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What Foods are Recommended for Cancer?
is a very common question. Personalized Nutrition Plans are foods and supplements which are personalized to a cancer indication, genes, any treatments and lifestyle conditions.

Foods for Bladder Urothelial Carcinoma!

Aug 4, 2023

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Introduction

Foods for Bladder Urothelial Carcinoma should be personalized for each individual and also must adapt when cancer treatment or tumor genetic change. The personalization and adaptation must consider all the active ingredients or bioactives contained in different foods with respect to cancer tissue biology, genetics, treatments, lifestyle conditions and diet preferences. Hence while nutrition is one of the very important decisions for a cancer patient and individual at risk of cancer to make – how to choose foods to eat is not an easy task.

Urothelial Carcinoma, a common form of bladder cancer, originates from the urothelial cells lining the bladder, with its pathology outlines being crucial for diagnosis, especially in variants like squamous differentiation. Staging, guided by detailed pathology outlines, determines treatment and prognosis, and involves assessing tumor invasion into the bladder wall and surrounding tissues. The ICD-10 coding system classifies bladder urothelial carcinoma for standardized healthcare tracking. Treatment and prognosis vary based on the stage at diagnosis, with advanced stages requiring more aggressive approaches. Hence, Urothelial Carcinoma is indeed a primary type of bladder cancer, where understanding its pathology, staging, and cellular differentiation is vital for effective management.



For Bladder Urothelial Carcinoma does it matter what vegetables, fruits, nuts, seeds one eats?

A very common nutrition question asked by cancer patients and individuals at-genetic risk of cancer is – for cancers like Bladder Urothelial Carcinoma does it matter what foods I eat and which I do not? Or if I follow a plant-based diet is that enough for cancer like Bladder Urothelial Carcinoma?

For example does it matter if vegetable Common Mushroom is consumed more compared to Groundcherry? Does it make any difference if fruit Pummelo is preferred over Purple Mangosteen? Also if similar choices are made for nuts/seeds like Butternut over Pili Nut and for pulses like Gram Bean over Pigeon Pea. And if what I eat matters – then how does one identify foods which are recommended for Bladder Urothelial Carcinoma and is it the same answer for everyone with the same diagnosis or genetic risk?

Yes! Foods you eat matters for Bladder Urothelial Carcinoma!

Food recommendations may not be the same for everyone and can be different even for the same diagnosis and genetic risk.

All cancers like Bladder Urothelial Carcinoma can be characterized by a unique set of biochemical pathways - the signature pathways of Bladder Urothelial Carcinoma. Biochemical pathways like DNA Repair, Folate Signaling, PI3K-AKT-MTOR Signaling, Focal Adhesion are part of the signature definition of Bladder Urothelial Carcinoma.

All foods (vegetables, fruits, nuts, seeds, pulses, oils etc.) and nutritional supplements are made up of more than one active molecular ingredient or bio-actives in different proportions and quantities. Each active ingredient has a unique mechanism of action – which can be activation or inhibition of different biochemical pathways. Simply stated foods and supplements which are recommended are those which do not cause an increase of molecular drivers of cancer but reduce them. Else those foods should not be recommended. Foods contain multiple active ingredients – hence when evaluating foods and supplements you need to consider the impact of all active ingredients cumulatively rather than individually.

For example Pummelo contains active ingredients Quercetin, Apigenin, Curcumin, Isoliquiritigenin, Formononetin. And Purple Mangosteen contains active ingredients Apigenin, Myricetin, Curcumin, Isoliquiritigenin, Formononetin and possibly others.

A common mistake made when deciding and choosing foods to eat for Bladder Urothelial Carcinoma – is to evaluate only selected active ingredients contained in foods and ignore the rest. Because different active ingredients contained in foods may have opposing effects on cancer drivers – you cannot cherry pick active ingredients in foods and supplements for making a nutrition decision for Bladder Urothelial Carcinoma.

YES – FOOD CHOICES MATTER FOR CANCER. NUTRITION DECISIONS MUST CONSIDER ALL ACTIVE INGREDIENTS OF FOODS.

Skills Needed for Nutrition Personalization for Bladder Urothelial Carcinoma?

Personalized nutrition for cancers like Bladder Urothelial Carcinoma consists of recommended foods / supplements; not recommended foods / supplements with example recipes which prioritize use of recommended foods. An example of personalized nutrition can be seen at this link.

Deciding which foods are recommended or not is extremely complicated, requiring expertise in Bladder Urothelial Carcinoma biology, food science, genetics, biochemistry along with good understanding of how cancer treatments work and associated vulnerabilities by which the treatments could stop being effective.

MINIMUM KNOWLEDGE EXPERTISE NEEDED FOR NUTRITION PERSONALIZATION FOR CANCER ARE: CANCER BIOLOGY, FOOD SCIENCE, CANCER TREATMENTS AND GENETICS.

Foods to Eat After Cancer Diagnosis!

No two cancers are the same. Go beyond the common nutrition guidelines for everyone and make personalized decisions about food and supplements with confidence.

Characteristics of cancers like Bladder Urothelial Carcinoma

All cancers like Bladder Urothelial Carcinoma can be characterized by a unique set of biochemical pathways – the signature pathways of Bladder Urothelial Carcinoma. Biochemical pathways like DNA Repair, Folate Signaling, PI3K-AKT-MTOR Signaling, Focal Adhesion are part of the signature definition of Bladder Urothelial Carcinoma. Each individual’s cancer genetics can be different and hence their specific cancer signature could be unique.

The treatments which are effective for Bladder Urothelial Carcinoma need to be cognizant of the associated signature biochemical pathways for each cancer patient and individual at genetic risk. Therefore different treatments with different mechanisms of actions are effective for different patients. Similarly and for the same reasons foods and supplements need to be personalized for each individual. Hence some foods and supplements are recommended for Bladder Urothelial Carcinoma when taking cancer treatment Methotrexate, and some foods and supplements are not recommended.

Sources like cBioPortal and many others provide population representative patient anonymized data from clinical trials for all cancer indications. This data consists of clinical trial study details like sample size / number of patients, age groups, gender, ethnicity, treatments, tumor site and any genetic mutations.

MUC16, TERT, TP53, KDM6A and RYR2 are the top ranked reported genes for Bladder Urothelial Carcinoma. MUC16 is reported in 2.1 % of the representative patients across all clinical trials. And TERT is reported in 1.3 %. The combined population patient data cover ages from 25 to 98. 76.9 % of the patient data are identified as men. The Bladder Urothelial Carcinoma biology along with reported genetics together define the population represented signature biochemical pathways for this cancer. If the individual cancer tumor genetics or genes contributing to the risk are also known then that should also be used for nutrition personalization.

NUTRITION CHOICES SHOULD MATCH WITH EACH INDIVIDUAL’S CANCER SIGNATURE.

Foods for Bladder Urothelial Carcinoma!

Food and Supplements for Bladder Urothelial Carcinoma

For Cancer Patients

Cancer patients on treatment or on palliative care need to make decisions on food and supplements – for the needed dietary calories, for managing any treatment side effects and also for improved cancer management. All plant-based foods are not equal and choosing and prioritizing foods which are personalized and customized to ongoing cancer treatment is important and complicated. Here are some examples providing guidelines for making nutrition decisions.

Choose Vegetable COMMON MUSHROOM or GROUNDCHERRY?

Vegetable Common Mushroom contains many active ingredients or bioactives such as Apigenin, Myricetin, Curcumin, Vitamin D3, Isoliquiritigenin. These active ingredients manipulate various biochemical pathways like Glucocorticoid Signaling, JAK-STAT Signaling, PI3K-AKT-MTOR Signaling and Epithelial to Mesenchymal Transition and others. Common Mushroom is recommended for Bladder Urothelial Carcinoma when ongoing cancer treatment is Methotrexate. This is because Common Mushroom modifies those biochemical pathways which have been scientifically reported to sensitize the effect of Methotrexate.

Some of the active ingredients or bioactives in vegetable Groundcherry are Apigenin, Myricetin, Curcumin, Isoliquiritigenin, Formononetin. These active ingredients manipulate various biochemical pathways like Oncogenic Cancer Epigenetics, Stem Cell Signaling and DNA Repair and others. Groundcherry is not recommended for Bladder Urothelial Carcinoma when ongoing cancer treatment is Methotrexate because it modifies those biochemical pathways which make the cancer treatment resistant or less responsive.

VEGETABLE COMMON MUSHROOM IS RECOMMENDED OVER GROUNDCHERRY FOR Bladder Urothelial Carcinoma AND TREATMENT Methotrexate.

Choose Fruit PURPLE MANGOSTEEN or PUMMELO?

Fruit Purple Mangosteen contains many active ingredients or bioactives such as Apigenin, Myricetin, Curcumin, Isoliquiritigenin, Formononetin. These active ingredients manipulate various biochemical pathways like JAK-STAT Signaling, RAS-RAF Signaling, Cell Cycle and PI3K-AKT-MTOR Signaling and others. Purple Mangosteen is recommended for Bladder Urothelial Carcinoma when ongoing cancer treatment is Methotrexate. This is because Purple Mangosteen modifies those biochemical pathways which have been scientifically reported to sensitize the effect of Methotrexate.

Some of the active ingredients or bioactives in fruit Pummelo are Quercetin, Apigenin, Curcumin, Isoliquiritigenin, Formononetin. These active ingredients manipulate various biochemical pathways like WNT Beta Catenin Signaling, Microtubule Dynamics and Heat Stress Response and others. Pummelo is not recommended for Bladder Urothelial Carcinoma when ongoing cancer treatment is Methotrexate because it modifies those biochemical pathways which make the cancer treatment resistant or less responsive.

FRUIT PURPLE MANGOSTEEN IS RECOMMENDED OVER PUMMELO FOR Bladder Urothelial Carcinoma AND TREATMENT Methotrexate.

Choose Nut BUTTERNUT or PILI NUT?

Butternut contains many active ingredients or bioactives such as Apigenin, Myricetin, Curcumin, Isoliquiritigenin, Formononetin. These active ingredients manipulate various biochemical pathways like Glucocorticoid Signaling, JAK-STAT Signaling, PI3K-AKT-MTOR Signaling and Epithelial to Mesenchymal Transition and others. Butternut is recommended for Bladder Urothelial Carcinoma when ongoing cancer treatment is Methotrexate. This is because Butternut modifies those biochemical pathways which have been scientifically reported to sensitize the effect of Methotrexate.

Some of the active ingredients or bioactives in Pili Nut are Apigenin, Myricetin, Curcumin, Isoliquiritigenin, Formononetin. These active ingredients manipulate various biochemical pathways like Oncogenic Cancer Epigenetics, Stem Cell Signaling and DNA Repair and others. Pili Nut is not recommended for Bladder Urothelial Carcinoma when ongoing cancer treatment is Methotrexate because it modifies those biochemical pathways which make the cancer treatment resistant or less responsive.

BUTTERNUT IS RECOMMENDED OVER PILI NUT FOR Bladder Urothelial Carcinoma AND TREATMENT Methotrexate.

For Individuals with Genetic Risk of Cancer

The question asked by individuals who have genetic risk of Bladder Urothelial Carcinoma or familial history is “What Should I Eat Differently from Before?” and how they should choose foods and supplements to manage risks of the disease. Since for cancer risk there is nothing actionable in terms of treatment – decisions of foods and supplements become important and one of the very few actionable things which can be done. All plant-based foods are not equal and based on identified genetics and pathway signature – the choices of food and supplements should be personalized.

Choose Vegetable CALABASH or OSTRICH FERN?

Vegetable Calabash contains many active ingredients or bioactives such as Apigenin, Curcumin, Lupeol, Formononetin, Daidzein. These active ingredients manipulate various biochemical pathways like Angiogenesis, Cell Cycle, JAK-STAT Signaling and P53 Signaling and others. Calabash is recommended for risk of Bladder Urothelial Carcinoma when associated genetic risk is KDM6A. This is because Calabash increases those biochemical pathways which counteract the signature drivers of it.

Some of the active ingredients or bioactives in vegetable Ostrich Fern are Apigenin, Curcumin, Lupeol, Formononetin, Daidzein. These active ingredients manipulate various biochemical pathways like Extracellular Matrix Remodelling and Stem Cell Signaling and others. Ostrich Fern is not recommended when risk of Bladder Urothelial Carcinoma when associated genetic risk is KDM6A because it increases the signature pathways of it.

VEGETABLE CALABASH IS RECOMMENDED OVER OSTRICH FERN FOR KDM6A GENETIC RISK OF CANCER.

Choose Fruit JAVA PLUM or ACEROLA?

Fruit Java Plum contains many active ingredients or bioactives such as Apigenin, Curcumin, Ellagic Acid, Lupeol, Formononetin. These active ingredients manipulate various biochemical pathways like Angiogenesis, Cell Cycle, JAK-STAT Signaling and P53 Signaling and others. Java Plum is recommended for risk of Bladder Urothelial Carcinoma when associated genetic risk is KDM6A. This is because Java Plum increases those biochemical pathways which counteract the signature drivers of it.

Some of the active ingredients or bioactives in fruit Acerola are Apigenin, Curcumin, Quercetin, Lupeol, Formononetin. These active ingredients manipulate various biochemical pathways like Stem Cell Signaling, PI3K-AKT-MTOR Signaling and MYC Signaling and others. Acerola is not recommended when risk of Bladder Urothelial Carcinoma when associated genetic risk is KDM6A because it increases the signature pathways of it.

FRUIT JAVA PLUM IS RECOMMENDED OVER ACEROLA FOR KDM6A GENETIC RISK OF CANCER.

Choose Nut COMMON HAZELNUT or EUROPEAN CHESTNUT?

Common Hazelnut contains many active ingredients or bioactives such as Curcumin, Quercetin, Lupeol, Formononetin, Daidzein. These active ingredients manipulate various biochemical pathways like Angiogenesis, Cell Cycle, JAK-STAT Signaling and P53 Signaling and others. Common Hazelnut is recommended for risk of Bladder Urothelial Carcinoma when associated genetic risk is KDM6A. This is because Common Hazelnut increases those biochemical pathways which counteract the signature drivers of it.

Some of the active ingredients or bioactives in European Chestnut are Apigenin, Curcumin, Quercetin, Ellagic Acid, Lupeol. These active ingredients manipulate various biochemical pathways like Stem Cell Signaling and others. European Chestnut is not recommended when risk of Bladder Urothelial Carcinoma when associated genetic risk is KDM6A because it increases the signature pathways of it.

COMMON HAZELNUT IS RECOMMENDED OVER EUROPEAN CHESTNUT FOR KDM6A GENETIC RISK OF CANCER.


In Conclusion

Foods and Supplements chosen are important decisions for cancers like Bladder Urothelial Carcinoma. Bladder Urothelial Carcinoma patients and individuals with genetic-risk always have this question: “What foods and nutritional supplements are recommended for me and which are not?” There is a common belief which is a misconception that all plant-based foods could be beneficial or not but would not be harmful. Certain foods and supplements can interfere with cancer treatments or promote molecular pathway drivers of cancer.

There are different types of cancer indications like Bladder Urothelial Carcinoma, each with different tumor genetics with further genomic variations across each individual. Further every cancer treatment and chemotherapy has a unique mechanism of action. Each food like Common Mushroom contains various bioactives in different quantities, which have an impact on different and distinct sets of biochemical pathways. The definition of personalized nutrition is individualized food recommendations for the cancer indication, treatments, genetics, lifestyle and other factors. Nutrition personalization decisions for cancer require knowledge of cancer biology, food science and an understanding of different chemotherapy treatments. Finally when there are treatment changes or new genomics is identified – the nutrition personalization needs re-evaluation.

The addon nutrition personalization solution makes the decision making easy and removes all the guesswork in answering the question, “What foods should I choose or not choose for Bladder Urothelial Carcinoma?”. The addon multi-disciplinary team includes cancer physicians, clinical scientists, software engineers and data scientists.


Personalized Nutrition for Cancer!

Cancer changes with time. Customize and modify your nutrition based on cancer indication, treatments, lifestyle, food preferences, allergies and other factors.

References

Scientifically Reviewed by: Dr. Cogle

Christopher R. Cogle, M.D. is a tenured professor at the University of Florida, Chief Medical Officer of Florida Medicaid, and Director of the Florida Health Policy Leadership Academy at the Bob Graham Center for Public Service.

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