Highlights
No two cancers are the same, nor are they treated the same, and neither should nutrition be the same for everyone. Nutrition includes foods like pulses, vegetables, fruits, nuts, oils, herbs and spices. Also nutrition includes supplements which are high concentrations of foods or high concentrations of individual ingredients found in foods. For cancers like Bladder Urothelial Carcinoma when undergoing chemotherapy or when you determine you have a genetic risk for developing Bladder Urothelial Carcinoma because of KDM6A and RYR2 gene mutations, a very important question is “What foods should I avoid and what foods are recommended specifically for me?”. The other related question is “What nutritional supplements should I avoid?”.
There is no one answer to this question for cancers such as Bladder Urothelial Carcinoma which can be found through internet searches. The answer to the question is “It Depends” because the nutrition plan needs to be personalized for you. Nutrition should depend on the cancer indication, genetic information, adult or pediatric, staging, primary or secondary, advanced, metastatic, relapsed or refractory, ongoing treatments if any, nutritional supplements being taken, age and factors like gender, weight, height, lifestyle, allergies and food preferences.
In short – the process to answer questions like “Should I Avoid eating fruit Quince” or “Include fruit Partridgeberry in my diet” or “Should I reduce consumption of vegetable Yardlong Bean” or “Can I take Ellagic Acid and Thunder God supplements” is not as simple as internet searches. The process is very complex and answers are based on knowhow of genetics, action of treatments, active ingredients in foods and their associated biological action. Finally the answer to the nutrition question needs to be personalized for you.
RECOMMENDATION: PERSONALIZE YOUR FOODS AND SUPPLEMENTS TO BLADDER UROTHELIAL CARCINOMA, TREATMENTS, GENETIC INFORMATION, AND OTHER CONDITIONS.
The overall objective of personalized nutrition for Bladder Urothelial Carcinoma is to minimize foods and nutritional supplements which have adverse interactions with cancer molecular drivers and ongoing treatments. And identify those foods and supplements which have a beneficial action. Whenever there are changes in treatments or diagnosis – it is important to remember that your foods and supplements need re-evaluation. And the answers to the nutrition question could be different based on the new context.
RECOMMENDATION: UPDATE YOUR NUTRITION FOR BLADDER UROTHELIAL CARCINOMA, WHEN TREATMENTS, DISEASE STATUS AND OTHER CONDITIONS CHANGE.
About Bladder Urothelial Carcinoma
cBioPortal is one source of collection of cancer patient data from clinical trials across 350 plus cancer indications. The data from each clinical trial includes the clinical trial name and study details like number of patients, ages, gender, ethnicity, treatments, tumor site, genetic aberrations found and analysis of all the data. The cBioPortal for Cancer Genomics was originally developed at Memorial Sloan Kettering Cancer Center (MSK). The public cBioPortal site is hosted by the Center for Molecular Oncology at MSK – https://www.cbioportal.org/about.
Following key highlights are derived from clinical data for Bladder Urothelial Carcinoma from cBioPortal. The patients enrolled in the studies for Bladder Urothelial Carcinoma are in ages between 25 to 98 with an average age of 69. 76.9% of males and 23.1% of females were the distribution of gender in these clinical studies. From a patient sample size of 2431; the top genes with mutations and other abnormalities for Bladder Urothelial Carcinoma include genes MUC16, TERT, TP53, KDM6A and RYR2. The occurrence frequency distribution for these genes respectively is 2.1%, 1.3%, 1.2%, 1.0% and 1.0%. These tumor genetic details of Bladder Urothelial Carcinoma are mapped to molecular biochemical pathway drivers of cancer thereby providing definition of characteristic features of Bladder Urothelial Carcinoma.
Significance of Nutrition for Bladder Urothelial Carcinoma
All foods and nutritional supplements consist of a collection of one or more active chemical ingredients in different proportions and quantities. The action of some active ingredients in a food can have adverse interactions while other active ingredients in the same food may be supportive from the context of Bladder Urothelial Carcinoma. Hence the same food has good and not-so-good actions and analysis of combined effect will be needed to come up with a personalized nutrition plan.
For example Quince includes active ingredients Oleic Acid, Vitamin C, Chlorogenic Acid, Linoleic Acid, Modified Citrus Pectin and others. And Partridgeberry contains active ingredients Resveratrol, Beta-sitosterol, Stigmasterol and others. It is likely that some of these active ingredients of the same food could have opposing effects and hence it is recommended to identify recommended foods based on analysis of all high quantity ingredients contained in foods.
For cancers like Bladder Urothelial Carcinoma, activation or inhibition of selected biochemical pathways like Cytoskeletal Dynamics, Ceramide Signaling, PI3K-AKT-MTOR Signaling, Focal Adhesion plays an important role in driving cancer growth. Similarly different treatments work via different molecular actions which should never be canceled out by your foods and supplements. The foods and nutritional supplements contain different active ingredients each of which have a specific molecular action on different biochemical pathways. Hence, eating some foods and nutritional supplements would be recommended with a specific treatment of Bladder Urothelial Carcinoma, while eating some other foods and supplements may not be recommended.
One common mistake when finding foods to eat or not – is to consider only a few active ingredients contained in foods based on internet searches and ignore the rest. Because different active ingredients contained in foods may have opposing effects on relevant biochemical pathways – it is recommended to consider all the high quantity active ingredients that are present in significant and much larger than trace amounts in the food.
RECOMMENDATION: TO FIND RECOMMENDED AND NON-RECOMMENDED FOODS FOR BLADDER UROTHELIAL CARCINOMA – CONSIDER HIGH QUANTITY ACTIVE INGREDIENTS CONTAINED IN FOODS.
Foods for Bladder Urothelial Carcinoma undergoing chemotherapy treatment
In Bladder Urothelial Carcinoma – the genes MUC16, TERT, TP53, KDM6A and RYR2 have high occurrences of genomic abnormalities. Not all of these genes necessarily are relevant for cancer – though they have been reported. Some of these genes directly or indirectly end up manipulating different cancer related biochemical biological pathways. Some of the pathways which are relevant drivers for Bladder Urothelial Carcinoma are Cytoskeletal Dynamics, Ceramide Signaling, Carbohydrate Metabolism and others. Vinblastine is one of the chemotherapies used for cancer treatment. The intent of treatment is to negate or cancel out effects of biochemical pathway drivers Cytoskeletal Dynamics, Ceramide Signaling, Carbohydrate Metabolism so as to reduce disease progression and inhibit growth. Those foods whose combined action of active ingredients support treatment action and do not enhance disease drivers are recommended foods and supplements which will be included in personalized nutrition. And similarly – those foods whose combined action of active ingredients is not supportive of treatment action but end up promoting disease drives will not be recommended in your personalized nutrition plan.
RECOMMENDATION: AVOID SUPPLEMENTS AND FOODS WHICH ARE NOT SUPPORTIVE OF CANCER TREATMENT ACTION AND RATHER ENHANCE DISEASE DRIVERS.
Eat more pulses, Common Pea or Yellow Wax Bean?
Pulses are an important part of many diets. The active ingredients contained in Common Pea are Daidzein, Lupeol, Linolenic Acid, Beta-sitosterol, Genistein among others. While the active ingredients contained in Yellow Wax Bean are Cianidanol, Vitamin C, Butyric Acid, Ferulic Acid, Palmitic Acid and others.
Beta-sitosterol can manipulate biochemical pathways NFKB Signaling, Apoptosis and Microtubule Dynamics. Vitamin C has biological action on biochemical pathways Carbohydrate Metabolism, Cell Cycle and PI3K-AKT-MTOR Signaling.
Palmitic Acid can manipulate biochemical pathways NFKB Signaling, PI3K-AKT-MTOR Signaling and Microtubule Dynamics. Vitamin A has biological action on biochemical pathways PI3K-AKT-MTOR Signaling. And so on.
When treating Bladder Urothelial Carcinoma with chemotherapy Vinblastine – Foods like Common Pea are recommended compared to Yellow Wax Bean. This is because the active ingredients Palmitic Acid and Vitamin A in Yellow Wax Bean interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Beta-sitosterol and Vitamin C contained in Common Pea support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.
RECOMMENDATION: COMMON PEA IS RECOMMENDED OVER YELLOW WAX BEAN FOR BLADDER UROTHELIAL CARCINOMA ON TREATMENT WITH CHEMOTHERAPY VINBLASTINE FOR SOME CONDITIONS.
Eat more vegetables, Amaranth or Yardlong Bean?
Vegetables are an important part of many diets. The active ingredients contained in Amaranth are Linolenic Acid, Beta-sitosterol, Oleic Acid, Vitamin C, Stigmasterol among others. While the active ingredients contained in Yardlong Bean are Linolenic Acid, Oleic Acid, Vitamin C, Linoleic Acid, Vitamin A and others.
Beta-sitosterol can manipulate biochemical pathways NFKB Signaling, Apoptosis and Microtubule Dynamics. Vitamin C has biological action on biochemical pathways Carbohydrate Metabolism, Cell Cycle and PI3K-AKT-MTOR Signaling.
Vitamin A can manipulate biochemical pathways PI3K-AKT-MTOR Signaling. Oleic Acid has biological action on biochemical pathways Cytoskeletal Dynamics. And so on.
When treating Bladder Urothelial Carcinoma with chemotherapy Vinblastine – Foods like Amaranth are recommended compared to Yardlong Bean. This is because the active ingredients Vitamin A and Oleic Acid in Yardlong Bean interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Beta-sitosterol and Vitamin C contained in Amaranth support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.
RECOMMENDATION: AMARANTH IS RECOMMENDED OVER YARDLONG BEAN FOR BLADDER UROTHELIAL CARCINOMA ON TREATMENT WITH CHEMOTHERAPY VINBLASTINE FOR SOME CONDITIONS.
Eat more fruits, Partridgeberry or Quince?
Fruits are an important part of many diets. The active ingredients contained in Partridgeberry are Resveratrol, Beta-sitosterol, Stigmasterol among others. While the active ingredients contained in Quince are Oleic Acid, Vitamin C, Chlorogenic Acid, Linoleic Acid, Modified Citrus Pectin and others.
Resveratrol can manipulate biochemical pathways Carbohydrate Metabolism, NFKB Signaling and Apoptosis. Beta-sitosterol has biological action on biochemical pathways Microtubule Dynamics, Cell Cycle and Cell Survival.
Quercitrin can manipulate biochemical pathways PI3K-AKT-MTOR Signaling. Vitamin A has biological action on biochemical pathways PI3K-AKT-MTOR Signaling. And so on.
When treating Bladder Urothelial Carcinoma with chemotherapy Vinblastine – Foods like Partridgeberry are recommended compared to Quince. This is because the active ingredients Quercitrin and Vitamin A in Quince interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Resveratrol and Beta-sitosterol contained in Partridgeberry support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.
RECOMMENDATION: PARTRIDGEBERRY IS RECOMMENDED OVER QUINCE FOR BLADDER UROTHELIAL CARCINOMA ON TREATMENT WITH CHEMOTHERAPY VINBLASTINE FOR SOME CONDITIONS.
Eat more nuts, Pecan Nut or Pumpkin Seeds?
Nuts are an important part of many diets. The active ingredients contained in Pecan Nut are Vitamin E, Linolenic Acid, Cianidanol, Oleic Acid, Linoleic Acid among others. While the active ingredients contained in Pumpkin Seeds are Linolenic Acid, Beta-sitosterol, Salicylic Acid, Gamma-linolenic Acid, Oleic Acid and others.
Vitamin E can manipulate biochemical pathways NFKB Signaling, Apoptosis and Cell Cycle. Cianidanol has biological action on biochemical pathways Microtubule Dynamics, Cell Survival and PI3K-AKT-MTOR Signaling.
Lecithin can manipulate biochemical pathways NFKB Signaling, PI3K-AKT-MTOR Signaling and Cytoskeletal Dynamics. Cucurbitacin I has biological action on biochemical pathways NFKB Signaling. And so on.
When treating Bladder Urothelial Carcinoma with chemotherapy Vinblastine – Foods like Pecan Nut are recommended compared to Pumpkin Seeds. This is because the active ingredients Lecithin and Cucurbitacin I in Pumpkin Seeds interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Vitamin E and Cianidanol contained in Pecan Nut support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.
RECOMMENDATION: PECAN NUT IS RECOMMENDED OVER PUMPKIN SEEDS FOR BLADDER UROTHELIAL CARCINOMA ON TREATMENT WITH CHEMOTHERAPY VINBLASTINE FOR SOME CONDITIONS.
Foods for Genetic Risk of Bladder Urothelial Carcinoma
One of the ways to assess risk of cancer is by checking for presence of genetic abnormalities in a set of genes. There is prior information on a list of genes whose mutations and other aberrations can play a role in risk to different cancers. KDM6A and RYR2 are two genes whose abnormalities are risk factors for Bladder Urothelial Carcinoma. In such a cancer risk situation – while there are typically no treatments which a physician can prescribe – the various biochemical pathways which are potentially molecular drivers of Bladder Urothelial Carcinoma can be used as a guide for coming up with a recommended personalized nutrition plan. For Bladder Urothelial Carcinoma gene KDM6A has causative impact on biological pathways like Suppressive Histone Methylation. And RYR2 has a causative impact on biological pathways like G-protein-coupled Receptor Signaling and G-protein-coupled Receptor Signaling. Foods and nutritional supplements which have molecular action to cancel out biochemical pathways effects of genes like KDM6A and RYR2 should be included in a personalized nutrition plan. And those foods and supplements which promote the effects of genes KDM6A and RYR2 should be avoided.
Eat more pulses, Scarlet Bean or Soy Bean?
The active ingredients contained in Scarlet Bean are Beta-sitosterol, Linolenic Acid, Vitamin C, Oleic Acid, Stigmasterol among others. While the active ingredients contained in Soy Bean are Lupeol, Daidzein, Vitamin E, Quercetin, Beta-sitosterol and others.
Beta-sitosterol can manipulate biochemical pathways Apoptosis, MYC Signaling and P53 Signaling. Vitamin C has biological action on biochemical pathways Cell Cycle Checkpoints, PI3K-AKT-MTOR Signaling and RAS-RAF Signaling.
Aescin can manipulate biochemical pathways Cell Cycle Checkpoints. Lecithin has biological action on biochemical pathways MYC Signaling and PI3K-AKT-MTOR Signaling. And so on.
For genetic risk of Bladder Urothelial Carcinoma due to abnormalities in genes KDM6A and RYR2 – Foods like Scarlet Bean are recommended compared to Soy Bean. This is because the active ingredients Aescin and Lecithin in Soy Bean further promote the effects of genes on the biochemical pathways. While the active ingredients Beta-sitosterol and Vitamin C contained in Scarlet Bean together have a canceling effect of genes on the biochemical pathways.
RECOMMENDATION: SCARLET BEAN IS RECOMMENDED OVER SOY BEAN FOR REDUCING THE GENETIC RISK OF BLADDER UROTHELIAL CARCINOMA DUE TO GENES KDM6A AND RYR2
Eat more vegetables, Jicama or Radish?
The active ingredients contained in Jicama are Vitamin C, Beta-carotene, Vitamin B3, Vitamin A, Folic Acid among others. While the active ingredients contained in Radish are Quercetin, Beta-sitosterol, Linolenic Acid, Vitamin C, P-coumaric Acid and others.
Vitamin C can manipulate biochemical pathways Apoptosis, MYC Signaling and P53 Signaling. Beta-carotene has biological action on biochemical pathways Cell Cycle Checkpoints, PI3K-AKT-MTOR Signaling and Apoptosis.
Pelargonidin can manipulate biochemical pathways MYC Signaling, Cell Cycle Checkpoints and PI3K-AKT-MTOR Signaling. Folic Acid has biological action on biochemical pathways Apoptosis, P53 Signaling and RAS-RAF Signaling. And so on.
For genetic risk of Bladder Urothelial Carcinoma due to abnormalities in genes KDM6A and RYR2 – Foods like Jicama are recommended compared to Radish. This is because the active ingredients Pelargonidin and Folic Acid in Radish further promote the effects of genes on the biochemical pathways. While the active ingredients Vitamin C and Beta-carotene contained in Jicama together have a canceling effect of genes on the biochemical pathways.
RECOMMENDATION: JICAMA IS RECOMMENDED OVER RADISH FOR REDUCING THE GENETIC RISK OF BLADDER UROTHELIAL CARCINOMA DUE TO GENES KDM6A AND RYR2
Foods to Eat After Cancer Diagnosis!
No two cancers are the same. Go beyond the common nutrition guidelines for everyone and make personalized decisions about food and supplements with confidence.
Eat more fruits, Feijoa or Strawberry?
The active ingredients contained in Feijoa are Lycopene, Vitamin C, Casuarinin, Folic Acid among others. While the active ingredients contained in Strawberry are Ellagic Acid, Lupeol, Beta-sitosterol, Linolenic Acid, Vitamin C and others.
Vitamin C can manipulate biochemical pathways Apoptosis, MYC Signaling and P53 Signaling. Lycopene has biological action on biochemical pathways Cell Cycle Checkpoints, PI3K-AKT-MTOR Signaling and RAS-RAF Signaling.
Fisetin can manipulate biochemical pathways MYC Signaling. Ellagic Acid has biological action on biochemical pathways Cell Cycle Checkpoints and MYC Signaling. And so on.
For genetic risk of Bladder Urothelial Carcinoma due to abnormalities in genes KDM6A and RYR2 – Foods like Feijoa are recommended compared to Strawberry. This is because the active ingredients Fisetin and Ellagic Acid in Strawberry further promote the effects of genes on the biochemical pathways. While the active ingredients Vitamin C and Lycopene contained in Feijoa together have a canceling effect of genes on the biochemical pathways.
RECOMMENDATION: FEIJOA IS RECOMMENDED OVER STRAWBERRY FOR REDUCING THE GENETIC RISK OF BLADDER UROTHELIAL CARCINOMA DUE TO GENES KDM6A AND RYR2
Eat more nuts, Pine Nut or Brazil Nut?
The active ingredients contained in Pine Nut are Vitamin E, Beta-sitosterol, Linolenic Acid, Oleic Acid, Linoleic Acid among others. While the active ingredients contained in Brazil Nut are Vitamin E, Linolenic Acid, Oleic Acid, Lecithin, Folic Acid and others.
Beta-sitosterol can manipulate biochemical pathways Apoptosis, MYC Signaling and P53 Signaling. Vitamin K has biological action on biochemical pathways Cell Cycle Checkpoints, PI3K-AKT-MTOR Signaling and MYC Signaling.
Lecithin can manipulate biochemical pathways MYC Signaling and PI3K-AKT-MTOR Signaling. Folic Acid has biological action on biochemical pathways Apoptosis, P53 Signaling and Cell Cycle Checkpoints. And so on.
For genetic risk of Bladder Urothelial Carcinoma due to abnormalities in genes KDM6A and RYR2 – Foods like Pine Nut are recommended compared to Brazil Nut. This is because the active ingredients Lecithin and Folic Acid in Brazil Nut further promote the effects of genes on the biochemical pathways. While the active ingredients Beta-sitosterol and Vitamin K contained in Pine Nut together have a canceling effect of genes on the biochemical pathways.
RECOMMENDATION: PINE NUT IS RECOMMENDED OVER BRAZIL NUT FOR REDUCING THE GENETIC RISK OF BLADDER UROTHELIAL CARCINOMA DUE TO GENES KDM6A AND RYR2
In Summary
An important thing to remember is that cancer treatments may not be the same for everyone – and neither should your nutrition be. Nutrition which includes food and nutritional supplements is a very effective tool controlled by you.
“What should I eat?” is the most frequently asked question in the context of cancer. The answer calculation is complex and depends upon cancer type, underlying genomics, current treatments, any allergies, lifestyle information, and factors like BMI.
The addon personalized nutrition plan recommends foods and supplements which minimizes adverse nutrition interactions and encourages support to treatments.
You can get started NOW and design a personalized nutrition plan for Bladder Urothelial Carcinoma by answering questions on type of cancer, current treatments, supplements, allergies, age group, gender, and lifestyle information.
What food you eat and which supplements you take is a decision you make. Your decision should include consideration of the cancer gene mutations, which cancer, ongoing treatments and supplements, any allergies, lifestyle information, weight, height and habits.
The nutrition planning for cancer from addon is not based on internet searches. It automates the decision making for you based on molecular science implemented by our scientists and software engineers. Irrespective of whether you care to understand the underlying biochemical molecular pathways or not - for nutrition planning for cancer that understanding is needed.
Get started NOW with your nutrition planning by answering questions on the name of cancer, genetic mutations, ongoing treatments and supplements, any allergies, habits, lifestyle, age group and gender.
References
- Msk Access 2021
- Genomic predictors of survival in patients with high-grade urothelial carcinoma of the bladder.
- β-Sitosterol targets Trx/Trx1 reductase to induce apoptosis in A549 cells via ROS mediated mitochondrial dysregulation and p53 activation.
- Vitamin C enhances epigenetic modifications induced by 5-azacytidine and cell cycle arrest in the hepatocellular carcinoma cell lines HLE and Huh7.
- Taurine improves low-level inorganic arsenic-induced insulin resistance by activating PPARγ-mTORC2 signalling and inhibiting hepatic autophagy.
- Vitamin A regulates Akt signaling through the phospholipid fatty acid composition.
- Resveratrol induces autophagy by directly inhibiting mTOR through ATP competition.
- Identification of quercitrin as an inhibitor of the p90 S6 ribosomal kinase (RSK): structure of its complex with the N-terminal domain of RSK2 at 1.8 Å resolution.
- Oleic acid-induced ANGPTL4 enhances head and neck squamous cell carcinoma anoikis resistance and metastasis via up-regulation of fibronectin.
- Gamma-tocotrienol inhibits nuclear factor-kappaB signaling pathway through inhibition of receptor-interacting protein and TAK1 leading to suppression of antiapoptotic gene products and potentiation of apoptosis.
- Cytotoxicity and apoptosis induction in human breast adenocarcinoma MCF-7 cells by (+)-cyanidan-3-ol.
- The recruitment of Raf-1 to membranes is mediated by direct interaction with phosphatidic acid and is independent of association with Ras.
- Activation of the NF-κB pathway by the STAT3 inhibitor JSI-124 in human glioblastoma cells.
- Lycopene metabolite, apo-10′-lycopenoic acid, inhibits diethylnitrosamine-initiated, high fat diet-promoted hepatic inflammation and tumorigenesis in mice.
- Crystal structure of a human cyclin-dependent kinase 6 complex with a flavonol inhibitor, fisetin.
- Indeno[1,2-b]indole derivatives as a novel class of potent human protein kinase CK2 inhibitors.
- The effect of Pasteurella haemolytica cytotoxin on bovine polymorphonuclear leukocytes can be attenuated by beta-adrenoceptor antagonists.
- Pelargonidin suppresses adipogenesis in 3T3-L1 cells through inhibition of PPAR-γ signaling pathway.
- Effects of folate deficiency on gene expression in the apoptosis and cancer pathways in colon cancer cells.
- Research progress on the anticancer effects of vitamin K2.
- Resveratrol, pterostilbene, and piceatannol in vaccinium berries.
- Fisetin: a dietary antioxidant for health promotion.
Personalized Nutrition for Cancer!
Cancer changes with time. Customize and modify your nutrition based on cancer indication, treatments, lifestyle, food preferences, allergies and other factors.