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What Foods are Recommended for Cancer?
is a very common question. Personalized Nutrition Plans are foods and supplements which are personalized to a cancer indication, genes, any treatments and lifestyle conditions.

Foods for Breast Angiosarcoma!

Aug 4, 2023

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Introduction

Foods for Breast Angiosarcoma should be personalized for each individual and also must adapt when cancer treatment or tumor genetic change. The personalization and adaptation must consider all the active ingredients or bioactives contained in different foods with respect to cancer tissue biology, genetics, treatments, lifestyle conditions and diet preferences. Hence while nutrition is one of the very important decisions for a cancer patient and individual at risk of cancer to make – how to choose foods to eat is not an easy task.

Angiosarcoma in the breast is a rare and aggressive form of cancer that arises from the blood vessels in breast tissue. Accurate diagnosis is aided by pathology outlines, which provide crucial insights into the characteristics of breast angiosarcoma. Radiology techniques, such as imaging tests, assist in visualizing the tumor and evaluating its extent. Treatment options for breast angiosarcoma include surgery, radiation therapy, and chemotherapy, tailored to each individual case. Survival rates and prognosis can vary depending on various factors, including the stage of the cancer and the patient’s overall health. Understanding the causes of angiosarcoma in the breast is an active area of research, and early detection is crucial for prompt intervention. Expert management and staging protocols help guide the treatment of breast angiosarcoma. By staying aware of the latest advancements in treatment and understanding the specific needs of breast angiosarcoma, healthcare providers can offer comprehensive care to patients.



For Breast Angiosarcoma does it matter what vegetables, fruits, nuts, seeds one eats?

A very common nutrition question asked by cancer patients and individuals at-genetic risk of cancer is – for cancers like Breast Angiosarcoma does it matter what foods I eat and which I do not? Or if I follow a plant-based diet is that enough for cancer like Breast Angiosarcoma?

For example does it matter if vegetable Cauliflower is consumed more compared to Romaine Lettuce? Does it make any difference if fruit Pummelo is preferred over Black Mulberry? Also if similar choices are made for nuts/seeds like Black Walnut over European Chestnut and for pulses like Green Bean over Catjang Pea. And if what I eat matters – then how does one identify foods which are recommended for Breast Angiosarcoma and is it the same answer for everyone with the same diagnosis or genetic risk?

Yes! Foods you eat matters for Breast Angiosarcoma!

Food recommendations may not be the same for everyone and can be different even for the same diagnosis and genetic risk.

All cancers like Breast Angiosarcoma can be characterized by a unique set of biochemical pathways - the signature pathways of Breast Angiosarcoma. Biochemical pathways like Angiogenesis, Hypoxia, Oncogenic Cancer Epigenetics, JAK-STAT Signaling are part of the signature definition of Breast Angiosarcoma.

All foods (vegetables, fruits, nuts, seeds, pulses, oils etc.) and nutritional supplements are made up of more than one active molecular ingredient or bio-actives in different proportions and quantities. Each active ingredient has a unique mechanism of action – which can be activation or inhibition of different biochemical pathways. Simply stated foods and supplements which are recommended are those which do not cause an increase of molecular drivers of cancer but reduce them. Else those foods should not be recommended. Foods contain multiple active ingredients – hence when evaluating foods and supplements you need to consider the impact of all active ingredients cumulatively rather than individually.

For example Pummelo contains active ingredients Apigenin, Quercetin, Formononetin, Phloretin, Delphinidin. And Black Mulberry contains active ingredients Apigenin, Quercetin, Formononetin, Phloretin, Delphinidin and possibly others.

A common mistake made when deciding and choosing foods to eat for Breast Angiosarcoma – is to evaluate only selected active ingredients contained in foods and ignore the rest. Because different active ingredients contained in foods may have opposing effects on cancer drivers – you cannot cherry pick active ingredients in foods and supplements for making a nutrition decision for Breast Angiosarcoma.

YES – FOOD CHOICES MATTER FOR CANCER. NUTRITION DECISIONS MUST CONSIDER ALL ACTIVE INGREDIENTS OF FOODS.

Skills Needed for Nutrition Personalization for Breast Angiosarcoma?

Personalized nutrition for cancers like Breast Angiosarcoma consists of recommended foods / supplements; not recommended foods / supplements with example recipes which prioritize use of recommended foods. An example of personalized nutrition can be seen at this link.

Deciding which foods are recommended or not is extremely complicated, requiring expertise in Breast Angiosarcoma biology, food science, genetics, biochemistry along with good understanding of how cancer treatments work and associated vulnerabilities by which the treatments could stop being effective.

MINIMUM KNOWLEDGE EXPERTISE NEEDED FOR NUTRITION PERSONALIZATION FOR CANCER ARE: CANCER BIOLOGY, FOOD SCIENCE, CANCER TREATMENTS AND GENETICS.

Foods to Eat After Cancer Diagnosis!

No two cancers are the same. Go beyond the common nutrition guidelines for everyone and make personalized decisions about food and supplements with confidence.

Characteristics of cancers like Breast Angiosarcoma

All cancers like Breast Angiosarcoma can be characterized by a unique set of biochemical pathways – the signature pathways of Breast Angiosarcoma. Biochemical pathways like Angiogenesis, Hypoxia, Oncogenic Cancer Epigenetics, JAK-STAT Signaling are part of the signature definition of Breast Angiosarcoma. Each individual’s cancer genetics can be different and hence their specific cancer signature could be unique.

The treatments which are effective for Breast Angiosarcoma need to be cognizant of the associated signature biochemical pathways for each cancer patient and individual at genetic risk. Therefore different treatments with different mechanisms of actions are effective for different patients. Similarly and for the same reasons foods and supplements need to be personalized for each individual. Hence some foods and supplements are recommended for Breast Angiosarcoma when taking cancer treatment Radiation, and some foods and supplements are not recommended.

Sources like cBioPortal and many others provide population representative patient anonymized data from clinical trials for all cancer indications. This data consists of clinical trial study details like sample size / number of patients, age groups, gender, ethnicity, treatments, tumor site and any genetic mutations.

DNMT3A, TET2, PPM1D, AMER1 and EPHB1 are the top ranked reported genes for Breast Angiosarcoma. DNMT3A is reported in 42.9 % of the representative patients across all clinical trials. And TET2 is reported in 35.7 %. The combined population patient data cover ages from to . 0.0 % of the patient data are identified as men. The Breast Angiosarcoma biology along with reported genetics together define the population represented signature biochemical pathways for this cancer. If the individual cancer tumor genetics or genes contributing to the risk are also known then that should also be used for nutrition personalization.

NUTRITION CHOICES SHOULD MATCH WITH EACH INDIVIDUAL’S CANCER SIGNATURE.

Foods for Breast Angiosarcoma!

Food and Supplements for Breast Angiosarcoma

For Cancer Patients

Cancer patients on treatment or on palliative care need to make decisions on food and supplements – for the needed dietary calories, for managing any treatment side effects and also for improved cancer management. All plant-based foods are not equal and choosing and prioritizing foods which are personalized and customized to ongoing cancer treatment is important and complicated. Here are some examples providing guidelines for making nutrition decisions.

Choose Vegetable CAULIFLOWER or ROMAINE LETTUCE?

Vegetable Cauliflower contains many active ingredients or bioactives such as Formononetin, Phloretin, Brassinin, Delphinidin, Stigmasterol. These active ingredients manipulate various biochemical pathways like MYC Signaling, Angiogenesis, JAK-STAT Signaling and Hypoxia and others. Cauliflower is recommended for Breast Angiosarcoma when ongoing cancer treatment is Radiation. This is because Cauliflower modifies those biochemical pathways which have been scientifically reported to sensitize the effect of Radiation.

Some of the active ingredients or bioactives in vegetable Romaine Lettuce are Apigenin, Formononetin, Phloretin, Delphinidin, Stigmasterol. These active ingredients manipulate various biochemical pathways like Angiogenesis and MYC Signaling and others. Romaine Lettuce is not recommended for Breast Angiosarcoma when ongoing cancer treatment is Radiation because it modifies those biochemical pathways which make the cancer treatment resistant or less responsive.

VEGETABLE CAULIFLOWER IS RECOMMENDED OVER ROMAINE LETTUCE FOR Breast Angiosarcoma AND TREATMENT Radiation.

Choose Fruit BLACK MULBERRY or PUMMELO?

Fruit Black Mulberry contains many active ingredients or bioactives such as Apigenin, Quercetin, Formononetin, Phloretin, Delphinidin. These active ingredients manipulate various biochemical pathways like MYC Signaling, Angiogenesis, JAK-STAT Signaling and Hypoxia and others. Black Mulberry is recommended for Breast Angiosarcoma when ongoing cancer treatment is Radiation. This is because Black Mulberry modifies those biochemical pathways which have been scientifically reported to sensitize the effect of Radiation.

Some of the active ingredients or bioactives in fruit Pummelo are Apigenin, Quercetin, Formononetin, Phloretin, Delphinidin. These active ingredients manipulate various biochemical pathways like Angiogenesis and MYC Signaling and others. Pummelo is not recommended for Breast Angiosarcoma when ongoing cancer treatment is Radiation because it modifies those biochemical pathways which make the cancer treatment resistant or less responsive.

FRUIT BLACK MULBERRY IS RECOMMENDED OVER PUMMELO FOR Breast Angiosarcoma AND TREATMENT Radiation.

Choose Nut BLACK WALNUT or EUROPEAN CHESTNUT?

Black Walnut contains many active ingredients or bioactives such as Apigenin, Quercetin, Formononetin, Ellagic Acid, Phloretin. These active ingredients manipulate various biochemical pathways like Angiogenesis and MYC Signaling and others. Black Walnut is recommended for Breast Angiosarcoma when ongoing cancer treatment is Radiation. This is because Black Walnut modifies those biochemical pathways which have been scientifically reported to sensitize the effect of Radiation.

Some of the active ingredients or bioactives in European Chestnut are Apigenin, Quercetin, Formononetin, Ellagic Acid, Phloretin. These active ingredients manipulate various biochemical pathways like Angiogenesis and MYC Signaling and others. European Chestnut is not recommended for Breast Angiosarcoma when ongoing cancer treatment is Radiation because it modifies those biochemical pathways which make the cancer treatment resistant or less responsive.

BLACK WALNUT IS RECOMMENDED OVER EUROPEAN CHESTNUT FOR Breast Angiosarcoma AND TREATMENT Radiation.

For Individuals with Genetic Risk of Cancer

The question asked by individuals who have genetic risk of Breast Angiosarcoma or familial history is “What Should I Eat Differently from Before?” and how they should choose foods and supplements to manage risks of the disease. Since for cancer risk there is nothing actionable in terms of treatment – decisions of foods and supplements become important and one of the very few actionable things which can be done. All plant-based foods are not equal and based on identified genetics and pathway signature – the choices of food and supplements should be personalized.

Choose Vegetable GIANT BUTTERBUR or TOWEL GOURD?

Vegetable Giant Butterbur contains many active ingredients or bioactives such as Curcumin, Apigenin, Lupeol, Lycopene, Protocatechuic Acid. These active ingredients manipulate various biochemical pathways like EPHRIN Signaling, PI3K-AKT-MTOR Signaling, Oncogenic Cancer Epigenetics and P53 Signaling and others. Giant Butterbur is recommended for risk of Breast Angiosarcoma when associated genetic risk is AMER1. This is because Giant Butterbur increases those biochemical pathways which counteract the signature drivers of it.

Some of the active ingredients or bioactives in vegetable Towel Gourd are Curcumin, Apigenin, Lupeol, Lycopene, Protocatechuic Acid. These active ingredients manipulate various biochemical pathways like Extracellular Matrix Remodelling, DNA Repair and MAPK Signaling and others. Towel Gourd is not recommended when risk of Breast Angiosarcoma when associated genetic risk is AMER1 because it increases the signature pathways of it.

VEGETABLE GIANT BUTTERBUR IS RECOMMENDED OVER TOWEL GOURD FOR AMER1 GENETIC RISK OF CANCER.

Choose Fruit NANCE or SASKATOON BERRY?

Fruit Nance contains many active ingredients or bioactives such as Curcumin, Apigenin, Lupeol, Protocatechuic Acid, Daidzein. These active ingredients manipulate various biochemical pathways like EPHRIN Signaling, PI3K-AKT-MTOR Signaling, Oncogenic Cancer Epigenetics and P53 Signaling and others. Nance is recommended for risk of Breast Angiosarcoma when associated genetic risk is AMER1. This is because Nance increases those biochemical pathways which counteract the signature drivers of it.

Some of the active ingredients or bioactives in fruit Saskatoon Berry are Curcumin, Apigenin, Lupeol, Lycopene, Protocatechuic Acid. These active ingredients manipulate various biochemical pathways like Extracellular Matrix Remodelling and DNA Repair and others. Saskatoon Berry is not recommended when risk of Breast Angiosarcoma when associated genetic risk is AMER1 because it increases the signature pathways of it.

FRUIT NANCE IS RECOMMENDED OVER SASKATOON BERRY FOR AMER1 GENETIC RISK OF CANCER.

Choose Nut COMMON HAZELNUT or CHESTNUT?

Common Hazelnut contains many active ingredients or bioactives such as Curcumin, Lupeol, Lycopene, Protocatechuic Acid, Daidzein. These active ingredients manipulate various biochemical pathways like Apoptosis, PI3K-AKT-MTOR Signaling, Oncogenic Cancer Epigenetics and P53 Signaling and others. Common Hazelnut is recommended for risk of Breast Angiosarcoma when associated genetic risk is AMER1. This is because Common Hazelnut increases those biochemical pathways which counteract the signature drivers of it.

Some of the active ingredients or bioactives in Chestnut are Curcumin, Apigenin, Ellagic Acid, Lupeol, Lycopene. These active ingredients manipulate various biochemical pathways like Extracellular Matrix Remodelling and DNA Repair and others. Chestnut is not recommended when risk of Breast Angiosarcoma when associated genetic risk is AMER1 because it increases the signature pathways of it.

COMMON HAZELNUT IS RECOMMENDED OVER CHESTNUT FOR AMER1 GENETIC RISK OF CANCER.


In Conclusion

Foods and Supplements chosen are important decisions for cancers like Breast Angiosarcoma. Breast Angiosarcoma patients and individuals with genetic-risk always have this question: “What foods and nutritional supplements are recommended for me and which are not?” There is a common belief which is a misconception that all plant-based foods could be beneficial or not but would not be harmful. Certain foods and supplements can interfere with cancer treatments or promote molecular pathway drivers of cancer.

There are different types of cancer indications like Breast Angiosarcoma, each with different tumor genetics with further genomic variations across each individual. Further every cancer treatment and chemotherapy has a unique mechanism of action. Each food like Cauliflower contains various bioactives in different quantities, which have an impact on different and distinct sets of biochemical pathways. The definition of personalized nutrition is individualized food recommendations for the cancer indication, treatments, genetics, lifestyle and other factors. Nutrition personalization decisions for cancer require knowledge of cancer biology, food science and an understanding of different chemotherapy treatments. Finally when there are treatment changes or new genomics is identified – the nutrition personalization needs re-evaluation.

The addon nutrition personalization solution makes the decision making easy and removes all the guesswork in answering the question, “What foods should I choose or not choose for Breast Angiosarcoma?”. The addon multi-disciplinary team includes cancer physicians, clinical scientists, software engineers and data scientists.


Personalized Nutrition for Cancer!

Cancer changes with time. Customize and modify your nutrition based on cancer indication, treatments, lifestyle, food preferences, allergies and other factors.

References

Scientifically Reviewed by: Dr. Cogle

Christopher R. Cogle, M.D. is a tenured professor at the University of Florida, Chief Medical Officer of Florida Medicaid, and Director of the Florida Health Policy Leadership Academy at the Bob Graham Center for Public Service.

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