mediated via inhibition of cell migration, cell cycle arrest, mitochondrial mediated apoptosis and inhibition of JAK/STAT signalling pathway.
- Identification of ellagic acid as potent inhibitor of protein kinase CK2: a successful example of a virtual screening application.
- Rutin Attenuates Hepatotoxicity in High-Cholesterol-Diet-Fed Rats.
- Negative regulation of signal transducer and activator of transcription-3 signalling cascade by lupeol inhibits growth and induces apoptosis in hepatocellular carcinoma cells.
- Synthesis and structure-activity relationship analysis of caffeic acid amides as selective matrix metalloproteinase inhibitors.
- Vitamin C enhances epigenetic modifications induced by 5-azacytidine and cell cycle arrest in the hepatocellular carcinoma cell lines HLE and Huh7.
- Activation of PPAR gamma and delta by conjugated linoleic acid mediates protection from experimental inflammatory bowel disease.
- Effects of folate deficiency on gene expression in the apoptosis and cancer pathways in colon cancer cells.
- β-Sitosterol targets Trx/Trx1 reductase to induce apoptosis in A549 cells via ROS mediated mitochondrial dysregulation and p53 activation.
- Gamma- and delta-tocotrienols exert a more potent anticancer effect than alpha-tocopheryl succinate on breast cancer cell lines irrespective of HER-2/neu expression.
- The recruitment of Raf-1 to membranes is mediated by direct interaction with phosphatidic acid and is independent of association with Ras.
- Resveratrol, a remarkable inhibitor of ribonucleotide reductase.
- Berberine acts as a putative epigenetic modulator by affecting the histone code.
- The effect of Pasteurella haemolytica cytotoxin on bovine polymorphonuclear leukocytes can be attenuated by beta-adrenoceptor antagonists.
- Functional lipidomics: Palmitic acid impairs hepatocellular carcinoma development by modulating membrane fluidity and glucose metabolism.
- Gallic acid provokes DNA damage and suppresses DNA repair gene expression in human prostate cancer PC-3 cells.
- HyperFoods: Machine intelligent mapping of cancer-beating molecules in foods.
- Berberine: Botanical Occurrence, Traditional Uses, Extraction Methods, and Relevance in Cardiovascular, Metabolic, Hepatic, and Renal Disorders.
Personalized Nutrition for Cancer!
Cancer changes with time. Customize and modify your nutrition based on cancer indication, treatments, lifestyle, food preferences, allergies and other factors.