Yimuphi umdlavuza ongazuza ngokufaka i-Naringenin ekudleni kwabo?

Amaphuzu avelele

I-Naringenin yaziwa kabanzi ngezinzuzo zayo zezempilo futhi ivame ukusetshenziswa iziguli ezinomdlavuza nalabo abasengozini yofuzo. Kodwa-ke, ukuphepha nokusebenza kahle kwe-Naringenin ezigulini ezinomdlavuza kuncike ezintweni eziningi ezifana nenkomba yomdlavuza, i-chemotherapy, ezinye izindlela zokwelapha, kanye nofuzo lwesimila. Ukwazi ukuthi okunye ukudla kanye nezithako zokudla, okufana ne-grapefruit nesipinashi, kungase kuhlanganyele kabi nemithi yomdlavuza futhi kubangele ukusabela okubi kubalulekile.

Ukudla kubalulekile ekwelapheni umdlavuza njengoba kungathinta imiphumela yokwelashwa. Iziguli ezinomdlavuza kufanele zikhethe ngokucophelela futhi zihlanganise ukudla okufanele kanye nezithako zokudla ezidliwayo. Isibonelo, i-Naringenin ingase izuze labo abane-Primary Urethral Adenocarcinoma abathola i-Radiation, kodwa kungase kungabi kuhle ezigulini ezithola i-Radiation for Primary Embryonal Carcinoma. Ngaphezu kwalokho, nakuba i-Naringenin ingasiza abantu abanesici sengozi yofuzo “ERBB2”, ingase ingaphakanyiswe kulabo abasengozini yofuzo ehlukile. Ukwenza kube ngokwakho izinhlelo zokudla ezisuselwe empilweni, ukwelashwa, kanye nofuzo kubalulekile.

Ukuqonda ukuthi ukwenza isinqumo ngokufaneleka kwe-Naringenin esigulini esinomdlavuza kudinga ukwenziwa umuntu ngamunye kubalulekile. Izici ezibalulekile njengohlobo lomdlavuza, izindlela zokwelapha, ukwakheka kofuzo, izingozi zofuzo, ubudala, isisindo somzimba, nendlela yokuphila zibalulekile ekunqumeni ukuthi i-Naringenin iyisinqumo esifanele yini. I-Genomics kanye ne-genomics, ikakhulukazi, ibhekwa njengento ebalulekile. Njengoba lezi zici zingashintsha, kubalulekile ukubuyekeza njalo futhi ulungise ukukhetha kokudla ukuze kufane nezinguquko zesimo sezempilo kanye nokwelashwa.

Sengiphetha, indlela ephelele yokukhetha ukudla ibalulekile, igxile emiphumeleni yonke yazo zonke izakhi ezisebenzayo ekudleni/izithasiselo ezifana ne-Naringenin esikhundleni sokuhlola isithako ngasinye esisebenzayo ngokwehlukana noma ukuziba ngokuphelele. Lo mbono obanzi ukhuthaza indlela enengqondo nengokwesayensi yokuhlelela ukudla komdlavuza.

Ukufingqiwe Okufushane

Ukusetshenziswa kokudla okusekelwe ezitshalweni nezithasiselo, njengamavithamini, amakhambi, amaminerali, ama-probiotics, kanye nezithako ezihlukahlukene ezikhethekile, ziyakhula phakathi kweziguli ezinomdlavuza. Lezi zithako zenzelwe ukuletha ukugxila okuphezulu kwezithako ezithile ezisebenzayo, eziningi zazo ezitholakala ekudleni okuhlukile. Ukugxila kanye nokwehlukahlukana kwezithako ezisebenzayo kuyahluka phakathi kokudla okuphelele nezithako zokudla. Ukudla ngokuvamile kunikeza uhla lwezithako ezisebenzayo kodwa ekugxiliseni okuphansi, kuyilapho izithako zinikeza ukugxila okuphezulu kwezithako ezithile.

Uma kucatshangelwa imisebenzi eyahlukene yesayensi neyebhayoloji yesithako ngasinye esisebenzayo ezingeni lamangqamuzana, kubalulekile ukulandisa ngemiphumela ehlanganisiwe yalezi zingxenye lapho unquma ngokudla nezithako okumelwe uzidle noma cha.

Umbuzo obalulekile ophakamayo: Ingabe kufanele ufake i-Naringenin ekudleni kwakho njengento yokudla noma isengezo? Ingabe kuyafaneleka ukuthi udle i-Naringenin uma unezakhi zofuzo ezitholakala kumdlavuza ohambisana nofuzo lwe-ERBB2? Kuthiwani uma esikhundleni salokho ingozi yakho yofuzo ivela esakhiweni sofuzo? Ingabe kunenzuzo ukufaka i-Naringenin ekudleni kwakho uma kutholakala ukuthi une-Primary Embryonal Carcinoma, noma uma ukuxilongwa kwakho kuyi-Primary Urethral Adenocarcinoma? Ngaphezu kwalokho, indlela osebenzisa ngayo i-Naringenin kufanele ilungiswe kanjani uma welashelwa I-Radiation noma uma uhlelo lwakho lokwelapha lusuka ku-Radiation luye ku-Radiation? Kubalulekile ukuqaphela ukuthi izisho ezilula njengokuthi 'i-Naringenin ingokwemvelo, ngakho-ke ihlale inenzuzo' noma 'i-Naringenin ithuthukisa ukungatheleleki' akwanele ekukhetheni ukudla/izithasiselo ezinolwazi.

Ukwengeza, kubalulekile ukuhlola kabusha ukufaneleka kokufaka i-Naringenin ekudleni kwakho uma kukhona izinguquko ohlelweni lwakho lokwelapha. Kafushane, lapho wenza izinqumo mayelana nokufaka ukudla noma izithasiselo ezifana ne-Naringenin ekudleni kwakho ukuze uthole izinzuzo zayo, kufanele ucabangele yonke imiphumela ye-biochemical yazo zonke izithako, ucabangela izici ezifana nohlobo lomdlavuza, ukwelashwa okuqondile okwenzayo, izakhi zofuzo. , nokukhetha indlela yokuphila.

Cancer

Umdlavuza useyinselele enkulu emkhakheni wezokwelapha, ngokuvamile obangela ukukhathazeka okusabalele. Kodwa-ke, intuthuko yakamuva iye yathuthukisa imiphumela yokwelashwa, ikakhulukazi ngezindlela zokwelashwa eziqondene nomuntu siqu, izindlela zokuqapha ezingahlaseli kusetshenziswa amasampula egazi namathe, kanye nokuthuthukiswa kwe-immunotherapy. Ukutholwa kusenesikhathi kanye nokungenelela okufika ngesikhathi kuye kwaba semqoka ekube nomthelela omuhle emiphumeleni yokwelapha iyonke.

Ukuhlolwa kofuzo kunikeza isithembiso esibalulekile ekuhloleni ubungozi bomdlavuza kanye nokuba sengozini kusenesikhathi. Kodwa-ke, kubantu abaningi abanomdlavuza womndeni kanye nezakhi zofuzo, izinketho zokungenelela kwezokwelapha, ngisho nokuqapha okuvamile, ngokuvamile kunqunyelwe noma akukho. Lapho kutholakala ukuthi unohlobo oluthile lomdlavuza, njenge-Primary Urethral Adenocarcinoma noma i-Primary Embryonal Carcinoma, amasu okwelapha kudingeka enziwe ngokwezifiso ngokusekelwe kufuzo lwesimila somuntu, isigaba sesifo, kanye nezici ezifana neminyaka nobulili.”

Ngemuva kokwelashwa, ukuqapha okuqhubekayo kubalulekile ukuze kutholwe noma yiziphi izimpawu zokubuya komdlavuza futhi nokwazisa izinqumo ezilandelayo. Iziguli eziningi ezinomdlavuza kanye nalezo ezisengozini zivame ukufuna izeluleko zokufaka ukudla okuthile nezithako zokudla ezikudlayo, okudlala indima ebalulekile ekuthathweni kwazo zonke izinqumo mayelana nokuphathwa kwezempilo.

Umbuzo obalulekile ngowokuthi kufanele kufakwe engcupheni yofuzo kanye nokuxilongwa okuthile komdlavuza lapho unquma ngokukhetha ukudla, njengeNaringenin. Ingabe ingozi yofuzo yomdlavuza osukela ekuguqukeni kwe-ERBB2 inemithelela efanayo ye-biochemical pathway njengokuguqulwa kwesinye isakhi sofuzo? Ngokombono wokudla okunempilo, ingabe ingozi ehambisana ne-Primary Urethral Adenocarcinoma ilingana ne-Primary Embryonic Carcinoma? Ngaphezu kwalokho, ingabe ukucatshangelwa kokudla kuhlala kunjalo kulabo abathola iRadiation njengalabo abathola iRadiation? Lokhu kucatshangelwa kubalulekile ekwenzeni ukukhetha kokudla okunolwazi kubantu abanezingozi zofuzo ezahlukene kanye nokwelashwa komdlavuza.

I-Naringenin - Isengezo Sokudla Okunomsoco

Isengezo i-Naringenin sihlanganisa uhla lwezithako ezisebenzayo, okuhlanganisa i-Naringenin ne-Naringetol, ngayinye ekhona ngokugxila okuhlukahlukene. Lezi zithako zithonya izindlela zamangqamuzana, ikakhulukazi i-TGFB Signaling, Oxidative Stress, WNT Beta Catenin Signaling kanye nePhospholipase Signaling, elawula izici ezibucayi zomdlavuza ezingeni lamaselula, njengokukhula kwesimila, ukusabalala, nokufa kweseli. Njengoba kunikezwe leli thonya lebhayoloji, ukukhetha izithasiselo ezifanele njenge-Naringenin, iyodwa noma ihlangene, kuba yisinqumo esibucayi kumongo wokudla komdlavuza. Uma ucabangela ukusebenzisa i-Naringenin yomdlavuza, kubalulekile ukucabangela lezi zici nezindlela ezihlukahlukene. Lokhu kungenxa yokuthi, ngokufana nokwelashwa komdlavuza, ukusetshenziswa kwe-Naringenin akusona isinqumo somhlaba wonke esilungele wonke umdlavuza kodwa sidinga ukwenziwa ngezifiso.

Ukukhetha Izithako zeNaringenin

Ukubhekana nombuzo othi 'Kufanele ngiyigweme nini i-Naringenin esimweni somdlavuza' kuyinselele ngoba impendulo iqondene nomuntu ngamunye kakhulu - imane nje 'Kuncike!'. Ngokufana nokuthi noma yikuphi ukwelashwa komdlavuza kungase kungasebenzi kuso sonke isiguli, ukubaluleka nokuphepha noma izinzuzo ze-Naringenin ziyahlukahluka kuye ngezimo zomuntu siqu. Izinto ezifana nohlobo oluthile lomdlavuza, izakhi zofuzo, ukwelashwa kwamanje, ezinye izithako ezithathwayo, imikhuba yokuphila, i-BMI, nanoma yikuphi ukungezwani komzimba nakho konke kunendima ekunqumeni ukuthi i-Naringenin ifanelekile noma kufanele igwenywe, kugcizelela ukubaluleka kokucatshangelwa komuntu siqu izinqumo ezinjalo.

1. Ingabe I-Naringenin Supplements izozizuzisa Iziguli Eziyi-Primary Embrynal Carcinoma ezelashwa ngeRadiation?

I-Primary Embryonal Carcinoma ibonakala ngokuguquguquka okuthile kofuzo, okuyi-CAPN7, B3GNT8 kanye ne-KNTC1, okuholela ekuguqulweni kwezindlela ze-biochemical, ikakhulukazi I-Oxidative Stress. Ukusebenza kokwelashwa komdlavuza, okufana neRadiation, kuncike endleleni yokusebenza kwayo kulezi zindlela ezithile. Isu elifanele libandakanya ukuvumelanisa isenzo sokwelashwa nezindlela ezishayela umdlavuza, ngaleyo ndlela kuqinisekiswe indlela yomuntu siqu nephumelelayo. Ezimweni ezinjalo, ukugwema ukudla noma izithasiselo zokudla okunomsoco ezingase zimelane nemiphumela yokwelashwa noma zinciphise lokhu kuqondanisa kubalulekile. Isibonelo, isithasiselo se-Naringenin, esithinta i-Oxidative Stress, kungase kungabi inketho elungile esimweni se-Primary Embryonal Carcinoma lapho ubhekene ne-Radiation. Lokhu kungenxa yokuthi kungase kubhebhethekise ukuqhubeka kwesifo noma kuphazamise ukusebenza kahle kokwelashwa. Lapho ukhetha uhlelo lokudla okunempilo, kubalulekile ukucabangela izici ezifana nohlobo lomdlavuza, ukwelashwa okuqhubekayo, ubudala, ubulili, i-BMI, indlela yokuphila, nanoma yikuphi ukuguqulwa kofuzo okwaziwayo.

2. Ingabe Izithasiselo ze-Naringenin zizozizuzisa Iziguli Eziyinhloko ze-Urethral Adenocarcinoma ezelashwa Ngemisebe?

I-Adenocarcinoma eyinhloko ye-Urethral ikhonjwa ngokuguqulwa kofuzo okukhethekile, okufana ne-KRAS, i-ATRX ne-SMO, okuholela ezinguqukweni zezindlela zamakhemikhali ezinto eziphilayo, ikakhulukazi i-TGFB Signaling, i-G-protein-coupled Receptor Signaling kanye ne-Growth Factor Signaling. Ukusebenza kokwelashwa komdlavuza, njengeRadiation, kunqunywa ukusebenzisana kwayo nalezi zindlela. Inhloso ukuqinisekisa ukuthi ukwelashwa kuhambisana kahle nezindlela eziqhuba umdlavuza, okwenza kube nendlela yokwelapha yomuntu siqu. Kulo mongo, ukudla noma izithasiselo ezihambisana nokwelashwa noma ezithuthukisa lokhu kuqondanisa kufanele kucatshangelwe. Isibonelo, isithasiselo se-Naringenin siyindlela enengqondo yalabo abane-Primary Urethral Adenocarcinoma abathola iRadiation. Lokhu kungenxa yokuthi i-Naringenin ithonya izindlela ezifana ne-TGFB Signaling, engavimbela izici ezishayela i-Primary Urethral Adenocarcinoma noma izuzise ukusebenza ngempumelelo KoMsebe.

3. Ingabe Izithasiselo ze-Naringenin Ziphephile Kubantu Abanempilo Enempilo Ene-ERBB2 Mutation Associated Genetic Risk?

I-ERBB2 idlala indima ebalulekile ekuhloleni ubungozi bomdlavuza. Ukuguqulwa kwezakhi zofuzo ku-ERBB2 kungaphazamisa izindlela ezibalulekile ze-biochemical, okuhlanganisa i-Phospholipase Signaling, i-Growth Factor Signaling kanye ne-PI3K-AKT-MTOR Signaling, enomthelela ekuthuthukisweni komdlavuza. Uma iphaneli yakho yofuzo yembula ukuguqulwa kwezakhi zofuzo ku-ERBB2 ehambisana ne-Esophageal Adenocarcinoma, cabanga ukufaka izithako ze-Naringenin ohlelweni lwakho lokudla. Lezi zithako zingaba nomthelela omuhle ezindleleni ezifana ne-Phospholipase Signaling, zizuze ngokunikeza ukusekelwa okufanelekile kubantu abanezinguquko ze-ERBB2 kanye nokukhathazeka kwezempilo okuhlobene.

Ekuphetheni

Izinto ezimbili ezibaluleke kakhulu okufanele uzikhumbule ukuthi ukwelapha umdlavuza nokudla okunempilo akufani kuwo wonke umuntu. Ukudla okunomsoco, okuhlanganisa ukudla nezithako ezifana ne-Naringenin, iyithuluzi elisebenzayo elingalawulwa nguwe ngenkathi ubhekene nomdlavuza.

“Kufanele ngidleni?” umbuzo ovame ukubuzwa yiziguli ezinomdlavuza nalabo abasengozini yomdlavuza. Impendulo efanele ukuthi incike ezintweni ezifana nohlobo lomdlavuza, ufuzo lwesimila, ukwelashwa kwamanje, ukungezwani komzimba nezinto ezithile, indlela yokuphila, kanye ne-BMI.

Thola umsoco wakho womdlavuza ku-addon ngokuchofoza isixhumanisi esingezansi futhi uphendule imibuzo emayelana nohlobo lomdlavuza wakho, ukwelashwa, indlela yokuphila, izinto ezingezwani nazo, iminyaka, nobulili.

Okubhekwayo

• Iqhaza le-KEAP1/NRF2 kanye ne-TP53 Ukuguqulwa Kwe-Lung Squamous Cell Carcinoma Development kanye Nokumelana Nemisebe.
• I-Hesperetin kanye ne-Naringenin ziqwashisa amaseli omdlavuza we-HER2 ekufeni ngokusebenza njenge-HER2 Tyrosine Kinase inhibitors.
• Ucwaningo lwe-molecule eyodwa lomthelela wokuvimbela we-Naringenin ekuguquleni isibopho sokukhula-β ligand-receptor.
• cBioPortal for Cancer Genomics
• cBioPortal for Cancer Genomics
• Ukumelana nomsakazo kumaseli omdlavuza webele kulamula nge-TGF-β signalling, hybrid epithelial-mesenchymal phenotype kanye namaseli omdlavuza.
• Isimo esiguquguqukayo somdlavuza we-metastatic sivezwe kusukela ekulandeleni okungase kube khona kweziguli eziyi-10,000.
• Amaphethini Eseli-Omsuka Abusa Ukuhlukaniswa Kwemolekyuli Yezimila Eziyi-10,000 Ezinhlotsheni Ezingu-33 Zomdlavuza.