Foods for Uterine Epithelioid Leiomyosarcoma!

Introduction

Foods for Uterine Epithelioid Leiomyosarcoma should be personalized for each individual and also must adapt when cancer treatment or tumor genetic change. The personalization and adaptation must consider all the active ingredients or bioactives contained in different foods with respect to cancer tissue biology, genetics, treatments, lifestyle conditions and diet preferences. Hence while nutrition is one of the very important decisions for a cancer patient and individual at risk of cancer to make – how to choose foods to eat is not an easy task.

For Uterine Epithelioid Leiomyosarcoma does it matter what vegetables, fruits, nuts, seeds one eats?

A very common nutrition question asked by cancer patients and individuals at-genetic risk of cancer is – for cancers like Uterine Epithelioid Leiomyosarcoma does it matter what foods I eat and which I do not? Or if I follow a plant-based diet is that enough for cancer like Uterine Epithelioid Leiomyosarcoma?

For example does it matter if vegetable Garden Cress is consumed more compared to Prairie Turnip? Does it make any difference if fruit Mammee Apple is preferred over Evergreen Blackberry? Also if similar choices are made for nuts/seeds like Common Walnut over Macadamia Nut and for pulses like Black-eyed Pea over Mung Bean. And if what I eat matters – then how does one identify foods which are recommended for Uterine Epithelioid Leiomyosarcoma and is it the same answer for everyone with the same diagnosis or genetic risk?

Yes! Foods you eat matters for Uterine Epithelioid Leiomyosarcoma!

Food recommendations may not be the same for everyone and can be different even for the same diagnosis and genetic risk.

All foods (vegetables, fruits, nuts, seeds, pulses, oils etc.) and nutritional supplements are made up of more than one active molecular ingredient or bio-actives in different proportions and quantities. Each active ingredient has a unique mechanism of action – which can be activation or inhibition of different biochemical pathways. Simply stated foods and supplements which are recommended are those which do not cause an increase of molecular drivers of cancer but reduce them. Else those foods should not be recommended. Foods contain multiple active ingredients – hence when evaluating foods and supplements you need to consider the impact of all active ingredients cumulatively rather than individually.

For example Mammee Apple contains active ingredients Apigenin, Curcumin, Lupeol, Lycopene, Daidzein. And Evergreen Blackberry contains active ingredients Ellagic Acid, Linalool, Eugenol, Beta-ionone, Alpha Pinene and possibly others.

A common mistake made when deciding and choosing foods to eat for Uterine Epithelioid Leiomyosarcoma – is to evaluate only selected active ingredients contained in foods and ignore the rest. Because different active ingredients contained in foods may have opposing effects on cancer drivers – you cannot cherry pick active ingredients in foods and supplements for making a nutrition decision for Uterine Epithelioid Leiomyosarcoma.

YES – FOOD CHOICES MATTER FOR CANCER. NUTRITION DECISIONS MUST CONSIDER ALL ACTIVE INGREDIENTS OF FOODS.

Skills Needed for Nutrition Personalization for Uterine Epithelioid Leiomyosarcoma?

Personalized nutrition for cancers like Uterine Epithelioid Leiomyosarcoma consists of recommended foods / supplements; not recommended foods / supplements with example recipes which prioritize use of recommended foods. An example of personalized nutrition can be seen at this link.

Deciding which foods are recommended or not is extremely complicated, requiring expertise in Uterine Epithelioid Leiomyosarcoma biology, food science, genetics, biochemistry along with good understanding of how cancer treatments work and associated vulnerabilities by which the treatments could stop being effective.

MINIMUM KNOWLEDGE EXPERTISE NEEDED FOR NUTRITION PERSONALIZATION FOR CANCER ARE: CANCER BIOLOGY, FOOD SCIENCE, CANCER TREATMENTS AND GENETICS.

Characteristics of cancers like Uterine Epithelioid Leiomyosarcoma

All cancers like Uterine Epithelioid Leiomyosarcoma can be characterized by a unique set of biochemical pathways – the signature pathways of Uterine Epithelioid Leiomyosarcoma. Biochemical pathways like TGFB Signaling, Apoptosis, Cell Cycle Checkpoints, Cell Cycle are part of the signature definition of Uterine Epithelioid Leiomyosarcoma. Each individual’s cancer genetics can be different and hence their specific cancer signature could be unique.

The treatments which are effective for Uterine Epithelioid Leiomyosarcoma need to be cognizant of the associated signature biochemical pathways for each cancer patient and individual at genetic risk. Therefore different treatments with different mechanisms of actions are effective for different patients. Similarly and for the same reasons foods and supplements need to be personalized for each individual. Hence some foods and supplements are recommended for Uterine Epithelioid Leiomyosarcoma when taking cancer treatment Paclitaxel, and some foods and supplements are not recommended.

Sources like cBioPortal and many others provide population representative patient anonymized data from clinical trials for all cancer indications. This data consists of clinical trial study details like sample size / number of patients, age groups, gender, ethnicity, treatments, tumor site and any genetic mutations.

TP53, PDGFRB, ATRX, MED12 and BRD4 are the top ranked reported genes for Uterine Epithelioid Leiomyosarcoma. TP53 is reported in 66.7 % of the representative patients across all clinical trials. And PDGFRB is reported in 33.3 %. The combined population patient data cover ages from to . 0.0 % of the patient data are identified as men. The Uterine Epithelioid Leiomyosarcoma biology along with reported genetics together define the population represented signature biochemical pathways for this cancer. If the individual cancer tumor genetics or genes contributing to the risk are also known then that should also be used for nutrition personalization.

NUTRITION CHOICES SHOULD MATCH WITH EACH INDIVIDUAL’S CANCER SIGNATURE.

Food and Supplements for Uterine Epithelioid Leiomyosarcoma

For Cancer Patients

Cancer patients on treatment or on palliative care need to make decisions on food and supplements – for the needed dietary calories, for managing any treatment side effects and also for improved cancer management. All plant-based foods are not equal and choosing and prioritizing foods which are personalized and customized to ongoing cancer treatment is important and complicated. Here are some examples providing guidelines for making nutrition decisions.

Choose Vegetable GARDEN CRESS or PRAIRIE TURNIP?

Vegetable Garden Cress contains many active ingredients or bioactives such as Curcumin, Lupeol, Daidzein, Phloretin, Bergapten. These active ingredients manipulate various biochemical pathways like Cell Cycle and Apoptosis and others. Garden Cress is recommended for Uterine Epithelioid Leiomyosarcoma when ongoing cancer treatment is Paclitaxel. This is because Garden Cress modifies those biochemical pathways which have been scientifically reported to sensitize the effect of Paclitaxel.

Some of the active ingredients or bioactives in vegetable Prairie Turnip are Apigenin, Curcumin, Lupeol, Lycopene, Daidzein. These active ingredients manipulate various biochemical pathways like TGFB Signaling and others. Prairie Turnip is not recommended for Uterine Epithelioid Leiomyosarcoma when ongoing cancer treatment is Paclitaxel because it modifies those biochemical pathways which make the cancer treatment resistant or less responsive.

VEGETABLE GARDEN CRESS IS RECOMMENDED OVER PRAIRIE TURNIP FOR Uterine Epithelioid Leiomyosarcoma AND TREATMENT Paclitaxel.

Choose Fruit EVERGREEN BLACKBERRY or MAMMEE APPLE?

Fruit Evergreen Blackberry contains many active ingredients or bioactives such as Ellagic Acid, Linalool, Eugenol, Beta-ionone, Alpha Pinene. These active ingredients manipulate various biochemical pathways like Cell Cycle, Apoptosis and MYC Signaling and others. Evergreen Blackberry is recommended for Uterine Epithelioid Leiomyosarcoma when ongoing cancer treatment is Paclitaxel. This is because Evergreen Blackberry modifies those biochemical pathways which have been scientifically reported to sensitize the effect of Paclitaxel.

Some of the active ingredients or bioactives in fruit Mammee Apple are Apigenin, Curcumin, Lupeol, Lycopene, Daidzein. These active ingredients manipulate various biochemical pathways like Cell Cycle and TGFB Signaling and others. Mammee Apple is not recommended for Uterine Epithelioid Leiomyosarcoma when ongoing cancer treatment is Paclitaxel because it modifies those biochemical pathways which make the cancer treatment resistant or less responsive.

FRUIT EVERGREEN BLACKBERRY IS RECOMMENDED OVER MAMMEE APPLE FOR Uterine Epithelioid Leiomyosarcoma AND TREATMENT Paclitaxel.

Choose Nut COMMON WALNUT or MACADAMIA NUT?

Common Walnut contains many active ingredients or bioactives such as Curcumin, Lupeol, Ellagic Acid, Daidzein, Phloretin. These active ingredients manipulate various biochemical pathways like Cell Cycle, Apoptosis and TGFB Signaling and others. Common Walnut is recommended for Uterine Epithelioid Leiomyosarcoma when ongoing cancer treatment is Paclitaxel. This is because Common Walnut modifies those biochemical pathways which have been scientifically reported to sensitize the effect of Paclitaxel.

Some of the active ingredients or bioactives in Macadamia Nut are Apigenin, Curcumin, Lupeol, Daidzein, Phloretin. These active ingredients manipulate various biochemical pathways like TGFB Signaling and MYC Signaling and others. Macadamia Nut is not recommended for Uterine Epithelioid Leiomyosarcoma when ongoing cancer treatment is Paclitaxel because it modifies those biochemical pathways which make the cancer treatment resistant or less responsive.

COMMON WALNUT IS RECOMMENDED OVER MACADAMIA NUT FOR Uterine Epithelioid Leiomyosarcoma AND TREATMENT Paclitaxel.

For Individuals with Genetic Risk of Cancer

The question asked by individuals who have genetic risk of Uterine Epithelioid Leiomyosarcoma or familial history is “What Should I Eat Differently from Before?” and how they should choose foods and supplements to manage risks of the disease. Since for cancer risk there is nothing actionable in terms of treatment – decisions of foods and supplements become important and one of the very few actionable things which can be done. All plant-based foods are not equal and based on identified genetics and pathway signature – the choices of food and supplements should be personalized.

Choose Vegetable GIANT BUTTERBUR or MALABAR SPINACH?

Vegetable Giant Butterbur contains many active ingredients or bioactives such as Apigenin, Curcumin, Lycopene, Lupeol, Daidzein. These active ingredients manipulate various biochemical pathways like Cell Cycle, P53 Signaling, Cell Cycle Checkpoints and MYC Signaling and others. Giant Butterbur is recommended for risk of Uterine Epithelioid Leiomyosarcoma when associated genetic risk is ATRX. This is because Giant Butterbur increases those biochemical pathways which counteract the signature drivers of it.

Some of the active ingredients or bioactives in vegetable Malabar Spinach are Apigenin, Curcumin, Lycopene, Quercetin, Lupeol. These active ingredients manipulate various biochemical pathways like TGFB Signaling and Oncogenic Histone Methylation and others. Malabar Spinach is not recommended when risk of Uterine Epithelioid Leiomyosarcoma when associated genetic risk is ATRX because it increases the signature pathways of it.

VEGETABLE GIANT BUTTERBUR IS RECOMMENDED OVER MALABAR SPINACH FOR ATRX GENETIC RISK OF CANCER.

Choose Fruit RED RASPBERRY or PUMMELO?

Fruit Red Raspberry contains many active ingredients or bioactives such as Curcumin, Ellagic Acid, Quercetin, Lupeol, Daidzein. These active ingredients manipulate various biochemical pathways like Cell Cycle, TGFB Signaling, MAPK Signaling and MYC Signaling and others. Red Raspberry is recommended for risk of Uterine Epithelioid Leiomyosarcoma when associated genetic risk is ATRX. This is because Red Raspberry increases those biochemical pathways which counteract the signature drivers of it.

Some of the active ingredients or bioactives in fruit Pummelo are Apigenin, Curcumin, Lycopene, Quercetin, Lupeol. These active ingredients manipulate various biochemical pathways like TGFB Signaling, DNA Repair and Cell Cycle Checkpoints and others. Pummelo is not recommended when risk of Uterine Epithelioid Leiomyosarcoma when associated genetic risk is ATRX because it increases the signature pathways of it.

FRUIT RED RASPBERRY IS RECOMMENDED OVER PUMMELO FOR ATRX GENETIC RISK OF CANCER.

Choose Nut COMMON HAZELNUT or CHESTNUT?

Common Hazelnut contains many active ingredients or bioactives such as Curcumin, Lycopene, Quercetin, Lupeol, Daidzein. These active ingredients manipulate various biochemical pathways like Cell Cycle, TGFB Signaling, P53 Signaling and MYC Signaling and others. Common Hazelnut is recommended for risk of Uterine Epithelioid Leiomyosarcoma when associated genetic risk is ATRX. This is because Common Hazelnut increases those biochemical pathways which counteract the signature drivers of it.

Some of the active ingredients or bioactives in Chestnut are Apigenin, Curcumin, Ellagic Acid, Lycopene, Lupeol. These active ingredients manipulate various biochemical pathways like DNA Repair and PI3K-AKT-MTOR Signaling and others. Chestnut is not recommended when risk of Uterine Epithelioid Leiomyosarcoma when associated genetic risk is ATRX because it increases the signature pathways of it.

COMMON HAZELNUT IS RECOMMENDED OVER CHESTNUT FOR ATRX GENETIC RISK OF CANCER.

In Conclusion

Foods and Supplements chosen are important decisions for cancers like Uterine Epithelioid Leiomyosarcoma. Uterine Epithelioid Leiomyosarcoma patients and individuals with genetic-risk always have this question: “What foods and nutritional supplements are recommended for me and which are not?” There is a common belief which is a misconception that all plant-based foods could be beneficial or not but would not be harmful. Certain foods and supplements can interfere with cancer treatments or promote molecular pathway drivers of cancer.

There are different types of cancer indications like Uterine Epithelioid Leiomyosarcoma, each with different tumor genetics with further genomic variations across each individual. Further every cancer treatment and chemotherapy has a unique mechanism of action. Each food like Garden Cress contains various bioactives in different quantities, which have an impact on different and distinct sets of biochemical pathways. The definition of personalized nutrition is individualized food recommendations for the cancer indication, treatments, genetics, lifestyle and other factors. Nutrition personalization decisions for cancer require knowledge of cancer biology, food science and an understanding of different chemotherapy treatments. Finally when there are treatment changes or new genomics is identified – the nutrition personalization needs re-evaluation.

The addon nutrition personalization solution makes the decision making easy and removes all the guesswork in answering the question, “What foods should I choose or not choose for Uterine Epithelioid Leiomyosarcoma?”. The addon multi-disciplinary team includes cancer physicians, clinical scientists, software engineers and data scientists.

References

• Msk Impact 2017
• Genomic Landscape of Uterine Sarcomas Defined Through Prospective Clinical Sequencing.
• Vitamin C selectively kills KRAS and BRAF mutant colorectal cancer cells by targeting GAPDH.
• Shikimic acid promotes estrogen receptor(ER)-positive breast cancer cells proliferation via activation of NF-κB signaling.
• Lycopene differentially induces quiescence and apoptosis in androgen-responsive and -independent prostate cancer cell lines.
• Gallic acid provokes DNA damage and suppresses DNA repair gene expression in human prostate cancer PC-3 cells.