Foods for Uterine Leiomyosarcoma!

Introduction

Foods for Uterine Leiomyosarcoma should be personalized for each individual and also must adapt when cancer treatment or tumor genetic change. The personalization and adaptation must consider all the active ingredients or bioactives contained in different foods with respect to cancer tissue biology, genetics, treatments, lifestyle conditions and diet preferences. Hence while nutrition is one of the very important decisions for a cancer patient and individual at risk of cancer to make – how to choose foods to eat is not an easy task.

Uterine leiomyosarcoma, a rare and aggressive type of uterine cancer, often presents symptoms similar to less serious conditions, making early diagnosis challenging. Identified in radiology, particularly through MRI and ultrasound, uterine leiomyosarcoma’s unique characteristics are further detailed in pathology outlines. Its staging, crucial for treatment planning, is guided by specific features seen in these imaging techniques. The ICD-10 code for uterine leiomyosarcoma aids in its classification and tracking in medical records. Treatment typically involves a combination of surgery, chemotherapy, and radiation, as outlined in uterine leiomyosarcoma treatment guidelines. Despite advances, the survival rate remains a concern, especially considering the potential for metastasis and recurrence. Understanding the risk factors and causes of uterine leiomyosarcoma, such as distinguishing it from benign fibroids, is vital for prevention and early intervention. The uterine leiomyosarcoma community, including discussions on platforms like Reddit, often explores questions like “Is uterine leiomyosarcoma curable?” and “How fast does uterine leiomyosarcoma grow?” to better understand this condition.

For Uterine Leiomyosarcoma does it matter what vegetables, fruits, nuts, seeds one eats?

A very common nutrition question asked by cancer patients and individuals at-genetic risk of cancer is – for cancers like Uterine Leiomyosarcoma does it matter what foods I eat and which I do not? Or if I follow a plant-based diet is that enough for cancer like Uterine Leiomyosarcoma?

For example does it matter if vegetable Brussel Sprouts is consumed more compared to Spinach? Does it make any difference if fruit Pummelo is preferred over Rabbiteye Blueberry? Also if similar choices are made for nuts/seeds like Common Walnut over Pistachio and for pulses like Broad Bean over Lentils. And if what I eat matters – then how does one identify foods which are recommended for Uterine Leiomyosarcoma and is it the same answer for everyone with the same diagnosis or genetic risk?

Yes! Foods you eat matters for Uterine Leiomyosarcoma!

Food recommendations may not be the same for everyone and can be different even for the same diagnosis and genetic risk.

All foods (vegetables, fruits, nuts, seeds, pulses, oils etc.) and nutritional supplements are made up of more than one active molecular ingredient or bio-actives in different proportions and quantities. Each active ingredient has a unique mechanism of action – which can be activation or inhibition of different biochemical pathways. Simply stated foods and supplements which are recommended are those which do not cause an increase of molecular drivers of cancer but reduce them. Else those foods should not be recommended. Foods contain multiple active ingredients – hence when evaluating foods and supplements you need to consider the impact of all active ingredients cumulatively rather than individually.

For example Pummelo contains active ingredients Quercetin, Caffeic Acid, Delphinidin, Lycopene, Phloretin. And Rabbiteye Blueberry contains active ingredients Quercetin, Gallic Acid, Ferulic Acid, Geraniol, Eugenol and possibly others.

A common mistake made when deciding and choosing foods to eat for Uterine Leiomyosarcoma – is to evaluate only selected active ingredients contained in foods and ignore the rest. Because different active ingredients contained in foods may have opposing effects on cancer drivers – you cannot cherry pick active ingredients in foods and supplements for making a nutrition decision for Uterine Leiomyosarcoma.

YES – FOOD CHOICES MATTER FOR CANCER. NUTRITION DECISIONS MUST CONSIDER ALL ACTIVE INGREDIENTS OF FOODS.

Skills Needed for Nutrition Personalization for Uterine Leiomyosarcoma?

Personalized nutrition for cancers like Uterine Leiomyosarcoma consists of recommended foods / supplements; not recommended foods / supplements with example recipes which prioritize use of recommended foods. An example of personalized nutrition can be seen at this link.

Deciding which foods are recommended or not is extremely complicated, requiring expertise in Uterine Leiomyosarcoma biology, food science, genetics, biochemistry along with good understanding of how cancer treatments work and associated vulnerabilities by which the treatments could stop being effective.

MINIMUM KNOWLEDGE EXPERTISE NEEDED FOR NUTRITION PERSONALIZATION FOR CANCER ARE: CANCER BIOLOGY, FOOD SCIENCE, CANCER TREATMENTS AND GENETICS.

Characteristics of cancers like Uterine Leiomyosarcoma

All cancers like Uterine Leiomyosarcoma can be characterized by a unique set of biochemical pathways – the signature pathways of Uterine Leiomyosarcoma. Biochemical pathways like NFKB Signaling, MAPK Signaling, PI3K-AKT-MTOR Signaling, TGFB Signaling are part of the signature definition of Uterine Leiomyosarcoma. Each individual’s cancer genetics can be different and hence their specific cancer signature could be unique.

The treatments which are effective for Uterine Leiomyosarcoma need to be cognizant of the associated signature biochemical pathways for each cancer patient and individual at genetic risk. Therefore different treatments with different mechanisms of actions are effective for different patients. Similarly and for the same reasons foods and supplements need to be personalized for each individual. Hence some foods and supplements are recommended for Uterine Leiomyosarcoma when taking cancer treatment Leuprolide, and some foods and supplements are not recommended.

Sources like cBioPortal and many others provide population representative patient anonymized data from clinical trials for all cancer indications. This data consists of clinical trial study details like sample size / number of patients, age groups, gender, ethnicity, treatments, tumor site and any genetic mutations.

MED12, TP53, ATRX, PTEN and BRCA1 are the top ranked reported genes for Uterine Leiomyosarcoma. MED12 is reported in 7.5 % of the representative patients across all clinical trials. And TP53 is reported in 6.0 %. The combined population patient data cover ages from 35 to 75. 0.0 % of the patient data are identified as men. The Uterine Leiomyosarcoma biology along with reported genetics together define the population represented signature biochemical pathways for this cancer. If the individual cancer tumor genetics or genes contributing to the risk are also known then that should also be used for nutrition personalization.

NUTRITION CHOICES SHOULD MATCH WITH EACH INDIVIDUAL’S CANCER SIGNATURE.

Food and Supplements for Uterine Leiomyosarcoma

For Cancer Patients

Cancer patients on treatment or on palliative care need to make decisions on food and supplements – for the needed dietary calories, for managing any treatment side effects and also for improved cancer management. All plant-based foods are not equal and choosing and prioritizing foods which are personalized and customized to ongoing cancer treatment is important and complicated. Here are some examples providing guidelines for making nutrition decisions.

Choose Vegetable BRUSSEL SPROUTS or SPINACH?

Vegetable Brussel Sprouts contains many active ingredients or bioactives such as Delphinidin, Phloretin, Biochanin A, Genistein, Formononetin. These active ingredients manipulate various biochemical pathways like Epithelial to Mesenchymal Transition, Growth Factor Signaling and MAPK Signaling and others. Brussel Sprouts is recommended for Uterine Leiomyosarcoma when ongoing cancer treatment is Leuprolide. This is because Brussel Sprouts modifies those biochemical pathways which have been scientifically reported to sensitize the effect of Leuprolide.

Some of the active ingredients or bioactives in vegetable Spinach are Quercetin, Caffeic Acid, Delphinidin, Phloretin, Biochanin A. These active ingredients manipulate various biochemical pathways like Epithelial to Mesenchymal Transition and NFKB Signaling and others. Spinach is not recommended for Uterine Leiomyosarcoma when ongoing cancer treatment is Leuprolide because it modifies those biochemical pathways which make the cancer treatment resistant or less responsive.

VEGETABLE BRUSSEL SPROUTS IS RECOMMENDED OVER SPINACH FOR Uterine Leiomyosarcoma AND TREATMENT Leuprolide.

Choose Fruit RABBITEYE BLUEBERRY or PUMMELO?

Fruit Rabbiteye Blueberry contains many active ingredients or bioactives such as Quercetin, Gallic Acid, Ferulic Acid, Geraniol, Eugenol. These active ingredients manipulate various biochemical pathways like Epithelial to Mesenchymal Transition, Growth Factor Signaling and NFKB Signaling and others. Rabbiteye Blueberry is recommended for Uterine Leiomyosarcoma when ongoing cancer treatment is Leuprolide. This is because Rabbiteye Blueberry modifies those biochemical pathways which have been scientifically reported to sensitize the effect of Leuprolide.

Some of the active ingredients or bioactives in fruit Pummelo are Quercetin, Caffeic Acid, Delphinidin, Lycopene, Phloretin. These active ingredients manipulate various biochemical pathways like Epithelial to Mesenchymal Transition and NFKB Signaling and others. Pummelo is not recommended for Uterine Leiomyosarcoma when ongoing cancer treatment is Leuprolide because it modifies those biochemical pathways which make the cancer treatment resistant or less responsive.

FRUIT RABBITEYE BLUEBERRY IS RECOMMENDED OVER PUMMELO FOR Uterine Leiomyosarcoma AND TREATMENT Leuprolide.

Choose Nut COMMON WALNUT or PISTACHIO?

Common Walnut contains many active ingredients or bioactives such as Quercetin, Ellagic Acid, Delphinidin, Phloretin, Biochanin A. These active ingredients manipulate various biochemical pathways like Epithelial to Mesenchymal Transition, Growth Factor Signaling and NFKB Signaling and others. Common Walnut is recommended for Uterine Leiomyosarcoma when ongoing cancer treatment is Leuprolide. This is because Common Walnut modifies those biochemical pathways which have been scientifically reported to sensitize the effect of Leuprolide.

Some of the active ingredients or bioactives in Pistachio are Quercetin, Caffeic Acid, Delphinidin, Phloretin, Biochanin A. These active ingredients manipulate various biochemical pathways like NFKB Signaling and others. Pistachio is not recommended for Uterine Leiomyosarcoma when ongoing cancer treatment is Leuprolide because it modifies those biochemical pathways which make the cancer treatment resistant or less responsive.

COMMON WALNUT IS RECOMMENDED OVER PISTACHIO FOR Uterine Leiomyosarcoma AND TREATMENT Leuprolide.

For Individuals with Genetic Risk of Cancer

The question asked by individuals who have genetic risk of Uterine Leiomyosarcoma or familial history is “What Should I Eat Differently from Before?” and how they should choose foods and supplements to manage risks of the disease. Since for cancer risk there is nothing actionable in terms of treatment – decisions of foods and supplements become important and one of the very few actionable things which can be done. All plant-based foods are not equal and based on identified genetics and pathway signature – the choices of food and supplements should be personalized.

Choose Vegetable WILD CARROT or BROCCOLI?

Vegetable Wild Carrot contains many active ingredients or bioactives such as Apigenin, Curcumin, Quercetin, Linalool, Lupeol. These active ingredients manipulate various biochemical pathways like MAPK Signaling, P53 Signaling, Angiogenesis and MYC Signaling and others. Wild Carrot is recommended for risk of Uterine Leiomyosarcoma when associated genetic risk is ATRX. This is because Wild Carrot increases those biochemical pathways which counteract the signature drivers of it.

Some of the active ingredients or bioactives in vegetable Broccoli are Curcumin, Quercetin, Resveratrol, Lupeol, Indole-3-carbinol. These active ingredients manipulate various biochemical pathways like DNA Repair and PI3K-AKT-MTOR Signaling and others. Broccoli is not recommended when risk of Uterine Leiomyosarcoma when associated genetic risk is ATRX because it increases the signature pathways of it.

VEGETABLE WILD CARROT IS RECOMMENDED OVER BROCCOLI FOR ATRX GENETIC RISK OF CANCER.

Choose Fruit NANCE or ALASKA BLUEBERRY?

Fruit Nance contains many active ingredients or bioactives such as Apigenin, Curcumin, Lupeol, Myricetin, Formononetin. These active ingredients manipulate various biochemical pathways like Stem Cell Signaling, P53 Signaling, Inositol Phosphate Signaling and Angiogenesis and others. Nance is recommended for risk of Uterine Leiomyosarcoma when associated genetic risk is ATRX. This is because Nance increases those biochemical pathways which counteract the signature drivers of it.

Some of the active ingredients or bioactives in fruit Alaska Blueberry are Apigenin, Curcumin, Lupeol, Myricetin, Formononetin. These active ingredients manipulate various biochemical pathways like TGFB Signaling, Stem Cell Signaling and DNA Repair and others. Alaska Blueberry is not recommended when risk of Uterine Leiomyosarcoma when associated genetic risk is ATRX because it increases the signature pathways of it.

FRUIT NANCE IS RECOMMENDED OVER ALASKA BLUEBERRY FOR ATRX GENETIC RISK OF CANCER.

Choose Nut COMMON HAZELNUT or EUROPEAN CHESTNUT?

Common Hazelnut contains many active ingredients or bioactives such as Curcumin, Quercetin, Lupeol, Myricetin, Formononetin. These active ingredients manipulate various biochemical pathways like TGFB Signaling, Stem Cell Signaling, P53 Signaling and Inositol Phosphate Signaling and others. Common Hazelnut is recommended for risk of Uterine Leiomyosarcoma when associated genetic risk is ATRX. This is because Common Hazelnut increases those biochemical pathways which counteract the signature drivers of it.

Some of the active ingredients or bioactives in European Chestnut are Apigenin, Curcumin, Quercetin, Ellagic Acid, Lupeol. These active ingredients manipulate various biochemical pathways like TGFB Signaling, Stem Cell Signaling and DNA Repair and others. European Chestnut is not recommended when risk of Uterine Leiomyosarcoma when associated genetic risk is ATRX because it increases the signature pathways of it.

COMMON HAZELNUT IS RECOMMENDED OVER EUROPEAN CHESTNUT FOR ATRX GENETIC RISK OF CANCER.

In Conclusion

Foods and Supplements chosen are important decisions for cancers like Uterine Leiomyosarcoma. Uterine Leiomyosarcoma patients and individuals with genetic-risk always have this question: “What foods and nutritional supplements are recommended for me and which are not?” There is a common belief which is a misconception that all plant-based foods could be beneficial or not but would not be harmful. Certain foods and supplements can interfere with cancer treatments or promote molecular pathway drivers of cancer.

There are different types of cancer indications like Uterine Leiomyosarcoma, each with different tumor genetics with further genomic variations across each individual. Further every cancer treatment and chemotherapy has a unique mechanism of action. Each food like Brussel Sprouts contains various bioactives in different quantities, which have an impact on different and distinct sets of biochemical pathways. The definition of personalized nutrition is individualized food recommendations for the cancer indication, treatments, genetics, lifestyle and other factors. Nutrition personalization decisions for cancer require knowledge of cancer biology, food science and an understanding of different chemotherapy treatments. Finally when there are treatment changes or new genomics is identified – the nutrition personalization needs re-evaluation.

The addon nutrition personalization solution makes the decision making easy and removes all the guesswork in answering the question, “What foods should I choose or not choose for Uterine Leiomyosarcoma?”. The addon multi-disciplinary team includes cancer physicians, clinical scientists, software engineers and data scientists.

References

• Msk Impact 2017
• Genomic Landscape of Uterine Sarcomas Defined Through Prospective Clinical Sequencing.
• Gallic acid indanone and mangiferin xanthone are strong determinants of immunosuppressive anti-tumour effects of Mangifera indica L. bark in MDA-MB231 breast cancer cells.
• Indole-3-carbinol-induced death in cancer cells involves EGFR downregulation and is exacerbated in a 3D environment.
• Dietary D-glucarate effects on the biomarkers of inflammation during early post-initiation stages of benzo[a]pyrene-induced lung tumorigenesis in A/J mice.
• Research progress on the anticancer effects of vitamin K2.
• Negative regulation of signal transducer and activator of transcription-3 signalling cascade by lupeol inhibits growth and induces apoptosis in hepatocellular carcinoma cells.
• The antitumor effects of geraniol: Modulation of cancer hallmark pathways (Review).