Foods for Chronic Myelogenous Leukemia!

Introduction

Foods for Chronic Myelogenous Leukemia should be personalized for each individual and also must adapt when cancer treatment or tumor genetic change. The personalization and adaptation must consider all the active ingredients or bioactives contained in different foods with respect to cancer tissue biology, genetics, treatments, lifestyle conditions and diet preferences. Hence while nutrition is one of the very important decisions for a cancer patient and individual at risk of cancer to make – how to choose foods to eat is not an easy task.

For Chronic Myelogenous Leukemia does it matter what vegetables, fruits, nuts, seeds one eats?

A very common nutrition question asked by cancer patients and individuals at-genetic risk of cancer is – for cancers like Chronic Myelogenous Leukemia does it matter what foods I eat and which I do not? Or if I follow a plant-based diet is that enough for cancer like Chronic Myelogenous Leukemia?

For example does it matter if vegetable Eggplant is consumed more compared to Rocket Salad (ssp.)? Does it make any difference if fruit Muscadine Grape is preferred over Lemon? Also if similar choices are made for nuts/seeds like Black Walnut over European Chestnut and for pulses like Moth Bean over Soy Bean. And if what I eat matters – then how does one identify foods which are recommended for Chronic Myelogenous Leukemia and is it the same answer for everyone with the same diagnosis or genetic risk?

Yes! Foods you eat matters for Chronic Myelogenous Leukemia!

Food recommendations may not be the same for everyone and can be different even for the same diagnosis and genetic risk.

All foods (vegetables, fruits, nuts, seeds, pulses, oils etc.) and nutritional supplements are made up of more than one active molecular ingredient or bio-actives in different proportions and quantities. Each active ingredient has a unique mechanism of action – which can be activation or inhibition of different biochemical pathways. Simply stated foods and supplements which are recommended are those which do not cause an increase of molecular drivers of cancer but reduce them. Else those foods should not be recommended. Foods contain multiple active ingredients – hence when evaluating foods and supplements you need to consider the impact of all active ingredients cumulatively rather than individually.

For example Muscadine Grape contains active ingredients Apigenin, Curcumin, Ellagic Acid, Myricetin, Isoliquiritigenin. And Lemon contains active ingredients Curcumin, D-limonene, Isoliquiritigenin, Luteolin, Linalool and possibly others.

A common mistake made when deciding and choosing foods to eat for Chronic Myelogenous Leukemia – is to evaluate only selected active ingredients contained in foods and ignore the rest. Because different active ingredients contained in foods may have opposing effects on cancer drivers – you cannot cherry pick active ingredients in foods and supplements for making a nutrition decision for Chronic Myelogenous Leukemia.

YES – FOOD CHOICES MATTER FOR CANCER. NUTRITION DECISIONS MUST CONSIDER ALL ACTIVE INGREDIENTS OF FOODS.

Skills Needed for Nutrition Personalization for Chronic Myelogenous Leukemia?

Personalized nutrition for cancers like Chronic Myelogenous Leukemia consists of recommended foods / supplements; not recommended foods / supplements with example recipes which prioritize use of recommended foods. An example of personalized nutrition can be seen at this link.

Deciding which foods are recommended or not is extremely complicated, requiring expertise in Chronic Myelogenous Leukemia biology, food science, genetics, biochemistry along with good understanding of how cancer treatments work and associated vulnerabilities by which the treatments could stop being effective.

MINIMUM KNOWLEDGE EXPERTISE NEEDED FOR NUTRITION PERSONALIZATION FOR CANCER ARE: CANCER BIOLOGY, FOOD SCIENCE, CANCER TREATMENTS AND GENETICS.

Characteristics of cancers like Chronic Myelogenous Leukemia

All cancers like Chronic Myelogenous Leukemia can be characterized by a unique set of biochemical pathways – the signature pathways of Chronic Myelogenous Leukemia. Biochemical pathways like Suppressive Histone Methylation, MAPK Signaling, Oncogenic Cancer Epigenetics, mRNA Splicing are part of the signature definition of Chronic Myelogenous Leukemia. Each individual’s cancer genetics can be different and hence their specific cancer signature could be unique.

The treatments which are effective for Chronic Myelogenous Leukemia need to be cognizant of the associated signature biochemical pathways for each cancer patient and individual at genetic risk. Therefore different treatments with different mechanisms of actions are effective for different patients. Similarly and for the same reasons foods and supplements need to be personalized for each individual. Hence some foods and supplements are recommended for Chronic Myelogenous Leukemia when taking cancer treatment Bosutinib, and some foods and supplements are not recommended.

Sources like cBioPortal and many others provide population representative patient anonymized data from clinical trials for all cancer indications. This data consists of clinical trial study details like sample size / number of patients, age groups, gender, ethnicity, treatments, tumor site and any genetic mutations.

TET2, ABL1, SF3B1, ASXL1 and BCOR are the top ranked reported genes for Chronic Myelogenous Leukemia. TET2 is reported in 30.0 % of the representative patients across all clinical trials. And ABL1 is reported in 20.0 %. The combined population patient data cover ages from to . 0.0 % of the patient data are identified as men. The Chronic Myelogenous Leukemia biology along with reported genetics together define the population represented signature biochemical pathways for this cancer. If the individual cancer tumor genetics or genes contributing to the risk are also known then that should also be used for nutrition personalization.

NUTRITION CHOICES SHOULD MATCH WITH EACH INDIVIDUAL’S CANCER SIGNATURE.

Food and Supplements for Chronic Myelogenous Leukemia

For Cancer Patients

Cancer patients on treatment or on palliative care need to make decisions on food and supplements – for the needed dietary calories, for managing any treatment side effects and also for improved cancer management. All plant-based foods are not equal and choosing and prioritizing foods which are personalized and customized to ongoing cancer treatment is important and complicated. Here are some examples providing guidelines for making nutrition decisions.

Choose Vegetable EGGPLANT or ROCKET SALAD (SSP.)?

Vegetable Eggplant contains many active ingredients or bioactives such as Curcumin, Quercetin, Myricetin, Isoliquiritigenin, Formononetin. These active ingredients manipulate various biochemical pathways like RAS-RAF Signaling, Cell Cycle, PI3K-AKT-MTOR Signaling and Suppressive Histone Methylation and others. Eggplant is recommended for Chronic Myelogenous Leukemia when ongoing cancer treatment is Bosutinib. This is because Eggplant modifies those biochemical pathways which have been scientifically reported to sensitize the effect of Bosutinib.

Some of the active ingredients or bioactives in vegetable Rocket Salad (ssp.) are Apigenin, Curcumin, Quercetin, Myricetin, Isoliquiritigenin. These active ingredients manipulate various biochemical pathways like Oncogenic Cancer Epigenetics and MAPK Signaling and others. Rocket Salad (ssp.) is not recommended for Chronic Myelogenous Leukemia when ongoing cancer treatment is Bosutinib because it modifies those biochemical pathways which make the cancer treatment resistant or less responsive.

VEGETABLE EGGPLANT IS RECOMMENDED OVER ROCKET SALAD (SSP.) FOR Chronic Myelogenous Leukemia AND TREATMENT Bosutinib.

Choose Fruit LEMON or MUSCADINE GRAPE?

Fruit Lemon contains many active ingredients or bioactives such as Curcumin, D-limonene, Isoliquiritigenin, Luteolin, Linalool. These active ingredients manipulate various biochemical pathways like MAPK Signaling, Cell Cycle, PI3K-AKT-MTOR Signaling and Cell Survival and others. Lemon is recommended for Chronic Myelogenous Leukemia when ongoing cancer treatment is Bosutinib. This is because Lemon modifies those biochemical pathways which have been scientifically reported to sensitize the effect of Bosutinib.

Some of the active ingredients or bioactives in fruit Muscadine Grape are Apigenin, Curcumin, Ellagic Acid, Myricetin, Isoliquiritigenin. These active ingredients manipulate various biochemical pathways like PI3K-AKT-MTOR Signaling, Oncogenic Cancer Epigenetics and MYC Signaling and others. Muscadine Grape is not recommended for Chronic Myelogenous Leukemia when ongoing cancer treatment is Bosutinib because it modifies those biochemical pathways which make the cancer treatment resistant or less responsive.

FRUIT LEMON IS RECOMMENDED OVER MUSCADINE GRAPE FOR Chronic Myelogenous Leukemia AND TREATMENT Bosutinib.

Choose Nut BLACK WALNUT or EUROPEAN CHESTNUT?

Black Walnut contains many active ingredients or bioactives such as Apigenin, Curcumin, Quercetin, Ellagic Acid, Myricetin. These active ingredients manipulate various biochemical pathways like Cell Cycle, PI3K-AKT-MTOR Signaling, MAPK Signaling and MYC Signaling and others. Black Walnut is recommended for Chronic Myelogenous Leukemia when ongoing cancer treatment is Bosutinib. This is because Black Walnut modifies those biochemical pathways which have been scientifically reported to sensitize the effect of Bosutinib.

Some of the active ingredients or bioactives in European Chestnut are Apigenin, Curcumin, Quercetin, Ellagic Acid, Myricetin. These active ingredients manipulate various biochemical pathways like PI3K-AKT-MTOR Signaling, Oncogenic Cancer Epigenetics and MYC Signaling and others. European Chestnut is not recommended for Chronic Myelogenous Leukemia when ongoing cancer treatment is Bosutinib because it modifies those biochemical pathways which make the cancer treatment resistant or less responsive.

BLACK WALNUT IS RECOMMENDED OVER EUROPEAN CHESTNUT FOR Chronic Myelogenous Leukemia AND TREATMENT Bosutinib.

For Individuals with Genetic Risk of Cancer

The question asked by individuals who have genetic risk of Chronic Myelogenous Leukemia or familial history is “What Should I Eat Differently from Before?” and how they should choose foods and supplements to manage risks of the disease. Since for cancer risk there is nothing actionable in terms of treatment – decisions of foods and supplements become important and one of the very few actionable things which can be done. All plant-based foods are not equal and based on identified genetics and pathway signature – the choices of food and supplements should be personalized.

Choose Vegetable BITTER GOURD or DAIKON RADISH?

Vegetable Bitter Gourd contains many active ingredients or bioactives such as Curcumin, Apigenin, Lupeol, Daidzein, Protocatechuic Acid. These active ingredients manipulate various biochemical pathways like Apoptosis, PI3K-AKT-MTOR Signaling, Oncogenic Cancer Epigenetics and P53 Signaling and others. Bitter Gourd is recommended for risk of Chronic Myelogenous Leukemia when associated genetic risk is ABL1. This is because Bitter Gourd increases those biochemical pathways which counteract the signature drivers of it.

Some of the active ingredients or bioactives in vegetable Daikon Radish are Curcumin, Apigenin, Lupeol, Daidzein, Protocatechuic Acid. These active ingredients manipulate various biochemical pathways like PI3K-AKT-MTOR Signaling and Oncogenic Cancer Epigenetics and others. Daikon Radish is not recommended when risk of Chronic Myelogenous Leukemia when associated genetic risk is ABL1 because it increases the signature pathways of it.

VEGETABLE BITTER GOURD IS RECOMMENDED OVER DAIKON RADISH FOR ABL1 GENETIC RISK OF CANCER.

Choose Fruit NANCE or PUMMELO?

Fruit Nance contains many active ingredients or bioactives such as Curcumin, Apigenin, Lupeol, Daidzein, Protocatechuic Acid. These active ingredients manipulate various biochemical pathways like Apoptosis, PI3K-AKT-MTOR Signaling, Oncogenic Cancer Epigenetics and P53 Signaling and others. Nance is recommended for risk of Chronic Myelogenous Leukemia when associated genetic risk is ABL1. This is because Nance increases those biochemical pathways which counteract the signature drivers of it.

Some of the active ingredients or bioactives in fruit Pummelo are Curcumin, Apigenin, Lupeol, Lycopene, Daidzein. These active ingredients manipulate various biochemical pathways like Cell Cycle Checkpoints and DNA Repair and others. Pummelo is not recommended when risk of Chronic Myelogenous Leukemia when associated genetic risk is ABL1 because it increases the signature pathways of it.

FRUIT NANCE IS RECOMMENDED OVER PUMMELO FOR ABL1 GENETIC RISK OF CANCER.

Choose Nut COMMON HAZELNUT or CHESTNUT?

Common Hazelnut contains many active ingredients or bioactives such as Curcumin, Lupeol, Lycopene, Daidzein, Quercetin. These active ingredients manipulate various biochemical pathways like Apoptosis, PI3K-AKT-MTOR Signaling, Oncogenic Cancer Epigenetics and P53 Signaling and others. Common Hazelnut is recommended for risk of Chronic Myelogenous Leukemia when associated genetic risk is ABL1. This is because Common Hazelnut increases those biochemical pathways which counteract the signature drivers of it.

Some of the active ingredients or bioactives in Chestnut are Curcumin, Apigenin, Ellagic Acid, Lupeol, Lycopene. These active ingredients manipulate various biochemical pathways like Cell Cycle Checkpoints and DNA Repair and others. Chestnut is not recommended when risk of Chronic Myelogenous Leukemia when associated genetic risk is ABL1 because it increases the signature pathways of it.

COMMON HAZELNUT IS RECOMMENDED OVER CHESTNUT FOR ABL1 GENETIC RISK OF CANCER.

In Conclusion

Foods and Supplements chosen are important decisions for cancers like Chronic Myelogenous Leukemia. Chronic Myelogenous Leukemia patients and individuals with genetic-risk always have this question: “What foods and nutritional supplements are recommended for me and which are not?” There is a common belief which is a misconception that all plant-based foods could be beneficial or not but would not be harmful. Certain foods and supplements can interfere with cancer treatments or promote molecular pathway drivers of cancer.

There are different types of cancer indications like Chronic Myelogenous Leukemia, each with different tumor genetics with further genomic variations across each individual. Further every cancer treatment and chemotherapy has a unique mechanism of action. Each food like Eggplant contains various bioactives in different quantities, which have an impact on different and distinct sets of biochemical pathways. The definition of personalized nutrition is individualized food recommendations for the cancer indication, treatments, genetics, lifestyle and other factors. Nutrition personalization decisions for cancer require knowledge of cancer biology, food science and an understanding of different chemotherapy treatments. Finally when there are treatment changes or new genomics is identified – the nutrition personalization needs re-evaluation.

The addon nutrition personalization solution makes the decision making easy and removes all the guesswork in answering the question, “What foods should I choose or not choose for Chronic Myelogenous Leukemia?”. The addon multi-disciplinary team includes cancer physicians, clinical scientists, software engineers and data scientists.

References

• Mds Mskcc 2020
• D-Limonene modulates inflammation, oxidative stress and Ras-ERK pathway to inhibit murine skin tumorigenesis.
• Hesperetin induces apoptosis of esophageal cancer cells via mitochondrial pathway mediated by the increased intracellular reactive oxygen species.
• Growth stimulation of human pulmonary adenocarcinoma cells and small airway epithelial cells by beta-carotene via activation of cAMP, PKA, CREB and ERK1/2.
• Geraniol, a component of plant essential oils, sensitizes human colonic cancer cells to 5-Fluorouracil treatment.
• Paederia foetida induces anticancer activity by modulating chromatin modification enzymes and altering pro-inflammatory cytokine gene expression in human prostate cancer cells.
• Gallic acid provokes DNA damage and suppresses DNA repair gene expression in human prostate cancer PC-3 cells.