No two cancers are the same and neither should your nutrition be. The most commonly asked question to dieticians and oncologists globally is “What Should I Eat?”. The answer is “It Depends”. It depends on the type of cancer, current treatment and supplements being taken, age, gender, BMI, lifestyle and any genetic information available. In short – the answer to “What Should I Eat” for Chronic Myeloid Leukemia (CML) needs to be personalized to minimize adverse interactions between nutrition (from foods/diet) and treatment, and to improve symptoms.
Foods like Arrowroot and Button Mushroom should be eaten when undergoing Cyclophosphamide treatment for Chronic Myeloid Leukemia. On the same lines, avoid foods like Cucumber and Marjoram with treatment of Cyclophosphamide for Chronic Myeloid Leukemia (CML). Also, Black Seed contains an active ingredient called Thymoquinone. Thymoquinone has CYP (drug metabolizing enzyme) interactions with Cyclophosphamide treatment and hence should be avoided.
You get the point – your nutrition needs to be personalized and it needs to be re-evaluated as soon as any of the conditions change. Create and follow a nutrition plan personalized to you to minimize adverse interactions of nutrition for cancers like Chronic Myeloid Leukemia (CML).
What is Chronic Myeloid Leukemia (CML)?
Chronic Myeloid Leukemia (CML), also known as Chronic Myelogenous Leukemia, is a rare cancer that affects the bone marrow and blood, by causing the body to make abnormally high numbers of white blood cells. The incidence rate of this cancer is only 1.4-2.4 per 1 lakh people per year. This cancer is commonly diagnosed in people who are about 65 years of age, however, it can occur in people of any age. According to the World Health Organization, CML diagnosis does not have any association with race or ethnicity.
Chronic Myeloid Leukemia has prevalence of certain genetic changes. Some of the genes such as BCR-ABL1, RUNX1, ASXL1, and ABL1 are known to have genetic abnormalities in this cancer resulting in a change of function.
The genetic abnormalities found in this cancer can influence specific biochemical pathways to drive these cancer cells to aggressive growth and survive the ongoing treatment. In addition, lifestyle conditions or habits like smoking, alcohol consumption and BMI (Body Mass Index) can have a big influence on the response to your physician prescribed treatments for Chronic Myeloid Leukemia. Numerous studies have consistently shown that your nutrition/diet – both food and nutritional supplements can adversely affect the treatment or be supportive or play no role. Hence, the triangulation of Chronic Myeloid Leukemia (CML) genomics, planned or ongoing therapies and lifestyle need to be thoroughly considered to make decisions on what foods and supplements to consider and avoid while designing diet/nutrition plan. Also, it is important to note that when any of these conditions change, like treatment or lifestyle or cancer diagnosis – it may impact the nutrition and the nutrition/diet plan for this cancer may have to be redesigned.
Why Eating Right Matters for Chronic Myeloid Leukemia?
In Chronic Myeloid Leukemia, activation or inhibition of some of the biochemical pathways including Oxidative Stress, Runx Signaling, Vitamin Metabolism, Hypoxia, P53 Signaling, PI3K-AKT-MTOR Signaling, Cell Cycle, Cancer Epigenetics and Growth Factor Signaling plays an important role in driving the disease. All foods and nutritional supplements contain active ingredients which have a specific molecular action on different biochemical pathways. Hence, while the intake of certain foods and nutritional supplements as part of the diet may support a specific treatment of Chronic Myeloid Leukemia, eating few other foods and supplements may lead to adverse interactions with the treatment or may increase the cancer progression.
Example Foods to “Not Eat” and Eat with Cyclophosphamide treatment for Chronic Myeloid Leukemia
The nutrition for cancer always depends on the type of cancer, treatments and supplements being taken (if any), age, gender, BMI, lifestyle and any genetic information available. Here we show changes in nutrition/diet for Chronic Myeloid Leukemia considering only the treatment changes.
Foods to Avoid with Cyclophosphamide treatment
Cucumber : Cucumber contains active ingredients such as Butyric Acid, Salicylic Acid, Cucurbitacin E and others. Butyric Acid interferes with the impact of Cyclophosphamide in Chronic Myeloid Leukemia by activating a specific biochemical pathway called Vitamin Metabolism. Hence, avoid foods like Cucumber with Cyclophosphamide treatment for Chronic Myeloid Leukemia (CML). (M Magni et al, Blood., 1996; Ronald Schilderink et al, Am J Physiol Gastrointest Liver Physiol., 2016; Edward A Copelan et al, Biol Blood Marrow Transplant., 2015)
Marjoram : Marjoram contains active ingredients such as Arbutin, Folic Acid, Ferulic Acid and others. Arbutin interferes with the impact of Cyclophosphamide in Chronic Myeloid Leukemia by blocking a specific biochemical pathway called Oxidative Stress. Hence, avoid foods like Marjoram with Cyclophosphamide treatment for Chronic Myeloid Leukemia (CML). (Hajar Safari et al, J Food Biochem., 2020; Miyun Tsai-Turton et al, Toxicol Sci., 2007; Edward A Copelan et al, Biol Blood Marrow Transplant., 2015)
Foods to Eat with Cyclophosphamide treatment
Arrowroot : Arrowroot contains active ingredients like Vitamin C, Quercetin and others. Intake of Vitamin C along with Cyclophosphamide treatment for Chronic Myeloid Leukemia causes a decrease in a specific biochemical pathway which is called PI3K-AKT-MTOR Signaling, and this is a very positive effect. Arrowroot hence should be eaten with Cyclophosphamide treatment for this cancer. (Lin Zhao et al, Mol Med Rep., 2020; J D Jensen et al, Ann Oncol., 2012; Edward A Copelan et al, Biol Blood Marrow Transplant., 2015; Q Li et al, Cancer Gene Ther., 2015)
Button Mushroom : Button Mushroom contains active ingredients like Beta-sitosterol, Linoleic Acid and Oleic Acid. Intake of Beta-sitosterol along with Cyclophosphamide treatment for Chronic Myeloid Leukemia causes a decrease in a specific biochemical pathway which is called PI3K-AKT-MTOR Signaling, and this is a very positive effect. Button Mushroom hence should be eaten with Cyclophosphamide treatment for this cancer. (Zhang-Qi Cao et al, Front Pharmacol., 2019; J D Jensen et al, Ann Oncol., 2012; Edward A Copelan et al, Biol Blood Marrow Transplant., 2015; Q Li et al, Cancer Gene Ther., 2015)
Should I take this Nutritional Supplement with Cyclophosphamide treatment?
Black Seed : Black Seed nutritional supplements contain active ingredients such as Thymoquinone which have CYP3A4 and CYP2C9 interactions with Cyclophosphamide treatment, and hence should not be used. Also, Black Seed supplement interferes with the impact of Cyclophosphamide in Chronic Myeloid Leukemia by increasing pathways like Vitamin Metabolism. Hence avoid taking Black seed supplements with Cyclophosphamide for this cancer. (Ahmed A Albassam et al, Saudi Pharm J., 2018; Priya P Gor et al, Breast Cancer Res., 2010)
Foods to Eat After Cancer Diagnosis!
No two cancers are the same. Go beyond the common nutrition guidelines for everyone and make personalized decisions about food and supplements with confidence.
What are the Symptoms of CML?
In the initial stages, most cancers including Chronic Myeloid Leukemia may not cause any signs or symptoms. However, as the disease progresses, it may start showing symptoms.
Following are some of the signs and symptoms that may be caused by this cancer.
- Bone pain
- Easy bruising and bleeding
- Loss of appetite
- Feeling full after small meals
- High fever
- Shortness of breath
- Night sweats
- Unexplained weight loss
- Pain on the left side of the stomach
- Pale skin
Though many of these symptoms may also be caused by various other health conditions, consult your doctor if you experience these symptoms to rule out the possible chances of Chronic Myeloid Leukemia.
What are the Treatment Options for this Cancer?
The treatment for Chronic Myeloid Leukemia may be decided based on different factors including the stage and extent of spread of the cancer, cancer characteristics, symptoms, patient’s general health and medical history, whether the cancer can be removed completely by surgery and whether the cancer was just diagnosed or had come back. The treatment options for this cancer include:
- Targeted therapy
- Bone marrow transplantation
As part of the diet, avoid including those foods and supplements that may adversely interact with the treatments for Chronic Myeloid Leukemia (CML).
The two most important things to remember are that cancer treatments and nutrition are never the same for everyone. Nutrition/diet which includes food and nutritional supplements is an effective tool which is controlled by you, while facing cancer such as Chronic Myeloid Leukemia.
What food you eat and which supplements you take is a decision you make. Your decision should include consideration of the cancer gene mutations, which cancer, ongoing treatments and supplements, any allergies, lifestyle information, weight, height and habits.
The nutrition planning for cancer from addon is not based on internet searches. It automates the decision making for you based on molecular science implemented by our scientists and software engineers. Irrespective of whether you care to understand the underlying biochemical molecular pathways or not - for nutrition planning for cancer that understanding is needed.
Get started NOW with your nutrition planning by answering questions on the name of cancer, genetic mutations, ongoing treatments and supplements, any allergies, habits, lifestyle, age group and gender.
Personalized Nutrition for Cancer!
Cancer changes with time. Customize and modify your nutrition based on cancer indication, treatments, lifestyle, food preferences, allergies and other factors.
Cancer patients often have to deal with different chemotherapy side effects which affect their quality of life and look out for alternative therapies for cancer. Taking the right nutrition and supplements based on scientific considerations (avoiding guesswork and random selection) is the best natural remedy for cancer and treatment related side-effects.